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High-Power Low-Frequency Ultrasound: A Review Of Tissue Dissection And Ablation In Medicine And Surgery, Brendan O'Daly, Edmund Morris, Graham Gavin, John O'Byrne, Garrett Mcguinness

Articles

High-power low-frequency ultrasound in the range 20–60 kHz has wide ranging clinical applications in surgical and medical instruments for biological tissue cutting, ablation or fragmentation, and removal. Despite widespread clinical application and common device operating characteristics, there is an incomplete understanding of the mechanism of tissue failure, removal and damage. The relative contribution of cavitation, direct mechanical impact and thermal effects to each process for specific tissue types remains unclear. Different and distinct mechanisms and rates of tissue removal are observed for interaction with soft and hard tissue types. Device operating parameters known to affect the interaction include frequency, peak–peak …

Visualization Of An Approach To Data Clustering, Marisabel Guevara

Computer Science and Computer Engineering Undergraduate Honors Theses

Using visualization and clustering goals as guidelines, this thesis explores a graphic implementation of a data clustering technique that repositions vertices by applying physical laws of charges and springs to the components of the graph. The resulting visualizations are evidence of the success of the approach as well as of the data sets that lend themselves to a clustering routine. Due to the visual product of the implementation, the algorithm is most useful as an aid in understanding the grouping pattern of a data set. Either for a rapid analysis or to assist in presentation, the visual result of the …

Hydrogen Production Through The Process Of Electrolysis Can Benefit Fuel Conservation In Automobiles, Wade D. Stahr

Graduate Research Papers

Every day over 8.5 million barrels of gasoline are consumed in America alone. Since fuel prices have skyrocketed there is more need than ever for a fuel-conserving device that the public can use in any automobile and will result in true savings both financially and environmentally. Many people and organizations have talked about an all hydrogen-powered vehicle; while this is a wonderful concept, the actuality of it happening throughout the entire country is less that probable. Due to many factors, mainly financial, the use of hydrogen to power vehicles on a mass scale could take many years to incorporate. However, …

Regenerative Peripheral Neurointerfacing Of Upper Extremity Prostheses, Kshitija Garde

Bioengineering Theses - Archive

Current robotic prosthetic devices provide limited functionality to the user as they rely on gross myogenic control and lack critical sensory feedback needed for fine movement control. Interfacing the nervous system with the robotic prosthesis would facilitate amputees to control them naturally, in resemblance to the human hand. Functional neuro-electrode connections have been demonstrated in the brain and peripheral nervous system; however, gliosis, micro hemorrhages, axonopathy and excessive inflammation limit their long-term use. We evaluated the possibility of enticing peripheral nerve regeneration through a multi-electrode array with an open architecture as an alternative to enhance longevity of nerve-electrode interface. Regenerative …

Analysis And Experiments For Tendril-Type Robots, Lara Cowan

All Theses

New models for the Tendril continuous backbone robot, and other similarly constructed robots, are introduced and expanded upon in this thesis. The ability of the application of geometric models to result in more precise control of the Tendril manipulator is evaluated on a Tendril prototype. We examine key issues underlying the design and operation of 'soft' robots featuring continuous body ('continuum') elements. Inspiration from nature is used to develop new methods of operation for continuum robots. These new methods of operation are tested in experiments to evaluate their effectiveness and potential.

2008 Epa’S Report On The Environment

United States Environmental Protection Agency: Publications

To accomplish its mission, the U.S. Environmental Protection Agency (EPA) must pay close attention to trends in the condition of the nation’s air, water, and land, and to associated trends in human exposure and health and the condition of ecological systems. Data on environmental trends serve two key purposes: they provide valuable input to EPA in developing its strategic outlook and priorities, and they allow EPA and the public to assess whether the Agency is succeeding in its overall mission to protect human health and the environment. EPA prepared this Report on the Environment (ROE) to accomplish these purposes.
In …

The Effects Of Physical And Chemical Modulating Agents On The Induction Of Vaccine-Induced Immune Responses, Andrea Nicole Ryan

