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Articles 3421 - 3450 of 15561
Full-Text Articles in Entire DC Network
Development Of A Chromatographic Method To Authenticate Aspirin Brands, Megan Guetzloff
Development Of A Chromatographic Method To Authenticate Aspirin Brands, Megan Guetzloff
Electronic Theses and Dissertations
Counterfeit pharmaceuticals pose a threat to society that can include inaccurate amounts of the active pharmaceutical ingredient (API), no API, or containing off-target compounds. For example, there are many recent examples of counterfeit pharmaceuticals containing potentially lethal doses (> 2 mg) of fentanyl (i.e., a synthetic opioid). Current measures to combat illicit pharmaceuticals (e.g., unique packaging and product serialization) have merit, however with evolved technologies, counterfeiters can relatively easily simulate these measures and continue to distribute illicit pharmaceuticals. The only accurate way to definitively determine that a suspected counterfeit is, in fact, counterfeit is advanced chemical analysis. However, current methods …
Assessment Of Quechers Extraction Protocol For The Lc-Ms/Ms Detection Of Emerging Fentanyl Analogs In Biological Specimens For Clinical And Forensic Purposes, Kylea M. Morris
Graduate Theses, Dissertations, and Problem Reports (ETD)
Drug abuse within the United States is a dynamic and pervasive issue that affects the quality and life expectancy of our society. One of the major drug classes that are constantly utilized is opioids. Opioids are prescribed for pain management in patients suffering from cancer and other medical illnesses. Long-term use of opioids could lead to tolerance in humans, which poses a risk of reaching fatal overdose levels. Unfortunately, opioids are abused recreationally, and in some instances, individuals are unaware of the presence of dangerous synthetic drugs like fentanyl, hidden in materials such as heroin, cocaine, oxycodone, and methamphetamine. Recent …
Synthesis Of Modified Nanocomposite Material And Its Use On Removal Of Cesium Fromaqueous Media, Bi̇lal Çeti̇n, Mustafa Özcan, Bektaş Karakelle
Synthesis Of Modified Nanocomposite Material And Its Use On Removal Of Cesium Fromaqueous Media, Bi̇lal Çeti̇n, Mustafa Özcan, Bektaş Karakelle
Turkish Journal of Chemistry
A nanocomposite containing Fe3O4, chitosan (Ch), and hexacyanoferrate (HCF) was synthesized in the form of powder. The physicochemical properties of this nanocomposite are determined using different techniques including Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), thermogravimetric analysis (TGA), scanning electron microscopy (SEM). The existence of Cs (Cs) ions onto the surface of the nanocomposite was verified by dispersive X-ray spectroscopy (EDX). FTIR spectra confirmed that the nanocomposite was well coordinated. The batch technique was applied to evaluate the influences of initial pH value, temperature, contact time, shaking rate, initial Cs concentration, and competing cations on the efficiency of Cs …
Virtual Screening, Drug-Likeness Analysis, And Molecular Docking Study Of Potentialsevere Acute Respiratory Syndrome Coronavirus 2 Main Protease Inhibitors, Nikola Nedeljkovic, Milos Nikolic, Ana Stankovic, Nevena Jeremic, Dusan Tomovic, Andriana Bukonjic, Gordana Radic, Marina Mijajlovic
Virtual Screening, Drug-Likeness Analysis, And Molecular Docking Study Of Potentialsevere Acute Respiratory Syndrome Coronavirus 2 Main Protease Inhibitors, Nikola Nedeljkovic, Milos Nikolic, Ana Stankovic, Nevena Jeremic, Dusan Tomovic, Andriana Bukonjic, Gordana Radic, Marina Mijajlovic
Turkish Journal of Chemistry
Due to the length of time required to develop specific antiviral agents, the World Health Organization adopted the strategy of repurposing existing medications to treat Coronavirus disease 2019 infection. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease is possible biological target for potential antiviral drugs. We selected various compounds from PubChem database based on the structure of main protease inhibitors in Protein Data Bank database. Ten compounds showed nontumorigenic and nonmutagenic potential and met Egan's and Lipinski's rules. Molecular docking analysis was performed using AutoDock Vina software. Based on number and type of key binding interactions, as well as …
