Digital Commons Network^™

A Service Provisioning Platform For Beyond 3g - The Telecommunication Service Exchange, Donna Griffin

Theses

From the inception of mobile communications one of the most important factors contributing to its success has been a good understanding of user requirements. In the first generation, mobile networks offered subscribers the freedom to communicate regardless of their locations and the joy of instant access to voice telephony services. This provided a competitive edge over wire line communication networks and resulted in large revenue streams. However over the past decade, mobile network operators have been faced with a number of factors that have incurred significant costs and resulting reduced revenue. These factors include deregulation, increased competition and technological progress …

Anaerobic Digestion: Decision Support Software, Marco Poliafico

Theses

Ireland has significant quantities of livestock; meat exportation is a vibrant sector of the economy. Environmental management of animal wastes has therefore become an important concern. On the other hand in the last decade, national and EU policy debate has highlighted the need to investigate alternative energy: in particular energy for transport.

This study investigates the quantities of animal wastes produced in Ireland and their potential treatment using Anaerobic Digestion technologies. In 2005 Ireland had over 8 millions animals (cattle and pigs) and the annual slaughter accounted for over 4.2 million of these creatures. These animals have been responsible for …

Resistance Of The Target Islet Tissue To Autoimmune Destruction Contributes To Genetic Susceptibility In Type 1 Diabetes., Natasha J. Hill, Aleksandr Stotland, Michelle Solomon, Patrick Secrest, Elizabeth Getzoff, Nora Sarvetnick

Journal Articles: Regenerative Medicine

Type 1 diabetes occurs when self-reactive T lymphocytes destroy the insulin-producing islet beta cells of the pancreas. The defects causing this disease have often been assumed to occur exclusively in the immune system. We present evidence that genetic variation at the Idd9 diabetes susceptibility locus determines the resilience of the targets of autoimmunity, the islets, to destruction. Susceptible islets exhibit hyper-responsiveness to inflammatory cytokines resulting in enhanced cell death and increased expression of the death receptor Fas. Fas upregulation in beta cells is mediated by TNFR2, and colocalization of TNFR2 with the adaptor TRAF2 in NOD beta cells is altered. …

An Evolutionary Programming Algorithm For Automatic Chromatogram Alignment, Bonnie Jo Schwartz

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Scientists use liquid chromatography/mass spectrometry (LC/MS) instruments to measure metabolic responses to external stimuli. The data from these instruments can be distorted due to changes in the testing environment. Automating the removal of distortions is crucial in processing the data. The purpose of this thesis is to develop an algorithm that will automate the process.

The data produced by the LC/MS instrument were treated as images and image registration techniques were applied. A polynomial transformation function was assumed. An evolutionary programming algorithm was used to determine the coefficients of the polynomial. The data was manipulated to determine the best registration …

Designing Computer Agents With Personality To Improve Human-Machine Collaboration In Complex Systems, Sasanka V. Prabhala

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The dynamic nature of complex systems and the overwhelming amount of data that must be handled by human operators requires the development of smart systems that augment human capabilities. For these systems human-agent collaboration is part of the system dynamic. Unfortunately the computer agent is not typically perceived by the human operator as a collaborative team member. This research addressed the key question of how to develop and evaluate computer agents with personality to enhance human-machine collaboration. To move towards this goal three research objectives were established: (1) develop agents with personality, (2) validate that humans perceive these agents as …

Data Mining And Analysis On Multiple Time Series Object Data, Chunyu Jiang

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Huge amount of data is available in our society and the need for turning such data into useful information and knowledge is urgent. Data mining is an important field addressing that need and significant progress has been achieved in the last decade. In several important application areas, data arises in the format of Multiple Time Series Object (MTSO) data, where each data object is an array of time series over a large set of features and each has an associated class or state. Very little research has been conducted towards this kind of data. Examples include computational toxicology, where each …

Oxidation Resistant Coatings On Microcelluar Carbon Foam Using Simple Scalable Techniques, Dakshinamurthy Sharma Nagalingam