Honors Scholar Theses

After the development of the viral-based prostate cancer vaccine, Ad5-PSA, much research has been orientated to help enhance the induced immune response by combining the vaccine with physical and chemical modulating agents, more specifically the polymers polyethylenimine (PEI), chitosan, and chitosan coated with CD3 complex antibodies; all previously shown to stimulate an immune response as isolated gene carriers. To compare the vaccine-induced immune responses between the naked vaccine and the polymer-vaccine combinations, a mouse model using the ovalbumin- specific Ad-OVA vaccine was tested using intracellular cytokine staining (ICS), tetramer staining, and cytotoxic T-cell lymphocyte assays to measure the activation of …

Conversion Of Biomass Resource To Useful Forms Of Energy And Other Products, Steven Jennings

Chemical Engineering Undergraduate Honors Theses

The United States is facing increasing pressure to find renewable energy sources due to rising energy costs. With world energy demand at an all time high, renewable energy has been thrust into the forefront of research as a means to mitigate this looming crisis. Throughout the United States, there is a large quantity of agricultural biomass that could be used to generate energy and lessen the dependence on diminishing resources. Specifically, animal feeding operations (AFOs) such as dairies generate large amounts of cow manure, which, when improperly handled, causes both air and water pollution. Currently, most manure is temporarily stockpiled …

Kinetics Determination Of Soybean Oil Transesterification In The Design Of A Continuous Biodiesel Production Process, Irwin Jacob, Ed Clausen, Danielle Julie Carrier

Biological and Agricultural Engineering Undergraduate Honors Theses

One-step batch transesterification consisting of three stepwise reversible reactions of pure soybean oil with methanol was conducted at two different mixing speeds (600 and 300 rpm) to produce soybean oil fatty acid methyl esters (biodiesel). In both batch reactions, sodium methoxide (1.09 wt% based on soybean oil) was used as the catalyst, the reaction temperature was 60oC, and the methanol-to-oil molar ratio was 6:1. The objectives were to determine and/or investigate: 1) the mechanism and order of the reaction, 2) the reaction rate constants, 3) the effect of changes in mixing intensity on the reaction rate, 4) the comparison of …

Mathematical Modeling Of Oral Cavity Mucositis, Jason White

Honors Scholar Theses

Oral Mucositis is a condition seen in post-treatment mouth cancer patients and is a condition of which the pathobiology is not entirely known. It is a condition that shares many common pathways with other alimentary tract injuries such as inflammatory bowel disease. Mathematical modeling of the system can help to identify gaps in the current knowledge base as well as assist in generating new hypotheses and predicting clinical outcomes of conditions. A detailed mathematical model would assist researchers in determining which drug targets are worthwhile investigating. Deterministic modeling and Virtual Cell&#; software were used to assign rate constants to each …

Artificial Neural Network Estimation Of Soil Erosion And Nutrient Concentrations In Runoff From Land Application Areas, Minyoung Kim, John E. Gilley

Department of Agricultural and Biological Systems Engineering: Faculty Publications

The transport of sediment and nutrients from land application areas is an environmental concern. New methods are needed for estimating soil and nutrient concentrations of runoff from cropland areas on which manure is applied. Artificial Neural Networks (ANNs) trained with a backpropagation (BP) algorithm were used to estimate soil erosion, dissolved P (DP) and NH₄–N concentrations of runoff from a land application site near Lincoln, Nebraska, USA. Simulation results from ANN-derived models showed that the amount of soil eroded is positively correlated with rainfall and runoff. In addition, concentrations of DP and NH₄–N in overland flow …

Cellular Arrays (Us Patent Application), Angela K. Pannier, Eric A. Ariazi, V. Craig Jordan, Lonnie D. Shea

Department of Agricultural and Biological Systems Engineering: Faculty Publications

The present invention relates to characterizing transcription within cells. In particular, the present invention provides transfected cell arrays (e.g., two-dimensional and/or three-dimensional arrays) and systems, kits and methods utilizing the same (e.g., for transcriptional activity characterization). Compositions and methods of the present invention find use in, among other things, research, drug discovery and clinical (e.g., diagnostic, preventative and therapeutic) applications.

