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Articles 1261 - 1290 of 15526
Full-Text Articles in Entire DC Network
Synthetic And Mechanistic Studies Of Ruthenium Catalyzed C–N And C–H Bond Activation Reactions, Krishna Prasad Gnyawali
Synthetic And Mechanistic Studies Of Ruthenium Catalyzed C–N And C–H Bond Activation Reactions, Krishna Prasad Gnyawali
Dissertations (1934 -)
Transition metal catalyzed C–H and C–N functionalization methods have emerged as an innovative tool for designing efficient synthesis of fine chemicals by using readily available starting materials without the formation of wasteful byproducts. One of the paramount challenges in C–H functionalization research field has been to promote regio- and stereoselective C–H bond activation on saturated hydrocarbon substrates. While much progress has been achieved on promoting selective sp2 C–H activation reactions on unsaturated hydrocarbon substrates in the past decades, catalytic sp3 C–H bond and functionalization methods on saturates hydrocarbon substrates remain as the frontier topic of C–H functionalization research. The well-defined …
Precision Deuteration And Hydrofunctionalization Of Aryl Alkynes And Alkenes, Samantha E. Sloane
Precision Deuteration And Hydrofunctionalization Of Aryl Alkynes And Alkenes, Samantha E. Sloane
Dissertations (1934 -)
The similar nature of the hydrogen atom to its isotope, deuterium, allows for the simple exchange of hydrogen atoms for deuterium atoms in drug molecules to alter the absorption, distribution, metabolism, and excretion properties. Installing the deuterium functionality into a specific site in the molecule is essential. Selective hydrofunctionalization reactions of alkynes and alkenes using the highly reactive catalytic Cu–H species have been well developed, and synthetic organic chemistry methods to selectively incorporate one or two deuterium atoms into the benzylic site of organic compounds, a key metabolic position, are elusive. A Cu–H catalytic approach offers selectivity and reactivity to …
Study Of Atypical Alarmone Synthesis In Clostridioides Difficile, Declan Nathaniel Butler
Study Of Atypical Alarmone Synthesis In Clostridioides Difficile, Declan Nathaniel Butler
Chemistry & Biochemistry Theses & Dissertations
Clostridioides difficile is a Gram-positive anaerobic bacterium that causes infections in humans that costs healthcare systems billions per year. C. difficile infection has high rates of recurrence due to multiple antibiotic resistance. When bacteria are in stressful environments, they produce hyperphosphorylated guanosine ribonucleotide signaling molecules called alarmones. The accumulation of alarmones activates the stringent response (SR), in which bacterial cells induce transcription of stress survival genes to delay growth and replication. The C. difficile SR is regulated by enzymatic activity of a bifunctional synthetase/hydrolase, RelA/SpoT homolog (RSH), and a monofunctional small alarmone synthetase (RelQ). Additionally, the SR is potentially regulated …
Students’ Science Literacy On Discussion-Based Contextual Approaches Of Human Reproductive System Learning, Yeni Mulyaningsih, Chaerul Rochman, Adam Malik, Tri Wahyu Agustina, Yulia Sukmawardani, Nur Hamidah, Nurul Annisa
Students’ Science Literacy On Discussion-Based Contextual Approaches Of Human Reproductive System Learning, Yeni Mulyaningsih, Chaerul Rochman, Adam Malik, Tri Wahyu Agustina, Yulia Sukmawardani, Nur Hamidah, Nurul Annisa
Jurnal Pendidikan Sains
The aim of this study was to enhance students’ science literacy through a discussion-based contextual approach in the learning of the human reproductive system. This quantitative research employed an experimental method with a quasi-experimental posttest-only design. The study involved 60 students, with 30 students each in class XI MIPA 4 serving as the experimental group and class XI MIPA 5 serving as the control group. The control group received instruction through a conceptual approach-based lecture method, whereas the experimental group engaged in learning through a contextual approach-based discussion method. The research instrument comprised 10 open-ended science literacy questions pertaining to …
