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A Simple And Rapid Rp-Hplc Method For The Assessment Of Cobalamin (Vitamin B12) Intilapia And Snoek Fishes, Labaran Ibrahim, Aminu Usman Jan 2022

A Simple And Rapid Rp-Hplc Method For The Assessment Of Cobalamin (Vitamin B12) Intilapia And Snoek Fishes, Labaran Ibrahim, Aminu Usman

Turkish Journal of Chemistry

This study developed a rapid reversed-phase high-performance liquid chromatography (RP-HPLC) method equipped with a UV-Vis detector. The aquaponics system?s tilapia and marine snoek fishes were extracted using an autoclaving process and enzymatic treatment. The technique enabled the separation and quantification of cobalamin present in these fishes extracts. Phenomenex Luna® 5 μm C18 (2) 100 A LC-column (150 × 4.6 mm) was used as a stationary phase, while the mobile phase consisted of methanol and phosphoric acid in a ratio of 35:65 (v/v), respectively. The developed method was revealed to be rapid (a retention time of less than 5.0 min), linear …

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Schiff Base Functionalized Silica Gel For Simultaneous Separation And Preconcentration Of Cu(Ii), Ni(Ii), And Cd(Ii) In Pharmaceuticals And Water Samples, Feyzullah Tokay, Sema Bağdat Jan 2022

Schiff Base Functionalized Silica Gel For Simultaneous Separation And Preconcentration Of Cu(Ii), Ni(Ii), And Cd(Ii) In Pharmaceuticals And Water Samples, Feyzullah Tokay, Sema Bağdat

Turkish Journal of Chemistry

A method for separation and preconcentration of Cu(II), Ni(II), and Cd(II) using N-N'-bis(5-methoxsalicylidene)-2-hydroxy-1,3-propanediamine modified silica gel was improved for aqueous samples and pharmaceuticals. Determination of the analytes was achieved by inductively coupled plasma optic emission spectrometry. The experimental conditions including pH value, sample volume, eluent type and volume, sorbent mass, sample, and eluent flow rates were optimized with univariate and multivariate optimization tools. The relative standard deviations of the method were 2.9% for Cu(II), 3.0% for Ni(II), and 3.3% for Cd(II) with recovery values between 98.8 ± 3.2-101.5 ± 3.0%. The limits of detection were found to be 62.4, 39.5, …

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A Bodipy Based Probe For The Reversible "Turn On" Detection Of Au(Iii) Ions, Muhammed Üçüncü Jan 2022

A Bodipy Based Probe For The Reversible "Turn On" Detection Of Au(Iii) Ions, Muhammed Üçüncü

Turkish Journal of Chemistry

A new "turn on" fluorescent probe for the rapid and selective detection of Au3+ ions over other metal ions was developed. The probe design was constructed on a BODIPY-2-aminopyridine skeleton showing a weak fluorescence emission signal which increased substantially after the coordination of Au3+ ions. The probe displayed remarkable sensing performances such as a low limit of detection (17 nM), a short response time (

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Preconcentration Of Trace Amount Cu(Ii) By Solid-Phase Extraction Method Usingactivated Carbon-Based Ion-Imprinted Sorbent, Kübra Turan, Ruki̇ye Saygili Canlidi̇nç, Orhan Murat Kalfa Jan 2022

Preconcentration Of Trace Amount Cu(Ii) By Solid-Phase Extraction Method Usingactivated Carbon-Based Ion-Imprinted Sorbent, Kübra Turan, Ruki̇ye Saygili Canlidi̇nç, Orhan Murat Kalfa

Turkish Journal of Chemistry

In this study, preconcentration conditions of trace amounts of copper ions were investigated with solid-phase extraction (SPE) method by synthesizing activated carbon-based ion-imprinted sorbent (Cu(II)-IAC) with a novel and selective approach. Flame atomic absorption spectrometry (FAAS) was used for the determination of metal ions concentrations. For the characterization of the sorbents, scanning electron microscopy, energy dispersive X-ray (SEM/EDX) analysis, and Fourier transform infrared spectroscopy (FTIR) were used. Optimum conditions for the SPE procedure, various parameters such as pH value, eluent type and concentration, sample volume, sample flow rate, adsorption capacity, and selectivity were studied. The adsorption isotherm was analyzed by …

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Development Of Dual Enzyme Responsive Molecular And Logic Gate, Sündüs Erbaş Çakmak Jan 2022

