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Depaul Digest Aug 2025

Depaul Digest

DePaul Magazine

College of Communication faculty Matthew Ragas and Ron Culp mentor students on gaining access to executive-level administration. News briefs on exciting developments at DePaul University’s 10 colleges and schools, from nursing students studying public health protocols in Prague to a new DePaul-hosted conference exploring AI in filmmaking. DePaul alumni volunteers share their experiences spreading the Vincentian mission nationwide.


Palpation Characteristics Of An Instrumented Virtual Cricothyroidotomy Simulator, Melih Turkseven, Trudi Di Qi, Ganesh Sankaranarayanan, Suvranu De Aug 2025

Palpation Characteristics Of An Instrumented Virtual Cricothyroidotomy Simulator, Melih Turkseven, Trudi Di Qi, Ganesh Sankaranarayanan, Suvranu De

Engineering Faculty Articles and Research

Cricothyroidotomy (CCT) is a critical, life-saving procedure requiring the identification of key neck landmarks through palpation. Interactive virtual simulation offers a promising, cost-effective approach to CCT training with high visual realism. However, developing the palpation skills necessary for CCT requires a haptic interface with tactile sensitivity comparable to human fingers. Such interfaces are often represented by plastic partial mannequins, which require further adaptation to integrate into virtual environments. This study introduces an instrumented physical palpation interface for CCT, integrated into a virtual surgical simulator, and tested on 10 surgeons who practiced the procedure over a training period. Data on haptic …


Multi-Layer Support For Component-Based Cyber-Physical Systems Applications, Oren Bell Aug 2025

Multi-Layer Support For Component-Based Cyber-Physical Systems Applications, Oren Bell

McKelvey School of Engineering Graduate Student Theses & Dissertations

Component-based design is a paradigm meant to aid in development of software applications by modularizing different functionalities of a system. This building-block approach is used extensively in cyber–physical and robotic systems. Common and established solutions to specific problems, such as perception nodes, state estimators, and motion planners, can be developed, verified, and reused as off-the-shelf modules. These modules may be integrated atop today’s heterogeneous hardware platforms, where an application can be distributed across GPUs, FPGAs, and CPU cores. When heterogeneous computational devices share the workload of a collection of components, the very act of integration may inject timing uncertainty. For …


Class A Biosolids Production Using Conventional And Low-Cost, Low-Tech Processes At Small Water Resource Recovery Facilities: A Multidimensional Sustainability Assessment, Janna Brown, Robert Handler, Eric Seagren, Jennifer Becker Aug 2025

Class A Biosolids Production Using Conventional And Low-Cost, Low-Tech Processes At Small Water Resource Recovery Facilities: A Multidimensional Sustainability Assessment, Janna Brown, Robert Handler, Eric Seagren, Jennifer Becker

Michigan Tech Publications

Producing Class A biosolids is a beneficial way to reuse wastewater treatment solids, but most conventional processes are energy-intensive and expensive. There is growing interest in the use of low-cost, low-tech (LCLT) Class A biosolids treatment processes, especially at small water resource recovery facilities (WRRFs). This study used a holistic sustainability assessment to examine the environmental, economic, and social sustainability of conventional and LCLT processes at small WRRFs. The technologies studied were Direct Heat Drying, Composting, Lagoon Storage, Air Drying, and Temperature-Phased Anaerobic Digestion (TPAD). Environmental impacts were determined by conducting life-cycle assessments for all technologies, which is described in …


A Contemporary Approach For Exploring The Influence Of Detoxification And Standardization Of Traditional Metallopharmaceutical Product Pharmacological And Toxicological Aspects, Malarvizhi K Aug 2025

A Contemporary Approach For Exploring The Influence Of Detoxification And Standardization Of Traditional Metallopharmaceutical Product Pharmacological And Toxicological Aspects, Malarvizhi K

