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Multi-Functional Gelatin-Dithiolane Hydrogels For Tissue Engineering, Saad Asim

Dissertations, Master's Theses and Master's Reports

Biomaterials that integrate multiple functionalities, mimic the extracellular matrix (ECM) microenvironment to support cellular growth, and adhere robustly to damaged tissues are highly needed to advance tissue engineering. Protein-based biomaterials are promising due to their inherent biocompatibility, biomimicry, biodegradation, and cell-supportive properties. Herein, by leveraging the unique ability of dithiolanes to generate on-demand in-situ thiols, we developed a new class of dithiolane-modified, protein-based biomaterial that combines unique, seemingly opposing functions for tissue engineering. Dithiolane-modified gelatin, a model protein used herein, enabled photoinitiator-free photo-crosslinking to form multi-functional gelatin-dithiolane (GelDT) hydrogels, which displayed exceptional long-term stability in cell culture media (>28 …

Analytical And Machine Learning Modeling Of Direct Carbonation Of Natural Silicate Minerals, William Hanson

Dissertations, Master's Theses and Master's Reports

The climate-altering effects of atmospheric CO₂ make it necessary to develop innovative technologies that can remove it from the atmosphere. Mineral carbonation is a scalable technology to sequestrate and store CO2 in a stable carbonate mineral form. The efficiency of the mineral carbonation process depends on both feed mineralogy and process parameters. Comprehensive modeling and prediction of mineral carbonation efficiency for different CO₂ – reactive rocks has not been achieved in the past. In this thesis work, analytical and machine learning models are developed to predict the carbonation efficiency of dunite reactions. It is found that random forest …

Implementing Associative Learning Using Neuromorphic Robot, Vinay Kumar Pillalamarri

Dissertations, Master's Theses and Master's Reports

Associative learning, a key cognitive process seen across the animal kingdom, enables organisms to form connections between stimuli and adapt their behaviors based on past experiences. A particularly powerful example is fear conditioning, where animals learn to associate a neutral stimulus with an aversive one, allowing them to predict and avoid potential threats. Inspired by this mechanism, this project implements associative learning on an unmanned ground vehicle (UGV) to develop adaptive behavior through neuromorphic principles. Utilizing Nengo for neural modeling, the UGV learns to associate visual (red color) and tactile (vibration) stimuli through Hebbian learning, a biologically inspired synaptic adaptation …

The Effects Of Phoslock And Water Treatment Residual On Phosphate Concentration Levels And Phosphate Adsorption, Anna Soehnlen

Williams Honors College, Honors Research Projects

Eutrophic, nutrient enriched water can induce adverse effects like harmful algal blooms (HABs) in aquatic ecosystems. Numerous studies have been conducted to control nutrients like phosphorus and nitrogen in order to mitigate the growth rate of HABs. During the spring semester of 2023, a research project investigated if the bentonite clay product, Phoslock, was able to remove phosphorus when it was added to distilled water and surface water under laboratory conditions. The researchers noted potential deficiencies in Phoslock’s ability to decrease the concentration of phosphorus while maintaining the initial value of adsorbed phosphorus. Expanding from this past research, two additional …

Precision Application Of Water To Equine Racing Surfaces, Sydney Rae Cannon

Theses and Dissertations--Biosystems and Agricultural Engineering

As the horseracing industry has come under more scrutiny as of late, horse and rider safety has become a priority. The best was to keep a rider safe is to keep them on their horse, and the best way to do that is to keep the horse upright. This all comes down to consistency both between tracks and across a single track. The most important method of managing track consistency is through moisture content. This study examined how track design can impact moisture application, how moisture content can impact the surface material, and what design elements can be implemented to …

Development Of Fungal Hydrogels For 3d Bioprinting And Cellular Agriculture, Lauren E. Doyle

Theses and Dissertations--Biosystems and Agricultural Engineering

Hydrogel scaffolds are an important component to cellular agriculture. There is a need for a sustainable alternative to the commonly used gelatin-sodium-alginate hydrogels. Specific edible fungus species may provide a suitable alternative. Many fungi possess high protein contents, ease of cultivation, and strong functional properties. However, functional characterizations and application of fungal flour and protein extracts in cellular agriculture are lacking in the literature. Therefore, this study’s objectives were to 1) Develop processes to create functional fungal protein fractions from different fungal strains and evaluate their characteristics, and 2) Quantify the printability of the resulting fungal gels for the creation …