Development Of Dual Enzyme Responsive Molecular And Logic Gate, Sündüs Erbaş Çakmak

Turkish Journal of Chemistry

Molecular logic gates are information processing devices that can respond to environmental signals and produce a readable output in response through Boolean logic operations. Molecules with these properties have been used to build smart sensors and therapeutic agents. In this work, dual enzyme-responsive molecular AND logic gate is developed with the intention to discriminate various combinations of enzyme level and/or activity. A resorufin-based sensor is substituted with self-immolative tyrosinase recognition site, 3-hydroxy benzyl group. The Hydroxyl group is protected with acetyl moiety which decreases the affinity of the enzyme. When both tyrosinase and esterase are present in the solution, the …

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A Systematic Review Of Rdrp Of Sars-Cov-2 Through Artificial Intelligence And Machine Learning Utilizing Structure-Based Drug Design Strategy, Fariha Imtiaz, Mustafa Kamal Pasha Jan 2022

A Systematic Review Of Rdrp Of Sars-Cov-2 Through Artificial Intelligence And Machine Learning Utilizing Structure-Based Drug Design Strategy, Fariha Imtiaz, Mustafa Kamal Pasha

Turkish Journal of Chemistry

Since the coronavirus disease has been declared a global pandemic, it had posed a challenge among researchers and raised common awareness and collaborative efforts towards finding the solution. Caused by severe acute respiratory coronavirus syndrome-2 (SARS-CoV-2), coronavirus drug design strategy needs to be optimized. It is understandable that cognizance of the pathobiology of COVID-19 can help scientists in the development and discovery of therapeutically effective antiviral drugs by elucidating the unknown viral pathways and structures. Considering the role of artificial intelligence and machine learning with its advancements in the field of science, it is rational to use these methods which …

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Synthesis, Predictions Of Drug-Likeness, And Pharmacokinetic Properties Of Some Chiral Thioureas As Potent Enzyme Inhibition Agents, Yusuf Sicak Jan 2022

Synthesis, Predictions Of Drug-Likeness, And Pharmacokinetic Properties Of Some Chiral Thioureas As Potent Enzyme Inhibition Agents, Yusuf Sicak

Turkish Journal of Chemistry

A series of chiral thioureas (1 - 17) were synthesized from and tested for their anticholinesterase, tyrosinase, and urease enzyme inhibitor activities. Various phenylisothiocyanates were added to solution of L-cysteine in methanol: water (1 : 1 v / v) at room temperature and stirred for 24 h. The precipitated solid was recrystallized from n-butanol. Pure compounds were characterized by NMR (1H and 13C), FTIR, and CHNS. Tertiary amine containing N-(4-(diethylamino)phenyl)-N'-(2-mercapto-carboxyethanyl)thiourea 17, N-(4-(dimethylamino)phenyl)-N'-(2-mercapto-carboxyethanyl)thiourea 16 and trimethoxy containing N-(3,4,5-trimethoxyphenyl)-N'-(2-mercapto-carboxyethanyl)thiourea 14 were more active than galantamine against AChE and BChE enzymes. In tyrosinase enzyme inhibition activity, compound 14, 10, 12, 6, 13, and …

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Synthesis Of 2-Aryl-5-(Arylsulfonyl)-1,3,4-Oxadiazoles As Potent Antibacterial Andantioxidant Agents, S N Murthy Boddapati, Subrahmanyam Talari, A Emmanuel Kola, Bhuvaneswari Chalapaka Jan 2022

Synthesis Of 2-Aryl-5-(Arylsulfonyl)-1,3,4-Oxadiazoles As Potent Antibacterial Andantioxidant Agents, S N Murthy Boddapati, Subrahmanyam Talari, A Emmanuel Kola, Bhuvaneswari Chalapaka

Turkish Journal of Chemistry

Ten novel 2-aryl-5-(arylsulfonyl)-1,3,4-oxadiazoles were produced and assessed for their in vitro antibacterial and antioxidant activities. Diverse spectroscopic methods li1H NMR, 13C NMR, IR, and LCMS were used for the characterization of the prepared samples and all the data was in good agreement with the anticipated structures. The prepared compounds 6a-j were screened for their in vitro antibacterial activity against bacterial strains Pseudomonas aeruginosa, Enterobacter aerogenes, Escherichia coli (grampositive), and Bacillus cerus, Staphylococcus aureus, Bacillus subtilis (gram-negative). The antimicrobial screening outcome revealed that the prepared 2-(3,4-dimethylphenyl)-5-tosyl-1,3,4-oxadiazole (6j), 2-(3-isopropylphenyl)-5-tosyl-1,3,4-oxadiazole (6c), and 2-(2-ethylphenyl)-5-tosyl-1,3,4-oxadiazole (6i) are most potent among all the examined compounds. Furthermore, …