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Carbon foam has many applications in the fields of thermal management, net-shape composites and electronic cooling due to its porous structure, low density, electrical and thermal conductivities. However it is prone to oxidation at high temperatures in air. Whereas some previous studies have reported oxidation protective coatings on other carbon structures such as graphite parts and fibers, there is very limited work on foam. Moreover, earlier methods have used vapor phase techniques such as Plasma Vapor Deposition (PVD) and Chemical Vapor Deposition (CVD). There is no known study involving such coatings using simple scalable liquid phase method. This thesis reports …

Investigating The Role Of Subunit Iii In The Structure And Function Of Rhodobacter Sphaeroides Cytochrome C Oxidase, R. Ryan Geyer

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The role of subunit III (SIII) in cytochrome c oxidase structure and function was investigated using enzyme isolated from the bacterium Rhodobacter sphaeroides. Energy minimization calculations suggested that in the absence of SIII, subunit I (SI) adopted a more open conformation. This observation was tested through the use of limited proteolysis using, á-chymotrypsin. The results showed that in the absence of SIII the solution structures of wild-type and I/II oxidase were not significantly different, and that proteolysis occurred exclusively at the N and C-termini of SI. Upon inactivation of I/II oxidase by catalytic turnover, and subsequent digestion with the protease …

Summaritive Digest For Large Document Repositories With Application To E-Rulemaking, Lijun Chen

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Large document repositories need to be organized and summarized to make them more accessible and understandable. Such needs exist in many applications, including web search, e-rulemaking (electronic rulemaking) and document archiving. Even though much has been done in the areas of document clustering and summarization, there are still many new challenges and issues that need to be addressed as the repositories become larger, more prevalent and dynamic. In this dissertation, we investigate more informative ways to organize and summarize large document repositories, especially e-rulemaking feedback repositories (ERFRs), so that the large repositories can be managed and digested more efficiently and …

Functional Interplay Between Subthreshold Ion Channels In Preautonomic Neurons Of The Hypothalamic Paraventricular Nucleus In Health And Disease Conditions, Patrick M. Sonner

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Under normal conditions, blood pressure is tightly regulated through autonomic tonic and reflex mechanisms. However, when the set-point for blood pressure is chronically elevated, hypertension occurs. Hypertension if untreated can lead to further complications including heart failure, stroke and kidney failure. Elevated sympathetic outflow is known to contribute to the development and/or maintenance of hypertension, and while the hypothalamic paraventricular nucleus (PVN), a preautonomic center, has been implicated in the elevation of sympathetic activity during hypertension, the precise pathophysiological mechanisms underlying sympathoexcitation remain unclear. Subthreshold ion channels, including the A-type K ⁺(I _A) and the T-type Ca ^{2+ …}

Fabrication And Testing Of Scaffolds For Cell Growth From Ionic Liquid Solubilized Fibroin, Maneesh Kumar Gupta

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The advent of tissue engineering has spurred research into developing materials to act as scaffolds for tissue growth. These scaffolds require materials capable of mimicking the in vivo conditions so that tissues can be grown effectively in vitro. Silk is an attractive biomaterial for use in tissue engineering applications because of its slow degradation, excellent mechanical properties, and biocompatibility. The major objective of the research in this thesis is to demonstrate a simple method to cast films directly from silk fibroin dissolved in an ionic liquid. The films cast from the silk ionic liquid solution were found to support normal …

A Hybrid Approach To Retrieving Web Documents And Semantic Web Data, Trivikram Immaneni

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The Semantic Web has been evolving into a property-linked web of RDF data, conceptually divorced from (but physically housed in) the World Wide Web of hyperlinked documents. Data Retrieval techniques are typically used to retrieve data from the Semantic Web while Information Retrieval techniques are used to retrieve documents from the Hypertext Web. Conceptually unifying the two webs enables the exploitation of their interconnections resulting in benefits to both data and document retrieval. Towards this end, we present the Unified Web model that integrates the two webs and formalizes the structure and the semantics of their interconnections. We present a …

Efficacy Of Removal Of Ccl Viruses Under Enhanced Coagulation Conditions, Morteza Abbaszadegan, Brooke K. Mayer, Hodon Ryu, Nena Nwachuku

