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Isolation, Identification And Antibiotic-Resistance Profiling Of Bacteria Isolated From Mobile Phone Surfaces In Karbala., Kawkab Abdullah Alsaadi, Zahraa Raheem Murshidy, Dhuha Ali Hussein, Sura Abd Ali Kadhim, Kawakib Aboudi Hanoon Apr 2026

Isolation, Identification And Antibiotic-Resistance Profiling Of Bacteria Isolated From Mobile Phone Surfaces In Karbala., Kawkab Abdullah Alsaadi, Zahraa Raheem Murshidy, Dhuha Ali Hussein, Sura Abd Ali Kadhim, Kawakib Aboudi Hanoon

Karbala International Journal of Modern Science

Due to the diverse environments that mobile phones are exposed to via human handling they become reservoirs of microorganisms. The objective of the current study was to determine the level and character of bacterial contamination on mobile phones by identifying bacterial strains, and the degree of antimicrobial susceptibility. A cross-sectional study was conducted from April to July 2025 where phones belonging to 115 individuals were randomly chosen from various departments and units at Kerbala University and swabbed. The VITEK 2 automated system was used to identify bacterial taxa and test for antimicrobial susceptibility, and 50 of the swabs exhibited bacterial …


Environmental Counseling As A Proposed Discipline And Its Associated Implications And Uses, Alexandria Rion Apr 2026

Environmental Counseling As A Proposed Discipline And Its Associated Implications And Uses, Alexandria Rion

Honors Projects

Individuals interact with their environment daily, and whether they realize it or not, these interactions can impact their health. Understanding the health impacts associated with the environment is important to human health at both an individual and population level. I am proposing a new field of environmental counseling that would incorporate principles from a variety of practices into one comprehensive discipline that can be used to promote public health. By studying populations that have had negative environmental exposures and looking at their outcomes, I was able to apply principles of environmental counseling to help determine if it would in fact …


Autoantibody Reactivity In Hidradenitis Suppurativa: Characterizing Keratinocyte And Apocrine Gland Targets Across Disease Progression And Anti-Tnf-Α Treatment, Talla Hamouche Apr 2026

Autoantibody Reactivity In Hidradenitis Suppurativa: Characterizing Keratinocyte And Apocrine Gland Targets Across Disease Progression And Anti-Tnf-Α Treatment, Talla Hamouche

Student Theses and Dissertations

Hidradenitis suppurativa (HS) is a chronic, relapsing inflammatory skin disease associated with impaired quality of life, representing one of the highest burdens among dermatological conditions. This debilitating disorder primarily affects apocrine-gland-bearing and flexural skin areas, most commonly the axillae, breast, buttocks, and groin. As lesions recur and new sites emerge, surgical excision does not guarantee prevention of disease reestablishment. Despite its substantial burden, HS remains among the least understood and most treatment-resistant inflammatory diseases. The mechanisms underlying this chronicity and the frequent failure of conventional anti-inflammatory therapies remain unresolved. An underappreciated autoimmune dimension may contribute to HS pathogenesis: the clonal …


Impact Of Human Disturbance On Moth Populations In Ecuador, Gianna Jones, Abbie Miller, Esther Frederickson, Grace Glerum Apr 2026

Impact Of Human Disturbance On Moth Populations In Ecuador, Gianna Jones, Abbie Miller, Esther Frederickson, Grace Glerum

Science Seminar

Habitat disturbance in the temperate zone has been shown to negatively impact moth biodiversity and population size through a reduction in moth food resources and light pollution. Our study sought to understand how human activity impacts moth population numbers and diversity (# unique taxa) in the tropics. Specifically, we sampled moth population and diversity using light traps on two different nights in a disturbed habitat (Mera township, Ecuador) and on two nights at a nearby ecolodge situated in dense tropical forest. Significantly fewer moths were observed during trapping sessions in the township, and many fewer distinct taxa were noted when …


Patterns Of Moth Diversity In Relationship To Human Disturbance And Forest Type, Gianna Jones, Abbie Miller, Esther Frederickson, Grace Glerum Apr 2026

Patterns Of Moth Diversity In Relationship To Human Disturbance And Forest Type, Gianna Jones, Abbie Miller, Esther Frederickson, Grace Glerum