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Ultrafiltration-Based Sample Preparation And Hplc-Uv Determination Of Diclofenac In Human Plasma Samples, Merve Nenni̇, Ayşegül Doğan, Mustafa Çelebi̇er, Murat Soyseven, Mustafa Si̇nan Kaynak, Hassan Y. Aboul-Enein, Göksel Arli̇ Jan 2022

Ultrafiltration-Based Sample Preparation And Hplc-Uv Determination Of Diclofenac In Human Plasma Samples, Merve Nenni̇, Ayşegül Doğan, Mustafa Çelebi̇er, Murat Soyseven, Mustafa Si̇nan Kaynak, Hassan Y. Aboul-Enein, Göksel Arli̇

Turkish Journal of Chemistry

The sample preparation step is the initial step in pharmaceutical analysis. While ultrafiltration is a well-known technique used in the food and pharmaceutical industries, it has rarely been used to measure the plasma concentration of active pharmaceutical ingredients. This study aimed to analyze diclofenac sodium (DS) in human plasma samples using ultrafiltration-based sample preparation before high-performance liquid chromatography (HPLC) analysis. The advantages and limitations of ultrafiltration-based sample preparation in bioanalysis were evaluated by comparing the results with conventional methods. The precipitating agent was used before ultrafiltration. The analysis was carried on an HPLC-UV system with a C18 column (250 ×4.6 …

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Adsorption Of Dimethyl Disulfide Onto Activated Carbon Cloth, Fi̇rdevs Mert, Numan Hoda, Ayhan Topuz, Leyla Budama Akpolat, Emrah Eroğlu Jan 2022

Adsorption Of Dimethyl Disulfide Onto Activated Carbon Cloth, Fi̇rdevs Mert, Numan Hoda, Ayhan Topuz, Leyla Budama Akpolat, Emrah Eroğlu

Turkish Journal of Chemistry

Dimethyl disulfide (DMDS) has a specific unpleasant odour and is profoundly toxic with an odour threshold of around 7-12 ppb. In this study, the removal of DMDS was investigated by adsorption on activated carbon cloth (ACC) in the gas phase. Kinetics and isotherm studies were performed. Adsorption kinetics followed by GC-MS and the data were processed using different models. When correlation coefficients (R2) of linear regression analysis are analyzed, it is seen that the concordance of experimental data to the pseudo-second-order equation is quite good. Isotherm data have been examined using Freundlich, Temkin and Langmuir models. The regression coefficient (R2) …

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Synthesis Of Novel Oxadiazole Derivatives And Their Cytotoxic Activity Against Various Cancer Cell Lines, Bi̇lgesu Onur Sucu, Eli̇f Beyza Koç Jan 2022

Synthesis Of Novel Oxadiazole Derivatives And Their Cytotoxic Activity Against Various Cancer Cell Lines, Bi̇lgesu Onur Sucu, Eli̇f Beyza Koç

Turkish Journal of Chemistry

Caffeic acid (CA), ferulic acid (FA) and caffeic acid phenethyl ester (CAPE) have a broad anticancer effect on various cell lines. In this study, nine ferulic and caffeic acid-based 1,2,4 and 1,3,4 oxadiazole molecular hybrids were synthesized and their cytotoxic activity was evaluated mainly against Glioblastoma (GBM) cell lines. Compounds 1 and 5 exhibited the highest inhibitory activity against three different GBM cell lines (LN229, T98G, and U87), without toxicity to healthy human mesenchymal stem cells (hMSC). In addition, their cytotoxicity was also evaluated against three additional cancer cell lines and more inhibitory results were found than GBM cell lines. …

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Selective Nanosensor Based On Folic Acid Imprinted Nanostructures, Kevser Kuşat, Serdar Şanli, Suna Ti̇mur, Si̇nan Akgöl Jan 2022

Selective Nanosensor Based On Folic Acid Imprinted Nanostructures, Kevser Kuşat, Serdar Şanli, Suna Ti̇mur, Si̇nan Akgöl