Theses and Dissertations

Polyherbomineral formulation possess unique medicinal properties due to the presence of metals and minerals as integral part, as processed in addition to specific herbals. There is an increased interest in metallopharmaceuticals in clinical and research areas, because of their immense therapeutic efficiency towards multiple diseases and evidence for non-toxic claim. Sivanar Amirtham is one of the polyherbomineral Siddha medicine recommended for the treatment of various respiratory diseases and other ailments including antidote therapy for poisonous bites. The present research work attempted for standardization of Sivanar Amirtham preparation as per the traditional standard protocols (including the detoxification process of raw materials) …


Design And Development Of Deep Learning Based Generic Platform For Promoting Precision Agriculture, Srilakshmi A Aug 2025

Design And Development Of Deep Learning Based Generic Platform For Promoting Precision Agriculture, Srilakshmi A

Theses and Dissertations

Precision agriculture also referred as precision farming or smart farming, is an innovative approach to agricultural management that leverages technology and data to optimize various aspects of the farming process. This approach aims to make farming more effective, sustainable, and profitable by affording farmers with the application tools and information they need to make more informed decisions.

Precision agriculture combines elements of agriculture, technology, and data science to enhance crop production, and resource utilization. Precision agriculture techniques can be highly effective in leaf disease detection within crop fields. Machine learning has been developed incredibly across multiple domains and shown it …


Facile Fabrication Of Protein-Polysaccharide Conjugate Multifilament Nerve Guidance Conduit For Peripheral Nerve Regeneration, Preethy Amruthavarshini R Aug 2025

Facile Fabrication Of Protein-Polysaccharide Conjugate Multifilament Nerve Guidance Conduit For Peripheral Nerve Regeneration, Preethy Amruthavarshini R

Theses and Dissertations

Long segmental defects in peripheral nerves impair sensory and motor function by disrupting neural impulse transmission. End-to-end autologous grafting with proper fascicular complementation has demonstrated functional recovery per the Medical Research Council Classification (MRCC). However, obtaining donor nerve tissue exceeding 30 mm remains a significant challenge. Artificial hollow conduits serve as an alternative but are limited to defects smaller than 30 mm due to inadequate innervation across the lumen.

Multichannel nerve guidance conduits (mNGCs) have emerged as a promising solution by enhancing fascicular complementation similar to autografts. This study presents a two-step approach for fabricating nerve conduits with precise fascicular …


Computational Studies On The Major Antioxidant Enzymes Of Wuchereria Bancrofti Towards The Development Of Anti Filarial Leads, Sureshan M Aug 2025

Computational Studies On The Major Antioxidant Enzymes Of Wuchereria Bancrofti Towards The Development Of Anti Filarial Leads, Sureshan M

Theses and Dissertations

Lymphatic filariasis (LF), or elephantiasis, is a mosquito-borne parasitic disease affecting the lymphatic system, primarily in tropical and subtropical regions. It is the second leading cause of long-term disability and a neglected tropical disease. According to WHO, LF threatens 882 million people in 44 countries, with over 9 billion treatments administered. The disease is caused by three nematodes: Wuchereria bancrofti (90% of cases worldwide, including India), Brugia malayi (10% in Southeast and Eastern Asia), and Brugia timori (found in Timor and nearby islands). Lymphatic filariasis (LF) is an ancient disease that continues to challenge scientists and physicians. Current treatments include …


Impact Of Ionic Liquids On The Treatment Of Various Derivatives Of Prosopis Juliflora For Removing Toxic Pollutants From Wastewater, Karthikeyan A Aug 2025

Impact Of Ionic Liquids On The Treatment Of Various Derivatives Of Prosopis Juliflora For Removing Toxic Pollutants From Wastewater, Karthikeyan A

Theses and Dissertations

Water resources are increasingly contaminated by toxic pollutants, particularly industrial effluents, posing significant environmental concerns. Addressing the toxicity of these pollutants, especially those released from textile industries, presents challenges due to their harmful effects on living organisms. Various treatment methods are employed to mitigate this issue, including coagulation, flocculation, membrane filtration, photocatalytic degradation, adsorption, anaerobic processes, and chemical oxidation. Among these, adsorption emerges as an effective and economical method due to its minimal secondary contamination, negligible sludge production, and the use of inexpensive agricultural and marine waste materials.