A Survey Of Strongyle Nematodes In New England Dairy Goats, D.J. Richardson, E.M. Wray, D. Watters, U. Hanif, E. Jalbert, E. Thompson, G. Trajkovic, A.R. Sirois, N. Pilotte

Journal of the Arkansas Academy of Science

The paucity of information concerning the occurrence of strongyle nematodes in New England dairy goats prompted a survey of 241 dairy goats from throughout New England. Of the 241 goats examined using the McMaster technique, 104 (42.7%) were infected with strongyles with a mean intensity (+ SE) of 369.7 + 45.8 eggs per gram. Subsequent molecular examination of 50 random samples from these goats revealed a prevalence of 88% infection specifically with Haemonchus contortus. Haemonchus contortus is the most important internal parasite of sheep and goats, exerting a crushing economic burden on the livestock industry worldwide due to lowered milk …

Electromechanical Mapping Of The In Vivo Porcine Heart And Stomach, Haley Nesmith Patton

All ETDs from UAB

Electrical excitation and mechanical function are integral to the physiologic activity of both the heart and stomach. Electrical depolarization through the myocardium triggers contraction in the heart. When normal sequences of electrical activity are disturbed, the heart’s mechanical function may also be disturbed, affecting its ability to pump blood effectively, sometimes fatally. Similarly, electrical waves called slow waves initiate gastric peristalsis. Abnormalities in slow wave propagation patterns can disturb the stomach’s ability to mechanically process gastric contents, sometimes resulting in delayed gastric emptying, nausea, and vomiting. The relationship between mechanical function and electrophysiology is not unidirectional, though. Mechanical stimuli can …

Characterization Of Antibody Repertoires Developed From Naive And Recall Responses, Nicholas C. Curtis

Dartmouth College Ph.D Dissertations

Adaptive immunity, comprised in part by the antibody repertoire, is the cornerstone of our ability to remain healthy amongst the plethora of pathogenic challenges we encounter daily. Despite the importance of understanding antibody repertoire development, much remains unknown about the composition and evolution of circulating antibodies in response to viral challenges. To better understand antibody repertoire development, we profiled the serum antibody repertoire using a combination of next-generation sequencing and serum antibody proteomics in the predominantly naïve response against SARS-CoV-2 spike and the recalled response to influenza hemagglutinin. The response to SARS-CoV-2 spike in four convalescent individuals was diverse (consisting …

Novel Engineering Approaches For Orthopedic Injury Treatment And Infection Diagnosis, Cynthia Co

Bioengineering Dissertations - Archive

Bioengineering has made significant contributions to the treatment of orthopedic injury through interdisciplinary approaches. Central to these advancements are many orthopedic implants, including anchors and joint replacements, which have been designed to restore mobility. Despite their functional efficacy, these products have limited lifespan and are associated with many complications, such as implant-associated infection. The success of implant design and function, both in the short and long term, is paramount for enhancing patient outcomes and overall well-being. Therefore, my thesis work is dedicated to addressing these critical challenges, aiming to maximize their treatment effect while minimizing the implant-associated complications.

Long-term patient …

Estimation Of Differential Pathlength Factor From Nirs Measurement In Skeletal Muscle, B. Koirala, A. Concas, A. Cincotti, Yi Sun, A. Hernández, M. L. Goodwin, L. B. Gladden, N. Lai

Electrical & Computer Engineering Faculty Publications

The utilization of continuous wave (CW) near-infrared spectroscopy (NIRS) device to measure non-invasively muscle oxygenation in healthy and disease states is limited by the uncertainties related to the differential path length factor (DPF). DPF value is required to quantify oxygenated and deoxygenated heme groups' concentration changes from measurement of optical densities by NIRS. An integrated approach that combines animal and computational models of oxygen transport and utilization was used to estimate the DPF value in situ. The canine model of muscle oxidative metabolism allowed measurement of both venous oxygen content and tissue oxygenation by CW NIRS under different oxygen delivery …

An Overview Of The Relationships Between The Food Industry And Nanotechnology, Mehdi Koushki, Nasrin Amiri-Dashatan, Hossein Pourghadamyari, Hadi Khodabandehloo, Fatemeh Bagheri, Masoumeh Farahani, Lobat Tayebi

Electrical & Computer Engineering Faculty Publications

Background and Objective: Due to the growth of the global population, food demands are increasing. Hence, the need to develop more efficient methods for producing better quality, safer, and more sustainable food seems essential. In the past decades, the use of nanoscale materials has increased greatly due to the unique chemical, physical, and biological characteristics of nanomaterials compared to bulk materials. This research presents nanotechnology role in improving sensorial properties (taste, appearance, and texture) and safety aspects as well as processing and packaging of foods. The use of nano-omics-based technologies and artificial intelligence-nanotechnology-based technologies in the food industry is also …