Science Seminar

Moths play a vital role in the health of tropical ecosystems, acting as important pollinators and food resources for a variety of species. Unfortunately, human habitat disturbance has been associated with declines in moth populations and diversity. To explore the impacts of habitat disturbance on taxonomic diversity in the tropics, we sampled moth populations at two different locations in the Pastaza Province (Mera township and an undisturbed forest at Tamandua Ecolodge). Though small in population (


The Impacts Of Wing-Flashing By Northern Mockingbirds On Foraging, Parental Care, And Reproductive Success, Anna Starman, Hayley Ponn Apr 2026

The Impacts Of Wing-Flashing By Northern Mockingbirds On Foraging, Parental Care, And Reproductive Success, Anna Starman, Hayley Ponn

Science Seminar

Foraging efficiency may be enhanced by flashing patches of white wing and tail feathers and has been documented in several avian species. Northern Mockingbirds (Mimus polyglottos, NOMO) exhibit this "wing-flashing" (WF) behavior while foraging, during displays, and in response to predators. In NOMOs, WF has been hypothesized to increase foraging success, but previous findings are inconclusive. To further investigate the biological role(s) of WF behavior in NOMOs, the ventral surface of white primary feathers of male NOMOs were artificially darkened and the foraging and provisioning rates of undarkened (control) males and their mates were compared. While foraging, undarkened males performed …


Foraging Load Size And Activity In Leaf-Cutter Ants In Rural And Urban Ecuador, Natalie Tollison, Anna Starman Apr 2026

Foraging Load Size And Activity In Leaf-Cutter Ants In Rural And Urban Ecuador, Natalie Tollison, Anna Starman

Science Seminar

Leaf cutter ants are important ecosystem engineers in Neotropical forests, moving a significant amount of nutrients from the forest canopy to the soil. We were interested in understanding how time (day vs. night), weather, and level of human disturbance would impact foraging activity in leaf-cutter ants (Atta spp.). To investigate, we sampled activity levels and leaf size along leaf-cutter ant trails in Mera (urban, N=17) and Tamandua (forest, N=27). During the daytime, ants in Mera carried significantly more leaves that were larger in size as well as more total items than did ants in Tamandua. Factors such as the level …


Biodiversity And Diet Patterns: Environmental Impacts On Ecuadorian Birds, Holly Hylton, Fin Bolt, Gracyn Herbst Apr 2026

Biodiversity And Diet Patterns: Environmental Impacts On Ecuadorian Birds, Holly Hylton, Fin Bolt, Gracyn Herbst

Science Seminar

The current biodiversity crisis is of great concern, particularly to bird species in temperate and tropical areas. We examined avian biodiversity patterns in Ecuador, one of the most bird-biodiverse countries in the world (1650+ species). In January 2026, birds were surveyed (visual and auditory) for 30 minutes on consecutive days in 4 different locations that differed in the degree of human development. As expected, species richness was much higher in undisturbed locations than disturbed locations. In addition, our comparison of dietary patterns between sites showed a much higher proportion of frugivorous and insectivorous species in areas with less human disturbance …


Pepper Spray Exposure And The Effect On Dna Profiling Of Blood, Brandon Schmakel Apr 2026

Pepper Spray Exposure And The Effect On Dna Profiling Of Blood, Brandon Schmakel

Honors Projects

Pepper spray is a common self defense tool used in both law enforcement and civilian settings, with the goal of incapacitating the sprayed individual. In real casework where pepper spray was used, a red-brown stain which tested positive presumptively for blood provided no DNA profile after further testing six months later. A previous graduate student, Emma Crawn, attempted to emulate these casework conditions and instead achieved a DNA profile with slight indications of inhibition or degradation. Further analysis of active pepper spray ingredients such as Oleoresin Capsicum (OC) and Chloroacetophenone (CN) reveals that there are observed reactions, such as oxidation, …


Cultivating Curiosity Across Academic Audiences: Biology And Evidence-Based Science Communication, Nathan D. Forbes Apr 2026

Cultivating Curiosity Across Academic Audiences: Biology And Evidence-Based Science Communication, Nathan D. Forbes

Whittier Scholars Program

Effective Science Communicators must speak to a variety of audiences, with varying quantities of prior interest and qualities of background knowledge. The purpose of this paper was to engage differing audiences in scientific learning. This was done through a hypothetical newsletter made up for four different segments exploring a variety of topics in biology. Each segment intends to speak to a different audience with a different level of interest and/or educational level. Simplifying or analogizing without sacrificing the statistical basis of this project was of paramount importance. In the two segments targeted towards younger audiences, the primary focus was on …