Recycled Human Hair-Derived Activated Carbon For Energy-Related Applications, Oğuzhan Kotan, Hati̇ce Bayrakçeken
Recycled Human Hair-Derived Activated Carbon For Energy-Related Applications, Oğuzhan Kotan, Hati̇ce Bayrakçeken
Turkish Journal of Chemistry
Activated carbon, having high surface area and porosity, is a carbonaceous material that comes from organic main sources. In this work, activated carbon materials were produced from human hair that belongs to people who can be classified into two age groups (0-18 or 18-40 years). Activated carbons were characterized by nitrogen adsorption/desorption isotherms (BET), X-ray diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), Raman spectroscopy, scanning electron microscopy (SEM), and elemental analysis techniques. Capacitances of the synthesized materials were determined by using cyclic voltammetry (CV). Characterization results showed that the structural properties of activated carbon materials and capacitance values are changed …
Investigation Of Biological Activities Of Plant Extract And Green Synthesis Silvernanoparticles Obtained From Gilaburu (Viburnum Opulus L.) Fruits, Bi̇rgütay Şahi̇n, Ali̇ Savaş Bülbül, İbrahi̇m Seyfetti̇n Çeli̇k, Nesri̇n Korkmaz, Ahmet Karadağ
Investigation Of Biological Activities Of Plant Extract And Green Synthesis Silvernanoparticles Obtained From Gilaburu (Viburnum Opulus L.) Fruits, Bi̇rgütay Şahi̇n, Ali̇ Savaş Bülbül, İbrahi̇m Seyfetti̇n Çeli̇k, Nesri̇n Korkmaz, Ahmet Karadağ
Turkish Journal of Chemistry
In this study, biological activities of silver nanoparticles (AgNP) synthesized by green synthesis method using the fruit extract of Gilaburu (Viburnum opulus L.) plant were investigated. The characterization of the synthesized AgNPs was performed by ultraviolet visible region spectroscopy (UV-Vis), Fourier transform - infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and X-ray diffraction (XRD) techniques. The crystal size was found to be 52.32 nm when the XRD data were calculated with the Debye- Scherrer's equation. The antimicrobial activities of extract and AgNPs were investigated by microdilution and disk diffusion methods. Antibiofilm activities were examined by the crystal violet technique. The …
Phytochemical Composition And Pharmacological Activities Of Teucrium Polium L. Collected From Eastern Turkey, Gi̇zem Gülsoy Toplan, Fati̇h Göger, Turgut Taşkin, Gülay Ecevi̇t Genç, Ayşe Ci̇vaş, Gökalp İşcan, Mi̇ne Kürkçüoğlu, Afi̇fe Mat, Kemal Hüsnü Can Başer
Phytochemical Composition And Pharmacological Activities Of Teucrium Polium L. Collected From Eastern Turkey, Gi̇zem Gülsoy Toplan, Fati̇h Göger, Turgut Taşkin, Gülay Ecevi̇t Genç, Ayşe Ci̇vaş, Gökalp İşcan, Mi̇ne Kürkçüoğlu, Afi̇fe Mat, Kemal Hüsnü Can Başer
Turkish Journal of Chemistry
Teucrium species that belong to the family Lamiaceae have been traditionally used for their medicinal properties. T. polium is one the most widespread members of the genus for its use in the treatment of several diseases. In this study, the essential oil and phenolic composition of the aerial parts from T. polium were assessed by GC-FID, GC/MS, and LC-MS/MS as well as for its total phenolic content. Several extracts such as n-hexane, chloroform, methanol, and infusion were prepared and their antimicrobial, antioxidant, and also acetylcholinesterase activities were studied. According to GC/MS results, β -caryophyllene (8.8%), t-cadinol (6.2%), (E)-nerolidol (5%), α …
Selective Catalytic Hydrogenation Of Cellulose Into Sorbitol With Ru-Based Catalysts, Ceren Orak, Aycan Sapmaz, Asli Yüksel Özşen
Selective Catalytic Hydrogenation Of Cellulose Into Sorbitol With Ru-Based Catalysts, Ceren Orak, Aycan Sapmaz, Asli Yüksel Özşen
Turkish Journal of Chemistry