Turkish Journal of Chemistry

Folic acid, which provides the transfer of single carbon atoms in synthesis reactions and metabolic cycles in metabolism, is very important for metabolism. Folic acid also plays an important role in nucleotide synthesis and methylation reactions. There are many disorders caused by defective folic acid metabolism and lack of folic acid. Today, innovative, cost-effective methods are needed to develop folic acid determination methods. The main objective of this study is the development of surface-printed carbon electrodes (SPCE) modified with folic acid imprinted nanostructures (FA-Imp-poly(MPTS-rGO-co-NAT), which will be used for the first time for folic acid determination in commercially human blood …

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Intrinsically Fluorescent And Quercetin Loaded Highly Crosslinked Polyphosphazene Nanospheres: Synthesis, Characterization And Fluorescence Properties, Si̇mge Meti̇noğlu Örüm Jan 2022

Intrinsically Fluorescent And Quercetin Loaded Highly Crosslinked Polyphosphazene Nanospheres: Synthesis, Characterization And Fluorescence Properties, Si̇mge Meti̇noğlu Örüm

Turkish Journal of Chemistry

Highly crosslinked, inorganic-organic hybrid and intrinsically fluorescent polyphosphazene nanospheres bearing hydroxyl groups on the surface are facilely generated via a one-pot polycondensation of octachlorocyclotetraphosphazene, fluorescein and quercetin. The resulting nanospheres were characterised by scanning electron microscopy (SEM), energy-dispersive X-ray analysis (EDX), Fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), X-ray diffraction analysis (XRD) and ultraviolet-visible spectroscopy (UV-vis) techniques. The average diameter of the nanospheres was determined as 379 nm. Also, quercetin which is both a monomer and an anticancer drug was loaded to the nanospheres as 446 mg g-1. The obtained nanospheres possess outstanding disperse ability in both aqueous …

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Development Of Software For The Calculation Of Kinetic Parameters From Solid Phase Reaction Data, Application To Synthesized N'-(4-Chlorobenzoyl)-N,N-Di-N-Butylthiourea Ligand And Its Nickel (Ii) Complex, Esra Kalem, Nevzat Külcü Jan 2022

Development Of Software For The Calculation Of Kinetic Parameters From Solid Phase Reaction Data, Application To Synthesized N'-(4-Chlorobenzoyl)-N,N-Di-N-Butylthiourea Ligand And Its Nickel (Ii) Complex, Esra Kalem, Nevzat Külcü

Turkish Journal of Chemistry

In gas and liquid phase reactions, the conversion of starting materials to products is directly controlled by the rate of the reaction, whereas in solid state reactions, it is determined by the rate of diffusion. When working with thermal analysis methods, tens of thousands of data to be obtained from measured differential thermal analysis (DTA), thermal gravimetry (TG), and differential thermal gravimetry (DTG) curves must first be digitized, and then these digitized data must be converted to concentrations and thermal values using appropriate software programs. Companies that produce devices using thermal analysis techniques generally adapt the encrypted software programs they …

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Photocatalytic Degradation Of Aquatic Organic Pollutants With Zn- And Zr-Based Metalorganic Frameworks: Zif-8 And Uio-66, Fatma Defne Çalik, Bi̇lgesu Erdoğan, Esra Yilmaz, Gi̇zem Saygi, Seher Fehi̇me Çakicioğlu Özkan Jan 2022

Photocatalytic Degradation Of Aquatic Organic Pollutants With Zn- And Zr-Based Metalorganic Frameworks: Zif-8 And Uio-66, Fatma Defne Çalik, Bi̇lgesu Erdoğan, Esra Yilmaz, Gi̇zem Saygi, Seher Fehi̇me Çakicioğlu Özkan

Turkish Journal of Chemistry

Water treatment has been an essential issue with the increasing population over 40 years. Researchers center on the major organic pollutants, such as dyes, pesticides, and pharmaceutical products. Photocatalytic degradation is one of the promising methods for aquatic organic pollutant treatment. Over the years, scientists have been working on developments for photocatalysts to enhance their pollutant degradation performances. From the reviewed studies, it is seen that properties like surface area, chemical, mechanical, and thermal stability, and uniform distribution of active sites are crucial, and an increase in these properties provides better degradation efficiency. In this sense, metal-organic frameworks as photocatalysts …