Analysis Of Genetic Engineering Material Misconceptions In Biology Textbooks For Ninth-Grade In Yogyakarta, Silfi Pratiwi, Purwanti Pratiwi Purbosari, Oktira Roka Aji, Rinaldi Rizal Putra
Analysis Of Genetic Engineering Material Misconceptions In Biology Textbooks For Ninth-Grade In Yogyakarta, Silfi Pratiwi, Purwanti Pratiwi Purbosari, Oktira Roka Aji, Rinaldi Rizal Putra
Jurnal Pendidikan Sains
Textbooks play a pivotal role in the pedagogical landscape, serving as indispensable aids for learning, founts of knowledge, and platforms for practical application. This study endeavors to scrutinize the content of textbooks, specifically focusing on ninth-grade biology textbooks within the educational milieu of Yogyakarta City, and to juxtapose these contents with existing literature to discern potential misconceptions. Employing a descriptive qualitative approach, the investigation centers on printed biology textbooks utilized in ninth-grade curricula across junior high schools in Yogyakarta. The selection of textbooks for analysis was based on their prevalence as instructional materials, as determined through survey data. Genetic engineering …
Problem-Based Learning Model Assisted With A Humanistic-Merdeka Belajar Approach Improved Biology Students’ Learning Ownership, Dita Tri Mulyani, Dwi Listyorini
Problem-Based Learning Model Assisted With A Humanistic-Merdeka Belajar Approach Improved Biology Students’ Learning Ownership, Dita Tri Mulyani, Dwi Listyorini
Jurnal Pendidikan Sains
Fostering ownership over learning constitutes a pivotal aspect for students to cultivate a comprehensive understanding, employ cognitive strategies effectively, hone essential skills, and refine learning methodologies. Preliminary studies have underscored a prevalent deficiency in the learning ownership among biology students, categorizing it as notably low. The purpose of this study is to ascertain the effect of the Project Based Learning (PBL) model assisted with a Humanistic-Merdeka Belajar (HMB) approach, in nurturing students’ ownership of their learning endeavors. Employing a quasi-experimental design, the research adopts a pre-test post-test non-equivalent control group configuration, administered both prior to and following the intervention within …
Asistensi Mengajar (Am) Program In Merdeka Belajar Kampus Merdeka (Mbkm) As A Pedagogical Mastery Accelerator For Vocational High School Teacher Candidates, Muhammad Idris Effendi, Yoto Yoto, Widiyanti Widiyanti
Asistensi Mengajar (Am) Program In Merdeka Belajar Kampus Merdeka (Mbkm) As A Pedagogical Mastery Accelerator For Vocational High School Teacher Candidates, Muhammad Idris Effendi, Yoto Yoto, Widiyanti Widiyanti
Jurnal Pendidikan Sains
This research delves into the issue of inadequate pedagogical proficiency among vocational high school (SMK) teacher candidates, primarily stemming from the constrained timeframe of educational internships, typically spanning a mere two months. As an option, this study suggests the implementation of an Asistensi Mengajar (AM) initiative within the framework of the Merdeka Belajar Kampus Merdeka Program (MBKM), extending over a semester’s duration. Employing a literature review methodology, the research highlights that the brevity of conventional two-month internships poses a significant impediment to the development of pedagogical acumen among SMK teacher candidates. The proposed option entails an AM program under MBKM, …
Identify Resources Activated By Students When Solving Straight Motion Kinematics Problems With Different Representation, Nur Utami Amaliah, Sutopo Sutopo, Eny Latifah, Hutkemri Zulnaidi
Identify Resources Activated By Students When Solving Straight Motion Kinematics Problems With Different Representation, Nur Utami Amaliah, Sutopo Sutopo, Eny Latifah, Hutkemri Zulnaidi
Jurnal Pendidikan Sains