Sorbitol is one of the platform chemicals and can be produced from various renewable and sustainable sources via different processes. Hydrothermal liquefaction is an effective and promising approach to produce sorbitol, since the subcritical reaction media and appropriate catalysts provide a selective production of platform chemicals. In this study, sorbitol was produced from different renewable sources (cellulose and glucose) in the presence of Ru-based catalysts (Ru/SiO2, Ru/AC, Ru/SBA-15, and Ru/SBA-15-SO3) under subcritical conditions. The highest cellulose conversion was achieved as 90% in the presence of Ru/SBA-15-SO3 for 1 h of reaction duration. The highest sorbitol yield (%) by hydrothermal liquefaction …
Fluorometric Determination Of Ornidazole By Using Bsa Coated Copper Nanoclusters As A Novel Turn Off Sensor, Mehmetcan Bi̇lkay, Hayri̇ye Eda Şatana Kara
Fluorometric Determination Of Ornidazole By Using Bsa Coated Copper Nanoclusters As A Novel Turn Off Sensor, Mehmetcan Bi̇lkay, Hayri̇ye Eda Şatana Kara
Turkish Journal of Chemistry
A fluorescent probe based on bovine serum albumin stabilized copper nanoclusters (BSA-CuNCs) was developed for the selective and sensitive determination of ornidazole (ORN). The nanoclusters were synthesized via a one-pot hydrothermal process in basic media. The synthesized and characterized BSA-CuNCs have less than 3 nm particle size and exhibited blue emission at 405 nm when excited at 325 nm. Synthesized and characterized nanoclusters were successfully applied as a turn-off fluorescent probe for the determination of ORN in pharmaceutical dosage forms. The quenching mechanism created an was inner filter effect (IFE). The method was linear in the concentration range of 0.52-13.56 …
Biological Potential Of Copper Complexes: A Review, Jamshaid Ashraf, Muhammad Asad Riaz
Biological Potential Of Copper Complexes: A Review, Jamshaid Ashraf, Muhammad Asad Riaz
Turkish Journal of Chemistry
This review comprises the inorganic compounds particularly metal coordinated complexes, as drugs play a relevant role in medicinal chemistry. It has been observed that copper complexes are potentially attractive as medicinal importance. In this review, the most remarkable achievements of copper complexes undertaken over the past few decades as antimicrobial, antioxidant, enzyme inhibition activity, and anti-cancer agents are discussed. This work was motivated by the observation that no comprehensive surveys of the diversity of biological activities of copper complexes were available in the literature.
Removal Of Cd2+ Metal Ions From Aqueous Solutions By Na-Alginate-Containingcomposite Biosorbent, Ramazan Donat
Removal Of Cd2+ Metal Ions From Aqueous Solutions By Na-Alginate-Containingcomposite Biosorbent, Ramazan Donat
Turkish Journal of Chemistry
This research is related to the effect of alginate-containing composite biosorbent on the sorption capacity of heavy metal Cd2+ ions. The study aims to determine the character and optimization of the sorption of Na-alginate-containing composite biosorbent on the sorption of heavy metal Cd2+ metal ions in an aqueous solution. Optimum conditions of parameters such as biosorbent amount, pH value effect, concentration effect, contact time, and temperature that affect the sorption of Cd2+ ions were determined. Langmuir, Freundlich, D-R isotherms were applied to the obtained data, and it was noted that the sorption Cd2+ ions are better explained with Freundlich and …
Design, Synthesis, And In Vitro Antitumor Activity Of 6-Aryloxyl Substituted Quinazolinederivatives, Meixia Fan, Lei Yao
Design, Synthesis, And In Vitro Antitumor Activity Of 6-Aryloxyl Substituted Quinazolinederivatives, Meixia Fan, Lei Yao
Turkish Journal of Chemistry