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Major Chemical Constituents From Illicium Griffithii Hook. F. & Thoms Of North East India And Their Cytotoxicity And Antimicrobial Activities, Deepjyoti Dutta, Bardwi Narzary, Snigdha Saikia, Kashyap J. Tamuli, Manobjyoti Bordoloi, Neipihoi Lhouvum, Shyamalendu Nath, Ranjan K. Sahoo, Barnali Gogoi, Surovi Saikia, Nayan K. Bhattacharyya Jan 2022

Major Chemical Constituents From Illicium Griffithii Hook. F. & Thoms Of North East India And Their Cytotoxicity And Antimicrobial Activities, Deepjyoti Dutta, Bardwi Narzary, Snigdha Saikia, Kashyap J. Tamuli, Manobjyoti Bordoloi, Neipihoi Lhouvum, Shyamalendu Nath, Ranjan K. Sahoo, Barnali Gogoi, Surovi Saikia, Nayan K. Bhattacharyya

Turkish Journal of Chemistry

Illicium griffithii Hook. f. & Thoms is an endemic medicinal plant of North East India found in the Eastern Himalayan region of biodiversity mega centre. Herein, chemical investigation of I. griffithii, afforded five compounds and their structures were determined through extensive use of NMR, HRMS, and FT-IR spectroscopy. The complete proton-proton, proton-carbon coupling network of compound 1 was determined using 1H-1H COSY, HSQC and NOESY NMR experiments. All the compounds were evaluated for their cytotoxic activity by MTT assay and antimicrobial activity by Agar well diffusion method. Compound 1 exhibited significant cytotoxicity activity against Lung cancer (A549) and pancreatic …

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Ultrasound Phantom With Solids Mimicking Cancerous Tissue For Needle Breast Biopsy, Işik İpek Avci Yayla, Meli̇s Bi̇lal, Artür Salmaslioğlu, Erol Erçağ, Esma Sezer, Belkis Ustamehmetoglu Jan 2022

Ultrasound Phantom With Solids Mimicking Cancerous Tissue For Needle Breast Biopsy, Işik İpek Avci Yayla, Meli̇s Bi̇lal, Artür Salmaslioğlu, Erol Erçağ, Esma Sezer, Belkis Ustamehmetoglu

Turkish Journal of Chemistry

This study aimed at synthesizing hydrogels to simulate opaque breast tissue (BT) and coloured cancerous tissues (CT) at different densities of the designed phantom to improve the biopsy-related skills along with ultrasonography. Both tissues are tear-resistant and therefore, the phantom can be trained multiple times in order to lower the price and improve the eye-hand coordination of users. For this purpose, self-healing (SH) polyacrylamide (PAAm) hydrogels (SH hydrogel) obtained by free-radical polymerization of AAm, in the presence of chemical cross-linker, BAAm, physical cross-linker stearyl methacrylate, C18, and ammonium persulfate APS as initiator were used in the design of phantoms. Psyllium …

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Study Of Silanized Nanostructures With Immobilized Fumarase For Production Of L-Malate, Nevra Öztürk Atay, Kevser Kuşat, Si̇nan Akgöl Jan 2022

Study Of Silanized Nanostructures With Immobilized Fumarase For Production Of L-Malate, Nevra Öztürk Atay, Kevser Kuşat, Si̇nan Akgöl

Turkish Journal of Chemistry

The conversion of fumaric acid into L-malate by fumarase immobilized on silanized nanostructures was analyzed experimentally. The enzyme was bound to the silanized nanostructures. We carried out scanning electron microscopy (SEM), fourier transform infrared spectroscopy (FTIR) analysis, zeta size analysis and surface area calculation for the characterization of the nanostructures. The effect of initial enzyme concentration and pH on immobilization procedure were investigated and the change of Michaelis-Menten constants (Km and Vmax) with immobilization was examined. The change in the storage stability of the enzyme by immobilization was also investigated. The stability of the immobilized enzyme was …

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Comparative Study And Dyeing Performance Of As-Synthesized Azo Heterocyclic Monomeric, Polymeric, And Commercial Disperse Dyes, Shehu Sa'ad Abdullahi, Haruna Musa, Shehu Habibu, Abdullahi Haruna Birniwa, Rania Edrees Adam Mohammad Jan 2022

Comparative Study And Dyeing Performance Of As-Synthesized Azo Heterocyclic Monomeric, Polymeric, And Commercial Disperse Dyes, Shehu Sa'ad Abdullahi, Haruna Musa, Shehu Habibu, Abdullahi Haruna Birniwa, Rania Edrees Adam Mohammad