This research aims to explore kinematic resources in linear kinematics by utilizing different forms of problem representation. The study was conducted by administering 15 reasoned multiple-choice questions to 146 high school students from three districts in Central Sulawesi, Indonesia. The research instrument covers topics in linear kinematics, including distance, displacement, speed, and velocity, presented through diagrammatic representations, graphs, and mathematical equations. The students’ written answers were analyzed both quantitatively and qualitatively. Quantitative analysis was conducted to determine descriptive statistics from the data, while qualitative analysis identified the resources students activated when solving these questions. The findings reveal that the various …
Effects Of The Biochar Of Senna Tora On The Soil Fertility Of Misau Farmlands, Bauchi State, Northern Nigeria, Ozoilo Onyeka Calistus, Umar Faruk Hassan, Auwal Adamu Mahmoud, Haruna Baba, Hamza Badamasi, Hannatu Akanang
Effects Of The Biochar Of Senna Tora On The Soil Fertility Of Misau Farmlands, Bauchi State, Northern Nigeria, Ozoilo Onyeka Calistus, Umar Faruk Hassan, Auwal Adamu Mahmoud, Haruna Baba, Hamza Badamasi, Hannatu Akanang
Journal of Bioresource Management
The use of biochar as an amendment to the soil is attracting the scientific community's attention because of its cost-effectiveness, eco-friendliness, and its promising success in increasing the fertility of the soil and crop yield. In the present study, the effects of biochar from Senna tora applications on soil characteristics and the availability of micronutrients in Misau, Bauchi State, Nigeria, were explored. A completely randomized approach was adopted and duplicated three times, with reference soil (no biochar), 30-day, and 60-day biochar treatments. The biochar was removed at the end of the treatment, and soil samples from the various treatments were …
Discovering Potential In Non-Cancer Medications: A Promising Breakthrough For Multiple Myeloma Patients., Omar S Al-Odat, Emily Nelson, Tulin Budak-Alpdogan, Subash C. Jonnalagadda, Dhimant Desai, Manoj K Pandey
Discovering Potential In Non-Cancer Medications: A Promising Breakthrough For Multiple Myeloma Patients., Omar S Al-Odat, Emily Nelson, Tulin Budak-Alpdogan, Subash C. Jonnalagadda, Dhimant Desai, Manoj K Pandey
College of Science & Mathematics Departmental Research
Multiple myeloma (MM) is a common type of cancer that unfortunately leads to a significant number of deaths each year. The majority of the reported MM cases are detected in the advanced stages, posing significant challenges for treatment. Additionally, all MM patients eventually develop resistance or experience relapse; therefore, advances in treatment are needed. However, developing new anti-cancer drugs, especially for MM, requires significant financial investment and a lengthy development process. The study of drug repurposing involves exploring the potential of existing drugs for new therapeutic uses. This can significantly reduce both time and costs, which are typically a major …
Harnessing Redox Polymer Dynamics For Enhanced Glucose-Oxygen Coupling In Dual Biosensing And Therapeutic Applications, Wassim El Housseini, Egor Baiarashov, Rokas Gerulskis, Adam Milam, Shelley D. Minteer
Harnessing Redox Polymer Dynamics For Enhanced Glucose-Oxygen Coupling In Dual Biosensing And Therapeutic Applications, Wassim El Housseini, Egor Baiarashov, Rokas Gerulskis, Adam Milam, Shelley D. Minteer
Chemistry Faculty Research & Creative Works
The burgeoning field of continuous glucose monitoring (CGM) for diabetes management faces significant challenges, particularly in achieving precise and stable biosensor performance under changing environmental conditions such as varying glucose concentrations and O2 levels. To address this, we present a novel biosensor based on the electroless coupling of glucose oxidation catalyzed by flavin-dependent glucose dehydrogenase (FAD-GDH) and O2 reduction catalyzed by bilirubin oxidase (BOD) via a redox polymer, dimethylferrocene-modified linear poly(ethylenimine), FcMe2-LPEI. Initial cyclic voltammetry tests confirm the colocalization of both enzymatic reactions within the potential range of the polymer, indicating an effective electron shuttle mechanism. …