The Awe Wall: A Novel Robotic Surface, Martha Kwoka

All Theses

In this thesis, we present fundamental contributions towards AWE, a novel 'Animated Work Environment', which seeks to introduce robotics at the architectural scale to modify environments in real time to the changing needs and moods of their occupants. Part of AWE is a robotic surface, or wall, featuring a multiple folding panel structure. The panels of the AWE wall feature embedded IT and adapt to the current movements and tasks of the user. We describe the overall AWE concept and discuss the construction of the robot surface, its motion planning and its control, and all experiments run to this point.

Physics-Based Shape Morphing And Packing For Layout Design, Hong Dong

All Dissertations

The packing problem, also named layout design, has found wide applications in the mechanical engineering field. In most cases, the shapes of the objects do not change during the packing process. However, in some applications such as vehicle layout design, shape morphing may be required for some specific components (such as water and fuel reservoirs). The challenge is to fit a component of sufficient size in the available space in a crowded environment (such as the vehicle under-hood) while optimizing the overall performance objectives of the vehicle and improving design efficiency. This work is focused on incorporating component shape design …

Study Of Electrospinning Of Property-Modulated Biomedical Microfibers, Scott Taylor

All Dissertations

Electrospinning technologies have been of great interest in recent years, due in large part to developments in the field of Bioengineering, including the preparation of novel polymers and advances in tissue engineering, specifically for therapeutic applications. The electrospinning process is, in general, a very benign process that allows the preparation, under mild conditions, of micro- and nano-scale fibers from fiberforming materials, as well as traditionally non-fiber forming materials. This process is of specific interest to the biomedical community because it affords an opportunity to create highly-tailored novel constructs with a multitude of possible uses. Some proposed uses for these materials …

A Laboratory Study Of Streambed Stability In Bottomless Culverts, Brian Mark Crookston

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Traditional culvert designs, in many cases, have become habitat barriers to aquatic animal species. In response, environmentally sensitive culvert designs have been developed to function as ecological bridges. Bottomless and buried invert culverts are examples of such designs and are commonly used for fish passage. Additional design guidance specific to streambed stability in buried-invert or bottomless culverts under high flow events is needed. This study investigated incipient motion conditions for four substrate materials in a 2-ft (0.61-m) diameter circular bottomless arch culvert and in a 1-ft (0.30-m) wide rectangular flume in a laboratory setting. General scour of the streambed within …

Algorithm Development Of The Aglite-Lidar Instrument, Christian Marchant

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Particulate emissions from agricultural operations are increasingly receiving attention from regulatory bodies as a potential source of air pollution. The Space Dynamics Laboratory (SDL) has developed the Aglite system, a suite of instruments including a lidar that is capable of measuring particulate emission levels from agricultural facilities. This system provides a novel method of measuring particulate mass (PM) pollution, allowing measurements to be taken of diverse types of facilities with high temporal and spatial resolution. This high resolution allows for the measurement of emission levels generated by specific activities, fostering the development and determination of best management practices.

The Aglite …

Nutrient Mobility From Biosolids Land Application Sites, Mai Anh Vu Tran

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Three types of biosolids (lime-stabilized, aerobically digested, and anaerobically digested biosolids) were applied on 0.13-ha test plots on disturbed rangelands in Western Utah at rates of up to twenty times (20X) the estimated N-based agronomic rate. Soil samples at depths up to 1.5 m were collected and analyzed for nitrogen, phosphorus, regulated metals, pH, and electrical conductivity for up to two years after biosolids application.

NH₄-N at the soil surface (0.2 m) was primarily lost through ammonia volatilization and nitrification. This observation was consistent with reported increases in nitrate (NO₃-N) concentrations found within the soil surface …

Seepage Evaluations In Cache Valley Irrigation Canals, Katerine N. Molina

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Estimation of seepage was done in 39 selected reaches of 11 irrigation canals in the Logan and Blacksmith Fork Irrigation Systems of Cache Valley, Utah. The measurements were performed from June to October, 2008, which includes part of the irrigation season for these canals. The inflow-outflow method was used to measure seepage, in which area and velocities were measured under steady flow conditions. Velocity measurements were done with an acoustic flow meter and the mean velocity was determined using the reduced-point method (velocity measurements at 0.2, 0.6 and or 0.8 of the depth from the water surface).