Turkish Journal of Chemistry

In this study poly (4-nitrophenylazo-3-aminopyridine - formaldehyde) (PNAAP-F) and poly (4-nitroarylazo-3-chloro-6-hydroxypyridine - formaldehyde) (NAACHP-F) were synthesized via diazotization, coupling and polycondensation reactions. The structural properties of the as-synthesized dyes were acquired using Fourier-transform infrared spectroscopy (FTIR) and UV-visible absorption maxima and their color, yield, melting point, solubility, and viscosity were determined via standard methods. UV-visible and FTIR results show successful formation of the polymeric dyes due to shift of wavelength of maximum absorption (λmax) (440-490 nm, 480-540 nm) and new absorption peak at around (2780-2995 cm-1) for methylene bridge respectively. The dyes were found to be …

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Adsorptive Removal Of Crystal Violet From Aqueous Solution By Ultrasonic-Assisted Synthesized Zirconium-2,6-Naphthalenedicarboxylate Metal-Organic Framework, Penmethsa Kiran Kumar, Sunkara Satya Veni Jan 2022

Adsorptive Removal Of Crystal Violet From Aqueous Solution By Ultrasonic-Assisted Synthesized Zirconium-2,6-Naphthalenedicarboxylate Metal-Organic Framework, Penmethsa Kiran Kumar, Sunkara Satya Veni

Turkish Journal of Chemistry

Zirconium-2,6-naphthalenedicarboxylate metal-organic framework (Zr-NDC MOF) was prepared using ultrasound-assisted synthesis and tested for the adsorptive removal of crystal violet (CV) dye from aqueous solution. The pristine Zr-NDC was characterized using powder X-ray diffraction, scanning electron microscopy, thermogravimetric analysis, and energy-dispersive X-ray spectroscopy, Fourier-transform infrared, elemental analysis, and dynamic light scattering techniques. The maximum percentage removal of CV dye was found to be 99.45% with an initial dye concentration of 10 mg L-1. The kinetics and adsorption isotherm models were used to investigate the removal of CV dye from aqueous solution using Zr-NDC. Langmuir adsorption isotherm model (R2 …

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Polyvinyl Alcohol-Citrate-Stabilized Silver Nanoparticles As An Optical Sensor For Selective Colorimetric Determination Of Sildenafil, Asi̇ye Aslihan Avan Jan 2022

Polyvinyl Alcohol-Citrate-Stabilized Silver Nanoparticles As An Optical Sensor For Selective Colorimetric Determination Of Sildenafil, Asi̇ye Aslihan Avan

Turkish Journal of Chemistry

A facile and sensitive colorimetric detection method for sildenafil citrate (SLDC) has been developed by using polyvinyl alcohol-citrate-stabilized silver nanoparticles (PVA-Cit-AgNPs). The sensitivity and selectivity of colorimetric detection were investigated in detail. The PVA-Cit-AgNPs could be induced to aggregate immediately in the presence of SLDC, especially after the addition of 0.1 M HCl solution. The SLD could be detected by the colorimetric response of AgNPs that could be monitored by a UV-Vis spectrophotometer or even the naked eye. The linear range was found to be 0.6-5.0 μM with the calculated detection limit of 0.1 μM and the naked-eye detection limit …

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Kinetic, Isotherm, And Thermodynamic Studies For Adsorptive Removal Of Basic Violet 14 From Aqueous Solution, Yasemi̇n Tamer, Hale Berber Jan 2022

Kinetic, Isotherm, And Thermodynamic Studies For Adsorptive Removal Of Basic Violet 14 From Aqueous Solution, Yasemi̇n Tamer, Hale Berber

Turkish Journal of Chemistry

In this study, the performance of chitosan based semi-IPN nanocomposite hydrogels for the adsorptive removal of basic violet 14 (BV14) from aqueous solution has been explored. Batch adsorption studies were conducted to determine the effect of various parameters on BV14 adsorption, and optimum values were reported as pH of 8, the adsorbent dosage of 0.025 g, initial BV14 concentration of 5 mg L-1 and contact time of 90 min at a temperature of 25 °C. The semi-IPN hydrogel containing 0.5% by weight GO showed the improved adsorption capacity for BV14 compared to the neat hydrogel adsorbent, and the maximum …

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Quaternarization And Polymerization Of 2-Chloroethyl Maleate Derivative Of Epoxidized Soybean Oil, Demet Gürbüz Jan 2022