This study examines the ability of Prosopis juliflora treated with imidazolium-based ionic …


Bioprospecting Of Wheat Straw Pyrolysis Aqueous Phase To Combat Multi-Drug Resistant Pathogens, Srividhya K Aug 2025

Bioprospecting Of Wheat Straw Pyrolysis Aqueous Phase To Combat Multi-Drug Resistant Pathogens, Srividhya K

Theses and Dissertations

Hospital-acquired infections (HAIs) significantly contribute to the emergence and spread of antimicrobial resistance (AMR), primarily through the contamination of high-touch surfaces. Current disinfectants have drawbacks like high environmental persistence, ecotoxicity, and resistance development, prompting the need for environmentally friendly alternatives.

One potential approach is pyrolysis, during which the biomass components are broken down into solid, liquid, and pyro-gas. The aqueous phase of the liquid fraction is usually discarded as waste, but it contains a variety of organic compounds that have the potential for antibacterial and antifungal activity. The present study assessed the anti-infective and anti-biofilm properties of wheat straw pyrolysis …


Performance Analysis Of Pem Fuel Cells Via Puma Optimizer With The Aid Of Practical Verifications, Hossamm Ashraf, Sameh O. Abdellatif, Mahmoud M. Elkholy \, Attia A. El-Fergany Aug 2025

Performance Analysis Of Pem Fuel Cells Via Puma Optimizer With The Aid Of Practical Verifications, Hossamm Ashraf, Sameh O. Abdellatif, Mahmoud M. Elkholy \, Attia A. El-Fergany

Electrical Engineering

This manuscript presents a novel application of the recently developed Puma Optimizer (PO) for identifying the unknown parameters in Mann’s model, which is widely used for characterizing the behavior of Polymer Electrolyte Membrane Fuel Cells (PEMFCs). The proposed PO-based methodology is rigorously evaluated using three test cases. One test case involves experimental I–V measurements under various operating conditions from a commercial PEMFC stack, the Horizon H-100 (100 W), which was assembled and tested in the laboratory. The other two cases are established benchmark PEMFC systems, the Ballard Mark V 5 kW and BCS 500 W units. Comprehensive statistical analyses over …


Functional Biopolymers Applied To Sustainable Technologies In The Environment And Healthcare, Fengjie He Aug 2025

Functional Biopolymers Applied To Sustainable Technologies In The Environment And Healthcare, Fengjie He

UNLV Theses, Dissertations, Professional Papers, and Capstones

Biodegradable polymeric materials (biopolymers) are naturally derived materials known for their excellent biocompatibility, biodegradability, sustainability, and versatile chemical functionality. They have attracted increasing attention in various applications as alternative to synthetic materials ranging from food packaging to tissue engineering. Meanwhile, with intrinsic advantages, biopolymers have also emerged as promising materials in addressing contemporary challenges in both biomedical and environmental fields. Motivated by the significant potential of biopolymers and the growing need for sustainable materials, my research focuses on the design and engineering of biodegradable polymers with novel modification methods and application directions. In this work, two representative biopolymers are selected: …


Learning Structure With Multivariate Information Bottleneck And Exploration Of New Methods In Sequential Decision Making, Volodymyr Makarenko Aug 2025

Learning Structure With Multivariate Information Bottleneck And Exploration Of New Methods In Sequential Decision Making, Volodymyr Makarenko

Master's Theses

Research in useful information extraction has been motivated by the increasing demand to extract insights from unstructured data, and by the need to store and transmit great volumes of information, often originating in unstructured data such as videos. Research in rate distortion and information bottleneck paved the path for understanding and guiding the design of lossy encoders, capable of extracting relevant information. Independently, research in deep representation learning has enabled numerous applications for unstructured high-dimensional data such as images. However, the interpretability of the deep learning methods remained limited. Several desired properties of learned representations have been suggested, including disentanglement. …


