Open Access. Powered by Scholars. Published by Universities.®
- Institution
-
- TÜBİTAK (1183)
- University of South Carolina (481)
- University of Nebraska - Lincoln (453)
- Missouri University of Science and Technology (427)
- Louisiana State University (416)
-
- Brigham Young University (396)
- Marquette University (350)
- Old Dominion University (329)
- Chulalongkorn University (304)
- University of Kentucky (302)
- City University of New York (CUNY) (289)
- Utah State University (281)
- Cleveland State University (272)
- University of New Mexico (268)
- Portland State University (258)
- Karbala International Journal of Modern Science (257)
- University of South Florida (250)
- University of Arkansas, Fayetteville (234)
- University of Texas Rio Grande Valley (212)
- Western Kentucky University (200)
- Chinese Chemical Society | Xiamen University (197)
- Chapman University (195)
- University at Albany, State University of New York (192)
- Wayne State University (185)
- Virginia Commonwealth University (181)
- University of Central Florida (178)
- University of Nevada, Las Vegas (176)
- The University of Southern Mississippi (175)
- Western Michigan University (170)
- Montclair State University (169)
- Keyword
-
- Chemistry (444)
- Synthesis (218)
- Nanoparticles (184)
- Mass spectrometry (182)
- Fluorescence (159)
-
- Pure sciences (140)
- Cancer (124)
- Department of Chemistry (122)
- NMR (104)
- Catalysis (103)
- 1 (101)
- Electrochemistry (98)
- Adsorption (93)
- Molecular dynamics (83)
- 2 (81)
- DNA (80)
- Spectroscopy (79)
- Biochemistry (77)
- Photochemistry (75)
- Kinetics (73)
- Copper (66)
- DFT (65)
- Cytotoxicity (64)
- Proteins (63)
- Mass Spectrometry (59)
- Proteomics (59)
- Chemistry and Biochemistry (58)
- Drug delivery (58)
- RNA (58)
- Oxidation (57)
- Publication Year
- Publication
-
- Turkish Journal of Chemistry (1183)
- Theses and Dissertations (830)
- Chemistry Faculty Publications (569)
- Electronic Theses and Dissertations (510)
- Faculty Publications (348)
-
- LSU Doctoral Dissertations (337)
- Dissertations (325)
- Chulalongkorn University Theses and Dissertations (Chula ETD) (304)
- Chemistry and Biochemistry Faculty Publications (300)
- Honors Theses (300)
- Chemistry Faculty Research & Creative Works (282)
- Chemistry and Chemical Biology ETDs (260)
- Karbala International Journal of Modern Science (257)
- USF Tampa Graduate Theses and Dissertations (228)
- Chemistry Faculty Research and Publications (220)
- Journal of Electrochemistry (197)
- Masters Theses (190)
- Legacy Theses & Dissertations (2009 - 2024) (162)
- Chemistry Faculty Publications and Presentations (161)
- Wayne State University Dissertations (154)
- Dissertations, Theses, and Capstone Projects (149)
- Department of Chemistry: Faculty Publications (147)
- Chemistry & Biochemistry Faculty Publications (144)
- Masters Theses & Specialist Projects (136)
- Open Access Theses & Dissertations (131)
- Dissertations and Theses (120)
- Journal of the South Carolina Academy of Science (120)
- Biology, Chemistry, and Environmental Sciences Faculty Articles and Research (116)
- Master's Theses (113)
- School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry) (113)
- Publication Type
- File Type
Articles 7021 - 7050 of 15584
Full-Text Articles in Entire DC Network
Voltammetric Determination Of Phenmedipham Herbicide Using A Multiwalled Carbon Nanotube Paste Electrode, Ersi̇n Demi̇r, Recai̇ İnam
Voltammetric Determination Of Phenmedipham Herbicide Using A Multiwalled Carbon Nanotube Paste Electrode, Ersi̇n Demi̇r, Recai̇ İnam
Turkish Journal of Chemistry
Phenmedipham is an herbicide used especially in the sugar beet harvest to fight against broad-leaved weeds and studies of its voltammetric behavior and detection have not been done before. The superior properties of carbon nanotubes such as electrical conductivity, mechanical strength, and wide potential ranges make them attractive for chemical sensors and the phenmedipham compound gave an oxidation peak at $+$1320 mV (vs. Ag/AgCl) on the nanostructured multiwalled carbon nanotube paste electrode. Square wave voltammetric measurements recorded for phenmedipham showed that the peak current increased linearly between 0.02 and 2.0 mg/L with a regression coefficient of $r$ = 0.9989, and …
A Novel One-Pot And Rapid Synthesis Of Polyfunctionalized Benzo[A]Pyrimido[5',4':5,6] Pyrido[2,3-C]Phenazine Derivatives Under Microwave Irradiation, Mahdieh Tabibian, Razieh Mohebat, Masoumeh Tabatabaee
A Novel One-Pot And Rapid Synthesis Of Polyfunctionalized Benzo[A]Pyrimido[5',4':5,6] Pyrido[2,3-C]Phenazine Derivatives Under Microwave Irradiation, Mahdieh Tabibian, Razieh Mohebat, Masoumeh Tabatabaee
Turkish Journal of Chemistry
A one-pot, environmentally friendly, and efficient protocol for the synthesis of novel polyfunctionalized benzo[$a$]pyrimido[5',4':5,6]pyrido[2,3-$c$]phenazine derivatives has been reported by a one-pot, four-component sequential reaction between 2-hydroxynaphthalene-1,4-dione, benzene-1,2-diamines, benzaldehydes, and 6-amino-1,3-dimethyluracil in the presence of $p$-TSA as a nontoxic, inexpensive, ecofriendly, and efficacious solid acid catalyst. Two C-C bonds, two C=N bonds, and one C-N bond, as well as two new rings, were formed in this reaction. Through this procedure, compounds with substantial biological and pharmaceutical properties are generated in a single operation. Factors such as high yields, less reaction time, operational simplicity, and lack of any dangerous reagents/solvents have made …