The Discovery Of First Ret Protac With In Vivo Activity, Yafeng Wang
The Discovery Of First Ret Protac With In Vivo Activity, Yafeng Wang
USF Tampa Graduate Theses and Dissertations
This report mainly discusses the development of RET Proteolysis targeting chimera PROTAC molecules based on Selpercatinib (LOXO-292) and Sulfono-γ-AApeptide PROTAC. A PROTAC molecule is a bifunctional molecule composed of two active domains and a linker. It works by inducing selective protein intracellular degradation. This technology was first discussed by Kathleen Sakamoto, Ray Deshaies and Craig Crews in 2001. Using various E3 Ligase, such as CRBN, pVHL, beta-TrCP1, Mdm2, DCAF15, DCAF16, RNF114, and c-IAP1, the PROTAC technology has been applied to several novel drug development,. Yale University licensed the PROTAC technology to Arvinas in 2013–14. For my research, Chapter one summarizes …
Electrochemical Detection Of Glucose Using A Prussian Blue Modified Electrodes Combined With Glucose Encapsulated Within A Xerogel, Daniel Baker, Sarah Davis, Drew Budner
Electrochemical Detection Of Glucose Using A Prussian Blue Modified Electrodes Combined With Glucose Encapsulated Within A Xerogel, Daniel Baker, Sarah Davis, Drew Budner
Journal of the South Carolina Academy of Science
Recent literature reports examples of electrochemical biosensor systems that have been developed based upon on the encapsulation of enzymes and metal nanoparticles into a xerogel. These systems have been utilized for the detection of biologically important compounds, such as glucose. These reports on these systems have found acceptable detection limits and linear ranges. At the same time, Prussian blue modified electrodes have been shown to have better operating parameters than metal electrodes for the detection of hydrogen peroxide. In this work, a biosensor system is described that incorporates the encapsulation of glucose oxidize within a xerogel combined with electrochemical detection …
The Asymmetric Total Synthesis Of Membranolide And Efforts Towards The Oxeatamides, Sean Bradley
The Asymmetric Total Synthesis Of Membranolide And Efforts Towards The Oxeatamides, Sean Bradley
USF Tampa Graduate Theses and Dissertations
Total synthesis is a discipline within organic chemistry that is a constant force that propels the field forward. In our lab, we have immersed ourselves within the field of total synthesis to gain access to complex natural products, perform SAR studies, as well as highlight interesting methodology. Within these endeavors, we have completed the first asymmetric synthesis of membranolide. This has allowed us to explore potential biofilm eradication in our efforts to develop novel therapeutics to combat the ESKAPE pathogens and multi-drug resistance. We have also begun to pursue the first asymmetric total synthesis of the oxeatamides. By utilizing our …
Microencapsulation Of Cosmos Caudatus Kunth Extract Using Sodium Alginate And In Vitro Antioxidant Activity Test, Safina Samara Nur Fadlila, Oktavia Eka Puspita, Zubaidah Ningsih, Anna Safitri
Microencapsulation Of Cosmos Caudatus Kunth Extract Using Sodium Alginate And In Vitro Antioxidant Activity Test, Safina Samara Nur Fadlila, Oktavia Eka Puspita, Zubaidah Ningsih, Anna Safitri
Makara Journal of Science
This study aims to encapsulate Cosmos caudatus K. leaf extract in sodium alginate crosslinked with calcium chloride (CaCl2) as coating materials through freeze-drying. Antioxidant assays were performed to evaluate the applicability of the microcapsules as antidiabetic medicines. Their characteristics, antioxidant activity, and encapsulation efficiency (EE) were also examined. Results indicated that the concentration of sodium alginate and pH influenced the manufacturing process of the microcapsules. The highest EE was obtained at pH 6 and alginate concentration of 2% (w/v). The IC50 for the antioxidant activity of the microcapsules was 139.96 ± 1.094 μg/mL. Scanning electron microscopy confirmed …