Quinazoline derivatives are a class of important antitumor drugs known as small molecule inhibitors that include epidermal growth factor receptor (EGFR) inhibitors. Based on the structure of poziotinib, a series of 6-aryloxyl substituted quinazoline derivatives were designed and synthesized. The in vitro antitumor activities of the compounds were evaluated by the 3-(4,5-dimethyl-thiazol-2- yl)2,5-diphenyltetrazolium bromide (MTT) method using the human gastric cancer N87 (HER2), nonsmall-cell lung cancer H1975 (EGFRT790M/L858R), and A549 (EGFRWT) cell lines. The most promising compound 4m exhibited potent antitumoral activities with IC50 values of 6.3 nM and 7.5 nM for N87 and H1975 cell lines, respectively. Meanwhile, it …
Boric Acid And Schiff Base-Based Fluorescent Sensor For Detection Of L-Tryptophan In Milk And Bsa Samples, Ümran Duru Kamaci, Musa Kamaci
Boric Acid And Schiff Base-Based Fluorescent Sensor For Detection Of L-Tryptophan In Milk And Bsa Samples, Ümran Duru Kamaci, Musa Kamaci
Turkish Journal of Chemistry
In the present paper, the fluorescence sensor based on Schiff base and boric acid was developed for easy and rapid detection of L-tryptophan in different samples such as milk and bovine serum albumin. The photoluminescence intensity was measured by using fluorescent measurements and the results indicated that the developed fluorescent sensor was exhibited selective, sensitive, reliable determination against L-tryptophan, and a series of various analytes such as cations, amino acids, and organic compounds were used to investigate the selectivity of the fluorescent chemosensor. The limit of detection and linear range of the chemosensor were calculated as 0.82 μM, and 0.1?500 …
The 4-(Dimethylaminoalkyl)Piperazine Inhibitors Of Α-Glucosidase: Allosteric Enzyme Inhibition And Identification Of Interacting Chemical Groups, Usman Ghani, Sajda Ashraf, Zaheer Ul Haq, Zafer Asim Kaplancikli, Fati̇h Demi̇rci̇, Yusuf Özkay, Sibtain Afzal
The 4-(Dimethylaminoalkyl)Piperazine Inhibitors Of Α-Glucosidase: Allosteric Enzyme Inhibition And Identification Of Interacting Chemical Groups, Usman Ghani, Sajda Ashraf, Zaheer Ul Haq, Zafer Asim Kaplancikli, Fati̇h Demi̇rci̇, Yusuf Özkay, Sibtain Afzal
Turkish Journal of Chemistry
In continuation of our interest in identifying new α-glucosidase inhibitors with potential to become antidiabetic drugs, this work focuses on the study of 4-(dimethylaminoalkyl)piperazine-1-carbodithioate derivatives as α-glucosidase inhibitors. The eight heterocyclic piperazine-dithiocarbamate complexes studied in this work contain a variety of substitutions on their benzene ring exhibiting potent, noncompetitive inhibition of α-glucosidase. Dithiocarbamate and piperazine moieties are important pharmacophores with promising therapeutic prospects featuring facilitated drug delivery due to their lipophilic nature in addition to their α-glucosidase inhibitory activity. Enzyme kinetics, molecular dynamics simulations, and docking studies revealed that the target compounds bind to a new allosteric site that is …
L-(+)-Tryptophan Methyl Ester Derived Polymeric Microbeads As An Efficient Heterogeneous Catalyst For Green Synthesis Of 2-Amino-4-(Nitromethyl)-4h-Chromene-3- Carbonitriles, Ayşe Haliç Poslu, Bi̇lgen Osman, Yunus Kaya, Ömer Koz, Gamze Koz
L-(+)-Tryptophan Methyl Ester Derived Polymeric Microbeads As An Efficient Heterogeneous Catalyst For Green Synthesis Of 2-Amino-4-(Nitromethyl)-4h-Chromene-3- Carbonitriles, Ayşe Haliç Poslu, Bi̇lgen Osman, Yunus Kaya, Ömer Koz, Gamze Koz
Turkish Journal of Chemistry
The cross-linked microbeads with average diameter of 106-300 μm, [poly(EGDMA-MATrp)], were obtained by copolymerization reaction of N-methacryloyl-L-(+)-tryptophan methyl ester (MATrp) with ethylene glycol dimethacrylate (EGDMA) and successfully applied as a heterogeneous catalyst in conjugate addition reaction of nitromethane to substituted 2-iminochromenes in aqueous media. A variety of 2-amino-4-(nitromethyl)-4H-chromene-3-carbonitriles has been synthesized in good yields. Polymeric microbeads were very durable and reused 5 times without a significant loss of activity. DFT calculations and experimental results revealed the significant role of π-π interactions as well as hydrogen bonding in the reaction mechanism.