Sleep Disorder Diagnosis Using Eeg Signals And Lstm Deep Learning Method, Mohammad Reza Yousefi, Reza Rahimi Aug 2025

Sleep Disorder Diagnosis Using Eeg Signals And Lstm Deep Learning Method, Mohammad Reza Yousefi, Reza Rahimi

NJF Intelligent Engineering Journal

Diagnosing brain disorders, particularly sleep disorders, has emerged as a critical area of research in both basic sciences and engineering. Sleep disorders encompass a range of conditions, including excessive or insufficient sleep, frequent awakenings, difficulty falling asleep, and challenges in reaching deep sleep stages. A key application of sleep disorder diagnosis lies in supporting the medical community through the development of advanced algorithms and models capable of accurately identifying these disorders based on individual brain signals, such as those captured by electroencephalography (EEG). These sophisticated approaches facilitate the creation of personalized treatment programs, paving the way for more targeted and …


A Meta-Analysis Of Historic Drinking Water Emergency Events Reported In News Articles, Victor Yu, Haiying Wang, Weiwei Mo Aug 2025

A Meta-Analysis Of Historic Drinking Water Emergency Events Reported In News Articles, Victor Yu, Haiying Wang, Weiwei Mo

Faculty Publications

This study seeks to investigate historical drinking water contamination events that reported by news media to find the key determinants of their outcomes, including the duration and economic cost, and to quantitatively describe the characteristics of past contamination events. ProQuest Global Newsstream and Regional Business News were used to identify an initial list of events and supplemented by additional search on specific information including the response actions, economic cost, and more. These events were analyzed using descriptive statistics, correlation analysis, and regression modeling. Smaller community water systems were found to be more frequently impacted by contamination events. Use restrictions, except …


Orbital Maneuvers And Interplanetary Trajectory Design Via Reinforcement Learning, Roberto Cuéllar Rangel Aug 2025

Orbital Maneuvers And Interplanetary Trajectory Design Via Reinforcement Learning, Roberto Cuéllar Rangel

Doctoral Dissertations and Master's Theses

This dissertation investigates the application of reinforcement learning (RL) to the design and optimization of low-thrust spacecraft trajectories, with an emphasis on autonomy, adaptability, and robustness in the presence of system uncertainties and unmodeled perturbations. Classical approaches to low-thrust trajectory design are predominantly grounded in optimal control theory, which relies on the availability of precise dynamical models and often requires problem-specific reformulation and solver tuning. While optimal control methods offer high accuracy under deterministic conditions, their sensitivity to stochastic disturbances and computational limitations in highly nonlinear or uncertain environments pose significant challenges for future autonomous space missions.

To address these …


Digital Trading Platform Selection Under Neutrosophic Numbers And Multi-Criteria Decision-Making Methodology: An Illustrative Example, Eman Sayed, Karam M. Sallam, Ibrahim Alrashdi Aug 2025

Digital Trading Platform Selection Under Neutrosophic Numbers And Multi-Criteria Decision-Making Methodology: An Illustrative Example, Eman Sayed, Karam M. Sallam, Ibrahim Alrashdi

Neutrosophic Systems with Applications

Uncertainty, vagueness, and incomplete information are pervasive in real-world decision-making scenarios, particularly in multi-criteria decision-making (MCDM) contexts involving expert judgments. To address these challenges, this study introduces a comprehensive decision-making framework that integrates Triangular Neutrosophic Numbers (TNNs) with the Weighted Aggregated Sum Product Assessment (WASPAS) method. The framework begins by capturing expert evaluations using TNNs, which effectively represent the degrees of truth, indeterminacy, and falsity inherent in subjective assessments. These evaluations are then transformed into crisp values using a novel score function that preserves the embedded uncertainty. The resulting decision matrices are aggregated into a unified structure to ensure consistency …