The Synthesis Of New 3,4-(Bisaryl)-1,8-Naphthalimide And 2,3-(Bisaryl)-7$H$-Benzimidazo[2,1-A]Benzo[D]Isoquinolin-7-One Compounds And An Investigation Of Their Photochromic Properties, Ersi̇n Orhan, Mahmut Köse, Tolga Yazan
The Synthesis Of New 3,4-(Bisaryl)-1,8-Naphthalimide And 2,3-(Bisaryl)-7$H$-Benzimidazo[2,1-A]Benzo[D]Isoquinolin-7-One Compounds And An Investigation Of Their Photochromic Properties, Ersi̇n Orhan, Mahmut Köse, Tolga Yazan
Turkish Journal of Chemistry
Three new photochromic compounds, 3-(2,5-dimethyl-3-thienyl)-4-(2-phenyl-5-methyl-4-thiazolyl)-1,8-napht- halimide (1-O), 2,3-bis(2-phenyl-5-methyl-4-thiazolyl)-7$H$-benzimidazo[2,1-a]benzo[de]isoquinolin-7-one (2-O), and 2,5-dimethyl-3-thienyl)-7$H$-benzimidazo[2,1-a]benzo[de]isoquinolin-7-one (3-O), were synthesized and their photochromic properties were studied. Compound 1-O was synthesized by two consecutive Suzuki coupling reactions using 2,5-dimethylthiophene-3-boronic acid and 5-methyl-2-phenylthiazole-4-boronic acid. Photochromic compounds 2-O and 3-O were prepared by multistep reactions starting with 3-iodo-4-bromo-1,8-naphthalic anhydride and 2,5-dimethylthiophene-3-boronic acid or 2-phenyl-5-methylthiazole-4-boronic acid. All photochromic compounds showed a color change from colorless (or light yellow) to blue-green, purple, or orange colors (depending on the nature of the structures) on exposure to UV light at 365 nm in ethyl acetate solutions. The colored solutions can be reversed to …
Differential Pulse Voltammetric Determination Of Dopamine Using Pd Nanoparticles Deposited On (3-Aminopropyl)Triethoxysilane Functionalized Ceo$_{2}$ Nanoparticles, Muhammet Güler
Turkish Journal of Chemistry
In this study, a novel and effective electrochemical sensor for determination of dopamine (DA) was successfully developed by the modification of a glassy carbon electrode (GCE) using Pd nanoparticles deposited on (3-aminopropyl)triethoxysilane functionalized nanoceria (Pd@CeO$_{2}$-APTES) and nafion used as a protective membrane. The synthesized nanocomposites were evaluated using X-ray diffraction, high-resolution transmission electron microscopy, and Fourier transform infrared spectroscopy. Moreover, the electrochemical properties of the modified electrodes were investigated using cyclic voltammetry, electrochemical impedance voltammetry, and differential pulse voltammetry (DPV). The Nf/Pd@CeO$_{2}$-APTES/GCE showed a linear range of 2.5--149.5 $\mu $M for DA by DPV with a notable sensitivity of 3.89 …
A Rapid And Sensitive Spectrofluorometric Method For The Determination Of Au(Iii) Based On Fluorescence Quenching Of A 1,3,5-Triphenyl-2-Pyrazoline, Aysel Başoğlu, Ümmühan Ocak, Seda Fandakli, Nuretti̇n Yayli
A Rapid And Sensitive Spectrofluorometric Method For The Determination Of Au(Iii) Based On Fluorescence Quenching Of A 1,3,5-Triphenyl-2-Pyrazoline, Aysel Başoğlu, Ümmühan Ocak, Seda Fandakli, Nuretti̇n Yayli
Turkish Journal of Chemistry
A simple, rapid, sensitive, and low-cost spectrofluorometric method was developed for the determination of Au(III) using 5-(2,3-dimethoxyphenyl)-3-(4-methoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole (L) in ethanol/water. The method is based on the change in the fluorescence intensity at 464 nm after excitation at 355 nm as a result of the reaction between the ligand and Au(III). The fluorescent emission of ligand at 464 nm decreased with the increasing of Au(III) concentration. The ligand concentration, pH effect, response time, and effect of foreign ions were determined. From the results of fluorescence titration experiments, it was found that the ligand (1 $\times $ 10$^{-7}$ M) was selective and …
Synthesis, Biological Evaluation, And In Silico Study Of Some Unique Multifunctional 1,2,4-Triazole Acetamides, Almas Sattar, Aziz Ur Rehman, Muhammad Athar Abbasi, Sabahat Zahra Saddiqui, Shahid Rasool, Hira Khalid, Muhammad Arif Lodhi, Farman Ali Khan
Synthesis, Biological Evaluation, And In Silico Study Of Some Unique Multifunctional 1,2,4-Triazole Acetamides, Almas Sattar, Aziz Ur Rehman, Muhammad Athar Abbasi, Sabahat Zahra Saddiqui, Shahid Rasool, Hira Khalid, Muhammad Arif Lodhi, Farman Ali Khan
Turkish Journal of Chemistry
The imperative demand for antibacterial agents and enzyme inhibitors prompted us to synthesize some new compounds, 6a-6k, bearing multifunctional moieties. The target acetamides were derived from 4-phenyl-5-(1-tosylpiperidin-4-yl)-4$H$-1,2,4-triazole-3-thiol (3). The structural analysis was carried out using modern spectroscopic techniques including IR, NMR, and EIMS spectral analysis. The antibacterial activity was screened against five bacterial strains including three gram-negative and two gram-positive ones. Enzyme inhibition was carried out against lipoxygenase enzyme and results were supported by in silico study. The synthesized compounds were proved to be potent antibacterial agents and enzyme inhibitors.
