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Abstracts Of Oral Presentations

CO2 Summit: Technology and Opportunity

Abstracts of Oral Presentations and Keynote Lectures

Greenhouse Gas Capture And Mitigation Techniques For Different Industries, Trapti Chaubey

CO2 Summit: Technology and Opportunity

No abstract provided.

Co2 Conversion To Organic Compounds And Polymeric Precursors, Jussara Lopes De Miranda

CO2 Summit: Technology and Opportunity

No abstract provided.

Challenges In Confronting Pandemic Influenza Using Novel Adjuvanted Vaccines, Louis F. Fries

Vaccine Technology III

Pandemic influenza is a recurring threat throughout history. Characterized by rapid spread and high attack rate, the features of pandemic influenza are grounded in the lack of immunologic experience with pandemic virus subtypes in the majority of the human population alive during the outbreak. Immunization is regarded as a key tool in preparing for, and mitigating, pandemic influenza. Unfortunately, capacity to manufacture sufficient inactivated influenza antigen by currently-licensed processes remains challenging, and this problem is amplified by the very short timeline for production and distribution that may be available. GSK has addressed the pandemic influenza challenge by application of the …

Development Of A Multi-Dose Formulation For Prevnar 13™, Lakshmi Khandke, Cindy Yang, Jingrun Fan, Hanyoung Han, Ksenia Krylova Abbas Rashidbaigi, Bruce A. Green, Kathrin U. Jansen

Vaccine Technology III

Streptococcus pneumoniae causes up to a million cases per year of invasive disease in young children and infants, most occurring in developing countries. Pfizer is partnering with WHO and the GAVI alliance to support the developing world on immunization against pneumococcal disease. Prevnar 13™ is currently approved for the prevention of invasive pneumococcal disease in twenty seven countries. If used widely, this pneumococcal conjugate vaccine could prevent hundreds of thousands of additional cases of child mortality each year.

Use of single-dose preservative-free vaccine formulations will raise the overall cost of vaccination programs and may jeopardize the effectiveness of immunization programs …

Innovative Therapeutic Cancer Vaccines In Cuba: An Update, Luis Enrique Fernández

Vaccine Technology III

Worldwide cancer affects more than 10 million new people each year while other 22 million are living with this devastating disease.

Cancer vaccines are the newest weapon in the battle against this disease, specifically increasing body's natural abilities to halt tumour progression. Currently, 141 distinct projects are at different stages of clinical development.

The Cuban Biotech System of Institutions has been actively involved in this field for almost 20 years, resulting that 8 innovative therapeutic cancer vaccine projects are currently under clinical investigation.

The main focus of these projects is to impact the principal cancer localizations afecting Cuban population, like …

Final Conference Program, Barry Buckland, John Aunins, Paula Marques Alves, Kathrin Jansen

Vaccine Technology III

List of talks during the conference.

Manufacturing Flu Vaccine In Mexico: A Major Public Health And Technology Transfer Challenge, Roger Vinas

Vaccine Technology III

As Health partner of Mexican Public authorities initiative, Sanofi Pasteur is committed to build a Flu Bulk Vaccine Site, on Mexican soil, in order, for this country, to be self-sufficient for supplying seasonal vaccine and, especially,in case of a Flu Pandemic event. This presentation will give highlights on key drivers to consider while transferring this kind of Technology from Europe to Mexico: - Technology Transfer guidelines: stepwise process - Getting Permits/Authorizations - Looking for partners/Contractors: Engineering and Construction phases - Staffing ramp-up for Manufacturing (Production and Quality Control) start-up

Building Process Understanding For Vaccine Manufacturing Using Data Mining, Matthew Wiener

Vaccine Technology III

The production of vaccines is a complex biological process, with long cycle times and a high level of variation in raw materials, biological growth rates, and test methods. While long-term shifts or cycles in yield are not unusual, it is important to build understanding of the causes of shifts and cycles, for greater control and predictability. Hundreds of variables are monitored for every batch of vaccine produced; however, the relationships between product quality and the many process variables are difficult to quantify. In this article, we describe how mining historical process data using random forests and partial least squares (PLS) …

New Vaccine Technologies: Promising Advances May Save More Lives, John Boslego

Vaccine Technology III

In the past 20 years, immunization has prevented nearly 20 million deaths from vaccine-preventable infections. Despite this success, poorer countries often lack access to newer and more expensive vaccines, and vaccines are not yet available for many illnesses. PATH is working to narrow the immunization gap between developed countries and developing countries by increasing the availability of existing vaccines, reducing the lag time for adoption of recently-licensed vaccines, developing technology in support of vaccines and immunization (e.g. vaccine vial monitor, Uniject, vaccine stabilization platforms) and working with partners to develop new vaccines.

