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Optimizing Park Locations While Considering Resident Behavior, Lu Liu Aug 2025

Optimizing Park Locations While Considering Resident Behavior, Lu Liu

All Theses

Urban parks and green-spaces significantly enhance community well-being by improving physical health, mental wellness, and environmental quality. Given these extensive benefits, ensuring fair and widespread access to urban parks represents a critical priority in urban planning. Despite the advantages of parks, optimizing their location poses unique and complex challenges distinct from traditional facility location problems, such as those involving emergency services or schools. The core distinction arises from the decentralized nature of residents’ park selection behaviors. Unlike centralized allocations typically managed by public administrators, park usage decisions are driven by individual preferences and behaviors. This decentralized decision-making introduces two additional …


Evaluation Of Performance Characteristics And Groundwater Contamination Risks Associated With On-Farm Swine Carcass Disposal Via Composting And Shallow Burial With Carbon, Gustavo Castro Garcia Aug 2025

Evaluation Of Performance Characteristics And Groundwater Contamination Risks Associated With On-Farm Swine Carcass Disposal Via Composting And Shallow Burial With Carbon, Gustavo Castro Garcia

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

This dissertation evaluates the performance of three on-farm swine carcass disposal methods: whole carcass composting (WCC), ground carcass composting (GCC), and shallow burial with carbon (SBC), focusing on biosecurity factors and groundwater contamination risks. Foreign animal diseases (FADs), such as African swine fever and classical swine fever, pose severe economic and animal well-being risks if introduced to the United States. With confirmation of an FAD, swine movement will be halted, creating an urgent need for practical, biosecure, and environmentally responsible on-farm disposal strategies for swine carcasses. Nebraska, as a leading swine-producing state, exemplifies the vulnerability of high-density livestock regions to …


The Advancement Of Automation In Beef Packaging Pack-Off Systems, Matthew Newman Aug 2025

The Advancement Of Automation In Beef Packaging Pack-Off Systems, Matthew Newman

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Marble Technologies has developed a new system for beef, pork, and lamb producers that improves quality and worker experience in the packing of products. This work explores the augmentation of this system with the introduction of robotic packing to further reduce labor, increasing worker availability for value-added tasks.

Experimentation conducted to date has explored handling delicate meat products in the standard Marble system and the proposed robotic systems. These mechanical subsystems are critical intermediaries in safely and reliably delivering products to robots and from robots to boxes. Two case studies are presented to walk through the process and challenges of …


Visceral, Neural, And Immunotoxicity Of Per- And Polyfluoroalkyl Substances: A Mini Review, Pietro Martano, Samira Mahdi, Tong Zhou, Yasmin Barazandegan, Rebecca Iha, Hannah Do, Joel Burken, Paul Ki-Souk Nam, Qingbo Yang, Ruipu Mu Aug 2025

Visceral, Neural, And Immunotoxicity Of Per- And Polyfluoroalkyl Substances: A Mini Review, Pietro Martano, Samira Mahdi, Tong Zhou, Yasmin Barazandegan, Rebecca Iha, Hannah Do, Joel Burken, Paul Ki-Souk Nam, Qingbo Yang, Ruipu Mu

Chemistry Faculty Research & Creative Works

Per- and polyfluoroalkyl substances (PFASs) have gained significant attention due to their widespread distribution in the environment and potential adverse health effects. While ingestion, especially through contaminated drinking water, is considered the primary route of human exposure, recent research suggests that other pathways, such as inhalation and dermal absorption, also play a significant role. This review provides a concise overview of the toxicological impacts of both legacy and emerging PFASs, such as GenX and perfluoro butane sulfonic acid (PFBS), with a particular focus on their effects on the liver, kidneys, and immune and nervous systems, based on findings from recent …


Low Energy Ion Irradiation Effects In Electronic Devices And Materials, David C. Mccall Aug 2025

Low Energy Ion Irradiation Effects In Electronic Devices And Materials, David C. Mccall

All Dissertations

The physics and engineering of ion-solid interactions are governed by the ion beam characteristics (flux, charge, energy) and target(s) in question. Here I present work on two projects related to the extraction of a high flux of low charge state Argon ions from a commercial plasma source and the irradiation of an engineered target, a transistor, with high charge state Argon ions.