A Sample Stacking-Capillary Electrophoresis Method For Simultaneous Determination Of Nitrate And Thiocyanate Ions Of Ultra-Heat-Treated Milk Samples, Fi̇li̇z Tezcan
Turkish Journal of Chemistry
Ultra-heat-treated (UHT) cow milk is mostly consumed in Turkey. Heating milk can cause some chemical and biochemical changes that affect different components of milk. However, studies on the constituents of UHT milk are scare. In the present study, nitrate and thiocyanate contents of commercial UHT~whole cow milk were determined simultaneously by sample stacking-capillary electrophoresis. The best separation of nitrate and thiocyanate ions was performed by reducing the electroosmotic flow at pH 4.0 using 30 mM formic acid and 30 mM sodium sulfate containing separation electrolyte. Analysis was completed in less than 3 min. The limits of detection obtained at a …
Tetrahydropyridine: A Promising Heterocycle For Pharmacologically Active Molecules, Noor Ul Amin Mohsin, Matloob Ahmad
Tetrahydropyridine: A Promising Heterocycle For Pharmacologically Active Molecules, Noor Ul Amin Mohsin, Matloob Ahmad
Turkish Journal of Chemistry
The tetrahydropyridine (THP) ring system has received considerable focus due to its excellent ability to act as a pharmacophore. It is recognized as a major constituent in natural alkaloids. THP derivatives have been reported for a diverse range of biological activities. Recent synthetic works contain syntheses of monosubstituted, disubstituted, trisubstituted, highly functionalized, and condensed structures. In this review, we summarize the recent literature dealing with the bioactive nature of this important heterocycle.
Antioxidant Potential And Secondary Reactivity Of Bis$\{$Diphenyl(2-Pyridyl)Phosphino$\}$Copper(Ii) Complex, Ezzat Khan, Adnan Shahzad, Muhammad Nawaz Tahir, Awal Noor
Antioxidant Potential And Secondary Reactivity Of Bis$\{$Diphenyl(2-Pyridyl)Phosphino$\}$Copper(Ii) Complex, Ezzat Khan, Adnan Shahzad, Muhammad Nawaz Tahir, Awal Noor
Turkish Journal of Chemistry
Copper-based complexes with the general formulas [Cu(L)$_{2}$]Cl$_{2}$ (1) and [Cu$_{2}$L$_{2}$($\mu_{2}$-L)$\mu_{2-}$Cl$_{2}$] (2) and a mixed-ligand anionic complex [Cu(L)$_{2}$dedtc][LCl] (3b), where L= diphenyl(2-pyridyl)phosphine and dedtc = diethyldithiocarbamate, were synthesized and structurally characterized. X-ray analysis revealed that the coordination environment around the copper atom in complexes 1-3 is distorted tetrahedral. In monomeric complexes 1 and 3b both diphenyl(2-pyridyl) phosphine ligands are monodentate and are coordinated through the P-atom. In complex 3b two phosphine ligands are attached to copper through the P-atom. The third phosphine ligand acts as a bridged ligand, coordinated to the metal centers through the P-atom and N-atom. Complexes 1 and …
Experimental And Theoretical Studies On Cis-Dioxomolybdenum(Vi) Complexes Of Onn-Donor~Thiosemicarbazone, Berat İlhan Ceylan, Ayberk Yilmaz, Olcay Bölükbaşi Yalçinkaya, Bahri̇ Ülküseven
Experimental And Theoretical Studies On Cis-Dioxomolybdenum(Vi) Complexes Of Onn-Donor~Thiosemicarbazone, Berat İlhan Ceylan, Ayberk Yilmaz, Olcay Bölükbaşi Yalçinkaya, Bahri̇ Ülküseven
Turkish Journal of Chemistry
Cis-dioxomolybdenum(VI) chelate complexes with 5-chloro-2-hydroxybenzophenone S-methyl-4-phenylthiose- micarbazone (L) were synthesized in the general formula (MoO$_{2}$(L)D), where D is an odd- or even-numbered alcohol (methanol (1), ethanol (2), n-propanol (3), n-butanol (4), and allyl alcohol (5)). The structures of 1-5 were verified by elemental analysis, Fourier transform infrared (FT-IR), and $^{1}$H NMR spectra. Complex 5 crystallizes in the monoclinic space group P21/n, and its crystalline data showed a dimeric structure formed by a pair of intermolecular hydrogen bonds with 1.92 Å. These dimers are stacked in a similar crystalline structure as a single molecule. The experimental data were compared with the …
Synthesis, Characterization, And Application Of Monodisperse Poly L-Dopa Microspheres, Azadeh Havasian, Elham Heydaripour, Mohammad Reza Nateghi, Mohammad Hossein Mosslemin, Forough Kalantari-Fotouh
