Operations Research, Systems Engineering and Industrial Engineering Commons^™

Quality By Design Procedure For Continuous Pharmaceutical Manufacturing: An Integrated Flowsheet Model Approach, Ashley Vezina

Electronic Theses and Dissertations

Pharmaceutical manufacturing is crucial to global healthcare and requires a higher, more consistent level of quality than any other industry. Yet, the traditional pharmaceutical batch manufacturing has remained largely unchanged in the last fifty years due to high R&D costs, shorter patent durations, and regulatory uncertainty. This has led regulatory bodies to promote modernization of manufacturing process to continuous pharmaceutical manufacturing (CPM) by introducing new methodologies including quality by design, design space, and process analytical technology (PAT). This represents a shift away from the traditional pharmaceutical manufacturing way of thinking towards a risk based approach that promotes increased product and …

Fire Safety And Emergency Evacuation Training For Occupants Of Building Using 3d Virtual Simulation, Sayli Bhide

Electronic Theses and Dissertations

With advancement in technology, building structures are becoming bigger and more complex. Incidences of horrifying fires that occur in such complex structures resulting in loss of property as well as lives are recorded worldwide. Emergency evacuation training can play a crucial role in mitigating damage not only in cases of fire, explosion or chemical spill but also in cases of natural calamities like floods and hurricanes. Conventional safety training provided in industries mostly comprises of unidirectional flow of information. Due to this passive learning style, response of employees in real life emergency situations is known to be ineffective. The proposed …

A Method For Key Performance Indicator Assessment In Manufacturing Organizations, Patrick Hester, Barry Ezell, Andrew Collins, John Horst, Kaleen Lawsure

VMASC Publications

Key Performance Indicators (KPIs) are an essential element of an organization’s ability to monitor its strategic health, helping to ensure the strategic goals of the organization are achieved. However, KPI assessment and improvement is often an ad hoc and consultant-driven process rather than one undertaken using scientific principles. This paper outlines the development and subsequent deployment of a method for KPI assessment founded in scholarly literature and balancing practitioner concerns for ease of use. The proposed method draws heavily on organizational stakeholder involvement at varying levels throughout the KPI assessment process, improving current methods by introducing a mathematical foundation based …

Sensitivity Analysis Method To Address User Disparities In The Analytic Hierarchy Process, Marie Ivanco, Gene Hou, Jennifer Michaeli

Mechanical & Aerospace Engineering Faculty Publications

Decision makers often face complex problems, which can seldom be addressed well without the use of structured analytical models. Mathematical models have been developed to streamline and facilitate decision making activities, and among these, the Analytic Hierarchy Process (AHP) constitutes one of the most utilized multi-criteria decision analysis methods. While AHP has been thoroughly researched and applied, the method still shows limitations in terms of addressing user profile disparities. A novel sensitivity analysis method based on local partial derivatives is presented here to address these limitations. This new methodology informs AHP users of which pairwise comparisons most impact the derived …

Systemic Intervention For Complex System Governance Development, Charles B. Keating, Polinpapilinho F. Katina,, John C. Pyne, Ra’Ed M. Jaradat

Engineering Management & Systems Engineering Faculty Publications

This paper explores the issues related to systemic intervention for Complex System Governance (CSG) development. Systemic intervention seeks to intentionally engage a system to influence trajectory or outcomes. CSG is an emerging field focused on the design, execution, and evolution of the functions necessary to provide continued system performance (stability) in the midst of incessant turbulence and increasing complexity. Integral to this field is the necessity to ‘intervene’ in a complex system to enhance system behavior, structure, or performance. Arguably, system interventions have an unremarkable record of success, ranging from declared success in improving a situation (system) to abysmal failure …

Development Of Post-Pareto Optimality Methods For Multiple Objective Optimization, Juan Valentin Fernandez

Open Access Theses & Dissertations

In the past years, multiple objective optimization has been considered, as an important research area since in many real life problems there exists multiple criteria that need to be optimized simultaneously. The use of evolutionary algorithms or metaheuristic methods as solution methodologies lead to a large number of Pareto solutions rather than a single unique optimum. This Pareto-optimal set most of the time tends to be very large and the decision maker now faces the challenge of reducing its size to analyze a feasible number of solutions, thus deciding the best possible solution. In this work, two methods will be …