As a result, …

Katp Channel Openers Have Opposite Effects On Mitochondrial Respiration Under Different Energetic Conditions, Matthias L. Riess, Amadou K.S. Camara, André Heinen, Janis T. Eells, Michele M. Henry, David F. Stowe

Biomedical Engineering Faculty Research and Publications

Mitochondrial (m) K_ATP channel opening has been implicated in triggering cardiac preconditioning. Its consequence on mitochondrial respiration, however, remains unclear. We investigated the effects of two different K_ATP channel openers and antagonists on mitochondrial respiration under two different energetic conditions. Oxygen consumption was measured for complex I (pyruvate/malate) or complex II (succinate with rotenone) substrates in mitochondria from fresh guinea pig hearts. One of two mK_ATP channel openers, pinacidil or diazoxide, was given before adenosine diphosphate in the absence or presence of an mK_ATP channel antagonist, glibenclamide or 5-hydroxydecanoate. Without ATP synthase inhibition, both mK_{ATP …}

Biodiesel Production From High Free Fatty Acid Content Feedstocks, Kaewta Suwannakarn

All Dissertations

Biomass, such as animal fats and grease, is one of the better sources for transportation fuels, e.g. biodiesel. Use of such biomass in the biodiesel synthesis decreases the need for fossil energy, provides an outlet for utilizing the abundant resources effectively and economically, results in a cleaner fuel that is biodegradable, renewable, and non-toxic. Free fatty acid (FFA) esterification and triglyceride (TG) transesterification with low molecular weight alcohols are the central reactions for the biodiesel production. The focus of this research is to establish a better fundamental insight into heterogeneous catalysis for biodiesel forming reactions, in an attempt to design …

Effect Of Shear On Performance And Microbial Ecology Of Continuously Stirred Anaerobic Digesters Treating Animal Manure, Rebecca A. Hoffmann, Marcelo L. Garcia, Mehul Veskivar, Khursheed Karim, Muthanna H. Al-Dahhan, Largus T. Angenent

Chemical and Biochemical Engineering Faculty Research & Creative Works

We Determined the Effect of Different Mixing Intensities on the Performance, Methanogenic Population Dynamics, and Juxtaposition of Syntrophic Microbes in Anaerobic Digesters Treating Cow Manure from a Dairy Farm. Computer Automated Radioactive Particle Tracking in Conjunction with Computational Fluid Dynamics Was Performed to Quantify the Shear Levels Locally. Four Continuously Stirred Anaerobic Digesters Were Operated at Different Mixing Intensities of 1,500, 500, 250, and 50 Revolutions Per Min (RPM) over a 260-Day Period at a Temperature of 34 ± 1°C. Animal Manure at a Volatile Solids (VS) Concentration of 50 G/L Was Fed into the Digesters Daily at Five Different …

Developing Lcfs For Biofuels: Getting It Right For Corn Ethanol, Kenneth Cassman, Adam Liska

Adam Liska Papers

• Corn ethanol will be first to test the newly developed LCFS assessment methods; substantial amounts of other biofuels will come several years later

• Accurate valuation of direct-effect GHG emissions from corn ethanol is the foundation of the LCFS process; these affects vary with ethanol biorefinery type and corn feedstock supply

• Different reference GHG emissions values are needed for each major class of ethanol plants

• The BESS model provides the most up-to-date, scientifically sound estimate of corn-ethanol GHG emissions; can BESS and GREET reach agreement?

• Certification and compliance tools are also needed

The Draft Genome Of The Transgenic Tropical Fruit Tree Papaya ( Carica Papaya Linnaeus), Ray Ming, Shaobin Hou, Yun Feng, Qinguyi Yu, Jyothi Thimmapuram

Cyber Center Publications

Papaya, a fruit crop cultivated in tropical and subtropical regions, is known for its nutritional benefits and medicinal applications. Here we report a 3 draft genome sequence of 'SunUp' papaya, the first commercial virus-resistant transgenic fruit tree¹ to be sequenced. The papaya genome is three times the size of the Arabidopsis genome, but contains fewer genes, including significantly fewer disease-resistance gene analogues. Comparison of the five sequenced genomes suggests a minimal angiosperm gene set of 13,311. A lack of recent genome duplication, atypical of other angiosperm genomes sequenced so far may account for the smaller papaya gene number in …

