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Simulation Modeling In Manufacturing Cell Design, Debra A. Hunke

Opportunities for Undergraduate Research Experience Program (OURE)

The interwoven phases of the manufacturing process in Computer Integrated Manufacturing (CIM) require a carefully designed facility. Simulation modeling can be combined with other techniques to provide a rigorous methodology for CIM system design. This paper describes CIM, simulation ana their relationship. A case study demonstrates the described methodology in the design of a flexible manufacturing cell.

The Detection And Quantification Of Atrophic Rhinitis Using Ditigal Image Processing Techniques, Timothy Mussman

Opportunities for Undergraduate Research Experience Program (OURE)

This project focuses its attention on the detection and quantification of Atrophic Rhinitis (A.R.), a disease prevalent in pigs. A.R. causes some of the bony structure in a pig's snout to atrophy, which exposes the animal to other diseases that may effect its growth. It is studied by examining a cross section of the pig's snout. By comparing areas and perimeters of the nasal cavity to bony structures, or turbinates in the snout, one can determine the severity of the atrophy. Currently, the veterinarians diagnosis is based on a subjective analysis of the snout. The problem with this method is …

Indiana Model Zoning Ordinance, T. William Patterson

Indiana Local Technical Assistance Program (LTAP) Publications

This HERPICC model is intended as a basis for helping Indiana counties, cities, and towns to write or revise local regulatory ordinances. Having such a model is especially urgent because field trips taken throughout the state have revealed that many jurisdictions are vulnerable to lawsuits because their ordinances are out of date and do not conform to the current provisions of the Indiana Code. This situation is made more serious by the lack of adequate professional planning staff or consultants available to local governments. Many may have received inaccurate advice from their attorneys. Too often, attorneys are not familiar enough …

Development And Characterization Of Monoclonal Antisperm Antibodies: Potential For Contraception, Dilrowshan H. Haque

Theses and Dissertations in Biomedical Sciences

There is an expressed need to develop a greater variety of safe contraceptive methods which would find acceptance worldwide, particularly in developing countries. Immunization against spermatozoa might be such a method as judged by the accumulated evidence from studies on human females and in a number of female animal species.

Two extraction techniques were used for sperm membrane antigen isolation. The first technique involved NP-40 detergent for antigen extraction from human motile sperm and the second technique employed homogenized human testis for antigen extraction. Using these immunogens, sperm membrane-specific monoclonal antibodies (MAbs) were developed. When these antisperm MAbs were subjected …

Simulator For Concurrent Processing Data Flow Architectures, Mahyar R. Malekpour

Electrical & Computer Engineering Theses & Dissertations

A software simulator capable of simulating execution of an algorithm graph on a given system under the Algorithm To Architecture Mapping Model (ATAMM) rules is presented in this thesis. ATAMM is capable of modeling the execution of large-grained algorithms on distributed data flow architectures. Investigating the behavior and determining the performance of an ATAMM based system requires the aid of software tools. The ATAMM Simulator presented in this thesis is capable of determining the behavior, performance, and reliability of a system without having to build a hardware prototype. Case studies are performed on four algorithms to demonstrate the capabilities of …

Analytical Modeling And Simulation For Investigation Of A Digital Gas Filter Correlation Radiometer, Catherine P. Mcgowan

Electrical & Computer Engineering Theses & Dissertations

This thesis investigates a digital gas filter correlation radiometer called the Tropospheric Radiometer for Atmospheric Chemistry and Environmental Research (TRACER), which will be used to remotely measure carbon monoxide at three levels in the troposphere. The nadir-viewing radiometer measures the differential absorption of radiation through the atmosphere at 4.67@m and 2.33pm wavelengths. This thesis develops an analytical model of the TRACER measurement process to evaluate the effect of varying certain system parameters on the measurement. The independent sampling criterion and the response of linear systems to random signals are explained. A parametric simulation model is also developed to evaluate the …

Prediction Of Loma Prieta Earthquake And Creation Of Awareness About It In Society, Arun Bapat

International Conferences on Recent Advances in Geotechnical Earthquake Engineering and Soil Dynamics

Prediction of earthquake as an exercise of academic interest is one activity. Creation of awareness about seismic disaster and its mitigation is more broad base social activity. It is necessary that the predicted seismic event is likely to occur, people in the vulnerable seismic area should be told about the utility of macroseismic, short-term reliable earthquake precursors, which could be observed by common man. The happenings involving both the above cases for Loma Prieta earthquake are discussed.