Synthesis, Characterization, And Application Of Monodisperse Poly L-Dopa Microspheres, Azadeh Havasian, Elham Heydaripour, Mohammad Reza Nateghi, Mohammad Hossein Mosslemin, Forough Kalantari-Fotouh
Turkish Journal of Chemistry
In this study, 3,4-dihydroxy-L-phenylalanine (L-Dopa) was solvothermally polymerized to monodisperse microspheres 1 $\mu $m in diameter. Polymerization was carried out in dimethylformamide containing appropriate amounts of urea and L-Dopa at 120 $^{\circ}$C for 24 h. Synthesis of the polymer in basic aqueous solution under hydrothermal conditions or via conventional heating resulted in the formation of bulky powders including irregularly shaped particles of the polymer. The morphologies of the synthesized polymers were characterized by scanning electron microscopy (SEM). The microspheres synthesized by solvothermal method (with $\sim $1 $\mu $m average diameter) were clearly observable in SEM micrographs. The thermal stability of …
Synthesis And Cytotoxicity Evaluation Of [(2,4-Dichlorophenoxy)Methyl]-5-Aryl-1,3,4-Oxadiazole/4$H$-1,2,4-Triazole Analogues, Mohamed Jawed Ahsan
Synthesis And Cytotoxicity Evaluation Of [(2,4-Dichlorophenoxy)Methyl]-5-Aryl-1,3,4-Oxadiazole/4$H$-1,2,4-Triazole Analogues, Mohamed Jawed Ahsan
Turkish Journal of Chemistry
We report herein the synthesis, characterization, and cytotoxicity evaluations of some newer oxadiazole and triazole analogues (5a-j). The cytotoxicity of all the title compounds were evaluated as per the National Cancer Institute protocol in a one-dose assay (10 $\mu $M) on nine different panels of 59 cancer cell lines. 2-$\{$5-[(2,4-Dichlorophenoxy)methyl]-1,3,4-oxadiazol-2-yl$\}$phenol (5e) showed the maximum cytotoxicity among the series of ten compounds. The cytotoxicity of 5e was comparable to that of the standard anticancer drug, 5-fluorouracil, and better than that of imatinib. The structure activity relationship was also discussed.
A Novel Core-Shell-Based Chromatographic Method Supported By Ratio Derivative Spectrophotometry For The Simultaneous Determination Of Perindopril, Indapamide, And Amlodipine Ternary Mixtures, Leyla Karadurmuş, Mehmet Gümüştaş, Sevi̇nç Kurbanoğlu, Bengi̇ Uslu, Si̇bel Ayşil Özkan
A Novel Core-Shell-Based Chromatographic Method Supported By Ratio Derivative Spectrophotometry For The Simultaneous Determination Of Perindopril, Indapamide, And Amlodipine Ternary Mixtures, Leyla Karadurmuş, Mehmet Gümüştaş, Sevi̇nç Kurbanoğlu, Bengi̇ Uslu, Si̇bel Ayşil Özkan
Turkish Journal of Chemistry
}In this work, ratio spectra of the first derivative spectrophotometric and liquid chromatographic methods have been described for the first time for the simultaneous determination of perindopril (PER), indapamide (IND), and amlodipine (AML) in dosage forms. For chromatographic separations several mobile phase compositions were tested for efficient separation with the use of a new column technology related to superficially porous particles. Optimum chromatographic separation was achieved using a Kinetex C18 column (150 $\times $ 4.6 mm I.D. 5 $\mu $m) at a flow rate of 1.5 mL min$^{-1}$. The separation was carried out at 30 $^{\circ}$C and the diode array …
Recent Synthetic Methodologies For Pyrimidine And Its Derivatives, Farhat Ibraheem, Furqan Ahmad Saddique, Sana Aslam, Asim Mansha, Tahir Farooq, Matloob Ahmad
Recent Synthetic Methodologies For Pyrimidine And Its Derivatives, Farhat Ibraheem, Furqan Ahmad Saddique, Sana Aslam, Asim Mansha, Tahir Farooq, Matloob Ahmad
Turkish Journal of Chemistry
Pyrimidine derivatives are well known due to their remarkable pharmacological potential in various fields of science, and they are also present in some natural substances like DNA and RNA. These scaffolds manifest diversified biological activities such as antimicrobial, antiinflammatory, anti-HIV, antitubercular, antitumor, antineoplastic, and antimalarial. A pyrimidine ring is constructed when chalcones, amidines, guanidine, nitriles, isocyanates, urea, thiourea, and aminopyrazoles undergo condensation, coupling, or cyclization reactions. In this context, the present review illustrates a variety of novel and efficient synthetic approaches towards the synthesis of pyrimidine and its derivatives that were reported recently.