Gold Nanorod-Mediated Photothermolysis Induces Apoptosis To Macrophages Via Damage Of Mitochondria, Ling Tong, Ji-Xin Cheng

Birck Poster Sessions

Alterations in macrophage functions contribute to a variety of autoimmune and inflammatory diseases. Diagnosis and eradication of activated macrophages is becoming a valid pharmaceutical target. In this work, gold nanorods conjugated with arginine-rich peptides were applied as theragonosis agents to detect activated macrophages via two-photon luminescence (TPL) and subsequent eradicate through optical hyperthermia. Functionalized gold nanorods could be selectively internalized by activated macrophages in live animals 0.5 h after intraperitoneal (i.p.) injection. Apoptosis of macrophage was induced under proper irradiation conditions to reduce secondary inflammation, through mitochondria-dependent pathway.

2008 - The Thirteenth Annual Symposium Of Student Scholars

Symposium of Student Scholars Program Books

The full program book from the Thirteenth Annual Symposium of Student Scholars, held on April 14, 2008. Includes abstracts from the presentations and posters.

Implementing Mass Nutrient Balance Procedures On Swine Production Facilities, Richard Koelsch, Alan Sutton

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Whole Farm Nutrient Balance (WFNB) approaches have been used to provide a measure of environmental performance (Aarts et al., 1992; Lanyon and Beegle, 1993; Klausner, 1995). Whole farm balance concepts are used as part of the Netherlands Mineral Accounting System public policy that includes compulsory mineral input and output reports from livestock farms and levies for excess imbalances (Jongbloed and Lenis, 1998). Procedures for measuring WFNB will be followed in measurements made on commercial swine facilities for 2006 and 2007. The conclusions developed based upon data from 13 for 2006 include:

• On average, the participating swine producers import 1.5 units …

Acquisition Of Cardiac Control Parameters From Whole Vagus Nerve Recordings, Marcia A. Pool

Doctoral Dissertations

Heart rate varies continuously depending on the amount of activity being performed or the emotional state of an individual. Both branches of the autonomic nervous system work to alter heart rate depending on the needs of the body. While healthy individuals are capable of altering their heart rate, individuals with certain types of heart disease do not have this ability. For these individuals, cardiac pacemakers are used to alter heart rate. Cardiac pacemakers use sensors to determine the pacing frequency for the heart; however, there is no current optimum sensor. In order to discover a better sensor, this study investigated …

Engineering@Nebraska - Spring 2008

Engineering@Nebraska (Alumni Magazine)

Table of Contents:

Front & Center
Engineering Students Enjoy Spain Firsthand: With Nebraska Engineering’s focus on international education, “live and learn” happens in amazing settings. Warm up to the wonders of winter break in Spain.
Spring Break at 35,000 Feet: Nebraska Engineering’s undergraduate research reaches new heights in service to NASA. Ride along with blog posts from an uplifting experience in microgravity.
UNL Experts Build Better Bridges: Atorod Azizinamini—professor of Civil Engineering, researcher and director of UNL's National Bridge Research Organization (NABRO)—leads a team in applying a $2 million grant for safer spans.
Tiny Fibers, Huge Potential: The longterm research …

Oxygen Diffusion Through Natural Extracellular Matrices: Implications For Estimating "Critical Thickness" Values In Tendon Tissue Engineering, Caroline Androjna, Jorge E. Gatica, Joanne M. Belovich, Kathleen A. Derwin

Chemical & Biomedical Engineering Faculty Publications

Oxygen is necessary for maintaining cell proliferation and viability and extracellular matrix (ECM) production in 3-dimensional tissue engineering. Typically, diffusion is the primary mode for oxygen transport in vitro; thus, ensuring an adequate oxygen supply is essential. In this study, we determined the oxygen diffusion coefficients of 3 natural ECMs that are being investigated as construct scaffolds for tendon tissue engineering: small-intestine submucosa (SIS), human dermis (Alloderm (R)), and canine fascia lata. Diffusion coefficients were determined using a standard diffusion cell system. The ranges for each matrix type were: SIS: 7 x 10(-6) - 2 x 10(-5) cm(2)/s, Alloderm (R): …