Civil and Environmental Engineering Faculty Research and Publications

The focus of coagulation as a water treatment process is shifting to accommodate recent regulatory additions that strive to balance the risks between microbial and chemical contamination of drinking water. In this work, enhanced coagulation using increased ferric chloride dose and/or pH adjustment was evaluated for removal efficacy of viruses on the United States Environmental Protection Agency (USEPA) Contaminant Candidate List (CCL), their surrogates, and dissolved organic carbon (DOC). Jar tests demonstrated that optimal DOC removal was achieved using 40 mg/L FeCl₃ at a pH between 5 and 6. Under these conditions, bench-scale testing resulted in a maximum removal …

A Prescriptive Analysis Of The Indiana Coal Transportation Infrastructure, Thomas F. Brady, Chad M. Pfitzer

JTRP Technical Reports

This report presents the findings of a scoping study of Indiana’s coal transportation infrastructure. Throughout the literature search and investigative phases of this project, it was clear that there exists growing awareness of the importance that transportation plays in the domestic coal industry. There is evidence that suggests transportation costs may be higher than the cost of mining coal. Numerous studies suggest that coal transportation can be developed and utilized for significant competitive economic advantage. The Powder River Basin area in Wyoming is a stellar example of how the combination of a large natural resource and careful transportation planning can …

Effective And Robust Coordination Of Traffic Signals On Arterial Streets, Volume 2, Guidelines Of Design, Wei Li, Andrew P. Tarko

JTRP Technical Reports

Many transportation agencies use Synchro and SimTraffic software package to optimize signal coordination. In general, this software package effectively reduces the efforts of traffic systems engineers and improves the quality of the designed coordination. Nevertheless, the initial solutions given by the software packages usually require adjustment, at both the design and implementation stages. The major objective of this research, therefore, is to reduce the time and effort needed in solution tuning and thus to improve the effectiveness and the efficiency of using Synchro/SimTraffic in arterial signal coordination design. The research outcome is expected to help traffic systems engineers reach reasonable …

Influence Of Speed Limits On Roadway Safety In Indiana, Nataliya V. Malyshkina, Fred L. Mannering, Samuel Labi

JTRP Technical Reports

The influence of speed limits on roadway safety is an extremely important social issue and is subject to an extensive debate in the State of Indiana and nationwide. With roughly 900 fatalities and sixty thousand injuries annually in Indiana, traffic accidents place an incredible social and economic burden on the state. Still, speed limits posted on highways and other roads are routinely exceeded as individual drivers try to balance safety and mobility (speed) as well as risks of penalties from enforcement efforts. This research explores the relationship between speed limits and roadway safety. Specifically, the research focuses on the influence …

C-Fos As A Proapoptotic Agent In Trail-Induced Apoptosis In Prostate Cancer Cells, Xiaoping Zhang, Liang Zhang, Hongmei Yang, Xu Huang, Hasan H. Otu, Towia A. Libermann, William C. Dewolf, Roya Khosravi-Far, Aria F. Olumi

Department of Electrical and Computer Engineering: Faculty Publications

Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL)/Apo-2L promotes apoptosis in cancer cells while sparing normal cells. Although many cancers are sensitive to TRAIL-induced apoptosis, some evade the proapoptotic effects of TRAIL. Therefore, differentiating molecular mechanisms that distinguish between TRAIL-sensitive and TRAIL-resistant tumors are essential for effective cancer therapies. Here, we show that c-Fos functions as a proapoptotic agent by repressing the antiapoptotic molecule c-FLIP(L). c-Fos binds the c-FLIP(L) promoter, represses its transcriptional activity, and reduces c-FLIP(L) mRNA and protein levels. Therefore, c-Fos is a key regulator of c-FLIP(L), and activation of c-Fos determines whether a cancer cell will undergo cell death …

Regional Mechanical Properties And Stress Analysis Of The Human Anterior Lens Capsule, Ryan M. Pedrigi, G. David, J. Dziezyc, J. D. Humphrey

Department of Mechanical and Materials Engineering: Faculty Publications

The lens capsule of the eye functions, in part, as a deformable support through which the ciliary body applies tractions that can alter lens curvature and corresponding refractive power during the process of accommodation. Although it has long been recognized that characterization of the mechanical properties of the lens capsule is fundamental to understanding this physiologic process as well as clinical interventions, prior data have been limited by one-dimensional testing of excised specimens despite the existence of multiaxial loading in vivo. In this paper, we employ a novel experimental approach to study in situ the regional, multiaxial mechanical behavior of …