Behavior Of A Geosynthetic Reinforced Sand, H. C. Liu, N. Y. Chang

International Conferences on Recent Advances in Geotechnical Earthquake Engineering and Soil Dynamics

The method of geosynthetic reinforced earth incorporates a flexible but tension resistant synthetic material in soil to increase the tensile resistance of the composite. In this study, both static and dynamic responses of an Ottawa 30-40 sand reinforced with a nonwoven geosynthet1c, Bidim C-34, were investigated. Static triaxial tests were first conducted to examine the influence of the reinforcement on strength, Young's modulus, and Poisson's ratio of the composite soil. Cyclic triaxial tests and resonant column tests were then conducted to examine the variation of shear modulus and damping ratio at different strain amplitudes. The influence of geosynthetic on both …

Pcbs And Related Compounds In Lake Hartwell, Alan W. Elzerman, Frank M. Dunnivant, Geoffrey G. Germann

Publications

No abstract provided.

Peripheral Nerve Bridges For Central Nervous System Regeneration, Silvio Varon, Theo Hagg, H. Lee Vahlsing, Marston Manthorpe

Cells and Materials

A neuronotrophic hypothesis for the adult central nervous system (CNS) has been increasingly supported by in vivo studies of Nerve Growth Factor (NGF) impacts on adult rat CNS cholinergic neurons. We have extended these investigations to NGF effects on cholinergic axonal regeneration in an adult rat septo-hippocampal model. A fimbriafornix lesion deprives the dorsal hippocampal formation (HF) of its cholinergic afferents and provides a cavity into which sciatic nerve segments can be implanted to serve as regeneration bridges from septum to HF. Septa! cholinergic fibers enter and course through fresh cell-containing nerve bridges to attain a maximal number by the …

Analysis Of Protein Adsorption On Retrieved Human Vascular Grafts Using Immunogold Labelling With Silver Enhancement, N. P. Ziats, N. S. Topham, D. A. Pankowsky, J. M. Anderson

Cells and Materials

The adsorption of proteins on biomedical materials such as vascular grafts is important in modulating thrombosis, one eventual cause of vascular graft failure. We have identified proteins expressed on the surfaces of retrieved vascular grafts to determine if certain proteins were present at the end stage of vascular failure. Scanning electron microscopic analysis of protein adsorption on the surfaces of retrieved vascular prostheses was determined using antibodies to human blood proteins fibrinogen, fibronectin, Hageman factor (factor XII) and factor VIII/von Willebrand Factor. The detection of these proteins on the blood contacting surface was evaluated by immunogold labelling with protein A-gold …

Scanning Electron Microscopic Evaluation Of The Fractured Surfaces Of Canine Calculi From Substrata With Different Surface Free Energy, H. M. W. Uyen, W. L. Jongebloed, H. J. Busscher

Cells and Materials

The strength of adhesion between dental calculus and enamel or dentin surfaces determines the ease with which the calculus can be removed by brushing or professional dental treatment. In this study, we examined the adhesion of canine calculi formed on substrata with different surface free energies (sfe) and roughness by means of scanning electron microscopy. In 4 beagle dogs fenestrated crowns were made on the upper fourth premolars. Subsequently, facings of glass (sfe = 120 mJ. m-2), bovine enamel (sfe = 85 mJ.m-2), bovine dentin (sfe = 92 mJ.m-2), polymethyl-methacrylate (PMMA, sfe = 56 mJ.m-2) and polytetrafluorethylene (PTFE, sfe = …

Polylysine Stimulation Of Ectopic Cartilage Formation, Rocky S. Tuan, Dina M. Turchi, David S. Kreitzer

