Industrial Engineering Commons^™

Mechanical Properties Of Nanoparticles In The Drug Delivery Kinetics, Kaivon Assani, Amy Neidhard-Doll, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

Nanoparticle formulation is a recently developed drug delivery technology with enhanced targeting potential. Nanoparticles encapsulate the drug of choice and delivers it to the target via a targeting molecules (ex. antigen) located on the nanoparticle surface. Nanoparticles can even be targeted to deeply penetrating tissue and can be modeled to deliver drugs through the blood brain barrier. These advancements are providing better disease targeting such as to cancer and Alzheimer’s. Various polymers can be manufactured into nanoparticles. The polymers examined in this paper are polycaprolactone (PCL), poly(lactic acid) (PLA), poly(lactic-co-glycolic acid) (PLGA), and poly(glycolic acid) (PGA). The purpose of this …

Assessing The Influence Of Health Policy And Population Mobility On Covid-19 Spread In Arkansas, Tayden Barretto

Industrial Engineering Undergraduate Honors Theses

The outbreak of COVID-19 has created a major crisis across the world since its start in 2019, and its influence on every realm of society is undeniable. Globally, more than 500 million cases have been recorded since March 2020, with almost 6 million deaths. In the wake of this crisis, many governments and health organizations have taken steps and precautions to mitigate its spread. These steps involve public mandates of information, reducing frequency of personal contact, and use of masks to minimize the risk of transmission. Current access to mobility data released from Google detailing population movements has provided a …

Analyzing Vulnerabilities In The Northwest Arkansas Highway Network Using Mathematical Optimization, Brandon Jerome

Industrial Engineering Undergraduate Honors Theses

The highway and bridge network is a critical infrastructure that allows for the free transportation of citizens and enables truck-borne freight transportation. Disruption of this system could be caused by a terrorist attack, natural disaster, growth of population, required repairs and upgrades, or collapse caused by old age or malfunction. In the event of a disruption cities and regions can experience increased traffic and supply chain shortages, thus causing cascading effects throughout surrounding areas. With this motivation, we develop a network interdiction optimization model to identify a limited subset of roads that, if disrupted, causes the greatest increase in the …

Implementing The Cms+ Sports Rankings Algorithm In A Javafx Environment, Luke Welch

Industrial Engineering Undergraduate Honors Theses

Every year, sports teams and athletes get cut from championship opportunities because of their rank. While this reality is easier to swallow if a team or athlete is distant from the cut, it is much harder when they are right on the edge. Many times, it leaves fans and athletes wondering, “Why wasn’t I ranked higher? What factors when into the ranking? Are the rankings based on opinion alone?” These are fair questions that deserve an answer. Many times, sports rankings are derived from opinion polls. Other times, they are derived from a combination of opinion polls and measured performance. …

A Spatiotemporal Analysis Of Food Pantry Accessibility In Washington County, Arkansas, Coleman Warren

Industrial Engineering Undergraduate Honors Theses

Food pantries are an essential resource for impoverished and food insecure communities. Washington County, Arkansas has a food insecurity rate of 14.3% as compared to the national average of 10.9% (Feeding America, 2019). The Northwest Arkansas Food Bank has a robust pantry network in Washington County to support families and individuals who struggle with food insecurity.

We conducted a spatiotemporal analysis of food pantry accessibility in Washington County, Arkansas to evaluate the effectiveness of the food pantry network in Washington County at supporting communities with the most need. This analysis was conducted using the Two-Step Floating Catchment Area (2SFCA) method …

Academic Advising Support Tool: An Optimization Approach, Spencer Loper

Industrial Engineering Undergraduate Honors Theses

More than ever, a college education is necessary to remain competitive in the job market. Therefore, colleges are dedicating numerous resources to ensure student success. Nonetheless, one of the most important factors of student success is proper academic advising. Students at the University of Arkansas and more specifically within the department of Industrial Engineering department are fortunate to have access to fantastic advising. However, given the volume of students, academic advisors do not have the time to talk through the nuance of every student’s long-term academic plan. The department does provide an eight-semester plan; however, students who have deviated from …

Selected Interdiction Games With Uncertain, Risk-Averse, And Simultaneous Play Considerations, Di H. Nguyen

All Dissertations

This dissertation examines two network interdiction problems: a shortest-path interdiction problem under uncertainty and a network interdiction problem in a simultaneous game. Both problems happen in two stages over a directed network, and involve a leader and a follower who have opposing interests.