A “Sprinkler” Vegetative Treatment System, Jason Gross, Chris G. Henry

Department of Agricultural and Biological Systems Engineering: Presentations and White Papers

Vegetative Treatment Systems have historically been a practice for the treatment and utilization of open lot livestock wastes. Use of these systems has been rejuvenated in recent years. A “sprinkler” vegetative treatment area (VTA) has been designed and developed as a proof of concept for addressing challenges experienced with small and medium Animal Feeding Operations. The focus of this paper is to report on the design, economics, challenges and the lessons learned on the development of this system. Cost data shows the cost of a “sprinkler” VTS to range between $31 to $63/head, compared to $51 to $170/head for a …

Protection With Recombinant Clostridium Botulinum C1 And D Binding Domain Subunit (Hc) Vaccines Against C And D Neurotoxins, Robert P. Webb, Theresa J. Smith, Patrick M. Wright, Vicki A. Montgomery, Michael M. Meagher, Leonard A. Smith

Michael Meagher Publications

Recombinant botulinum Hc (rBoNT Hc) vaccines for serotypes C1 and D were produced in the yeast Pichia pastoris and used to determine protection against four distinct BoNT C and D toxin subtypes. Mice were vaccinated with rBoNT/C1 Hc, rBoNT/D Hc, or with a combination of both vaccines and challenged with BoNT C1, D, C/D, or D/C toxin. Mice receiving monovalent vaccinations were partially or completely protected against homologous toxin and not protected against heterologous toxin. Bivalent vaccine candidates completely survived challenges from all toxins except D/C toxin. These results indicate the recombinant C1 and D Hc vaccines are not only …

Spatiotemporal Variations In Growing Season Exchanges Of Co2, H2o, And Sensible Heat In Agricultural Fields Of The Southern Great Plains, Marc L. Fischer, Dave P. Billesbach, Joseph A. Berry, William J. Riley, Margaret S. Torn

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Climate, vegetation cover, and management create finescale heterogeneity in unirrigated agricultural regions, with important but not well quantified consequences for spatial and temporal variations in surface CO2, water, and heat fluxes. Eddy covariance fluxes were measured in seven agricultural fields—comprising winter wheat, pasture, and sorghum—in the U.S. Southern Great Plains (SGP) during the 2001–03 growing seasons. Land cover was the dominant source of variation in surface fluxes, with 50%–100% differences between fields planted in winter–spring versus fields planted in summer. Interannual variation was driven mainly by precipitation, which varied more than twofold between years. Peak aboveground biomass and growing season …

Energy And Environmental Contributions Of Corn-Ethanol, Adam Liska, Kenneth Cassman, Haishun Yang

Adam Liska Papers

Rapid development of regulatory mechanisms to mitigate greenhouse gas (GHG) emissions requires that the biofuel industry employ standard methods to evaluate biofuel systems comprising both crop production systems and biorefineries. Biofuel systems associated with a variety of organic feedstocks have a range of performance capabilities, and recent life-cycle assessment studies of these different systems have used inconsistent methods, leading to confusion about biofuel energy efficiency and GHG mitigation. Hence, there is a critical need for well documented life-cycle metrics for consistent biofuel evaluation that are established and supported by a national or international governing body. Standardization of net energy and …

Rapid Structural Mapping Of Ternary Metallic Alloy Systems Using The Combinatorial Approach And Cluster Analysis, C. J. Long, Jason R. Hattrick-Simpers, M. Murakami, R. C. Srivastava, I. Takeuchi, V. L. Karen, X. Li

Faculty Publications

We are developing a procedure for the quick identification of structural phases in thin film composition spread experiments which map large fractions of compositional phase diagrams of ternary metallic alloy systems. An in-house scanning x-ray microdiffractometer is used to obtain x-ray spectra from 273 different compositions on a single composition spread library. A cluster analysissoftware is then used to sort the spectra into groups in order to rapidly discover the distribution of phases on the ternary diagram. The most representative pattern of each group is then compared to a database of known structures to identify known phases. Using this method, …