Vibrational Dynamics Of The Intramolecular H-Bond In Β-Diketones And Intermolecular H Bonding In Halide-Receptor Complexes Investigated With Transient And 2d Ir Spectroscopy, Jessika Lira-Santos Dean
Vibrational Dynamics Of The Intramolecular H-Bond In Β-Diketones And Intermolecular H Bonding In Halide-Receptor Complexes Investigated With Transient And 2d Ir Spectroscopy, Jessika Lira-Santos Dean
Arts & Sciences Graduate Student Theses and Dissertations
Hydrogen bonding (H-bond) interactions are essential in dictating structures and properties of chemical and biological systems and are pivotal mediators in charge transport reactions and chemical recognition. Accurate description of H-bonds requires thorough characterization of the shared proton’s potential energy surface (PES) and molecular dynamics. Ultrafast nonlinear spectroscopic techniques, in particular, transient absorption (TA) and two dimensional infrared (2D IR) spectroscopy, have proven themselves valuable tools for probing molecular structures and dynamics mediated by H-bonding interactions. Herein, I describe the implementation of TA and 2D IR experiments to investigate the vibrational dynamics of the intramolecular H-bond in a series of …
Interpenetrated Lattices Of Quaternary Chalcogenides Displaying Magnetic Frustration, High Na-Ion Conductivity, And Cation Redox In Na-Ion Batteries, Santhoshkumar Sundaramoorthy, Srikanth Balijapelly, Sudip Mohapatra, Sutapa Bhattacharya, Kartik Ghosh, Amitava Choudhury
Interpenetrated Lattices Of Quaternary Chalcogenides Displaying Magnetic Frustration, High Na-Ion Conductivity, And Cation Redox In Na-Ion Batteries, Santhoshkumar Sundaramoorthy, Srikanth Balijapelly, Sudip Mohapatra, Sutapa Bhattacharya, Kartik Ghosh, Amitava Choudhury
Chemistry Faculty Research & Creative Works
A series of quaternary selenides, NaxMGaSe4 (M = Mn, Fe, and mixed Zn/Fe), have been synthesized for the first time employing a high-temperature solid-state synthesis route through stochiometric or polychalcogenide flux reactions. Along with the selenides, a previously reported sulfide analogue, NaxFeGaS4, is also revisited with new findings. These compounds form an interpenetrated structure made up of a supertetrahedral unit. The electrochemical evaluations exhibit a reversible (de)intercalation of ∼0.6 and ∼0.45 Na-ions, respectively, from Na2.87FeGaS4 (1a) and Na2.5FeGaSe4 (2) involving Fe2+/Fe3+ redox when cycled between 1.5 and 2.5 …
Potent And Selective Small Molecule Mcl-1 Inhibitor Demonstrates Anti-Myeloma Activity And Overcomes Chemotherapy Resistance, Omar Sami Faleh Al-Odat
Potent And Selective Small Molecule Mcl-1 Inhibitor Demonstrates Anti-Myeloma Activity And Overcomes Chemotherapy Resistance, Omar Sami Faleh Al-Odat
Theses and Dissertations
Despite a record number of clinical studies investigating various anti-myeloma treatments, the 5-year survival rate for multiple myeloma (MM) patients in the US is only 55%, and nearly all patients relapse. Poor patient outcomes demonstrate that myeloma cells are "born to survive” which means they can adapt and evolve following treatment. Thus, new therapeutic approaches to combat survival mechanisms and target treatment resistance are required. Importantly, Mcl-1, anti-apoptotic protein, is required for the development of MM and treatment resistance. This study looks at the possibility of KS18, a selective Mcl-1 inhibitor, to treat MM and overcome resistance. Our investigation demonstrates …
Synthetic Assembly Of Antibacterial Agents And Metal Chelating Ligands, Zachary Joseph Liveris
Synthetic Assembly Of Antibacterial Agents And Metal Chelating Ligands, Zachary Joseph Liveris
Dissertations