A Cubesat Communication System Development For Gto Mission, Ashiqur Rahman

Open Access Theses & Dissertations

Tracking, telemetry and command (TT&C) systems on traditional small satellites have advanced significantly in last few decades. The capabilities, requirements and expectations of the communication system have been increased significantly for the smaller satellites. Small satellites are now performing the tasks near to the bigger satellites which increases the dependency on the communication system in terms of reliability and data management. This Thesis paper will focus on development of the communication system of a 1U cube Satellite named Orbital Factory II (OFII). The satellite will be launched into a geostationary transfer orbit (GTO) onboard a United Launch Alliance (ULA) Atlas …

Risk Mitigation In The Supply Chain Caused By Multitple Phase-In And Phase-Out Components Using Simio Simulation, Anabel Renteria Marquez

Open Access Theses & Dissertations

Manufacturing is constantly changing, adapting to new technologies and making improvements on their products design, while dealing with engineering design changes can represent an improvement or savings to the company it can also end up as a huge risk of disruption in the Supply Chain if there is not a safety phase-in and phase-out components transition because the network became more complex and affected processes needs to be revalidated, here comes the importance to set up an strategy to mitigate any possible risk and maximize total revenue.

A case study for a two tiers level Supply Chain system is evaluated …

Image Data Mining For Quality Control Of Nanofiber Reinforced Piezoelectric Nanocomposites Based On Sem Images, Zhonghua Hu

Open Access Theses & Dissertations

Recently, portable and wireless nano-scaled devices have been widely used in environmental monitoring, medical implants, defense technology, industrial safety, and personal electronics, such as the nanowire-based gas and chemical sensors and programmable nanowire circuit for nano-processors. There has been an increasing demand for high energy density capacitors that can be engineered for various applications in advanced devices. In it, piezoelectric nanofiber materials play critical role in producing new products. A piezo-ceramic polymer composite contains a polymer of high dielectric strength and high permittivity ceramic inclusions, making it well suited as a high energy density capacitor. Furthermore, the research shows that …

Renewable Energy Systems Optimization Using Monte Carlo Simulation And Evolutionary Algorithms, Nicolas Lopez

Open Access Theses & Dissertations

This Dissertation explores the Renewable Energy Integration Problem, and proposes a Genetic Algorithm embedded with a Monte Carlo simulation to solve large instances of the problem that are impractical to solve via full enumeration. The Renewable Energy Integration Problem is defined as finding the optimum set of components to supply the electric demand to a hybrid

microgrid. The components considered are solar panels, wind turbines, diesel generators, electric batteries, connections to the power grid and converters, which can be inverters and/or rectifiers. The methodology developed is explained as well as the combinatorial formulation. In addition, 2 case studies of a …

Attitudes Towards Face-To-Face Meetings In Virtual Engineering Teams: Perceptions From A Survey Of Defense Projects, Lawrence R. Blenke, Abhijit Gosavi, William Daughton

Engineering Management and Systems Engineering Faculty Research & Creative Works

Modes of communication used in virtual defense projects have changed dramatically over the years with tools such as email and video-conferencing dominating face-to-face (FTF) meetings. We conducted a survey at a defense firm with an aim to test current attitudes towards FTF meetings – with respect to significant problems faced, project success, transfer of technical requirements, preference for FTF vis-à-vis virtual meetings, differences between virtual and co-located environments, criticality of various forms of communication, and whether FTF meetings were scheduled as often as desired. Our survey participants, about one hundred in number, were experienced engineers, technicians, and program managers – …

Implicit Leadership And Followership Theories: Does Congruency Matter?, Daniel Bashore

Browse all Theses and Dissertations

Leadership research largely has ignored the extent to which followers influence leaders and the leadership process. Even fewer studies have examined the effect of Implicit Leadership Theories (ILTs) and Implicit Followership Theories (IFTs) on performance and affective outcomes. In prior research, there is an implicit assumption that ILTs and IFTs are compatible, but little research has examined the presence of incongruent ILTs and IFTs and potential effects incongruence might have on organizational outcomes. The current study examined the effect of ILT/IFT congruence on organizational outcomes (performance, satisfaction, and perceived leader effectiveness) in two different samples: a student sample (N = …

Chocolate Bar Wrapping Machine, Austin M. Hoff, Daniel R. Trepke, Caleb B. Krichbuam

Williams Honors College, Honors Research Projects

Gilbert Chocolates has proposed to manufacture a machine to wrap chocolate bars. This machine is intended to replace two people wrapping the chocolate bars by hand, which is a time consuming method. This is especially apparent between October and January when the workers are working long hours in preparation for the Christmas rush of customers. Currently wrapping a bar takes about a minute and Gilbert Chocolates wants this time reduced down to 20-30 seconds. The budget for this project is set at $1000, and is being funded by the company. This machine needs to fit in a cubic foot of …