Vaccine development is expensive and manufacturers often focus …

The Challenge Of Developing New Generation Vaccines For Control And Eradication Of Foot And Mouth Disease In South America, Susana Levy

Vaccine Technology III

Foot and mouth disease (FMD) is a highly infectious viral disease that affects food producing animals such as cattle, pigs and sheep. The FMD status given by the World Organization for Animal Health (OIE) has a huge financial impact on countries that have economies based on meat trade. In the past 15 years the MERCOSUR countries (Argentina, Brazil, Paraguay and Uruguay) have consolidated industrial processes to supply the region with safe and efficacious vaccines to prevent FMD in livestock. Control and eradication programs rely heavily on compulsory vaccination with multivalent whole virus inactivated vaccines. Currently, vaccines are industrially obtained by …

Vaccine Stabilization – Research, Commercialization, And Impact, Ray Cummings, Debra Kristensen, Dexiang Chen, Michel Zaffran

Vaccine Technology III

Improving the stability of vaccines and removing vaccines from refrigerated storage for all or part of their shelf life have been proposed as strategies to help ensure vaccine effectiveness and to mitigate cold chain storage capacity constraints and escalating costs associated with the introduction of new vaccines into developing countries. Over the last six years, PATH has conducted research on stabilization of measles, Haemophilus influenzae type b (Hib), hepatitis B, enterotoxgenic Escherichia coli, conjugate meningococcal A, and pentavalent (Diphtheria-Tetanus-Pertussis-hepatitis B-Hib) vaccines in collaboration with 22 technical partners and 10 vaccine development groups. Results will be shared and include marked improvement …

Process Scale-Up And Optimization For Production Of High Efficacy Oral Rabies Vaccine, Amine Kamen, Chun Fang Shen, Stephane Lanthier, Danielle Jacob, Johnny Montes, Andrew Beresford

Vaccine Technology III

Rabies is an important causative agent of disease resulting in an acute infection of the nervous system and death of the individual. Rabies remains an important public health program in developing countries, and the indigenous threat of rabies continues in developed countries because of wildlife reservoirs. Globally, there are about 55,000 fatal human cases of rabies each year [WHO, 2007]. Control of rabies in wildlife remains an important challenge for government offices.

There are numbers of rabies vaccines commercially available for controls of wildlife rabies. However, these vaccines currently distributed to wildlife do not effectively immunize all at-risk species, especially …

The Global Manufacture Of Polio Vaccine In The Endgame Of Eradication, Philip Minor

Vaccine Technology III

The manufacture of medicines is increasingly globalised but biological products such as vaccines are more complex and their production raises significantly different issues to that of chemical entities. New producers in any region of the world may have difficulty in recognising all the concerns involved and can benefit from technology transfer exercises and a strong and scientifically competent regulatory authority. The issues will be discussed in the context of the Global Polio Eradication Initiative in its terminal phases and future needs for the manufacture of polio vaccine.

Potent, Rapid And Cost-Effective Influenza Vaccines Made In E. Coli, Thomas Hofstaetter

Vaccine Technology III

The traditional influenza vaccine, trivalent inactivated virus (TIV) has been in use in the United States in one form or another since the 1940s. The system for production involves injecting influenza virus into embryonated hen’s eggs, harvesting the allantoic fluid containing the virus, inactivation with formalin, disruption of the virus with non-ionic detergent, zonal centrifugation to enrich for antigen and a second inactivation step. The recent appearance of the H1N1 swine virus has provided an opportunity to test the pandemic response system established over the past ten years. What we find is that the public health system seems to work …

Application Of Animal-Free Recombinant Bioactive Protein Supplements To Improve The Performance Of Cell-Based Viral Vaccine Production, Kenneth Bertram, Marina Ross, Domenica Cavallaro, Larissa Chirkova, Geoffrey Francis