Quaternarization And Polymerization Of 2-Chloroethyl Maleate Derivative Of Epoxidized Soybean Oil, Demet Gürbüz

Turkish Journal of Chemistry

As a potent antibacterial, antifungal or antiviral material, synthesis of quaternarized epoxidized soybean oil was demonstrated in this work. The first step of the synthesis is the reaction of epoxidized soybean oil (ESO) with 2-chloroethyl maleic acid (Cl-MA-ESO). The last step is quaternarization of this condensate with triethylamine (Q-MA-ESO). All the synthesized monomers were characterized by FTIR and 1H NMR techniques. Homopolymer of the quaternarized derivative (Q-MA-ESO) was not obtained. However, styrene copolymers were obtained and characterized. Thermal properties of the copolymers were determined by TGA and DSC techniques. Additionally, swelling properties of the materials were also evaluated. The …

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Removal Of Polycyclic Aromatic Hydrocarbons (Pahs) From Water Through Degradable Polycaprolactone Electrospun Membrane, Fuat Topuz Jan 2022

Removal Of Polycyclic Aromatic Hydrocarbons (Pahs) From Water Through Degradable Polycaprolactone Electrospun Membrane, Fuat Topuz

Turkish Journal of Chemistry

Polycyclic aromatic hydrocarbons (PAHs) are common and persistent environmental pollutants produced during the incomplete combustion of fuels. They are known for their carcinogenic and mutagenic properties. Thus, their removal from water bodies is highly crucial and has become a critical issue globally. As a solution, here an electrospun polycaprolactone (PCL) membrane with a mean fiber diameter of 2.74 ± 1.3 μm was produced by electrospinning. Water contact angle (WCA) analysis confirmed the hydrophobic nature of the PCL membrane with a WCA of 124°, which remained stable over time. Differential scanning calorimetry analysis (DSC) revealed the semicrystalline nature of the membrane …

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Impacts Of Some Metal Ions On Glutathione S-Transferase In The Liver Of Chalcalburnus Tarichi: An Endemic Species Of Lake Van, Muhammet Serhat Özaslan, Mehmet Çi̇ftci̇ Jan 2022

Impacts Of Some Metal Ions On Glutathione S-Transferase In The Liver Of Chalcalburnus Tarichi: An Endemic Species Of Lake Van, Muhammet Serhat Özaslan, Mehmet Çi̇ftci̇

Turkish Journal of Chemistry

Glutathione-S-transferase (GSTs) is a multifunctional enzyme that provides homeostasis by catalyzing the first step of the formation of mercapturic acid, the end product in detoxification metabolism. They can prevent reactive electrophilic compounds from harming the body by covalently binding the same type of compounds to each other. In this study, we determined the in vitro inhibitory effects of metal ions such as Cu2+, Cd2+, Ag+, and Co2+ on GST enzyme activity. For this aim, GST was purified from C. tarichi Pallas liver with 37.36% yield and 29.304 EU/mg specific activity using the chromatographic method. The Vmax values of liver GST …

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Preparation And Characterisation Of Ethambutol With Β-Cyclodextrin: A Comprehensive Molecular Insight Into Host-Guest Interaction, Soen Qeng Goh, Qiao Hui Chan, Rohana Adnan, Nurul Yani Rahim Jan 2022

Preparation And Characterisation Of Ethambutol With Β-Cyclodextrin: A Comprehensive Molecular Insight Into Host-Guest Interaction, Soen Qeng Goh, Qiao Hui Chan, Rohana Adnan, Nurul Yani Rahim

Turkish Journal of Chemistry

The increase in new cases of drug resistance to first-line drugs such as ethambutol (ETB) makes it necessary to develop improvements for antituberculosis drugs. A new method for improving the bioavailability of active pharmaceutical ingredient (API) was investigated for preventing drug resistance and side-effects of antituberculosis drugs. In this study, an antituberculosis drug delivery system using β-cyclodextrin (β-CD) as the supramolecular carrier of ETB was prepared using the kneading method. The inclusion behaviour of β-CD/ETB inclusion complex in solid and liquid state was investigated. The inclusion complex was characterized using Fourier transform infrared spectroscopy, thermogravimetric analysis, nuclear magnetic resonance (NMR) …