Determination Of Morin On An Electrochemically Activated Carbon-Paste Electrode, Alexander Chebotarev, Konstantin Pliuta, Denys Snigur
Determination Of Morin On An Electrochemically Activated Carbon-Paste Electrode, Alexander Chebotarev, Konstantin Pliuta, Denys Snigur
Turkish Journal of Chemistry
In this paper, the possibility of using an electrochemically activated carbon-paste electrode (ECA-CPE) for the determination of morin has been studied. It is established that the oxidation current increases 1.85 times in comparison with untreated CPE. The adsorption nature of the anodic current and the number of electrons taking part in the oxidation of morin on ECA-CPE was established. The optimal conditions for the determination of morin (pH $=$ 4, E$_{ads\, }=$ 200~mV, t$_{ads\, }=$ 180 s) were established. Using square-wave voltammetry (A $=$ 35 mV, $\nu =$ 25 Hz, $\upsilon =$ 100 mV/s) it is possible to determine morin …
Exploring Inhibition Of Chemiluminescence Mechanisms With Fluorescence Quenching Studies And Interaction Energy Calculations, Zhenbo Liu, Tangmi Yuan, Yongming Liu, Wenzuo Li, Qingzhong Li, Bo Xiao, Jianbo Cheng
Exploring Inhibition Of Chemiluminescence Mechanisms With Fluorescence Quenching Studies And Interaction Energy Calculations, Zhenbo Liu, Tangmi Yuan, Yongming Liu, Wenzuo Li, Qingzhong Li, Bo Xiao, Jianbo Cheng
Turkish Journal of Chemistry
Carbamates weaken the luminol-H$_{2}$O$_{2}$ chemiluminescence (CL) catalyzed by sodium copper chlorophyll (SCC). The capacity to inhibit the CL of three carbamates is in the order of carbaryl (CBL) \textgreater carbofuran (CBF) \textgreater metolcarb (MTC). Mechanisms of carbamates inhibiting SCC-luminol-H$_{2}$O$_{2}$ CL are investigated using fluorescence quenching and quantum chemistry simulations for the first time in this work. Carbamate-SCC interactions studied using fluorescence spectroscopy show that with the increasing concentration of the SCC, the fluorescence of carbamate is quenched regularly, and the quenching mechanism is a static quenching process. Binding constants ($K_{B})$ of the three carbamates with SCC are CBL (4.39 x …
Synthesis And Antimicrobial And Antioxidant Activities Of Hybrid Molecules Containing Benzotriazole And 1,2,4-Triazole, Mahesh Chand, Reena Kaushik, Subhash Chand Jain
Synthesis And Antimicrobial And Antioxidant Activities Of Hybrid Molecules Containing Benzotriazole And 1,2,4-Triazole, Mahesh Chand, Reena Kaushik, Subhash Chand Jain
Turkish Journal of Chemistry
Eleven novel 1,2,4-triazolylbenzotriazoles have been prepared using 1-(hydrazinylcarbonylmethyl)-1$H$-benzot- riazole (3) as a potent intermediate. Compound 3, however, was obtained from benzotriazole in two steps. All synthesized compounds were characterized by detailed spectral studies like IR, $^{1}$H NMR, $^{13}$C NMR, and mass spectrometry. All synthesized compounds were evaluated for their \textit{in vitro} antimicrobial activity against seven strains of bacteria and four strains of fungi. Compounds 13, 17, 19, 20, and 21}were found to possess antibacterial activity comparable to that of ciprofloxacin against a Klebsiella pneumoniae strain. Except for compounds2 and 13, all compounds showed good antifungal activity against an Aspergillus niger …
Effect Of Ph On The Complexation Of Irbesartan With $\Beta $-, Hydroxypropyl-$\Beta $-, And $\Gamma $-Cyclodextrin: Solubility Enhancement And Physicochemical Characterization, Fakhri Yousef
Turkish Journal of Chemistry
The affinity of irbesartan (IRB) to form inclusion complexes with $\beta $-cyclodextrin ($\beta $-CD), hydroxypropyl-$\beta $-cyclodextrin (HP-$\beta $-CD), and $\gamma $-cyclodextrin ($\gamma $-CD) was investigated in aqueous buffered solutions at pH 1.7, 4.1, and 7.0. Analysis of the UV absorption-pH profiles revealed that IRB has two p$K_{a}$ values: p$K_{a1\, }=$ 3.60 (imidazolinone ring moiety) and p$K_{a2\, }=$ 4.70 (tetrazole moiety). In the presence of 5.0 mmol L$^{-1} \beta $-CD, the tetrazole moiety became more acidic, indicating its inclusion within the $\beta $-CD cavity. Phase-solubility diagrams (PSDs) were obtained for IRB in aqueous buffered solutions of $\beta $-CD, HP-$\beta $-CD, and …
4d-Qsar Analysis And Pharmacophore Modeling For Alkynylphenoxyacetic Acids As Crth2 (Dp2) Receptor Antagonists, Semi̇ha Köprü, Emi̇n Saripinar
4d-Qsar Analysis And Pharmacophore Modeling For Alkynylphenoxyacetic Acids As Crth2 (Dp2) Receptor Antagonists, Semi̇ha Köprü, Emi̇n Saripinar