Cells and Materials

Cartilage development, or chondrogenesis, is a process which involves the condensation of prechondrogenic mesenchymal cells, followed by the expression of the cartilage phenotype characterized by the biosynthesis of cartilage-specific, extracellular matrix components. We have previously shown that the cationic biopolymer, polylysine (PL), is able to stimulate chondrogenesis by embryonic limb bud mesenchymal cells in vitro. In this study, we have evaluated the chondrogenesis-stimulating activity of PL in vivo using an experimental system consisting of chick embryonic muscle explants, which were grafted onto the chorioallantoic membrane of chick embryos maintained in long-term shell-less culture. The muscle grafts were treated with PL …

Adhesion Of Staphylococci To Breast Prosthesis Biomaterials: An Electron Microscopic Evaluation, T. A. Fassel, J. E. Van Over, C. C. Hauser, C. E. Edmiston, J. R. Sanger

Cells and Materials

Gram-positive coagulase-negative staphylococci have been implicated in breast prosthesis infection. Staphylococcus au re us, Staphylococcus epidermidis, and Staphylococcus hominis strains were examined for adhesion and proliferation morphology to polyurethane foam and smooth silicone rubber prosthetic biomaterials. Ruthenium red, alcian blue and ruthenium red-lysine in en bloc procedures were applied to optimally visualize the polysaccharide slime. Ruthenium red processing resulted in observation of additional outer material close to the cell wall, more than seen in the absence of cationic reagent. Alcian blue preserved fibrous or netlike strands or meshworks of material. Ruthenium red-lysine preserved considerable amounts of slime covering the cocci …

A Comparative Study Of Bovine Pericardium Mineralization: A Basic And Practical Approach, Branko B. Tomazic, Chakwan Siew, Walter E. Brown

Cells and Materials

The biomineralization of bovine pericardium (BP) heart valve bioprostheses was investigated by simulation of the process under in vitro and in vivo conditions. The nature and composition of calcific deposits that formed in human heart valve bioprostheses were compared with the mineral formed on BP discs immersed in a calcifying medium or subcutaneously implanted into Sprague-Dawley rats. The early stage of experimental biomineralization in vitro took place on the surface only, while in vivo deposition appeared to be intrinsic, as documented by histological cross sections. The chemical composition of the initial mineral phase formed under in vitro conditions had a …

The Articular Cartilage Of The Rabbit Knee: A Scanning Electron Microscopy Study, Daniel Levanon, Haim Stein

Cells and Materials

The surface morphology of eight sectors in the rabbit knee articular cartilage was studied using scanning electron microscopy. Cartilage surfaces showed wide variation in the shape, dimensions , and density of gaps and acellular processes. Patellas and load-bearing condyles revealed a relatively higher density of processes than did load-free condyles. Surface processes and gaps were abundant. They might represent a condensation product(s) of hyaluronic acid/protein complex that accrues during cycles of loading/weight bearing.

Preservation Of The Cell-Biomaterial Interface At The Ultrastructural Level, J. M. Schakenraad, J. A. Oosterbaan, E. H. Blaauw

Cells and Materials

Studying the tissue-biomaterial interface at the ultrastructural level is not without problems. Dissolution of the biomaterial in one of the dehydration or embedding media causes holes and shatter during sectioning or dislodgement of the biomaterial. The fine tuning of the hardness of both biomaterial and embedding medium, as well as the introduction of butyl-2,3- epoxypropylether as an intermediate between the dehydration series and the Epon resin , improving the impregnation , will solve many of the problems mentioned. With this improved technique good results were obtained with materials ranging from teflon, poly(Lactic acid) and polyurethanes to tissue culture polystyrene. No …

Surface Modification Of Polymers To Permit Endothelial Cell Growth, C. James Kirkpatrick, Detlef Mueller-Schulte, Marc Roye, Guenter Hollweg, Claudia Gossen, Horst Richter, Christian Mittermayer

Cells and Materials

The interaction between endothelial cells (EC) and polymers has become relevant to medicine as a result of attempts to improve the biocompatibility of vascular prostheses. In man, endothelialization is minimal, so that vascular surgeons have attempted to pre-seed vascular grafts with autologous EC. The poor results of EC seeding of commonly used materials for vascular grafts, such as expanded polytetrafluoroethylene (ePTFE) or woven polyester (Dacron) has led to attempts to modify the surface of these and other polymers. Three principal modification techniques have been employed : 1. adsorption of bioactive molecules from applied solutions. Examples are fibronectin, collagen types I …

The Development Of A Concrete Interlocking Partition Walling Unit, Haldane L. Johnson

Graduate Student Work

This research aimed to develop a better method of erecting internal partition walls for the Jamaican housing industry. An interlocking concrete block wall unit was considered appropriate because it used local materials and required semi-skilled labor to erect.