Advancing Environmental Engineering: The Role Of Artificial Intelligence In Sustainable Solutions - A Short Review, Amirreza Talaie, Hesam Kamyab, Ashkan Razmfarsa

Management Faculty Publications

Artificial intelligence (AI) has emerged as a transformative force in environmental engineering, offering innovative solutions to complex environmental challenges. From air pollution monitoring and water resource management to waste management, climate change mitigation, and ecological preservation, AI is revolutionizing the way we address environmental issues. Machine learning, neural networks, and other AI technologies are enabling more accurate predictions, optimizing resource use, and improving conservation efforts. However, despite its many advantages, AI also faces challenges such as data availability, energy consumption, ethical concerns, and the need for transparency. This review explores the diverse applications of AI in environmental engineering, highlighting the …

Distal Urogenital Anatomy And Epithelial Morphology In The Male Cajun Chorus Frog, Pseudacris Fouquettei (Anura: Hylidae), S.E. Trauth

Journal of the Arkansas Academy of Science

I examined the microanatomy of the distal urogenital system in male Cajun Chorus Frogs (Pseudacris fouquettei) from a small sample (n = 6) collected in central Arkansas in March 2018 and February 2023. Specifically, my primary objectives were to investigate the following: (1) the paired Wolffian (urogenital) ducts caudally from the kidneys to their merging with the urodeum of the cloaca, (2) the structure of seminal vesicles (if present), and (3) the epithelial morphologies among the distal urogenital tract, the posterior alimentary canal, and cloaca. My histological analysis confirmed the presence of ampullae (sperm storage structures) as mid-duct expansions of …

Shell Damage Patterns In Limpkin Mussel Middens At Bois D’Arc Lake, Arkansas, G.R. Graves

Journal of the Arkansas Academy of Science

The Limpkin (Aramus guarauna) is rapidly colonizing the lower Mississippi Valley from recently established Gulf Coast populations. Anecdotal reports indicate that it feeds on freshwater mussels and gastropods in Arkansas, but without documentation. Here I report an analysis of Limpkin shell middens from Bois d’Arc Lake in Hempstead Co. Limpkins at this location preyed heavily on Pyganodon grandis (Giant Floater), a large mussel species widely distributed in the Mississippi Valley. Limpkins employ vigorous bill blows to pierce holes in mussels and usually attack the anterior end of the shell. Video and photographs of feeding birds provide new insight on the …

Characterizing The Beneficial Uses Of The Arcata Marsh Constructed Wetland Treatment System And Wildlife Sanctuary, Andrew S. Wolff

Cal Poly Humboldt theses and projects

The Arcata Marsh Constructed Wetland Treatment System and Wildlife Sanctuary, located in Arcata California, has been in operation since 1986. Not only has it served as the wastewater treatment facility for the city, it has also provided other beneficial uses such as acting as a sanctuary for bird, mammal, amphibian, and macroinvertebrate species. With facility upgrades currently underway, it has become important to revisit the beneficial uses of the Arcata Marsh. This project aimed to identify and characterize these beneficial uses. Literature review was conducted, and eleven beneficial uses were identified. Existing and newly obtained data were analyzed to characterize …

Enhancing 5g Fixed Wireless Access In Rural Settings Via Machine Learning-Driven Resource Optimization, Maryam Amini

Graduate Theses, Dissertations, and Problem Reports (ETD)

Providing broadband access to rural communities continues to be an important societal problem whose solution would help to break down the digital divide. While 5G wireless networks may be used for rural broadband, a key challenge is the placement of base stations, which is exacerbated by the use of high frequencies in the millimeter-wave band. Such technology requires an unobstructed line of sight, demanding meticulous planning of the number, height, and location of base stations for optimal coverage. Conventional methods, such as ray-tracing to simulate signal propagation across varied terrain, are computational costly and not feasible for vast coverage areas. …

Highlighting Opportunities For Anaerobic Co-Digestion Of Food Waste From Universities With Pulp And Paper Mill Sludge, Md Nizam Uddin

College of Graduate Studies: Theses & Dissertations

The disposal of food waste (FW) in landfills presents significant environmental and economic challenges, including greenhouse gas emissions and loss of potential resources. Concurrently, the pulp and paper industry, a major sector in the United States, generates substantial quantities of recalcitrant organic waste that is high in lignocellulosic content. Anaerobic co-digestion of FW with pulp and paper mill sludge (PPMS) emerges as a potential strategy to address both waste streams simultaneously, potentially enhancing organic matter degradation and biogas yield. However, the efficacy of this co-digestion approach and its broader sustainability implications remain insufficiently characterized. This study employs laboratory-scale experiments to …