The exploitation of chemical synthesis exemplifies the notion of bridging both innovation and curiosity for the strategic assembly of sophisticated molecular infrastructures. By exerting this continuously evolving and versatile tool, synthesis has been applied in the development and influence of a myriad of ligands, biological probes, and persists to direct pharmaceutical innovation and modern medicine alike. Since pathogenic multidrug-resistant (MDR) microbial strains remain to be a persistent threat to both clinical healthcare and society, the need to develop selective and efficacious antibacterial agents that can impede microbe pathogenicity and regulate cellular mortality is paramount. In contrast to pharmaceutical development, organic …
A Cost-Effective Enzyme Kinetics And Inhibition Model For Biochemistry Education And Research, Lauren Vandee, Alyssa Teague, Taylor East, Kim Rhona Jacinto, Macie Carter, Jacey Totty, Paul D. Adams, Djamali Muhoza
A Cost-Effective Enzyme Kinetics And Inhibition Model For Biochemistry Education And Research, Lauren Vandee, Alyssa Teague, Taylor East, Kim Rhona Jacinto, Macie Carter, Jacey Totty, Paul D. Adams, Djamali Muhoza
Chemistry & Biochemistry Faculty Publications and Presentations
Enzyme kinetics and inhibition studies are crucial in biochemistry education and research. Conventional methods often require expensive equipment and reagents, potentially limiting their accessibility in limited resource settings. Our approach sought to develop a cost-effective experimental design for studying enzyme kinetics and inhibition. Lactase was chosen as a protein model and its activity was investigated by measuring glucose production from lactose hydrolysis. In the study, commercially available lactase pills were used as an enzyme source, while milk was used as a substrate. Instead of scientific equipment, glucometers were used to measure lactase activity. Enzyme kinetics were evaluated using Michaelis–Menten and …
Senggani Fruit (Melastoma Malabathricum Linn.) Extract As A Natural Indicator In Ph-Responsive Pva-Taro Starch Plastic Packaging, Rika Risma Dewi, Intan Syahbanu, Winda Rahmalia
Senggani Fruit (Melastoma Malabathricum Linn.) Extract As A Natural Indicator In Ph-Responsive Pva-Taro Starch Plastic Packaging, Rika Risma Dewi, Intan Syahbanu, Winda Rahmalia
Turkish Journal of Chemistry
Polyvinyl alcohol (PVA)-starch-based bioplastics are widely used in many applications. pH-responsive plastic packaging was produced through the incorporation of senggani (Melastoma malabathricum Linn.) fruit extract into PVA-taro starch-based plastic packaging. The objective of this research was to examine the characteristics of senggani fruit extract under different pH conditions and explore its application as a pH indicator in intelligent packaging. The senggani fruit was extracted through the maceration method using a solvent comprising 96% ethanol and 3% citric acid, with a ratio of 85:15 (v/v). The senggani fruit extract solution underwent color changes, appearing pink at pH levels below 6, pale …
Dft Modeling Of Water-Assisted Hydrogen Peroxide Formation From A C(4a)-(Hydro)Peroxyflavin, Yilmaz Özkiliç
Dft Modeling Of Water-Assisted Hydrogen Peroxide Formation From A C(4a)-(Hydro)Peroxyflavin, Yilmaz Özkiliç
Turkish Journal of Chemistry
The cofactor of a class A monooxygenase is reduced at an external location of the enzyme and is subsequently pulled back into the active site after the reduction. This observation brings the question; is there any defense mechanism of the active site of a monooxygenase against the formation of the harmful hydrogen peroxide from the reactive C(4a)-(hydro)peroxide intermediate? In this study, the barrier energies of one to three water molecule-mediated uncoupling reaction mechanisms in water exposed reaction conditions were determined. These were found to be facile barriers. Secondly, uncoupling was modeled in the active site of kynurenine 3-monooxygenase complex which …
Effect Of Quince Seed Gum (Qsg) On The Performance Of Injectable Hyaluronic Acid Hydrogels In Terms Of The Rheological, Morphological, And Mechanical Aspect, Serdar Kolay, Ni̇lhan Kayaman Apohan, Erdi̇nç Babuç, Gökay Gün