An end-Hall ion source that produces a a high current plasma of ions and electrons in a rough vacuum environment is characterized. Using a Langmuir probe and multiple pressure measurements, the ion and electron content of the source …


Population Analysis Of Cyanobacteria In Rotating Algal Biofilm Reactors, Eric H. Matthews Aug 2025

Population Analysis Of Cyanobacteria In Rotating Algal Biofilm Reactors, Eric H. Matthews

All Graduate Theses and Dissertations, Fall 2023 to Present

Algal biofilms have numerous applications in wastewater treatment and bioproduct production. The Sustainable Waste-to-Bioproducts Engineering Center at Utah State University is working to develop rotating algal biofilm reactors (RABRs) to remove excess nitrogen and phosphorus from wastewater effluent while producing biomass for downstream production.

Genetic analysis of algal biofilms on various RABRs was performed to gain improved understanding of the biofilm populations. This analysis focuses on a pilot-scale RABR and how it compares to several other RABRs. Additionally, old methods of genetic analysis filtered out important cyanobacterial populations. A new method was developed to identify the cyanobacteria within the biofilms. …


Enhancing Emotional Accuracy And Behavioral Novelty In Robot Behaviors: A Generative-Discriminative Approach, Rista Baral Aug 2025

Enhancing Emotional Accuracy And Behavioral Novelty In Robot Behaviors: A Generative-Discriminative Approach, Rista Baral

Boise State University Theses and Dissertations

Recent advancements in language modeling have improved robotic emotion expressiveness, yet several challenges remain. Many existing robotic expression models rely on fixed rules and static frameworks, which limit their ability to capture the dynamic nature of emotional expression. Additionally, these systems often struggle to balance emotional accuracy with generating novel and varied behaviors. These limitations underscore the need for method capable of delivering both emotionally accurate and diverse robot behaviors.

In this thesis, we addresses these challenges by introducing a new framework for expressive behavior generation in robots. We develop a generative model that generates robot behavior sequences that align …


Aging Effect On Effective Connectivity Within The Prefrontal-Motor Network And Postural-Related Muscle Responses During Dual-Task Paradigms, Jiahao Pan Aug 2025

Aging Effect On Effective Connectivity Within The Prefrontal-Motor Network And Postural-Related Muscle Responses During Dual-Task Paradigms, Jiahao Pan

Boise State University Theses and Dissertations

Falls are a significant global public issue for older adults, leading to severe health and social impacts. To understand the underlying mechanism of increased fall risk with aging, loss of postural automaticity has been suggested as increased prefrontal cortex and motor cortices activation, as well as worse balance performance in response to the secondary cognitive task. However, the interaction within these cortical regions and its effects on postural-related muscle responses are poorly understood. This dissertation investigated age-related changes in effective connectivity within the prefrontal-motor network, postural related lower limb muscle response, and biomechanical characteristics in response to the secondary cognitive …


Mechanoregulation Of Osteogenesis And Adipogenesis Of Human Mesenchymal Stem Cells, Justin Caron Aug 2025

Mechanoregulation Of Osteogenesis And Adipogenesis Of Human Mesenchymal Stem Cells, Justin Caron

Master's Theses

Bone-related diseases (e.g., osteoporosis) are primarily treated with pharmacologic therapies that often exhibit limited efficacy and substantial side effects. Currently, bone marrow derived mesenchymal stem cells (MSCs) have become one of most important cell options in bone regeneration due to readily available sources, strong proliferation abilities, weak immune rejection responses, and strong osteogenic differentiation potential. While identifying the most effective approach to enhance osteogenic differentiation of MSCs for bone regeneration is challenging, understanding the regulatory mechanisms is crucial for improving therapeutic efficacy. Recent research has focused on developing strategies to enhance osteogenesis, which involve biophysical and biochemical stimulation. Mechanical and …