High Performance Ae-Cnn Model Enhanced Via Gaussian Augmentation For Rssi-Dependent Indoor Positioning In Wireless Sensor Networks, Kahlaa K. Al-Nassrawy, Ghaidaa A Al-Sultany Apr 2026

High Performance Ae-Cnn Model Enhanced Via Gaussian Augmentation For Rssi-Dependent Indoor Positioning In Wireless Sensor Networks, Kahlaa K. Al-Nassrawy, Ghaidaa A Al-Sultany

Karbala International Journal of Modern Science

Precise indoor positioning system remains a significant challenge within Wireless Sensor Networks (WSNs) due to the instability and noise sensitivity of Received Signal Strength Indicator (RSSI) data. This paper proposes an advanced hybrid deep learning framework designed for 2D indoor localization, utilizing RSSI measurements to predict human or object position. Furthermore, to enhance the robustness of the model against signal variance and promote its generalization capability under this uncertainty, a data augmentation strategy is applied using three methods: Gaussian Noise Injection (GNI), Gaussian Mixture Model (GMM), and Bayesian Gaussian Mixture Model (BGMM). The purpose of data augmentation is to simulate …


Parasite Prevalence In Local Grasshopper Populations, Lucia B. Freund, Ali Gronquist Apr 2026

Parasite Prevalence In Local Grasshopper Populations, Lucia B. Freund, Ali Gronquist

Research & Creative Achievement Day

Spur-throated grasshoppers (genus Melanoplus) are a common agricultural pest in North America. Spur-throated grasshoppers are also a common host to several parasitic organisms. Horsehair worms (phylum Nematomorpha) are parasitic organisms known for their ability to manipulate the behavior of its insect host, particularly grasshoppers and crickets, by urging the host to enter water so it can complete its life cycle. Along with being a host to parasitic worms, they are a frequent target of grasshopper mites. Grasshopper mites (Eutrombidium locustarum) is a short-lived parasite that can negatively influence the reproductive ability of their host. Because grasshoppers are a major agricultural …


Characterization Of Bacteria In Cattle Specimens, Jacob D. Hanson, Josie M. Tieskoetter Apr 2026

Characterization Of Bacteria In Cattle Specimens, Jacob D. Hanson, Josie M. Tieskoetter

Research & Creative Achievement Day

Cattle nasal cavities provide a favorable environment for microbial colonization and can habit a wide population of bacteria, including opportunistic and pathogenic species. The objective of this research was to isolate, characterize, and identify bacteria present is nasal swap specimen collected from multiple calves. Samples were cultured and analyzed using selective and differential media, Gram staining, spore staining, and a range of biochemical assays. Several bacterial species were identified including the genus Corynebacterium and Streptococcus while some isolates could not be identified using classical biochemical methods alone. These results demonstrate that calf nasal specimens commonly contain diverse bacterial populations, some …


Modulating Acute Stress Reactivity: Behavioral Interventions And Caffeine-Linked Stress Physiology In College Students, Kaitlyn Smith Apr 2026

Modulating Acute Stress Reactivity: Behavioral Interventions And Caffeine-Linked Stress Physiology In College Students, Kaitlyn Smith

Honors Theses

College students frequently rely on caffeine to manage academic demands, yet its physiological and psychological effects on acute stress remain poorly understood. Although caffeine is known to increase cardiovascular arousal and self‑reported anxiety, little research has compared different caffeine sources within the same individuals or examined whether brief behavioral interventions can buffer these effects. Self‑affirmation, a short writing exercise centered on personal values, has been shown to reduce stress reactivity, but its interaction with caffeine‑induced arousal has not been tested. This within‑subjects study examines how coffee, energy drinks, and a no‑caffeine control influence acute cardiovascular and self‑reported stress responses, and …


Cognition In Pair-Living Owl Monkeys: The Role Of Partner Affiliation In The Willingness To Cooperate To Solve A Cognitive Task, Aaron J. Mencia Apr 2026

Cognition In Pair-Living Owl Monkeys: The Role Of Partner Affiliation In The Willingness To Cooperate To Solve A Cognitive Task, Aaron J. Mencia