Effect Of Quince Seed Gum (Qsg) On The Performance Of Injectable Hyaluronic Acid Hydrogels In Terms Of The Rheological, Morphological, And Mechanical Aspect, Serdar Kolay, Ni̇lhan Kayaman Apohan, Erdi̇nç Babuç, Gökay Gün
Turkish Journal of Chemistry
Injectable hydrogels play an important role in tissue engineering as a filling and repairing material. This study aimed to develop a new injectable hydrogel based on hyaluronic acid (HA) and quince seed gum (QSG) and investigate the effect of QSG on hydrogel performance. The amount of unreacted 1,4-Butanediol diglycidyl ether (BDDE) is maintained at an undetectable level for HA-QSG hydrogels. Amino acid analysis showed that the HA-QSG hydrogel had rich amino acid concentrations of leucine, arginine, and valine. After thermal sterilization, the elastic modulus of HA-QSG gels for dermal and intra-articular filler applications is 63 Pa and 92 Pa respectively. …
Antiviral And Cytotoxic Activities And Chemical Profiles Of Two Species Of Abies Nordmanniana From Türkiye, Nazli Sarikahya, Gaye Sümer Okkali, Furkan Ozan Çöven, Sevda Zeinali̇, Gülce Gucur, Ayşe Di̇la Çağlar, Ece Uyar, Ahmet Ceyhan Gören, Ayşe Nalbantsoy
Antiviral And Cytotoxic Activities And Chemical Profiles Of Two Species Of Abies Nordmanniana From Türkiye, Nazli Sarikahya, Gaye Sümer Okkali, Furkan Ozan Çöven, Sevda Zeinali̇, Gülce Gucur, Ayşe Di̇la Çağlar, Ece Uyar, Ahmet Ceyhan Gören, Ayşe Nalbantsoy
Turkish Journal of Chemistry
Abies is an important genus of the family Pinaceae, with about 50 species found in the highlands of Asia, Europe, North Africa, and North and Central America. The principal aim of the present work was to investigate the chemical content and biological potential of the resin and cone from Abies nordmanniana subsp. bornmulleriana and Abies nordmanniana subsp. equi-trojani, respectively. The flavonoid and phenolic contents of the resin and cones were evaluated using liquid chromatography-high resolution mass spectrometry (LC-HRMS). Additionally, the essential oil and fatty acid compositions were analyzed using gas chromatography-mass spectrometry (GC-MS) and gas chromatography-flame ionization detector (GC-FID).. Cytotoxicity …
Design And Characterization Of Phosphonic Acid-Functionalized Grafted Sepiolite Nanohybrids And Their Adsorption Studies For Removal Of Copper Ions From Aqueous Solution, Mehwish Tahir, Asif Raza, Amara Nasir, Tariq Yasin, Shamila Imtiaz
Design And Characterization Of Phosphonic Acid-Functionalized Grafted Sepiolite Nanohybrids And Their Adsorption Studies For Removal Of Copper Ions From Aqueous Solution, Mehwish Tahir, Asif Raza, Amara Nasir, Tariq Yasin, Shamila Imtiaz
Turkish Journal of Chemistry
In this study, we synthesized novel, economically efficient phosphonic acid-functionalized grafted sepiolite nanohybrids for selective elimination of copper ions from water. These nanohybrids were prepared by graft polymerization of glycidyl methacrylate onto sepiolite. We utilized free radical graft polymerization to graft glycidyl methacrylate (GMA) onto silanized sepiolite. The nanohybrids obtained exhibited a grafting percentage of 479% at 0.3 g of KPS initiator, 15% GMA monomer, and after 4 h of reaction. In pursuit of selectively removing metal ions from water, the nanohybrid with the highest grafting (PGE3) was chemically treated with phosphoric acid to introduce phosphonic acid groups on it. …
Rapid Synthesis Of Azoindolizine Derivatives Via Aryldiazonium Salts, Ferruh Lafzi̇
Rapid Synthesis Of Azoindolizine Derivatives Via Aryldiazonium Salts, Ferruh Lafzi̇
Turkish Journal of Chemistry
A practical, rapid, and efficient method for the synthesis of azoindolizine derivatives via aryldiazonium salts with excellent yields was reported. Firstly, the corresponding aniline derivatives were synthesized via a simple and rapid method. Then, the optimal reaction conditions were investigated using a variety of protic and aprotic solvents that demonstrating the robustness of the approach. Finally, the applicability of this method to various sources of indolizine and phenyldiazonium tetrafluoroborate salts was expanded.