Chemical Compositions And Biological Activities Of The Oils From The Genus Taxus And Factors Limiting The Regeneration Of Endangered Yews: A Review, Sagar Dhakal, Prem Kumar Khosla, Tokuma Getahun
Chemical Compositions And Biological Activities Of The Oils From The Genus Taxus And Factors Limiting The Regeneration Of Endangered Yews: A Review, Sagar Dhakal, Prem Kumar Khosla, Tokuma Getahun
Turkish Journal of Chemistry
The genus Taxus (yews) is the largest genus of the family Taxaceae. It comprises about 24 species with 55 varieties distributed mainly in Asia, Europe, North Africa, and North America. In addition to the taxane diterpenoids and the cancer drug taxol, its species contain many essential oils with actual or potential biological activity. This review covers the chemical constituents as well as biological activities of these oils that have been studied in fourteen countries over 46 years (1975-2021). It also discusses the biotic and abiotic factors that limit the regeneration of these economically and medicinally important plants.
Design, Synthesis, And Greener Pasture Biological Assessment Of A Novel Nucleoside: 1-(Α-D-Ribofuranosyl)-6,7-Difluoro-2-Methyl-4-Quinazolinone As An Inhibitor Of Covid-19 And Alzheimer's Disease, Laila M. Break, Adil A. Gobouri, Wafa S. Al-Harthi, Mohamed Hagar, Nadia S. Alkaff, Musa A. Said
Design, Synthesis, And Greener Pasture Biological Assessment Of A Novel Nucleoside: 1-(Α-D-Ribofuranosyl)-6,7-Difluoro-2-Methyl-4-Quinazolinone As An Inhibitor Of Covid-19 And Alzheimer's Disease, Laila M. Break, Adil A. Gobouri, Wafa S. Al-Harthi, Mohamed Hagar, Nadia S. Alkaff, Musa A. Said
Turkish Journal of Chemistry
Synthesis of a new fluorinated nucleoside of 6,7-difluoro-2-methyl-4-quinazolinone was described. 2-Amino-4,5-difluorobenzoic acid 1 reacts with (CH3CO)2O followed by ammonia to form (1H)-6,7-difluoro-2-methyl-4-quinazolinone 3a. Ribosylation of a silylated 4 with l-O-acety1-2,3-5-tri-O-benzoyl-α-D-ribofuranose 5 forms a protected nucleoside 6 then unprotected from 6 to give a free nucleoside 7. Greener pasture biological docking of the cystine protease of COVID-19 [Mpro, code 7BQY, PDB] by novel nucleoside and fluoroquinazoline compounds is presented. LIGPLOT (2D) representations calculated for the same ligands are shown. A superposition of remdesivir approved medicine, N3 inhibitor, and our ligands docked …
The Sweet And Embellishing Lycium Arabicum Schweinf. Ex Boiss. Fruit Oil: A Potential Source Of Essential Ω-6 And Ω-9 Fatty Acids, Phytosterols, And Carotenoids, Jawhar Fakhfakh, Marwa Affes, Hazem Jabeur, Mohamed Ayadi, Noureddine Allouche
The Sweet And Embellishing Lycium Arabicum Schweinf. Ex Boiss. Fruit Oil: A Potential Source Of Essential Ω-6 And Ω-9 Fatty Acids, Phytosterols, And Carotenoids, Jawhar Fakhfakh, Marwa Affes, Hazem Jabeur, Mohamed Ayadi, Noureddine Allouche
Turkish Journal of Chemistry
In our current phytochemical investigation on the Tunisian plant Lycium arabicum Schweinf. ex Boiss., we attempted to explore the oil obtained from its fruits. This oil was extracted by cold maceration with ethanol and was analyzed to estimate its sterol and fatty acid content. The physicochemical parameters of the oil were also examined. They were specified in terms of acid value (0.8 ± 0.01 mg KOH g-1 oil), peroxide value (10.9 ± 0.02 meq O2 kg-1 oil), saponification value (162.97 ± 0.03 mg KOH g-1 oil), chlorophylls (1.011 ± 0.03 mg kg-1 oil) and carotenoids …
Gold Nanoparticles/Over-Oxidized Poly-Eriochrome Black T Film Modified Electrode For Determination Of Arsenic, Mürşi̇de Ceren Afşar, Aydan Elçi̇, Zekerya Dursun
Gold Nanoparticles/Over-Oxidized Poly-Eriochrome Black T Film Modified Electrode For Determination Of Arsenic, Mürşi̇de Ceren Afşar, Aydan Elçi̇, Zekerya Dursun
Turkish Journal of Chemistry