Impact Of Cysteine And Tyrosine Dipeptides On Cho Cell Performance In A Perfusion Mimic, Corrin L. Pruitt Aug 2025

Impact Of Cysteine And Tyrosine Dipeptides On Cho Cell Performance In A Perfusion Mimic, Corrin L. Pruitt

All Theses

Perfusion cell cultures typically achieve higher cell densities and generate higher volumetric productivities than fed-batch cultures due to continuous nutrient supply and spent media removal. Despite these advantages, perfusion cell cultures remain underutilized for licensed product manufacturing, primarily due to the lack of small-scale perfusion models for high-throughput process development and the complexities involved in media formulation capable of supporting high cell densities during long-term continuous operation. To avoid nutrient limitation at high cell densities, current perfusion processes rely on using higher perfusion rates, which results in significant media wastage and downstream product dilution. Therefore, there has been an effort …


Dealuminated Metakaolin In Supplementary Cementitious Material And Alkali-Activated Systems: A Review, Amany G. Micheal Prof., Mostafa Adel Elsebaei Eng., Maria Mavroulidou Prof., Maria Centeno Assoc. Prof., Rabee Shamass Senior Lec., Ottavia Rispolio Mrs. Aug 2025

Dealuminated Metakaolin In Supplementary Cementitious Material And Alkali-Activated Systems: A Review, Amany G. Micheal Prof., Mostafa Adel Elsebaei Eng., Maria Mavroulidou Prof., Maria Centeno Assoc. Prof., Rabee Shamass Senior Lec., Ottavia Rispolio Mrs.

Architectural Engineering

This paper presents a comprehensive review of dealuminated metakaolin (DK), a hazardous industrial by-product generated by the aluminium sulphate (alum) industry and evaluates its potential as a component in cementitious systems for the partial or full replacement of Portland cement (PC). Positioned within the context of waste valorisation in concrete, the review aims to establish a critical understanding of DK formation, properties, and reactivity, particularly its pozzolanic potential, to assess its suitability for use as a supplementary cementitious material (SCM), or as a precursor in alkali-activated cement (AAC) systems for concrete. A systematic methodology is used to extract and synthesise …


Multiple View Neural Regression Of A Facial Shape Model, Xiang Li Aug 2025

Multiple View Neural Regression Of A Facial Shape Model, Xiang Li

All Dissertations

Creating re-topologized 3D facial meshes is a critical step in high-quality facial animation pipelines, yet it remains a labor-intensive and time-consuming task. Traditional approaches typically rely on multiview stereo reconstruction and specialized photometric environments to acquire accurate geometric and reflectance data under controlled conditions. This dissertation presents work toward more efficient capture of production-ready meshes including (1) developmental aspects of VarIS, a custom-designed light sphere capable of capturing high-resolution stereo geometry and reflectance maps—including diffuse, specular, and normal components under programmable illumination; (2) a study of the effects of camera parameters on automatic 2D and 3D landmarking methods, (3) methods …


Studies On The Effects Of Operator Fatigue On Performance, Trust, And Workload Demand In Human-In-The-Loop Ai-Enabled Drone Systems, Snowil Lopes Aug 2025

Studies On The Effects Of Operator Fatigue On Performance, Trust, And Workload Demand In Human-In-The-Loop Ai-Enabled Drone Systems, Snowil Lopes

All Dissertations

Civil infrastructure must be regularly inspected to ensure its safety and reliability. Traditionally, risk engineers performed these inspections manually and in person. However, with the introduction of drones equipped with artificial intelligence (AI), inspections of civil infrastructure can now be conducted remotely. These AI-enabled drones capture and analyze images, helping engineers monitor large and complex structures from a distance. However, working with integrated systems consisting of multiple drones, especially those with varying levels of reliability, can be challenging. Operators must divide their attention, determine how much to trust each drone, and manage mental workload, which can affect their performance. Another …


Drift Dynamics Of Early Life-Stage Invasive Carps, Saurav Karki Aug 2025

Drift Dynamics Of Early Life-Stage Invasive Carps, Saurav Karki

Department of Civil and Environmental Engineering: Dissertations, Theses, and Student Research