Heterogeneous Resources In Infrastructures Of The Edge Network Paradigm: A Comprehensive Review, Qusay S. Alsaffar, Leila Ben Ayed
Heterogeneous Resources In Infrastructures Of The Edge Network Paradigm: A Comprehensive Review, Qusay S. Alsaffar, Leila Ben Ayed
Karbala International Journal of Modern Science
The late 1990s saw the rise of the edge computing network paradigm, as well as an increase in the number of IoT de-vices. This concept is viewed as a link between cloud servers and end-devices, bringing processing and storage re-sources closer to clients. As a result of its low latency and high performance, researchers and developers have expressed interest in it. However, this paradigm confronts a number of obstacles and restrictions, including restricted and hetero-geneous resources at network edges. In this paper, we provide a detailed review of heterogeneous resources in edge network infrastructures using a three-dimensional method. These three …
Integrated Computational Approaches: Elucidating Molecular Mechanisms Of Pathogenic Proteins And Designing Novel Inhibitors Against Mycobacterium Tuberculosis And Sars-Cov-2, Justin David Carbone
Integrated Computational Approaches: Elucidating Molecular Mechanisms Of Pathogenic Proteins And Designing Novel Inhibitors Against Mycobacterium Tuberculosis And Sars-Cov-2, Justin David Carbone
Theses and Dissertations
Chapter 1 introduces computational strategies in computer aided drug design (CADD), focusing on physics-based methodologies to enhance drug discovery. This chapter also discusses the theoretical foundations and practical applications of molecular dynamics (MD) simulations including free energy and stochastic kinetic analysis. In Chapter 2, CADD methods lead to development of inhibitors targeting the RNA Dependent RNA Polymerase (RdRP) of SARS-CoV-2. Inspired by the nucleotide inhibitor Molnupiravir, we aim to design a combinatorial library of 72 novel inhibitors capable of impeding a dual threat inhibition mechanism inducing lethal mutations along with stalling viral replication with specific selectivity to RdRp over Human …
Incorporating Oxygen Isotopes Of Oxidized Reactive Nitrogen In The Regional Atmospheric Chemistry Mechanism, Version 2 (Icoin-Racm2), Wendell W. Walter, Masayuki Takeuchi, Nga L. Ng, Meredith G. Hastings
Incorporating Oxygen Isotopes Of Oxidized Reactive Nitrogen In The Regional Atmospheric Chemistry Mechanism, Version 2 (Icoin-Racm2), Wendell W. Walter, Masayuki Takeuchi, Nga L. Ng, Meredith G. Hastings
Faculty Publications
The oxygen isotope anomaly (Δ17O = δ17O − 0.52 × δ18O > 0) has proven to be a robust tool for probing photochemical cycling and atmospheric formation pathways of oxidized reactive nitrogen (NOy). Several studies have developed modeling techniques to implicitly model Δ17O of NOy molecules based on numerous assumptions that may not always be valid. Thus, these models may be oversimplified and limit our ability to compare model Δ17O values of NOy with observations. In this work, we introduce a novel method for explicitly tracking Δ …
Zinc Oxide Nanostructures Synthesized By Hot Water Treatment For The Photocatalytic Degradation Of Organic Pollutants In Water, Ranjitha Kumarapuram Hariharalakshmanan
Zinc Oxide Nanostructures Synthesized By Hot Water Treatment For The Photocatalytic Degradation Of Organic Pollutants In Water, Ranjitha Kumarapuram Hariharalakshmanan
Theses and Dissertations
Photocatalysis using nanostructured semiconductors for the degradation of organic pollutants has received significant attention as an advanced water treatment method. A photocatalyst absorbs light with energy greater than or equal to its band gap and generates electron-hole pairs. These electrons and holes take part in redox reactions in water to generate reactive oxygen species, such as hydroxyl radicals and superoxide anions, which can break down organic contaminants. However, this method has some challenges, such as electron-hole recombination, which reduces the efficiency, high cost of nanostructure synthesis, and reduced durability of nanostructured photocatalysts in suspension form. The immobilization of photocatalyst nanostructures …