Turkish Journal of Chemistry
In this study, we performed the pharmacophore modeling and 4D-QSAR research of alkynylphenoxyacetic acid analogues as CRTh2 receptor opponent agents by utilizing the electron conformational genetic algorithm method. Quantum chemical calculations and conformational analyses of the compounds were carried out at HF/6-31G* level. Then electron conformational matrices of congruity were prepared for each conformer of each compound, which are represented by electronic and structural properties. As a result of the comparison of the matrices that are called electron conformational submatrices of activity, the pharmacophoric group of the compounds responsible for the activity was found at the determined tolerance intervals. The …
Design And Synthesis Of New Naphtho[2,1-$B$]Pyrano [2,3-$D$]Pyrimidinones Under Classical And Microwave Conditions, Maher Cherif, Mariem Debbabi, Sarra Chortani, Anis Romdhane, Hichem Ben Jannet
Design And Synthesis Of New Naphtho[2,1-$B$]Pyrano [2,3-$D$]Pyrimidinones Under Classical And Microwave Conditions, Maher Cherif, Mariem Debbabi, Sarra Chortani, Anis Romdhane, Hichem Ben Jannet
Turkish Journal of Chemistry
A fast and efficient method for the synthesis of naphthopyranopyrimidinones derivatives in excellent yields was developed through cyclocondensation reaction between previously prepared pyrimidinic hydrazides and some electrophilic species such as 2,4-pentanedione, 2,5-hexanedione, cyclic anhydrides, and phenylthioisocyanate under microwave irradiation. Compared to the conventional methods applied, it was found that better yields and shorter reaction times were achieved using microwave-assisted synthesis. Structures of all synthesized compounds were established on the basis of spectroscopic methods including $^{1}$H NMR, $^{13}$C NMR, and HRMS-ES.
Quantification Of Flavonoids Isolated From \Textit{Mentha Spicata} In Selected Clones Of Turkish Mint Landraces, Ramazan Erenler, İsa Telci̇, Mahfuz Elmastaş, Hüseyi̇n Akşi̇t, Fati̇h Gül, Ali̇ Riza Tüfekçi̇, İbrahi̇m Demi̇rtaş, Ömer Kayir
Quantification Of Flavonoids Isolated From \Textit{Mentha Spicata} In Selected Clones Of Turkish Mint Landraces, Ramazan Erenler, İsa Telci̇, Mahfuz Elmastaş, Hüseyi̇n Akşi̇t, Fati̇h Gül, Ali̇ Riza Tüfekçi̇, İbrahi̇m Demi̇rtaş, Ömer Kayir
Turkish Journal of Chemistry
Mint has been used extensively in traditional medicines, spices, and herbal teas throughout the world. Isolation of flavonoids from Mentha spicata and quantification of these compounds in selected clones of Turkish mints landraces were achieved. M. spicata was dried in shade and then boiled in water. After filtration, the aqueous extract was partitioned with ethyl acetate. The solvent was removed under reduced pressure to yield the extract, subjected to silica gel column chromatography to isolate 5-demethyl sinensetin (1), hesperidin (2), didymin (3), and linarin (4), the structures of which were elucidated by 1D NMR, 2D NMR, and LC-TOF/MS. The isolated …
Experimental And Theoretical Study Of Nh$_{3}$ Adsorption And Desorption Over A Cu-Chabazite Nh$_{3}$-Scr Catalyst, Selmi̇ Eri̇m Bozbağ, Mutlu Şi̇mşek, Onur Demi̇r, Deni̇z Şanli Yildiz, Hüseyi̇n Barkin Özener, Gökhan Hi̇sar, Can Erkey
Experimental And Theoretical Study Of Nh$_{3}$ Adsorption And Desorption Over A Cu-Chabazite Nh$_{3}$-Scr Catalyst, Selmi̇ Eri̇m Bozbağ, Mutlu Şi̇mşek, Onur Demi̇r, Deni̇z Şanli Yildiz, Hüseyi̇n Barkin Özener, Gökhan Hi̇sar, Can Erkey
Turkish Journal of Chemistry
NH$_{3}$ adsorption and desorption behavior of a commercial Cu-chabazite (CHA) NH$_{3}$ selective catalytic reduction (NH$_{3}$-SCR) catalyst was studied in the presence and absence of H$_{2}$O. NH$_{3}$ uptake values at various adsorption temperatures were obtained during various steps of the adsorption and temperature-programmed desorption (TPD) experiments. Total NH$_{3}$ uptake decreased from 4.6 to 1.6 g NH$_{3}$/L catalyst when the adsorption temperature was increased from 50 to 300 $^{\circ}$C. Three major adsorption sites for NH$_{3}$ adsorption could be identified and quantified using TPD experiments, namely loosely, moderately, and strongly bound NH$_{3}$ with peak centers at around 147, 266, and 447 $^{\circ}$C. The …
Novel Optical Sensor-Based Method For Determining Total Tocopherol Content In Serum, Mustafa Bener, Mustafa Reşat Apak
Novel Optical Sensor-Based Method For Determining Total Tocopherol Content In Serum, Mustafa Bener, Mustafa Reşat Apak