Asian carp species pose significant ecological threats to North American freshwater systems due to their invasive nature and prolific reproduction. Their semi buoyant eggs develop while drifting downstream with the river current. Understanding early life-stage transport is therefore critical for predicting recruitment potential and guiding management efforts. Existing fluvial egg drift models, including those relying on 1-D hydraulics and fully 3-D CFD-based models, are either inadequate for complex braided rivers or too computationally demanding for large-scale application. The Platte River in Nebraska, characterized by wide, shallow, multi-threaded channels, is dominated by two-dimensional flow conditions, making a depth-averaged 2-D modeling approach …


Advancing Smart And Adaptive Living Spaces Through Design And Development Of Reconfigurable Multifunctional Robot Rooms, Nithesh Kumar Aug 2025

Advancing Smart And Adaptive Living Spaces Through Design And Development Of Reconfigurable Multifunctional Robot Rooms, Nithesh Kumar

All Dissertations

This work explores and introduces prototype hardware for a new category of robots: ‘Robot Rooms’, in an effort to refine the concept of traditional smart spaces and human-robot interaction. Unlike traditional robots that tend to be compact and exist within a space, this new category of robots is designed to be expansive: they do not exist within a space but rather shape space around them. We present several design concepts for potential robotic elements of a Robot Room. We then develop and demonstrate, at full scale, a new and novel concept: a ‘slice’ of a Robot Room. This slice changes …


Designing Self-Healable Aromatic Copolymers And Olefinic Composites, Samruddhi Yashwant Gaikwad Aug 2025

Designing Self-Healable Aromatic Copolymers And Olefinic Composites, Samruddhi Yashwant Gaikwad

All Dissertations

Self-healing polymers capable of recovering from mechanical damage are promising materials for advanced applications, especially those involving mechanical and/or physical fatigue. In these studies, we have developed techniques to achieve autonomous self-healing in commodity Styrene/n-butyl acrylate copolymers. The mechanism of self-healing in the designed polymers involves inter-and/or intrachain non-covalent interactions between π-cloud and polar linkages of acrylic nBA in random/preferentially alternating copolymers. A combination of spectroscopic tools, thermo-mechanical analysis, and molecular dynamics (MD) simulations has been used to elucidate the mechanism of self-healing. These studies further show the incorporation of dipolar C-F groups to understand the effect of having fluorinated …


From Waste To Solution: Modeling And Characterization Of Grape Seed Bio-Waste For Phosphate Removal From Wastewater, Abeer Al-Bsoul, Zakaria Al-Qodah, Muhammad Tawalbeh, Khalid Bani-Melhem, Khalideh Al Bkoor Alrawashdeh, Mohammad Hailat, Ahmed A. Al-Taani, Eid Gul Aug 2025

From Waste To Solution: Modeling And Characterization Of Grape Seed Bio-Waste For Phosphate Removal From Wastewater, Abeer Al-Bsoul, Zakaria Al-Qodah, Muhammad Tawalbeh, Khalid Bani-Melhem, Khalideh Al Bkoor Alrawashdeh, Mohammad Hailat, Ahmed A. Al-Taani, Eid Gul

All Works

In this study, particles of ground grape seeds were utilized to adsorb phosphate ions from a prepared solution, aiming to reduce phosphate concentration. Through a series of adsorption experiments, the effects of the adsorbent concentration, initial phosphate ion concentration, temperature, and pH on the phosphate ion uptake were studied. The removal efficiency of the phosphate ion decreased from 77 to 61% as a 25 to 45 °C increment in temperature was observed, which indicated the exothermicity in the adsorption process. The phosphate ion movement onto the adsorbent surface that exhibited the highest uptake value favored a neutral reaction environment with …


Genwriter: Reducing Gender Cues In Biographies Through Text Rewriting, Shweta Soundararajan, Sarah Jane Delany Aug 2025

Genwriter: Reducing Gender Cues In Biographies Through Text Rewriting, Shweta Soundararajan, Sarah Jane Delany