Note For Quadripartitioned Neutrosophic Offset, Pentapartitioned Neutrosophic Offset, And Heptapartitioned Neutrosophic Offset, Takaaki Fujita Aug 2025

Note For Quadripartitioned Neutrosophic Offset, Pentapartitioned Neutrosophic Offset, And Heptapartitioned Neutrosophic Offset, Takaaki Fujita

Neutrosophic Systems with Applications

Neutrosophic sets assign each element three independent membership values—truth, indeterminacy, and falsity—and their partitioned extensions introduce additional components subject to sum-bounded constraints. Notable examples include quadripartitioned, pentapartitioned, and heptapartitioned neutrosophic sets. The O set concept further extends this framework by allowing membership values outside the standard [0, 1] interval, including negative values and values exceeding one. In this paper, we introduce and analyze the Quadripartitioned Neutrosophic O set, Pentapartitioned Neutrosophic O set, and Heptapartitioned Neutrosophic O set. These extensions are intended to enhance the expressiveness of neutrosophic theory and to stimulate further research in neutrosophic and fuzzy uncertainty.


Some Properties Of Neutrosophic Cubic Hypersoft Sets, Lubna Nayab, Muhammad Gulistan, Fawad Hussain Aug 2025

Some Properties Of Neutrosophic Cubic Hypersoft Sets, Lubna Nayab, Muhammad Gulistan, Fawad Hussain

Neutrosophic Systems with Applications

This study addresses the limitations of NCS in managing uncertainties associated with multiple attributes and their further bifurcation. To address this challenge, we propose a generalization of the neutrosophic cubic soft set, introducing the concept of "neutrosophic cubic hyper soft set." Within this framework, we define internal and external neutrosophic cubic hypersoft sets, along with operations such as P-intersection, P-union, P-restricted union, P-extended intersection, P-OR operator, P-AND operator, R-intersection, R-union, R-restricted union, R-extended intersection, R-OR operator, R-AND operator, complement, and relative complement of neutrosophic cubic hyper soft sets. The study explores and presents relevant results, demonstrating the enhanced capability of …


Application Of Multi-Criteria Decision Analysis For Quantifying Responsibility In Ml-Based Intrusion Detection System, Mona Mohamed, Zekra Sakr Aug 2025

Application Of Multi-Criteria Decision Analysis For Quantifying Responsibility In Ml-Based Intrusion Detection System, Mona Mohamed, Zekra Sakr

Neutrosophic Systems with Applications

With the swift growth in Internet of Things (IoT), certifying secure and trustworthy networks has turned to be a critical challenge, particularly as IoT devices are increasingly vulnerable to sophisticated cyberattacks. As a remedy, intelligent intrusion detection systems (IDS) evolved as promising solutions in recent years, but deciding on the appropriate model remains difficult because of competing performance and trustworthiness criteria. To this end, this paper explores a novel application of an ML-augmented decision-making framework to enhance security-related decision-making in IoT environments. The framework systematically evaluates and ranks ML-based IDS systems according to different evaluation criteria with distinct trade-offs, including …


64th Annual Rocky Mountain Conference On Magnetic Resonance Aug 2025

64th Annual Rocky Mountain Conference On Magnetic Resonance

Rocky Mountain Conference on Magnetic Resonance

Final program, abstracts, and information about the 64th annual meeting of the Rocky Mountain Conference on Magnetic Resonance. Held in the Snowbird Resort and Conference Center, Snowbird, Utah, August 3-7, 2025.