A timber mold was made to manually produce the 4 x 4 x 8 inch block. The concrete mix used had a cement to aggregate ratio of 1:7.5 and a sand to gravel ratio of 1:2 and a water cement ratio of 0.753. The average compressive strength of the block determined after three days was 351.56 psi. This translates into an expected …

Peripheral Nerve Regeneration Within Tubular Prosthesis: Effects Of Laminin And Collagen Matrices On Cellular Ingrowth, Ivar J. Kljavin, Roger D. Madison

Cells and Materials

Bridging a severed peripheral nerve with a tubular conduit, "entubulation repair" , allows manipulation of the microenvironment encountered by regenerating axons. In the present study, we placed the ends of severed mouse sciatic nerves into nonpermeable Tygon tubes to bridge a 4 mm nerve gap. The tube lumen was filled with either a collagen or laminin matrix. The matrices formed a stable 3-D structure connecting both proximal and distal stumps, and provided a scaffolding for the regenerating axons and their supporting cells. We examined with scanning electron microscopy (SEM), transmission electron microscopy (TEM) and light microscopy, the initial events of …

Ultrastructural Study Of Bone Formation On Synthetic Hydroxyapatite In Osteoblast Cultures, J. M. Sautier, J. R. Nefussi, N. Forest

Cells and Materials

Collagenase isolated rat calvaria cells forming a mineralized matrix in vitro were cultured in the presence of synthetic hydroxyapatite. Interactions between bone cells and hydroxyapatite biomaterial were followed by transmission electron microscopy. The appearance of a granular, collagen free, electron-dense layer at the periphery of the material was noted initially. Progressively, an amorphous, granular material formed and extended between the hydroxyapatite aggregates. Osteoblastic cells then synthesized an osteoid matrix which mineralized on the first formed granular collagen free layer, following a classical pattern of calcification . Demineralization of ultrathin sections confirmed the presence of this interface between the material and …

Interactions Of Bacteria And Amoebae With Ocular Biomaterials, Thomas John

Cells and Materials

The use of biomaterials in periocular and intraocular sites has resulted in some ocular inflammations and infections which can result in vision-threatening ocular disease. This review addresses bacterial interactions with, and adherence to ocular biomaterials such as soft contact lenses, surgical suture materials, and intraocular lenses. In addition, adherence of Acanthamoeba to soft contact lenses is described, and the role of these lenses in the development of Acanthamoeba keratitis is discussed.

Evaluation Of The Images Of Specular Microscopy Of The Cells On Implanted Intraocular Lenses In Vivo, Kiyoshi Okada, Keiko Takahashi, Hiroaki Sagawa, Kuniomi Abe

Cells and Materials

Specular microscopy , an optical method to study the anterior segment of the eye, was applied to observe the cells on implanted intraocular lenses in vivo. The images from specular microscopy were evaluated by comparing the morphology of the same cells on intraocular lenses implanted in rabbit eyes by specular microscopy , light microscopy and scanning electron microscopy (SEM). The time lapse study in living human eyes and the optical evaluation of jts interference images were performed to elucidate its image formation.