Conference papers

Gendered language is the use of words that indicate an individual’s gender. Though useful in certain context, it can reinforce gender stereotypes and introduce bias, particularly in machine learning models used for tasks like occupation classification. When textual content such as biographies contains gender cues, it can influence model predictions, leading to unfair outcomes such as reduced hiring opportunities for women. To address this issue, we propose GenWriter, an approach that integrates Case-Based Reasoning (CBR) with Large Language Models (LLMs) to rewrite biographies in a way that obfuscates gender while preserving semantic content. We evaluate GenWriter by measuring gender bias …


Towards Improving Computational Modeling Of The Lumbar Spine - Impact Of Material Properties And Laminotomy On Spinal Biomechanics, Isaac K. Kumi Aug 2025

Towards Improving Computational Modeling Of The Lumbar Spine - Impact Of Material Properties And Laminotomy On Spinal Biomechanics, Isaac K. Kumi

Mechanical & Aerospace Engineering Theses & Dissertations

Spinal ligaments play a crucial role in maintaining the mechanical stability of the lumbar spine. These dense, collagenous tissues not only resist excessive motion but also distribute loads between spinal components to protect neural structures. Traditionally, the mechanical response of ligaments has been modeled using linear elastic assumptions, which treat the tissue as having a constant stiffness regardless of loading history. While this simplifies analysis, it fails to capture the time-dependent behaviors, such as creep, stress relaxation, and hysteresis, that are characteristic of biological tissues.

Viscoelastic modeling may provide a more physiologically accurate representation by incorporating both elastic and viscous …


Polymer-Enhanced Nanopore Sensing, Eugene Gyasi Agyemang Aug 2025

Polymer-Enhanced Nanopore Sensing, Eugene Gyasi Agyemang

Graduate Theses and Dissertations

The resistive pulse technique characterizes single analytes by detecting fluctuations in the ion current as they pass through a narrow orifice connecting two electrolyte-filled chambers, each containing a single electrode. The amplitude, shape, frequency, and duration of these fluctuations primarily provide information about the analyte’s size, shape, concentration, and net surface charge, respectively. One configuration for resistive pulse measurements is of an electrolyte-filled nanopipette immersed in a bath, where the nanopipette tip acts as the nanoscale orifice. It was previously shown that incorporating the large quantities polymer polyethylene glycol (PEG 8K, 50% w/v) into the external electrolyte bath dramatically enhanced …


Evaluating Cyanotoxins In Surface Water And Aerosols Near Utah Lake, Dylan R. Mcpeake Aug 2025

Evaluating Cyanotoxins In Surface Water And Aerosols Near Utah Lake, Dylan R. Mcpeake

All Graduate Theses and Dissertations, Fall 2023 to Present

Utah Lake is a freshwater lake in Utah County near Provo, Utah. It is the third- largest lake in Utah and is important for recreation and local businesses. However, from June to October, the lake often has cyanobacteria harmful algal blooms (cHABs), which contain a toxin called cyanotoxin. These toxins can be dangerous to people who come into contact with the water. Government agencies regularly check for cHABs and warn people when the water is unsafe for activities like swimming. Collecting water samples to test for cHABs can be risky because it can possibly result in direct contact with the …


Cellular And Noncellular Influences On Lipid Nanoparticle Tropism In The Liver, Mario Yomir Mata Corral Aug 2025

Cellular And Noncellular Influences On Lipid Nanoparticle Tropism In The Liver, Mario Yomir Mata Corral

Open Access Theses & Dissertations

Hepatocellular carcinoma (HCC) is currently ranked as the second leading cause of cancer-related mortality worldwide, causing more than 700,000 deaths a year. The liver is important in blood filtration and metabolism, and for this reason is a prime target for drug delivery, with lipid nanoparticles (LNPs) showing promise as carriers due to their natural hepatic tropism. However, LNP efficacy is decreased in HCC due to the limited understanding of liver physiology in cancerous environments. This project proposes to address this gap by using a tissue-clearing technique known as CLARITY along with a chemically tagged LNP for comprehensive visualization of LNPs …