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Synthesis Of Highly Reactive Sulfone Iminium Fluorides And Their Use In Deoxyfluorination And Sulfur Fluoride Exchange Chemistry, James A. Vogel, Rania Hammami, Ara Ko, Hiya Datta, Yael N. Eiben, Karley J. Labenne, Ellis C. Mccarver, Ebrar Z. Yilmaz, Patrick R. Melvin Jan 2022

Synthesis Of Highly Reactive Sulfone Iminium Fluorides And Their Use In Deoxyfluorination And Sulfur Fluoride Exchange Chemistry, James A. Vogel, Rania Hammami, Ara Ko, Hiya Datta, Yael N. Eiben, Karley J. Labenne, Ellis C. Mccarver, Ebrar Z. Yilmaz, Patrick R. Melvin

Chemistry Faculty Research and Scholarship

We report the synthesis of sulfone iminium fluorides (SIFs), a reactive class of sulfur(VI) molecules. The synthesis is tolerant of a variety of substituents on the sulfur and nitrogen components. The SIF reagents were applied to the deoxyfluorination of alcohols and carboxylic acids, providing high yields of fluorinated products in 60 s at room temperature. The SIF reagents were then utilized in sulfur fluoride exchange (SuFEx), creating the first ionic SuFEx products to date.

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Electron Deficient Fluoroarenes: Bridging Deoxyfluorination And Anion-Π Interactions To Produce New Fluorination Reagents, Jordan Houston Kramer Jan 2022

Electron Deficient Fluoroarenes: Bridging Deoxyfluorination And Anion-Π Interactions To Produce New Fluorination Reagents, Jordan Houston Kramer

Dissertations and Theses

Fluorination is a ubiquitous in modern materials and pharmaceuticals due to organofluorine compounds possessing unique physicochemical properties. However, this process is a demanding task due to difficulty in handling key reagents for selective fluorination. One strategy is the usage of deoxyfluorination reagents due to the wide availability of oxygen in many functional moieties. These reagents have allowed to production of new fluorinated materials and pharmaceuticals, yet the costs of several reagents and instabilities for others lead to restricted conditions, functional group tolerance, and safety risks for both users and the environment. Reported here is the culmination of a new hypothesis …

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Mapping The Dna Damaging Effects Of Polypyridyl Copper Complexes With Dna Electrochemical Biosensors, Anna Banasiak, Nicolò Zuin Fantoni, Andrew Kellett, John Colleran Jan 2022

Mapping The Dna Damaging Effects Of Polypyridyl Copper Complexes With Dna Electrochemical Biosensors, Anna Banasiak, Nicolò Zuin Fantoni, Andrew Kellett, John Colleran

Articles

Several classes of copper complexes are known to induce oxidative DNA damage that mediates cell death. These compounds are potentially useful anticancer agents and detailed investigation can reveal the mode of DNA interaction, binding strength, and type of oxidative lesion formed. We recently reported the development of a DNA electrochemical biosensor employed to quantify the DNA cleavage activity of the well-studied [Cu(phen)2]2+ chemical nuclease. However, to validate the broader compatibility of this sensor for use with more diverse—and biologically compatible—copper complexes, and to probe its use from a drug discovery perspective, analysis involving new compound libraries is …

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Expression And Purification Of A Cleavable Recombinant Fortilin From Escherichia Coli For Structure Activity Studies, Maranda S. Cantrell, Jackson D. Wall, Xinzhu Pu, Matthew Turner, Luke Woodbury, Owen M. Mcdougal, Lisa R. Warner Jan 2022

Expression And Purification Of A Cleavable Recombinant Fortilin From Escherichia Coli For Structure Activity Studies, Maranda S. Cantrell, Jackson D. Wall, Xinzhu Pu, Matthew Turner, Luke Woodbury, Owen M. Mcdougal, Lisa R. Warner

Chemistry and Biochemistry Faculty Publications and Presentations

Complications related to atherosclerosis account for approximately 1 in 4 deaths in the United States and treatment has focused on lowering serum LDL-cholesterol levels with statins. However, approximately 50% of those diagnosed with atherosclerosis have blood cholesterol levels within normal parameters. Human fortilin is an anti-apoptotic protein and a factor in macrophage-mediated atherosclerosis and is hypothesized to protect inflammatory macrophages from apoptosis, leading to subsequent cardiac pathogenesis. Fortilin is unique because it provides a novel drug target for atherosclerosis that goes beyond lowering cholesterol and utilization of a solution nuclear magnetic resonance (NMR) spectroscopy, structure-based drug discovery approach requires milligram …

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