Turkish Journal of Chemistry
Lipid-soluble endogenous antioxidants, such as tocopherols, protect biological structures from oxidative damage through their chain-breaking ability and thus the development of a simple method for tocopherol determination is important. In this study, a novel optical sensor-based method was proposed for determining total tocopherol content (TTC) of serum, with selectivity for $\alpha $-tocopherol over $\beta $-carotene. The proposed method is based on the use of a copper(II)-neocuproine complex (Cu(II)-Nc) reagent immobilized onto a Nafion membrane, and the absorbance changes associated with the formation of Cu(I)-Nc chelate on the membrane strip as a result of reaction with serum tocopherols were measured at …
A New Cocrystal Explosive Trinitrotoluene (Tnt):1-Amino-4-Bromonaphthalene With Reduced Sensitivity, Ni̇lgün Şen
A New Cocrystal Explosive Trinitrotoluene (Tnt):1-Amino-4-Bromonaphthalene With Reduced Sensitivity, Ni̇lgün Şen
Turkish Journal of Chemistry
A 1:1 cocrystal of TNT and 1-amino-4-bromonaphthalene was prepared via solvent evaporation. The structure of the cocrystal was determined via single-crystal and powder X-ray diffraction. Crystal structure determination studies indicated that the main mechanism of cocrystallization originates from the intermolecular hydrogen bonding (amino-nitro), halogen bonding, and $\pi -\pi $ stacking. Investigation of intermolecular interactions by Hirshfeld surface and fingerprint plot analysis revealed that the structures were stabilized by H...H, O...H, C...C ($\pi -\pi )$ and Br...O interactions. Hirshfeld surfaces showed that these weak interactions were significant for crystal packing. We analyzed the crystal packing and showed how this may influence …
Synthesis And Biological Evaluation Of Quinoline-Triazole And Quinolone-Triazole Conjugates, Ayşegül Gümüş, Veysi̇ Okumuş
Synthesis And Biological Evaluation Of Quinoline-Triazole And Quinolone-Triazole Conjugates, Ayşegül Gümüş, Veysi̇ Okumuş
Turkish Journal of Chemistry
One-pot synthesis of novel quinoline- and quinolone-substituted 1,2,3-triazoles has been performed from the key intermediates, quinoline- and quinolone-substituted propargyl derivatives 1-3 (48%-88% yields). The antioxidant properties of the newly synthesized compounds, 1a-1c, 2a-2c, and 3a-3c, were evaluated by monitoring DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging abilities, metal chelating effects, and reducing power. The scavenging effects of compounds on the free radical decreased in the order of 3b$>$ 3a$>$ 1b} and were found to be 36.3%, 34.9%, and 27.6% at the concentration of 500 $\mu $g/mL, respectively. All of the compounds showed low chelating capacity. Furthermore, the antibacterial activity was studied …
The Interaction Between A Zinc(Ii) Phthalocyanine Compound Bearing Octakis Phenoxyacetamide Substituents And Calf Thymus Dna, Ali̇ Arslantaş, Mehmet Sali̇h Ağirtaş
The Interaction Between A Zinc(Ii) Phthalocyanine Compound Bearing Octakis Phenoxyacetamide Substituents And Calf Thymus Dna, Ali̇ Arslantaş, Mehmet Sali̇h Ağirtaş
Turkish Journal of Chemistry
In this study, a zinc(II) phthalocyanine compound (PcZn) substituted with octakis phenoxyacetamide was synthesized and characterized. Calf thymus DNA (CT-DNA) was used to determine the DNA binding properties of the zinc(II) phthalocyanine compound. This interaction of CT-DNA with PcZn was investigated using electronic absorption spectra, emission spectroscopy, a thermal melting temperature study, cyclic voltammetry, and viscosity measurements in a Tris-HCl buffer solution at a pH of 7.2. The findings showed that zinc(II) phthalocyanine interacts with calf thymus DNA via partial intercalative binding mechanisms. In addition to the techniques above, a gel electrophoresis study was also carried out to verify the …
Synthesis Of $E$-Stilbene Azomethines As Potent Antimicrobial And Antioxidant Agents, Ahsan Iqbal, Zulfiqar Ali Khan, Sohail Anjum Shahzad, Muhammad Usman, Shakeel Ahmad Khan, Abdul H. Fauq, Ayesha Bari, Muhammad Aamir Sajid
Synthesis Of $E$-Stilbene Azomethines As Potent Antimicrobial And Antioxidant Agents, Ahsan Iqbal, Zulfiqar Ali Khan, Sohail Anjum Shahzad, Muhammad Usman, Shakeel Ahmad Khan, Abdul H. Fauq, Ayesha Bari, Muhammad Aamir Sajid
Turkish Journal of Chemistry