A Methodology For Internet Of Things Business Modeling And Analysis Using Agent-Based Simulation, Mohammed Basingab

Electronic Theses and Dissertations

Internet of Things (IoT) is a new vision of an integrated network covering physical objects that are able to collect and exchange data. It enables previously unconnected devices and objects to become connected using equipping devices with communication technology such as sensors and radio frequency identification tags (RFID). As technology progresses towards new paradigm such as IoT, there is a need for an approach to identify the significance of these projects. Conventional simulation modeling and data analysis approaches are not able to capture the system complexity or suffer from a lack of data needed that can help to build a …

The Value Of A Collegiate Far Part 141 Jeopardy-Crew Resource Management (Crm)-Simulation Event, Samuel M. Vance

Journal of Aviation/Aerospace Education & Research

This article explores the viability of using a FAR Part 141 collegiate crew resource management (CRM) flight simulator scenario event as a jeopardy event (a graded, syllabus item) in an upper-level professional pilot curriculum course. Ultimately, the objective is to suggest this approach as a value-added curriculum consideration for other collegiate professional pilot programs. The selection of four CRM criteria to be examined was made by the course professor. Using the four principles, the students assembled the grading rubric for their event. The simulator scenario placed students in airspace, geography and weather dissimilar to that in which they were training …

Program Requirements: Complexity, Myths, Radical Change, And Lean Enablers, Bohdan W. Oppenheim

Systems Engineering Faculty Works

This paper presents a comprehensive discussion on the difficulties of formulating good and stable requirements early in complex engineering programs and the consequences on program execution. Formal classical systems engineering and program management (CSEPM) methodology is based on the assumption that the knowledge to anticipate all interfaces and create good requirements exists early in the program, and that it is a matter of working out the details to build extremely complex devices such as satellites, aircraft, refineries, nuclear power plants, and high-speed rail. The author argues that classical systems engineering and program management works well only for well-understood systems, but …

Scheduling Strategies For Construction Project Managers Toward On Time Delivery, Paul Shamp

Walden Dissertations and Doctoral Studies

Construction management projects involve complex, dynamic environments resulting in uncertainty and risk, compounded by demanding time constraints. Research indicated project managers have struggled to identify best practices for scheduling construction projects via critical path methodologies while searching for tools to increase timely job completions and budget profits. The purpose of this single case study was to explore the strategies that construction project managers used to manage scheduled construction project delivery on time. The constructivist philosophical worldview was used as the framework for this study. Data were collected from semistructured interviews from 7 project managers from 5 different construction companies selected …

Assessing Effectiveness Of Information Presentation Using Wearable Augmented Display Device For Emergency Response, Sriram Raju Chandran

Browse all Theses and Dissertations

Small screen wearable devices are becoming ubiquitous in the medical field; especially in the fields of surgery and trauma care. Technological intervention that supports data transfer of sending summary of the patient vitals through the transfer of care would be of great benefit to trauma care department. This research focuses on information presentation for wearable augmented reality device to improve human decision making during transfer of care for emergency response, and to improve user experience and reduce cognitive workload. Google Glass ™ device acts as heads up display for users, in this case being medical responders in hospital trauma care. …

A Framework For Centralizing Inventory In Pharmaceutical Supply Chains, Kerry Kathleen Ward

Browse all Theses and Dissertations

Effectively choosing the location of inventory in a pharmaceutical supply chain is central to the mission of pharmaceutical distributors. These supply chains are a critical backbone to the healthcare delivery process: the distributors must deliver products to pharmacies, hospitals and retailers at low cost and with a high level of reliability. This thesis provides a method for analyzing demand data to gain insight on the value of centralizing the inventory into either a hub-and-spoke or national network for a pharmaceutical distribution company. Demand data is analyzed using an off-the-shelf analysis tool as well as a new tool developed in SQL …

Evaluating Mobile Information Display System In Transfer Of Care, Katelyn Berberich

Browse all Theses and Dissertations

Transfer of care continuum is highly dynamic in nature and there are multiple complexities associated with man-man interaction and man-machine interaction. During transfer of patient care, which occurs from an emergency medical team (EMT) to an emergency department, adequate information related to the patient must be communicated very quickly and precisely. Challenges EMTs and emergency department personnel face are communicating and obtaining all the essential information to ensure the patient receives the best care. Providing the receiving emergency department with patient vitals and pre-hospital procedures that occurred en route could allow for enhanced preparation and improved communication during the transfer …