A glassy carbon electrode, modified with gold nanoparticles/over-oxidized poly-eriochrome black T film, was fabricated for sensitive determination of As(III) by stripping voltammetry in an acidic medium. The electrode surface properties were characterized by cyclic voltammetry, electrochemical impedance spectroscopy, scanning electron microscope (SEM), and X-ray photoelectron spectroscopy (XPS). The electrode demonstrated a good response towards As(III), with a detection of 0.077 μM and good linearity in the range of 0.1 to 10 μM (R2 = 0.9977). For the determination of As(III), the fabricated electrode was placed in different mineral water samples, acidified with 0.75 M HCl solution, spiked with various …
Non-Chromatographic Oligonucleotide Purification And Automated Polyethyleneglycol Synthesis, Dhananjani N. A. M. Eriyagama
Non-Chromatographic Oligonucleotide Purification And Automated Polyethyleneglycol Synthesis, Dhananjani N. A. M. Eriyagama
Dissertations, Master's Theses and Master's Reports
Synthetic oligodeoxynucleotides (ODN) have various applications in many areas such as, synthetic biology, chemical biology, antisense drug development, and data storage. As a result, there is a high demand for synthetic ODNs. Many advances have been made with ODN synthesis the purification still remains a bottleneck. The non-chromatographic purification method is developed to address this problem. Similarly, polyethylene glycols (PEGs) have been used in many areas including pharmaceutical applications, surface science, and nanomedicine due to its unique properties. However, monodispersed PEG synthesis is expensive with existing methods. A novel automated solid phase synthesis method is developed to obtain monodispersed PEGs. …
Multilevel Computational Investigation Into The Dynamics And Reaction Mechanisms Of Non-Heme Iron And 2-Oxoglutarate Dependent Enzymes, Shobhit Sanjeev Chaturvedi
Multilevel Computational Investigation Into The Dynamics And Reaction Mechanisms Of Non-Heme Iron And 2-Oxoglutarate Dependent Enzymes, Shobhit Sanjeev Chaturvedi
Dissertations, Master's Theses and Master's Reports
Computational chemistry methods have been extensively applied to investigate biological systems. This dissertation utilizes a multilevel computational approach to explore the dynamics and reaction mechanisms of two groups of enzymes belonging to non-heme Fe(II) and 2-oxoglutarate (2OG) dependent superfamily – histone lysine demethylases from class 7 and ethylene forming enzyme (EFE). Chapter 2 uncovers the role of conformational dynamics in the substrate selectivity of histone lysine demethylases 7A and 7B. The molecular dynamics (MD) simulations of the two enzymes revealed the importance of linker flexibility and dynamics in relative orientations of the reader (PHD) and the catalytic (JmjC) domains. Chapter …
Chromatography-Mass Spectroscopy Analysis Of Native American Pottery For Maple Syrup Residues, Alexis Wirtz
Chromatography-Mass Spectroscopy Analysis Of Native American Pottery For Maple Syrup Residues, Alexis Wirtz
Honors Program Theses
The research conducted regards whether or not Native Americans understood how to create maple syrup before the influence of Europeans. The analytical technique that was used is gas chromatography-mass spectrometry (GC-MS). This technique assisted in understanding what organic residues resided within the pottery and what those organic residues tell us about Native American history. An analysis of organic residues was performed on the following types of pottery: proof of concept pottery, weathered pottery (an analog of the proof of concept), and Native American pottery. The residues used in analysis were obtained through the usage of different solvent systems - Acetone: …
Understanding And Harnessing The Structural Features That Govern Hmg-Coa Reductase Activity, Edwin Ragwan
Understanding And Harnessing The Structural Features That Govern Hmg-Coa Reductase Activity, Edwin Ragwan
Bryn Mawr College Dissertations and Theses
The enzyme 3-hydroxy-3-methylglutaryl coenzyme-A reductase (HMGR), which catalyzes the reduction of HMG-CoA to mevalonate using two equivalents of the cofactor NAD(P)H, is part of the mevalonate pathway, found in all kingdoms of life. This pathway is at the heart of natural product biosynthesis constituting one of the obligate routes to producing the building blocks for isoprenoids, which represent the largest and most diverse class of natural products. Natural products and its derivatives continue to provide important compounds in the fields of drug development, biomedical engineering, and commercially-driven products. Therefore, HMGR, which performs the rate-limiting step of the mevalonate pathway garners …