Technology-Enabled Foreign Object (Fo) Prevention, Christopher Lee Colaw Aug 2025

Technology-Enabled Foreign Object (Fo) Prevention, Christopher Lee Colaw

Open Access Theses & Dissertations

The aviation industry incurs $14 billion per year in cost due to Foreign Object (FO) damage and the prevention and resolution techniques associated with foreign object debris. While aircraft loss, material scrap and rework contribute to that cost impact, a traditional approach to aircraft design and manufacturing which is based on human performance is also a significant driver. Failure modes and effects analysis of human based aircraft manufacturing reveals that two of the largest risks are associated with unknown potential for FO creation and the inability to recall or objectively provide evidence of FO conformity for cases of inquiry, learning, …


Advancement Of Biocarbon Materials In Sustainable Thermal And Electrochemical Energy Storage With Future Outlooks, Md Shahriar Mohtasim, Barun K. Das Aug 2025

Advancement Of Biocarbon Materials In Sustainable Thermal And Electrochemical Energy Storage With Future Outlooks, Md Shahriar Mohtasim, Barun K. Das

Research outputs 2022 to 2026

Biocarbon exhibits significant potential in thermal and electrochemical energy storage owing to its higher surface area, flexible porosity, and superior thermal stability, facilitating effective energy absorption, storage, and conversion. Additionally, its sustainable and cost-effective nature, derived from renewable biomass, aligns with the growing demand for eco-friendly solutions. There is not enough review work that offers comprehensive details on the unique properties of biocarbon (both animal and plant-derived), synthesis and characterization methods, the root level mechanism of biocarbon's interaction with phase change materials (PCMs) matrix, the generalization of thermal and electrochemical regulation with an emphasis on the benefits to the environment …


Techno-Economic Analysis (Tea) And Life-Cycle Assessment (Lca) Of Sustainable Aviation Fuel (Saf) Production Through Circular Economy (Ce) Practices: A Focus On Supply Chain Optimization And Policy Implications, Edmund Gyandoh Jul 2025

Techno-Economic Analysis (Tea) And Life-Cycle Assessment (Lca) Of Sustainable Aviation Fuel (Saf) Production Through Circular Economy (Ce) Practices: A Focus On Supply Chain Optimization And Policy Implications, Edmund Gyandoh

Chemical and Biological Engineering ETDs

This study provides a comprehensive systems-level evaluation of an integrated circular biorefinery for sustainable aviation fuel (SAF) production. Employing supply chain optimization, technoeconomic analysis, lifecycle analysis, policy modeling, and multicriteria decision analysis, the research assesses technical feasibility, economic viability, and environmental performance. The circular economy model demonstrates exceptional resource efficiency, achieving a 92.3% overall circularity score with strong material recycling, water reuse, waste minimization, and near-complete energy recovery, resulting in net-negative carbon emissions and net energy export. Scaling the facility to commercial capacity (500 million liters per year) enables significant economic improvements. The minimum fuel selling price (MFSP) decreases from …


Coal Mining Reclamation: Lessons Learned From Tropical And Subtropical Countries, Priyaji Agung Pambudi, Suyud Warno Utomo, Roni Setyo Handoko Jul 2025

Coal Mining Reclamation: Lessons Learned From Tropical And Subtropical Countries, Priyaji Agung Pambudi, Suyud Warno Utomo, Roni Setyo Handoko

Journal of Environmental Science and Sustainable Development

This study addresses the persistent environmental challenges associated with coal mining in tropical and subtropical regions, where complex microclimates and ecological variability hinder effective reclamation. Despite the increasing global coal demand, comparative cross-country insights remain limited. This research fills the gap by evaluating the best practices. This study employs a qualitative methodology with a comparative case study design, uses systematic literature review to evaluate ecology based reclamation policies and implementation practices. Data were sourced from peer-reviewed journals from Scopus and the Web of Science database and institutional reports, and analyzed using McHarg’s landscape ecology theory to evaluate reclamation policies, ecological …