Statistical Analysis For Water Quality Data Using Anova (Case Study- Lake Burullus Influent Drains), Mohamed Hussein Hegazy

Civil Engineering

Lake Burullus is considered one of the most valuable northern lakes in Egypt due to its unique ecological system and special location. Over the past four decades, the lake has suffered from high contamination levels due to expansion in fish farming and increasing of agricultural drainage water entering the southern side of the lake through eight influent drains. This research aims to assess the current situation of the lake’s influent drains. For this purpose, two types of statistical analysis, Mean average method, and Analysis of Variance (ANOVA) were used. The water quality conditions for six major drains (Therah (Tira), Nashart, …

Lecturer Assistant, Aya Hassan

Civil Engineering

Lake Burullus is considered one of the most valuable northern lakes in Egypt due to its unique ecological system and special location. Over the past four decades, the lake has suffered from high contamination levels due to expansion in fish farming and increasing of agricultural drainage water entering the southern side of the lake through eight influent drains. This research aims to assess the current situation of the lake’s influent drains. For this purpose, two types of statistical analysis, Mean average method, and Analysis of Variance (ANOVA) were used. The water quality conditions for six major drains (Therah (Tira), Nashart, …

Applying The Normative Design Approach To Civil Engineering, Justin R. Vander Werff

Faculty Work Comprehensive List

In 1986, the book Responsible Technology [1] was published as an important compilation from a number of thoughtful Christians engaged in technology and engineering in that era. In many ways, this book and those involved with it laid the foundation for what has become the Christian Engineering Society. A particularly valuable aspect of this work was that it laid out a biblically normative framework for doing engineering based on Herman Dooyeweerd’s modal aspects [2], fleshing out how the higher aspects such as faith, ethics, and justice should play an integral role in engineering development, even though we often have a …

Stormwater Alters The Resistome Of Urban Surface Water, An Impact That Can Be Mitigated By Green Stormwater Infrastructure, Kassidy N. O'Malley, Walter M. Mcdonald, Patrick J. Mcnamara

Civil and Environmental Engineering Faculty Research and Publications

Antibiotic resistance poses an escalating threat to global health, with environmental reservoirs being pivotal areas of concern, as well as opportunities for potential mitigation. Stormwater systems are an important type of environmental reservoir in the urban water cycle with a dearth of research related to impacts on antibiotic resistance. In particular, there has been limited research exploring the impact of diverse antibiotic resistance genes (ARGs) carried by stormwater from various land uses on surface water, nor has there been an examination of the role played by green stormwater infrastructure (GSI) in mitigating this impact. Therefore, this study sought to elucidate …

Love Bash Event Branding For Potter League, Shea Lambert, Julia Schiels

Student Research Design & Innovation Symposium

As part of a Directed Experiential Education course, we worked with Potter League for Animals to design new branding for their 2025 Love Bash event. The Love Bash event is a premier spring fundraiser that takes place at the Wyndham Newport Hotel in Middletown, Rhode Island. We were responsible for designing a logo and defining brand standards for this event that aligned with Potter League’s existing brand. We were given extensive creative freedom with limited constraints. These constraints consisted of incorporating the logo mark and brand colors so that the brand identity was recognizable. Our designs for the new Love …

Run-Of-River Device For Hydropower From The Crum Creek, Paula Suder , '24

Senior Theses, Projects, and Awards

With the onset of climate change from excess carbon emissions, renewable energy sources, especially in the form of hydropower, can offer comparatively low-emission alternatives to conventionally used fossil fuels that may lessen the environmental effects of energy generation. Although most hydroelectric facilities utilize dams to store water and channel flow, diversion facilities, also called “run-of-river” facilities, operate utilizing a portion of the natural flow and eliminate the need for dams and their associated construction and environmental concerns. To design and construct a small scale run-of-river device, an iterative design process was implemented over two prototypes, including spiral axial hydropower turbine …

Sustainable Materials For Environment − Multifunctional Material Made From Dead Leaves And Nanostructured Materials For Antibiotic Degradation, Siyuan Fang

Dissertations, Master's Theses and Master's Reports

As environmental pollution from industrial processes and human activities continues to rise, finding efficient approaches to recycle waste materials and degrade persistent contaminants becomes increasingly critical. Dead leaves, an abundant but underutilized biomass, present an opportunity for creating value-added materials if their biocomponents can be preserved and transformed. Simultaneously, antibiotics such as tetracycline are widely found in water bodies but pose serious ecological and health risks, necessitating effective degradation methods. This dissertation addresses these challenges by leveraging natural and nanostructured materials to develop multifunctional products and advanced photocatalytic processes.