Vaccine Technology III

Animal cell culture for the production of viral vaccines has been performed for more than 50 years, and currently this technology is expanding rapidly to meet present and future demands of the health sector. The development and regulatory approval of continuous cell lines for manufacturing viral vaccines has brought numerous benefits to production processes. However, greater advances in the last decade have been achieved in mammalian cell production of biological therapeutics, including monoclonal antibodies, hormones, growth factors, cytokines and clotting factors. We and others have contributed to these upstream advances by improving cell culture media with the development of animal-free …

Establishing A Platform For Spray Drying Inhalable Vaccines In South Africa, Willem Germishuizen, L Venter, A Khosa, F Mudau, P.B. Fourie, B Pulliam, M Kabadi, A Schiermeier, D.A . Edwards

Vaccine Technology III

Mycobacterium bovis BCG is the current vaccine for tuberculosis (TB). However, BCG as it is currently administered shows highly variable efficacy in protecting adults against TB. The natural route of infection of TB is via inhalation of bacilli-containing aerosols and it is postulated that immunization by the natural route of infection may lead to a greater immunity given the fact that the lungs are the primary target of infection. By eliciting both local and systemic immune responses, it is anticipated that an inhaled form of BCG will offer greater protection against pulmonary TB.

Current commercial BCG vaccine preparations are filled …

Ergonomic Methods To Improve Safety In The Construction Sector And Reduce Costs, Mona Barjasteh

Industrial and Manufacturing Engineering

Many small construction companies have difficulty providing a safe working environment for their employees because of their lack of resources. There is a need to provide a manual for small construction companies employing 10 or fewer workers with the best ergonomic solutions of the top most common injuries. Accidents in the construction field are very high with nearly 175,00o nonfatal injuries and 1,121 deaths in 2002. The nonfatal cases occur 7.1 times per 100 full time workers, while serious injuries occur 2.8 times per 100 full time workers. This information reveled the importance of focusing on minor injuries in order …

Statistical Quality Control In The Health Care Industry, Roberto Arce

Industrial and Manufacturing Engineering

In recognition to the increased length of stay of discharge patients, deteriorating patient care and staff satisfaction in a emergency department (ED), this project was set to improve these measures without reducing staff, adding new workers, and without increasing the number of beds. Lean methods such as value stream mapping (VSM) formed the basis of the project. This tool helped identify the patient process flow through the (ED) as well as the valued added and non-value added steps of the process. This project describes value stream map development in the emergency department at a community hospital. A current-state value stream …

An Alternative To Stretch Wrap Using Triple Bottom Line, Christian Guirola

Industrial and Manufacturing Engineering

Packaging products has always been a major sector of industries. Mass producing manufacturing companies use wooden pallets to store and transport items; these products are stacked and then secured by wrapping stretch wrap around them. The main issue with this packaging method is that millions of pounds of waste is produced. Some of the other effects include green house gas emissions during its production, limited recycling, and high packaging costs. In order to reduce the amounts of stretch wrap used by industries and distribution centers, there was a need to research and evaluate alternate methods to secure products on pallets. …

Feasibility Of Manipulating Correlated Color Temperatures With A Phosphor Converted High-Powered Light Emitting Diode White Light Source, Matthew Michael Little

Master's Theses

In this thesis we examine the feasibility of developing a white light source capable of producing colors between 2500 and 7500 Kelvin on the black-body radiator spectrum by simply adjusting amperage to a blue and ultraviolet (UV) light emitting diode (LED). The purpose of a lighting source of this nature is to better replicate daylight inside a building at a given time of day. This study analyzes the proposed light source using a 385 nm UV LED, a 457 nm blue LED, a 479 nm blue LED, a 562 nm peak cerium doped yttrium aluminum garnet (YAG:Ce) phosphor, and a …

The Characterization And Analysis Of In-Vitro And Elevated Temperature Repassivation Of Ti-6al-4v Via Afm Techniques, Aaron J. Guerrero

Master's Theses

ABSTRACT

The Characterization and Analysis of In-vitro and Elevated Temperature Repassivation of

Ti-6Al-4V via AFM Techniques

Aaron J Guerrero

Research in the corrosion of orthopaedic implants is a growing research field where implants have been known to show adverse effects in patients who have encountered the unfortunate dissolution of their implants due to corrosion. Once corrosion begins within the body, many adverse biological reactions can occur such as late on-set infections resulting in severe health complications. The focus of this research is specifically related to the problem of late on-set infections caused by localized corrosion of orthopaedic implants. In medical …

Minimum Description Length (Mdl) Principle As A Possible Approach To Arc Detection, Jan Beck, David Nemir, Vladik Kreinovich

Departmental Technical Reports (CS)

Detecting arcing faults is an important but difficult-to-solve practical problem. In this paper, we show how the Minimum Description Length (MDL) Principle can help in solving this problem.