The same giant cells, as observed in vivo by specular microscopy, proved to be multinucleated cells. It …

Fertilization Of Crops With Feedlot Manure, Elbert C. Dickey, Gerald Bodman

Department of Agricultural and Biological Systems Engineering: Faculty Publications

The application of animal manure to farmland is an appropriate and environmentally sound management practice for most feedlot operators. Land application returns nutrients from manure to the soil and helps build and maintain soil fertility. In addition to containing nitrogen, phosphorus and potassium, manure contains trace "elements such as calcium, magnesium, iron and zinc. Manure has also been shown to improve soil tilth, increase water-holding capacity, lessen wind and water erosion and improve aeration. Land application of manure should be viewed as a means to utilize crop nutrients present in the manure for crop production rather than utilizing the land …

Electronic Controls For Swine Buildings, Douglas G. Overhults, R. S. Gates

Agricultural Engineering Extension Updates

This fact sheet discusses the use of electronic controllers to maintain the environment within swine barns. There are some special considerations when using electronic controllers to replace traditional control systems. Three main items are addressed in this fact sheet: 1) the selection of a controller, 2) installation considerations, and 3) protection against controller failure.

Master Of Science, Computer Science 1991, Nova Southeastern University

College of Engineering and Computing Course Catalogs

No abstract provided.

Kentucky Traffic Accident Facts 1991 Report, Kentucky State Police

Kentucky Transportation Center Research Report

KENTUCKY'S TRAFFIC ACCIDENT FACTS report for 1991 is based on accident reports submitted to the Accident Unit housed in the Kentucky State Police Information Services Branch, Records Section. As required by Kentucky Revised Statutes 189 .635, "every law enforcement agency whose officers investigate a vehicle accident of which a report must be made ... shall file a report of the accident ... within ten days after investigation of the accident upon forms supplied by the bureau." The stated purpose of this requirement is to utilize data on traffic accidents" for such purposes as will improve the traffic safety program in …

Endothelial Superoxide Production In The Isolated Rat Heart During Early Reperfusion After Ischemia -- A Histochemical Study, Charles F. Babbs, Meloney D. Cregor, John J. Turek, Stephen F. Badylak

Weldon School of Biomedical Engineering Faculty Publications

This paper describes a histochemical study of superoxide generation in buffer-perfused, isolated rat hearts during the first 2 minutes of reperfusion after 60 minutes of warm ischemia. Superoxide radical production was demonstrated by a modification of Karnovsky's manganese/diaminobenzidine technique, in which superoxide oxidizes Mn++ to Mn+++ ions, which in turn oxidize diaminobenzidine to form amber, osmiophilic polymers, observable by light or electron microscopy. Isolated hearts were rendered ischemic, reperfused with oxygen equilibrated buffer containing Mn++ and diaminobenzidine, fixed by perfusion with Trump's solution, and processed for light and electron microscopy. The method consistently demonstrated evidence of superoxide generation near the …

Methylene Blue As An Inhibitor Of Superoxide Generation By Xanthene Oxidase: A Potential New Drug For The Attenuation Of Ischemia/Reperfusion Injury, Steven C. Salaris, Charles F. Babbs, William D. Voorhees

Weldon School of Biomedical Engineering Faculty Publications

Tissue oxidases, especially xanthine oxidase, have been proposed as primary sources of toxic oxygen radicals in many experimental models of disease states. Among these, ischemia-reperfusion injury may be of the greatest clinical interest. In this paper we propose the use of methylene blue as a means of suppressing the production of superoxide radicals, O2, by acting as an alternative electron acceptor for xanthine oxidase. Previous work has indicated that methylene blue accepts electrons from xanthine oxidase at the iron-sulfur center. Initial experiments in our laboratory demonstrated that (1) pairs of electrons from each enzymatic oxidation are transferred to methylene blue, …

Design And Evaluation Of Closed-Loop Feedback Control Of Minimum Temperatures In Human Intracranial Tumors Treated With Interstitial Hyperthermia, J A. Deford, Charles F. Babbs, U H. Patel, N E. Fearnot, J A. Marchosky, C J. Moran

Weldon School of Biomedical Engineering Faculty Publications

The dynamic nature of blood flow during hyperthermia therapy has made the control of minimum tumor temperature a difficult task. This paper presents initial studies of a novel approach to closed-loop control of local minimum tissue temperatures utilizing a newly developed estimation algorithm for use with conductive interstitial heating systems. The local minimum tumor temperature is explicitly estimated from the power required to maintain each member of an array of electrically heated catheters at a known temperature, in conjunction with a new bioheat equation-based algorithm to predict the ‘droop’ or fractional decline in tissue temperature between heated catheters. A closed …