Sex-Dependent Differences In Cardiac Function And Strain In Doxorubicin-Induced Cardiomyopathy, Anna J. A. Webb, Bea O. Cabot, Aasish Chowdary, Wilhelm S. Smith, Benjamin Zeidler, Cortland H. Johns, Craig J. Goergen Jul 2025

Sex-Dependent Differences In Cardiac Function And Strain In Doxorubicin-Induced Cardiomyopathy, Anna J. A. Webb, Bea O. Cabot, Aasish Chowdary, Wilhelm S. Smith, Benjamin Zeidler, Cortland H. Johns, Craig J. Goergen

Discovery Undergraduate Interdisciplinary Research Internship

Doxorubicin is a chemotherapeutic agent used to treat many types of cancer. While effective, doxorubicin can cause cardiomyopathy, a disease affecting the heart muscle. Although the effects of doxorubicin on the heart are well studied, the mechanisms leading to cardiomyopathy are not well understood. Previous studies have used murine models to study the cardiotoxicity of doxorubicin. These reports showed that cardiac dysfunction is more pronounced in male compared to female mice. The goal of this study is to further evaluate sex differences in doxorubicin induced cardiomyopathy using 4-dimensional strain mapping techniques. In this study, both female and male C57Bl/6J mice …


Exploring Immune System Through Computational Modeling: A Comprehensive Study Of Lymph Nodes And Immune Response Scaling, Vaccine Efficacy, And Large-Scale Extreme First Passage Time, Jannatul Ferdous Jul 2025

Exploring Immune System Through Computational Modeling: A Comprehensive Study Of Lymph Nodes And Immune Response Scaling, Vaccine Efficacy, And Large-Scale Extreme First Passage Time, Jannatul Ferdous

Computer Science ETDs

The adaptive immune response is a complex defense mechanism that develops over time to recognize and eliminate pathogens with remarkable precision and durability. This dissertation investigates the dynamics, scaling, and efficiency of the adaptive immune response through a synthesis of computational modeling, mathematical analysis, and agent-based simulations. First, we analyze the topology of the lymphatic network and investigate the T cell search time to find the lymph node that is containing the matching dendritic cell. Second we show how the scaling of lymph node number and volume with body mass, leads to scale-invariant search times for T cells locating antigen-bearing …


Optimization And Model Averaging Of Histogram-Based Place Cell Firing Rate Maps Using The Point Process Framework, Murat Okatan Jul 2025

Optimization And Model Averaging Of Histogram-Based Place Cell Firing Rate Maps Using The Point Process Framework, Murat Okatan

Turkish Journal of Electrical Engineering and Computer Sciences

The firing rate of hippocampal place cells depends on the spatial position of the organism in an environment. This position dependence is often quantified by constructing spike-in-location and time-in-location histograms, the ratio of which yields a firing rate map. The purpose of this study is to present a new method for optimizing the spatial resolution of histogram-based firing rate maps. It is pointed out that histogram-based firing rate maps are conditional intensity functions of inhomogeneous Poisson process models of neural spike trains, and, as such, they can be optimized through model selection within the point process framework. The point process …


Optimal Water Hammer Protection Strategies For Low-Head Hydraulic Systems: A Case Study Using Bentley Hammer, Ahmed A. Abdel-Naby, Mostafa A. Abdel-Moaty, Eslam R. Lotfy Jul 2025

Optimal Water Hammer Protection Strategies For Low-Head Hydraulic Systems: A Case Study Using Bentley Hammer, Ahmed A. Abdel-Naby, Mostafa A. Abdel-Moaty, Eslam R. Lotfy

Mansoura Engineering Journal

The analysis of water hammer in low-head hydraulic systems holds significant importance compared to that in high-head systems, particularly given instances where Thorley’s equation may fall short in providing accurate pump inertia values. In situations where manufacturer data are unavailable, proactive measures to mitigate potential hammering incidents become imperative. While Bentley HAMMER software provides robust simulation capabilities, optimal protection strategies for low-head systems remain underexplored. This case study focuses on a scenario involving multistage centrifugal pumps that lift water from the basement floor of a building to its roof via a polypropylene pipeline. The investigation revealed a novel configuration: relocating …