Airborne Fungal Spore Review, New Advances And Automatisation, Moisés Martínez-Bracero, Emma Markey, Jerry Hourihane Clancy, Eoin Mcgillicuddy, Gavin Sewell, David J. O'Connor
Airborne Fungal Spore Review, New Advances And Automatisation, Moisés Martínez-Bracero, Emma Markey, Jerry Hourihane Clancy, Eoin Mcgillicuddy, Gavin Sewell, David J. O'Connor
Articles
Fungal spores make up a significant portion of Primary Biological Aerosol Particles (PBAPs) with large quantities of such particles noted in the air. Fungal particles are of interest because of their potential to affect the health of both plants and humans. They are omnipresent in the atmosphere year-round, with concentrations varying due to meteorological parameters and location. Equally, differences between indoor and outdoor fungal spore concentrations and dispersal play an important role in occupational health. This review attempts to summarise the different spore sampling methods, identify the most important spore types in terms of negative effects on crops and the …
Investigation Of Hazelnut Shells Driven Hard Carbons As Anode For Sodium-Ion Batteriesproduced By Hydrothermal Carbonization Method, Eli̇f Canbaz, Meral Aydin, Rezan Demi̇r Çakan
Investigation Of Hazelnut Shells Driven Hard Carbons As Anode For Sodium-Ion Batteriesproduced By Hydrothermal Carbonization Method, Eli̇f Canbaz, Meral Aydin, Rezan Demi̇r Çakan
Turkish Journal of Chemistry
To be used as Na-ion battery anodes, hard carbon electrodes are synthesized from biomass, explicitly hazelnut shell (HS): via hydrothermal carbonization (HTC) followed by further pyrolysis at different temperatures (500, 750, 1000 °C). Then, the resulting hazelnut shell-based hard carbons are investigated using various methods including Fourier-transform infrared spectroscopy, scanning electron microscope, X-ray diffraction, galvanostatic charge/discharge, and electrochemical impedance spectroscopy. The effects of binders (PVdF, Na-alginate, CMC, and PAA) on electrochemical performance are determined. The obtained composite electrodes with different binders are tested in sodium half-cell configurations. A strong correlation is recognized between carbonization temperature and electrochemical performances and structural …
New Bis-Isoxazole With Monoterpenic Skeleton: Regioselective Synthesis, Spectroscopicinvestigation, Electrochemical, And Density Functional Theory (Dft) Studies, Ali Oubella, Meryem Hrimla, Mouhi Eddine Hachim, Mourad Fawzi, Abdoullah Bimoussa, Lahoucine Bahsis, Aziz Boutouil, Aziz Auhmani, Abdelkhalek Riahi, My Youssef Ait Itto
New Bis-Isoxazole With Monoterpenic Skeleton: Regioselective Synthesis, Spectroscopicinvestigation, Electrochemical, And Density Functional Theory (Dft) Studies, Ali Oubella, Meryem Hrimla, Mouhi Eddine Hachim, Mourad Fawzi, Abdoullah Bimoussa, Lahoucine Bahsis, Aziz Boutouil, Aziz Auhmani, Abdelkhalek Riahi, My Youssef Ait Itto
Turkish Journal of Chemistry
A novel bis-isoxazole was synthesized from (R)-Carvone and p-methylbenzaldoxime, via two successive [3+2] cycloaddition reactions (32CA). The newly obtained bis-isoxazole has been fully characterized by HRMS and NMR spectroscopy. The HMBC experiment was performed to determine the stereo and the regioselectivity of the reaction. The electrochemical behavior of the studied compound, in oxidation and reduction processes, was examined using the cyclic voltammetry technique. In addition, the regioselectivity of the [3+2] cycloaddition reaction and the molecular structure of the title compound was performed by density functional theory (DFT). The HOMO and LUMO orbitals were investigated to determine the electronic properties of …
Determination Of Triacylglycerol And Fatty Acid Compositions Of Impatiens Seed Oils Using Reverse Phase High Performance Liquid Chromatography, Anh Van Nguyen, Anh Thi Ngoc Vu, Victor Ivanovic Deineka, Huy-Trung-Kien Nguyen