Optical Trapping For The Study Of The Chemical And Physical Dynamics Of Single Particles, Yukai Ai Aug 2025

Optical Trapping For The Study Of The Chemical And Physical Dynamics Of Single Particles, Yukai Ai

Theses and Dissertations

This dissertation explores the combined technique of optical trapping and Raman spectroscopy (OT-RS) to study the physical and chemical properties, as well as the dynamic surface changes, of single aerosol particles in air. The study covers a wide range of aerosol types, including bioaerosols (such as pollen, bacteria, and fungi), dust particles (such as black carbon, terrestrial, and extraterrestrial materials), and liquid droplets (such as sea-spray aerosols). The optical trapping system used in this work is based on the universal optical trap (UOT), which is capable of trapping and manipulating a wide variety of particle types. These include both transparent …


Novel Nanomaterials For Developing Bone Scaffolds And Tissue Regeneration, Nazim Uddin Emon, Lu Zhang, Shelby Dawn Osborne, Mark Allen Lanoue, Yan Huang, Z. Ryan Tian Aug 2025

Novel Nanomaterials For Developing Bone Scaffolds And Tissue Regeneration, Nazim Uddin Emon, Lu Zhang, Shelby Dawn Osborne, Mark Allen Lanoue, Yan Huang, Z. Ryan Tian

Cell and Molecular Biology Faculty Publications and Presentations

Nanotechnologies bring a rapid paradigm shift in hard and soft bone tissue regeneration (BTR) through unprecedented control over the nanoscale structures and chemistry of biocompatible materials to regenerate the intricate architecture and functional adaptability of bone. This review focuses on the transformative analyses and prospects of current and next-generation nanomaterials in designing bioactive bone scaffolds, emphasizing hierarchical architecture, mechanical resilience, and regenerative precision. Mainly, this review elucidated the innovative findings, new capabilities, unmet challenges, and possible future opportunities associated with biocompatible inorganic ceramics (e.g., phosphates, metallic oxides) and the United States Food and Drug Administration (USFDA) approved synthetic polymers, including …


Mae Enewsbrief Apr- June 2025, Department Of Mechanical And Aerospace Engineering, Michigan Technological University Aug 2025

Mae Enewsbrief Apr- June 2025, Department Of Mechanical And Aerospace Engineering, Michigan Technological University

Department of Mechanical and Aerospace Engineering eNewsBrief

No abstract provided.


Reinforcement Learning And Virtual Human Animation: A Novel Approach To Data-Driven Animation, Portraying Dynamic, Flexible Human-Like Behaviours, Vihanga Gamage Aug 2025

Reinforcement Learning And Virtual Human Animation: A Novel Approach To Data-Driven Animation, Portraying Dynamic, Flexible Human-Like Behaviours, Vihanga Gamage

Dissertations

Virtual characters require animation capable of portraying dynamic, context-sensitive human-like behaviours. Several approaches to generating such animation have been developed, but each carries limitations. Motion capture can produce high-fidelity animation but is expensive and ill-suited to systems that must respond in real time. Physics-based reinforcement learning (RL) enables flexible, dynamic behaviour portrayal, yet relies on simulation feedback signals that are unavailable for social gestures. Supervised approaches can learn social behaviours from motion capture data but yield agents with limited flexibility and generalisation.

This thesis presents RLAnimate, a model-based, data-driven RL framework for character animation that enables a single agent to …


An Injectable, Dual-Curing Hydrogel For Controlled Bioactive Release In Regenerative Endodontics, Meisam Omidi, Daniela S. Masson-Meyers, Jeffrey M. Toth Aug 2025

An Injectable, Dual-Curing Hydrogel For Controlled Bioactive Release In Regenerative Endodontics, Meisam Omidi, Daniela S. Masson-Meyers, Jeffrey M. Toth

Biomedical Engineering Faculty Research and Publications

Regenerative endodontics seeks to restore the vascularized pulp–dentin complex following conventional root canal therapy, yet reliable neovascularization within the constrained root canal remains a key challenge. This study investigates the development of an injectable, dual-curing hydrogel based on methacrylated decellularized amniotic membrane (dAM-MA) and compares its performance to a conventional gelatin methacryloyl (GelMA). The dAM-MA platform was designed for biphasic release, incorporating both free vascular endothelial growth factor (VEGF) for an initial burst and matrix-metalloproteinase-cleavable VEGF conjugates for sustained delivery. The dAM-MA hydrogel achieved shape-fidelity via thermal gelation at 37 °C and possessed tunable stiffness (0.5–7.8 kPa) after visible-light irradiation. …