Electronic Theses and Dissertations

Cooperative problem-solving tasks, including the loose-string paradigm, require individuals to coordinate their actions simultaneously to obtain a shared reward. These paradigms have been used extensively to assess social cognition, behavioral coordination, and partner preferences across taxa. Although the loose-string paradigm has been widely tested, it has not been applied to pair-bonded, monogamous primates such as owl monkeys (Aotus nancymaae), which exhibit affiliative behaviors including food sharing and bi-parental care. Investigating cooperation in this species may offer some clarification on whether more stable social bonds are associated with cooperative and cognitive task success as compared to those observed in …


The Effects Of Oleuropein In Olive Leaf Extract Alone Or Combined With Calcitriol On The Viability And Migration Of Human Endometrial Cells In Vitro, Katelyn Devereaux Apr 2026

The Effects Of Oleuropein In Olive Leaf Extract Alone Or Combined With Calcitriol On The Viability And Migration Of Human Endometrial Cells In Vitro, Katelyn Devereaux

Electronic Theses and Dissertations

Endometriosis is a chronic inflammatory disease affecting approximately 10% of reproductive-aged women worldwide and is commonly associated with pelvic pain, infertility, and reduced quality of life. Current management strategies, including hormonal therapies and surgical intervention, often provide only temporary relief and are associated with recurrence and adverse effects. These limitations highlight the need for alternative, non-hormonal therapeutic approaches that target underlying inflammatory and cellular mechanisms of disease progression.

This study evaluated the effects of oleuropein, contained within an olive leaf extract, and calcitriol, the active form of vitamin D, on cellular viability and migration in immortalized human endometriotic epithelial (12Z) …


Tree Resin Effects On Environmental Microbial Growth In Tetramorium Ant Colonies, Abigail Peralta, Emma Crisman Apr 2026

Tree Resin Effects On Environmental Microbial Growth In Tetramorium Ant Colonies, Abigail Peralta, Emma Crisman

Biology Student Scholarship

No abstract provided.


Trial Of Vaginal Microbiome Transplant To Prevent Recurrent Bacterial Vaginosis, Grace Pierson Apr 2026

Trial Of Vaginal Microbiome Transplant To Prevent Recurrent Bacterial Vaginosis, Grace Pierson

Biology Student Scholarship

Comparative Inhibition Testing for Personalized Microbiota Selection

This case report evaluates a strategy for selecting optimal donor material for Cervicovaginal Secretion (CVS) transplantation. To identify a suitable match, CVS from four healthy, Lactobacillus-dominated donors was tested against a patient’s sample to observe microbial inhibition. Theoretically, effective donor material should produce a visible inhibition zone (halo), indicating suppressed growth of pathogenic bacteria. However, initial testing yielded unreadable results with no conclusive evidence of inhibition. Consequently, my study pivoted to analyze the direct effects of donor samples on the growth of specific pathogens, Gardnerella vaginalis and Prevotella bivia.


Altered Clock Genes Affect Fly Circadian Rhythms And Rhythms Of Cell Respiration In The Brain, Connor Enestvedt, Campbell Bridges, Anna Costello, Brenda Rodrigues, Jake Antosca Apr 2026

Altered Clock Genes Affect Fly Circadian Rhythms And Rhythms Of Cell Respiration In The Brain, Connor Enestvedt, Campbell Bridges, Anna Costello, Brenda Rodrigues, Jake Antosca

Biology Student Scholarship

Drosophila have circadian rhythms which are daily biological rhythms synchronized by an internal clock. These rhythms regulate behavioral and physiological systems within their bodies. The endogenous fly clock—made of an oscillating gene-protein feedback loop found in central pacemaker cells in the brain— sets endocrine, locomotor, and metabolic rhythms to the 24-hour Earth day The central clock signals to peripheral clocks, setting measurable rhythms. Mutations to these clock genes disrupts the oscillator, resulting in rhythm changes. In this project, we will study how flies’ circadian rhythms and cell respiration in the brain changes with mutations to clock genes. By measuring oxygen …


Wheel-Running As A Window Into The Pten-Ko Neurological Clock, Jake Antosca, Campbell Bridges, Elizabeth Burke, Chris Sama Apr 2026