Determination Of Triacylglycerol And Fatty Acid Compositions Of Impatiens Seed Oils Using Reverse Phase High Performance Liquid Chromatography, Anh Van Nguyen, Anh Thi Ngoc Vu, Victor Ivanovic Deineka, Huy-Trung-Kien Nguyen
Turkish Journal of Chemistry
In the present work, triacylglycerol and fatty acid compositions of Impatiens balsamina L. and Impatiens walleriana Hook.f. seed oils were determined using reverse phase high performance liquid chromatography with both refractive index and spectrophotometric detections. The presence of conjugated octadecatetraenoic moieties was confirmed by UV and IR spectroscopy. Triacylglycerol (TAG) compositions were performed using an incremental approach and confirmed by the results of MS and electronic spectra. The quantitative analysis of TAG was achieved by careful calibration, introducing correction factors for the sensitivity of each compound. The results showed that both Impatiens seed oils contain the same 23 TAGs. The …
The Effect Of Fuel On The Physiochemical Properties Of Znfe2o4 Synthesized By Solution Combustion Method, Fahma Riyanti, Widia Purwaningrum, Nova Yuliasari, Sasmita Putri, Nabila Aprianti, Poedji Loekitowati Hariani
The Effect Of Fuel On The Physiochemical Properties Of Znfe2o4 Synthesized By Solution Combustion Method, Fahma Riyanti, Widia Purwaningrum, Nova Yuliasari, Sasmita Putri, Nabila Aprianti, Poedji Loekitowati Hariani
Turkish Journal of Chemistry
The synthesis of ZnFe2O4 nanoparticles was performed using the solution combustion method with three types of fuel, namely urea, glycine, and ethylenediamine tetra-acetic acid (EDTA) with precursors (Zn(NO3)2.6H2O and Fe(NO3)3.9H2O. The combustion process was conducted in an open space at 300 °C for ± 1 h, resulting in a brownish-black ZnFe2O4. Meanwhile, the fuel type used in the process affects the physicochemical properties of ZnFe2O4. XRD analysis showed that ZnFe2O4 synthesized using urea, glycine, …
Improvement Of Hydrodynamics And Heat Transfer In Biomass Fluidized Bed Combustor With Immersed Tubes Using Cfd-Dem, Krittin Korkerd
Improvement Of Hydrodynamics And Heat Transfer In Biomass Fluidized Bed Combustor With Immersed Tubes Using Cfd-Dem, Krittin Korkerd
Chulalongkorn University Theses and Dissertations (Chula ETD)
Computational Fluid Dynamics coupled with Discrete Element Method (CFD-DEM) has been extensively utilized for studying hydrodynamics and heat transfer in fluidization processes. This study specifically focuses on improving hydrodynamics and heat transfer in a biomass fluidized bed combustor with immersed tubes. The investigation involves the use of mixed biomass, exploring the effects of biomass types, biomass loading, and blending ratios to propose criteria for selecting suitable biomass fuel for the system. Design parameters related to the immersed tubes, such as the angle between tubes, tube diameters, and distance between tubes, were also considered. A data-driven model was developed based on …
Chemical Constituents From The Fresh Pericarps Of Mature Mangosteen Fruit Garcinia Mangostana, Ahmad Tijani Azeez
Chemical Constituents From The Fresh Pericarps Of Mature Mangosteen Fruit Garcinia Mangostana, Ahmad Tijani Azeez
Chulalongkorn University Theses and Dissertations (Chula ETD)
α-Mangostin has been identified as a major chemical constituent in the pericarps of mangosteen (Garcinia mangostana Linn.) Over time, dried pericarps of mangosteen have been subjected to studies in literature. This study aimed to explore isolation of α-mangostin and other chemical constituents from the fresh pericarps of mature mangosteen fruits and investigate their relative antioxidant and anticancer activities. Repeated column chromatography on ethyl acetate and methanol extracts of fresh mature mangosteen pericarps led to the isolation of α-mangostin (33.25% of crude extracts) as the major compound, beta-mangostin (0.225%) and gartanin (7.57%). Their antioxidant scavenging activity was investigated against 2,2-diphenyl-1-picrylhydrazyl (DPPH) …