Chapter 3 of this dissertation addresses the challenge of converting waste …

Research And Design A Lifeboat Virtual Reality Simulation System For Maritime Safety Training In Vietnam, Nguyen Dinh Thach, Nguyen Van Hung

Journal of Marine Science and Technology–Taiwan

Ensuring maritime safety and security is crucial for all nations. Training trainees and operational officers in this field aims to enhance their professional skills and ability to manage and resolve incidents at sea. This article outlines the development of a lifeboat simulation system that integrates Virtual Reality (VR) technology in accordance with international maritime regulations. It describes the creation of an algorithm designed to optimize data transmission between simulation systems using the ant colony optimization technique in conjunction with intelligent control algorithms on Unity 3D software for human interaction. In particular, the system combines training with a maritime simulation framework …

Optimizing Large Language Models And Multimodal Approaches For Biomedical Publication And Satellite Imagery, Youngsun Jang

Electronic Theses and Dissertations

This dissertation comprises two main sections: the first focuses on natural language processing (NLP) for extracting key information from scientific literature using large language models (LLMs), and the second addresses remote sensing for detecting natural disasters, such as floods, from satellite imagery using a multimodal approach. The first section investigates methods to enhance Transformer-based models in classifying and extracting information from biomedical scientific publications. Key contributions include the development of a custom dataset for classification and Question and Answering (Q&A) tasks, fine-tuning Transformer models like the Bidirectional Encoder Representations from Transformers (BERT) and addressing multi-span answer issues with the TAg-based …

Nano-Pulse Treatment Overcomes The Immunosuppressive Tumor Microenvironment To Elicit In Situ Vaccination Protection Against Breast Cancer, Anthony Nanajian, Megan Scott, Niculina I. Burcus, Brittney L. Ruedlinger, Edwin A. Oshin, Stephen J. Beebe, Siqi Guo

Bioelectrics Publications

We previously reported that nano-pulse treatment (NPT), a pulsed power technology, resulted in 4T1-luc mammary tumor elimination and a strong in situ vaccination, thereby completely protecting tumor-free animals against a second live tumor challenge. The mechanism whereby NPT mounts effective antitumor immune responses in the 4T1 breast cancer predominantly immunosuppressive tumor microenvironment (TME) remains unanswered. In this study, orthotopic 4T1 mouse breast tumors were treated with NPT (100 ns, 50 kV/cm, 1000 pulses, 3 Hz). Blood, spleen, draining lymph nodes, and tumors were harvested at 4-h, 8-h, 1-day, 3-day, 7-day, and 3-month post-treatment intervals for the analysis of frequencies, death, …

Prevalence Of Resistant Escherichia Coli Isolated From Local Meats Sold In Tema Metropolis, Ghana, Frederick Adzitey, Innocent Allan Anachinaba, Charles Addo-Quaye Brown, Nurul Huda, Masmuniri Rambli

ASEAN Journal on Science and Technology for Development

Contamination of meat by Escherichia coli (E. coli) can take its source from the live animal or by cross contamination. The study determined the prevalence of resistance of E. coli isolated from locally produced meats in the Tema Metropolis. Beef (n=200), chicken (n=200) and pork (n=200) were randomly selected and evaluated for the presence of E. coli using the procedure in the Bacteriological Analytical Manual of USA-FDA. The disc diffusion method was used for antibiotic susceptibility test of E. coli (n=55) isolates. Locally produced beef (67%), chicken (41%) and pork (23%) were contaminated by E. coli. Escherichia coli isolates were …

A Rule-Based Hybrid Translation Model For Context-Aware Speech To Indian Sign Language Tasks, Dania Jaison

Master's Projects

In India, one of the most significant tools to communicate with the Deaf and Hard of Hearing (DHH) communities is Indian Sign Language(ISL). The issue of a scarcity of computational resources for ISL is even more pronounced when it comes to the translation of written or spoken English into ISL. This paper proposes a rule-based model for translation where the spoken english sentences are translated into ISL by focusing on the specific syntactic and grammatical differences between these two languages. ISL uses a simplified syntax unlike the nuanced sentence structures in English — we omit most of the auxiliary verbs …