Wheel-Running As A Window Into The Pten-Ko Neurological Clock, Jake Antosca, Campbell Bridges, Elizabeth Burke, Chris Sama

Biology Student Scholarship

The phosphatase and tensin homolog protein (PTEN) is a critical regulator of the PI3K/AKT/mTOR signaling pathway, which governs cellular growth and metabolic balance. Mutations in the PTEN gene are strongly linked to macrocephaly and Autism Spectrum Disorder (ASD) in humans. While PTEN deficiency is known to cause neuronal hypertrophy and metabolic stress, its impact on the< endogenous circadian clock, the internal timing system that regulates daily physiological cycles, remains poorly understood. Proper circadian function is vital for metabolic homeostasis, which may be dysregulated in PTEN-deficient models.

In this poster, we compare PTEN conditional knockout mice with CRE controls to test whether PTEN-related cerebellar dysfunction alters entrainment to a light-dark cycle, free-running period in constant conditions, and food-anticipatory activity in age-matched animals between approximately 130 and …


Characterizing The Functional Diversity Of Rocky Intertidal Environments Of Southern New England, Hailey Arman Apr 2026

Characterizing The Functional Diversity Of Rocky Intertidal Environments Of Southern New England, Hailey Arman

Biology Student Scholarship

Tidal pools are a diverse ecosystem that are home to a wide range of important species that support our environment and marine habitats. Tidal pools along the New England coastline have been greatly affected by human activity, through direct contact with humans, as well as the increasing effects of climate change. Adapting the protocols from UC Santa Cruz Multi-Agency Rocky Intertidal Network (MARINe) and the National Park Service Northeast Temperate Network’s (NETN), we set up multi-year plots to track abundances intertidal species throughout Rhode Island. Ultimately, by gaining a better understanding of how these systems change over time, we can …


Advancing Early Detection Of Diabetic Retinopathy At Clínica Esperanza/Hope Clinic, Rachel Burke Apr 2026

Advancing Early Detection Of Diabetic Retinopathy At Clínica Esperanza/Hope Clinic, Rachel Burke

Biology Student Scholarship

No abstract provided.


Clec7a Deficiency Affects Cerebellar Microglia Development And Purkinje Cell Axon Myelination, Olivia Barbarini, Grace Belt, Lauren Bedford, Julia Carson, Kayla Fordyce, Michael Martinez, Lindsay Walsh Apr 2026

Clec7a Deficiency Affects Cerebellar Microglia Development And Purkinje Cell Axon Myelination, Olivia Barbarini, Grace Belt, Lauren Bedford, Julia Carson, Kayla Fordyce, Michael Martinez, Lindsay Walsh

Neuroscience Program Student Scholarship

No abstract provided.


Exploring How Light Source Influences Bluegill Positioning And Behavior, Anthony Aldana Mendez Apr 2026

Exploring How Light Source Influences Bluegill Positioning And Behavior, Anthony Aldana Mendez

Biology Student Scholarship

No abstract provided.


Image Analysis Of Pupal Sex Ratio In Honey Bee Hives, Anna R. Tattelman, Grace E. O’Brien Apr 2026

Image Analysis Of Pupal Sex Ratio In Honey Bee Hives, Anna R. Tattelman, Grace E. O’Brien

Biology Student Scholarship

No abstract provided.


Wild Bee Foraging And Movement Behavior In Urban Gardens, Claire Crowther, Maggie Ritchie Apr 2026

Wild Bee Foraging And Movement Behavior In Urban Gardens, Claire Crowther, Maggie Ritchie

Biology Student Scholarship

No abstract provided.


Ultrasound-Assisted Enzymatic Extraction Improves The Antiinflammatory Activity Of Red Dragon Fruit Peel Pectin, Bao Le, Seung Hwan Yang, Hoang Dang Khoa Ta Apr 2026

Ultrasound-Assisted Enzymatic Extraction Improves The Antiinflammatory Activity Of Red Dragon Fruit Peel Pectin, Bao Le, Seung Hwan Yang, Hoang Dang Khoa Ta