Optimal Prices In The Presence Of Discounts: A New Economic Application Of Choquet Integrals, Hung T. Nguyen, Vladik Kreinovich

Departmental Technical Reports (CS)

In many real-life situations, there are ``package deals'', when customers who buy two or more different items get a special discount. For example, when planning a trip, a deal including airfare and hotel costs less than the airfare and hotel on their own; there are often also special deals when we combine airfare with car rental, and deals that cover all three items plus tickets to local tourist attractions, etc.

Usually, there are several such deals with different combinations and different discounts. What if we plan to buy several different copies of each item: e.g., we plan a group tour …

How To Describe Spatial Resolution: An Approach Similar To The Central Limit Theorem, Omar Ochoa, Martine Ceberio, Vladik Kreinovich

Departmental Technical Reports (CS)

For spatially distributed quantities v(x), there are two main reasons why the measured value is different from the actual value. First, the sensors are imprecise, so the measured value is slightly different from the actual one. Second, sensors have a finite {\it spatial resolution}: they do not simply measure the value at a single point, they are "blurred", i.e., affected by the values of the nearby points as well. It is known that uncertainty can be often described by the Gaussian distribution. This possibility comes from the Central Limit Theorem, according to which the sum of many independent small measurement …

Increasing Production Capacity At A Start Up Biomedical Company, Traci J. Otsuji

Industrial and Manufacturing Engineering

The following senior project was first introduced during a summer internship at a biomedical company called Asthmatx Inc. Asthmatx is responsible for the development and manufacturing of a catheter‐based device for moderate to severe cases of asthma. Upon the approval of FDA, Asthmatx had planned to ramp up their production capacity significantly in order to accommodate the potential growth.

The first step in the process improvement was a facility reconfiguration that involved the adjustment of process sequencing and the implementation of ergonomic catheter channels. Next, time studies were conducted to gain more accurate time standards of the production process. After …

Process Improvement For The Department Of Surgery Sierra Vista Medical Center, Jessica Paz

Industrial and Manufacturing Engineering

This report proposes and analyzes process improvement methods for the Surgical Services Department at Sierra Vista Regional Medical Center. The department currently operates with an average of 25% of elective cases starting on time. This can be attributed to a number of inefficiencies that occur throughout the hospital.

The following Industrial Engineering methods were utilized to improve patient flow:  creation of a data collection system to quantify delays  use of simulation and facility redesign techniques to determine feasibility and benefits of moving towards a surgical center model  development of a user interfaced database to record and analyze …

Mapping The Medical Device Development Process, Scott T. Ham

Industrial Technology and Packaging

This project examined the use of process mapping as a tool to show the process of developing medical devices from a broad perspective that includes research, innovation, development, regulation, and marketing. The medical device development cycle, on a broad scope, is not well defined. The lack of a universal language with which to describe this process has made it difficult to understand and communicate. In this project, data was collected from peer-reviewed sources, summarized in a literature review, drawn out by hand into a series of lower-level process maps and finally assembled into a single process map. This project is …

The Gel Documentation System: A Cornerstone To The Implementation Of The Introduction To Biotechnology And Introduction To Bioinformatics Cross-Disciplinary Course Series, Marcy Kelly, Gregory Lampard, Constance Knapp

Cornerstone 3 Reports : Interdisciplinary Informatics

No abstract provided.

Towards A More Adequate Defuzzification Of Interval-Valued Fuzzy Sets, Vladik Kreinovich, Van Nam Huynh, Yoshiteru Nakamori

Departmental Technical Reports (CS)

It is known that interval-valued fuzzy sets [m(x)] provide a more adequate description of expert uncertainty than the more traditional "type-1" (number-valued) fuzzy techniques. Specifically, an interval-valued fuzzy set can be viewed as a class of possible fuzzy sets m(x) from [m(x)]. In this case, as a result of defuzzification, it is natural to return the range [u] of all possible values u(m) that can be obtained by defuzzifying membership functions m(x) from this class. In practice, it is reasonable to restrict ourselves only to fuzzy numbers m(x), i.e., to "unimodal" fuzzy sets. Under this restriction, in general, we get …