The Development And Application Of A Method To Simulate Commotio Cordis Inducing Impacts For The Evaluation Of Football Chest Protective Equipment, Bianca J. Henline Aug 2025

The Development And Application Of A Method To Simulate Commotio Cordis Inducing Impacts For The Evaluation Of Football Chest Protective Equipment, Bianca J. Henline

All Theses

As one of the most widely played and watched contact sports in the United States, football presents a significant risk of blunt chest trauma. Thus, effective chest protection is essential to prevent rare but fatal injuries like commotio cordis. Despite this, current test methods for certifying chest protective equipment fail to account for injury metrics relevant to commotio cordis events. Recent literature identifies rib deformation and viscous criterion as critical predictors of commotio cordis, yet these metrics are not adequately addressed in the existing testing standard. Furthermore, this standard exclusively assesses chest gear specific to baseball and lacrosse through projectile …


Polyphenols For The Mitigation Of Vascular Calcification; In Vitro And In Vivo Studies, Abdullah Altuhami Aug 2025

Polyphenols For The Mitigation Of Vascular Calcification; In Vitro And In Vivo Studies, Abdullah Altuhami

All Theses

Globally, cardiovascular diseases, in most cases associated with calcification, are the main cause of death. However, currently, the only effective cure is to undergo surgery to augment or receive a healthy donor heart, which could be very difficult due to the long waiting list and the associated risks. The possibility of body rejection of the foreign organs is attributed to immunoreaction or the risk of infection, since the donor must be on immunosuppressant drugs that lower the body's immunity and facilitate the body's acceptance of the new organ as one of its own. Taking that into consideration, using tissue-engineered vascular …


Effect Of Cigarette Smoke Extract And Nutrient Deficiency On Energy Metabolism And Biosynthesis: An In Vitro Intervertebral Disc Explant Culture Study, Avery E. Madden Aug 2025

Effect Of Cigarette Smoke Extract And Nutrient Deficiency On Energy Metabolism And Biosynthesis: An In Vitro Intervertebral Disc Explant Culture Study, Avery E. Madden

All Theses

Low back pain consistently ranks among the leading causes of disability worldwide, with degenerative changes in spinal intervertebral discs (IVDs) recognized as a key contributor. Degeneration arises from the disruption of mechanical and biological cues within the disc’s cartilaginous tissue, often exacerbated by aging or injury. In recent decades, cigarette smoking has also been identified as a significant risk factor, as IVD degeneration is more prevalent among individuals with a history of smoking. Smoke inhalation is thought to promote degeneration both directly, by exposing cells to water-soluble toxic chemicals in smoke; and indirectly, through nutrient deficiency resulting from vasoconstriction and …


Quantifying The Effect Of Initial Molecular Weight Distribution On The Degradation Of Linear Polyethylene At High Temperatures Using Dissipative Particle Dynamics, Cassandra L. Simpson Aug 2025

Quantifying The Effect Of Initial Molecular Weight Distribution On The Degradation Of Linear Polyethylene At High Temperatures Using Dissipative Particle Dynamics, Cassandra L. Simpson

All Theses

Polyolefins are the primary contributors to greenhouse gas emissions and supply chain energy requirements with respect to other commodity polymers. In order to explore more efficient methods for recycling and upcycling these plastics, it is important to consider the kinetics of polymer fragments during the degradation process to more accurately reflect experimental outcomes. The molecular weight distribution of synthetic polymers is an important factor to consider when synthesizing, processing, and manufacturing industrial plastics. The breadth of this distribution, or dispersity, is determined by the ratio of the weight average molecular weight to the number average molecular weight, and is correlated …