Stochastic Models For Enhancing Agility Of Supply Chains, Alok K. Verma

Engineering Technology Faculty Publications

This paper deals with the application of stochastic inventory model to the three-tier supply chain and verifying the values obtained by mathematical model with discrete event simulation. We investigate three-stage serial supply chain with stochastic demand and fixed replenishment lead-time. Inventory holding costs are charged at each stage, and each stage may incur a consumer backorder penalty cost charged by primary supplier to secondary supplier. The customer-demand follows Poisson distribution. We implement Base Stock model for inventory control at both suppliers. Computer simulation is then designed in such a way that it satisfied all the assumptions for mathematical model. Simulation …

Temporal And Spatial Correspondence Of Intramural Rotors And Epicardial Breakthrough Patterns During Ventricular Tachycardia And Fibrillation In The Swine Heart, Jong Jin Kim

All ETDs from UAB

The mechanisms of life threatening cardiac arrhythmias such as ventricular tachycardia (VT) and fibrillation (VF) are very complex. The 3D reconstruction of electrical activity helps us to understand these complex arrhythmias. A new isolated heart preparation and combined electrical and optical mapping system was developed to simultaneously record surface and intramural activation patterns. Epicardial activity on a 6 cm by 6 cm region of the left ventricular wall was recorded optically with 1mm by 1mm spatial resolution using voltage sensitive fluorescent dye (di-4-ANNEPS) and a high speed CCD video camera. Intramural activation patterns were recorded using specially fabricated fiberglass plunge …

Synthesis And Control Of Microstructure, Mechanical Properties, And Bioactivity In Biphasic And Preferentially Oriented Calcium Phosphate Bioceramics, Hyunbin Kim

All ETDs from UAB

Calcium phosphate bioceramics are recognized as one of the most biocompatible materials and are widely used in systems for bone repair and regeneration. In this work, the pulsed laser deposition technique was chosen to produce calcium phosphate materials with different crystallographic texture and chemical composition for investigation of their structural, mechanical, as well as biological properties. Various calcium phosphate coatings were obtained on Ti6Al4V substrates using a KrF excimer laser (248 nm) with an energy density of 4−8 J/cm2 and substrate temperature of 625−730 °C. A method was developed that enables the deposition of highly textured hydroxyapatite by controlling the …

Regulation Issues And Prediction Of Natural Estrogen Loads For Wastewater Treatment Plants, Michelle E. Jarvie

Dissertations, Master's Theses and Master's Reports - Open

No abstract provided.

Models Of Disparity Gradient Estimation In The Visual Cortex, Alexander Zotov

All ETDs from UAB

The binocular disparity of an object slanted in depth from the frontoparallel plane is not constant and changes with coordinate. Objects oriented in such way have non-zero disparity gradient. The processes that take place in the brain to recover disparity gradient and to create the correct perception of slant in depth are not well understood. Changes in local disparity are an obvious disparity gradient cue. Here, we consider an alternative means of disparity gradient detection exploiting the differential projection of oriented edges to each eye. Two retinal images of an object slanted in depth differ by the amount of horizontal …

Discovering Software Reliability Patterns Based On Multiple Software Projects, Yi Liu, Gerald Adkins, Jeng-Foung Yao, Gita Williams

Journal of International Technology and Information Management

Discovering patterns that indicate software reliability provides valuable information to software project managers. Software Quality Classification (SQC) modeling is a methodology that can be used to discover reliability patterns of large software projects. However, the patterns found by SQC modeling may not be accurate and robust owing to insufficient information used in the training process. This study compares two genetic programming-based SQC models using different volumes of data. These data were extracted from seven different NASA software projects. The results demonstrate that combining data from different projects can produce more accurate and reliable patterns.

A Cognitive Robotics Approach To Comprehending Human Language And Behaviors, Deryle W. Lonsdale, D. Paul Benjamin, Damian Lyons

Faculty Publications

The ADAPT project is a collaboration of researchers in linguistics, robotics and artificial intelligence at three universities. We are building a complete robotic cognitive architecture for a mobile robot designed to interact with humans in a range of environments, and which uses natural language and models human behavior. This paper concentrates on the HRI aspects of ADAPT, and especially on how ADAPT models and interacts with humans.