Turkish Journal of Biology

Background/aim: Inflammatory bowel disease is a chronic inflammatory disorder characterized by excessive immune activation, primarily mediated by nitric oxide and proinflammatory cytokines. This condition encompasses ulcerative colitis and Crohn’s disease, both of which significantly impair patients’ quality of life and pose persistent challenges in clinical management. Pectin, a complex carbohydrate found in plant cell walls, has shown promise in reducing inflammation. Materials and methods: In this study, pectin was extracted from red dragon fruit peel using two methods: ultrasound-assisted extraction and ultrasound-assisted enzymatic extraction. The structural characteristics and antiinflammatory effects of the extracted pectin were evaluated in lipopolysaccharide-stimulated RAW 264.7 …


Single-Walled Carbon Nanotube-Mediated Plasmid Dna Delivery In The Model Monocot Brachypodium Distachyon, Kaya İşleyen Bi̇lge, Bahar Soğutmaz Özdemi̇r Apr 2026

Single-Walled Carbon Nanotube-Mediated Plasmid Dna Delivery In The Model Monocot Brachypodium Distachyon, Kaya İşleyen Bi̇lge, Bahar Soğutmaz Özdemi̇r

Turkish Journal of Biology

Background/aim: Plant genetic engineering is a valuable approach for improving stress tolerance, crop productivity, and quality traits. However, its progress is limited by the drawbacks of traditional transformation methods. Commonly used techniques, such as Agrobacterium-mediated transformation and biolistics, are restricted by genotype dependency, lengthy tissue culture steps, and low efficiency, particularly in monocot species. Therefore, the development of alternative gene delivery strategies remains an ongoing research focus in plant biotechnology. Nanoparticle-based delivery systems have recently gained attention due to their physiochemical properties, biocompatibility, and potential for alternative gene delivery approaches in plant systems.Materials and methods: We investigated the use of …


Combinatorial Effect Of Epirubicin And 5-Fluorouracil In The Treatment Of Temozolomide-Resistant Glioblastoma Cells, Mehrsa Bayat, Muhli̇s Akman, Türker Kiliç, Ti̇muçi̇n Avşar Apr 2026

Combinatorial Effect Of Epirubicin And 5-Fluorouracil In The Treatment Of Temozolomide-Resistant Glioblastoma Cells, Mehrsa Bayat, Muhli̇s Akman, Türker Kiliç, Ti̇muçi̇n Avşar

Turkish Journal of Biology

Background: Glioblastoma (GBM) is a highly aggressive form of brain tumor characterized by rapid proliferation and invasiveness. It is associated with a poor prognosis due to acquired resistance to temozolomide (TMZ). In this study, we investigated whether a combination of epirubicin, 5-fluorouracil (5-FU), and TMZ could improve TMZ sensitivity in resistant GBM cells and help overcome resistance.Materials and methods: TMZ resistance was established in the U87MG cell line. The MTT assay was used to measure cell viability. Reactive oxygen species (ROS) and apoptosis were measured using flow cytometry. RNA-seq was used to evaluate genomic changes based on treatment with drugs …


Modulating Microtubule Stability Via Α-Tubulin Acetylation Partially Restores Golgi Fragmentation In Spinal Muscular Atrophy, Peli̇n Zobaroğlu Özer, Memet Gözüböyük, Özge Çeti̇n, Niko Hensel, Güzi̇n Emecen, Adam Malik, Melissa Bowerman, Peter Claus, Hayat Erdem Yurter, Gamze Bora Akoğlu Apr 2026

Modulating Microtubule Stability Via Α-Tubulin Acetylation Partially Restores Golgi Fragmentation In Spinal Muscular Atrophy, Peli̇n Zobaroğlu Özer, Memet Gözüböyük, Özge Çeti̇n, Niko Hensel, Güzi̇n Emecen, Adam Malik, Melissa Bowerman, Peter Claus, Hayat Erdem Yurter, Gamze Bora Akoğlu

Turkish Journal of Biology

Background/aim: Spinal muscular atrophy (SMA) is a neurodegenerative disease caused by the loss of survival of motor neuron (SMN) protein. SMN deficiency leads to perturbations of the cytoskeleton, including microtubules, which are mainly involved in motilityrelated cellular processes. However, the molecular mechanisms of microtubule dysregulation in SMA remain elusive. Alpha (α)-tubulin is a structural component of microtubules, and its posttranslational modifications affect microtubule dynamics. Here, we aimed to investigate α-tubulin acetylation and related molecular mechanisms in SMA. Materials and methods: Two different SMA mouse models, the Drosophila melanogaster model and patient-derived fibroblasts, were used in the study. Western blot and …