A series of new extensively conjugated $E$-stilbene azomethines (5a-5h) were synthesized and screened for their antioxidant and antimicrobial activity. The compounds were tested against bacterial (Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, and Bacillus subtilis) and fungal strains (Aspergillus niger, A. flavus, and Trichoderma harzianum) using the agar well diffusion method. Among the tested compounds, $N$'-(4-nitrobenzylidene)-2-(($E)$-styryl)benzohydrazide (5g) was found to possess potent antimicrobial activity higher than some drugs with significant activity reported in the literature, e.g., cefradine and terbinafine hydrochloride. Additionally, compounds 5a-5h were also evaluated for antioxidant potential using DPPH free radical scavenging and ferric thiocyanate (FTC) assays. Among these, …
Synthesis, Spectroscopic Characterization, And Computational Studies Of 2-Cyano-6-Hydroxybenzothiazole: A Key Synthetic Intermediate Of Firefly Luciferin, Ghasem Shahmoradi, Saeid Amani
Synthesis, Spectroscopic Characterization, And Computational Studies Of 2-Cyano-6-Hydroxybenzothiazole: A Key Synthetic Intermediate Of Firefly Luciferin, Ghasem Shahmoradi, Saeid Amani
Turkish Journal of Chemistry
Firefly luciferin is widely applied as a biotechnological tool for visualizing various biological processes in vitro and in vivo. Chemically, 2-cyano-6-hydroxybenzothiazole, as a key synthetic intermediate of firefly luciferin, is obtained from 2-cyano-6-methoxybenzothiazole by changing the methoxy with a hydroxy group. However, this approach is costly and not suited for large-scale synthesis. Here we report cost-effective and efficient syntheses of 2-cyano-6-hydroxybenzothiazole through the catalytic Sandmeyer-type cyanation reaction. Our approach employs diazonium tetrafluoroborate salt of 2-amino-6-hydroxybenzothiazole as a cyanation substrate. The cyanation reaction proceeds efficiently under mild conditions by using Cu(I)/Cu(II)/N,N,N\textquotesingle,N\textquotesingle-tetramethylethylenediamine as a catalyst. In addition, computational studies of the 2-cyano-6-hydroxybenzothiazole …
Synthesis Of Acetamide Derivatives Of 1,2,4-Triazole Bearing Azinane And Their Binding Interactions With Bovine Serum Albumin Using Spectroscopic Techniques, Javed Iqbal, Aziz Ur Rehman, Muhammad Athar Abbasi, Sabahat Zahra Siddiqui, Hira Khalid, Sabina Jhaumeer Laulloo, Nausheen Joondan, Aniisah Banu Taupass, Shahid Rasool, Syed Adnan Ali Shah
Synthesis Of Acetamide Derivatives Of 1,2,4-Triazole Bearing Azinane And Their Binding Interactions With Bovine Serum Albumin Using Spectroscopic Techniques, Javed Iqbal, Aziz Ur Rehman, Muhammad Athar Abbasi, Sabahat Zahra Siddiqui, Hira Khalid, Sabina Jhaumeer Laulloo, Nausheen Joondan, Aniisah Banu Taupass, Shahid Rasool, Syed Adnan Ali Shah
Turkish Journal of Chemistry
A new series of acetamide derivatives containing 1,2,4-triazole and azinane moieties has been synthesized and characterized using $^{1}$H NMR, $^{13}$C NMR, IR, and EI-MS spectroscopic analysis. The intermediate triazole was synthesized through a sequential synthesis of carboxylate and carbohydrazide. The bovine serum albumin (BSA) binding of the newly synthesized 1,2,4-triazole derivatives was evaluated along with thermodynamics, site-selective binding, and synchronous study. The results obtained by BSA binding as well as thermodynamic studies justify that all the compounds show spontaneous interaction with BSA and could be effectively distributed and eliminated from the body. Therefore, the triazole-based analogs might be a useful …
An Efficient Water-Mediated Synthetic Route For The Alkylation Of Heteroarenes, Pinar Seyi̇tdanlioğlu, Essam Hamied Ahmed Hanashalhalshahaby, Canan Ünaleroğlu
An Efficient Water-Mediated Synthetic Route For The Alkylation Of Heteroarenes, Pinar Seyi̇tdanlioğlu, Essam Hamied Ahmed Hanashalhalshahaby, Canan Ünaleroğlu
Turkish Journal of Chemistry
An efficient synthetic route has been described for the alkylation of 1$H$-indole, 1$H$-benzimidazole, and 1$H$-benzotriazole. This approach features the alkylation of heteroaromatics through in situ generated enones from ketonic Mannich bases under metal-free conditions. A series of alkylated heteroaromatics have been synthesized via the K10 catalyzed alkylation reactions of these heteroaromatics with a variety of ketonic Mannich bases. Environmentally benign K10 catalyst, water-mediated mild reaction conditions, and the efficient synthesis of alkylated products are the advantages of this alkylation method.