In the first problem, the leader acts first to lengthen a subset of arcs, and a follower acts second to select a shortest path across the network. The cost for a follower’s arc consists of a base cost if the arc is not interdicted, plus an additional cost that is incurred if the arc is interdicted. The …

Design And Analysis Of Efficient Freight Transportation Networks In A Collaborative Logistics Environment, Vishal Badyal

All Dissertations

The increase in total freight volumes, reducing volume per freight unit, and delivery deadlines have increased the burden on freight transportation systems of today. With the evolution of freight demand trends, there also needs to be an evolution in the freight distribution processes. Today's freight transportation processes have a lot of inefficiencies that could be streamlined, thus preventing concerns like increased operational costs, road congestion, and environmental degradation. Collaborative logistics is one of the approaches where supply chain partners collaborate horizontally or/and vertically to create a centralized network that is more efficient and serves towards a common goal or objective. …

Comparing Actively Managed Mutual Fund Categories To Index Funds Using Linear Regression Forecasting And Portfolio Optimization, Luke Weiner

Industrial Engineering Undergraduate Honors Theses

The global investment industry offers a wide variety of investment products especially for individual investors. One such product, index funds, which are younger than actively managed mutual funds, have typically outperformed managed funds. Despite this phenomenon, investors have displayed a tendency to continue investing in actively managed funds. Although only a small percentage of actively managed funds outperform index funds, the costs of actively managed funds are significantly higher. Also, managed fund performances are most often determined by their fund category such as growth or real estate. I wanted to answer the following question for individual investors: can we …

Interdiction Models To Disrupt The Operations Of Sex Trafficking And Other Forced Illicit Labor Networks, Michael T. Clark

All Theses

Sex traffickers often force their victims to work in both commercial sex markets and perform other illicit activities (e.g., drug dealing, theft, and fraud). Current literature has failed to address interdiction models that aim to disrupt all components of a sex traffickers’ operation, including these other illicit activities. In this thesis, we present a interdiction problem, and its single-level linear optimization reformulation, to reduce the profit of a human trafficking network concurrently operating in the commercial sex market and other illicit activity markets. Our novel formulation aims to investigate the practical implications of interdiction decisions made to disrupt a human …

Investigations Of External Resources And The Impact Of Imaging On Patient Flow In The Emergency Department, Marisa Shehan

All Theses

The problems associated with Emergency Department (ED) crowding are numerous, varied, and complex. Though overcrowded Emergency Departments are frequently attributed to overcrowded hospitals, crowding is also impacted by bottlenecks in patient flow. While discrete-event simulation (DES) is commonly used to model ED flow, external resources are typically excluded from these models due to their complexity and the limited amount of known information for these processes. Instead, external resources such as consults, labs, and imaging are modeled using estimation and/or educated guesswork. In this study, the impact of imaging on patient flow was assessed through data analysis of specific imaging factors, …

Supervised Representation Learning For Improving Prediction Performance In Medical Decision Support Applications, Phawis Thammasorn

Graduate Theses and Dissertations

Machine learning approaches for prediction play an integral role in modern-day decision supports system. An integral part of the process is extracting interest variables or features to describe the input data. Then, the variables are utilized for training machine-learning algorithms to map from the variables to the target output. After the training, the model is validated with either validation or testing data before making predictions with a new dataset. Despite the straightforward workflow, the process relies heavily on good feature representation of data. Engineering suitable representation eases the subsequent actions and copes with many practical issues that potentially prevent the …

Predicting The Likelihood And Scale Of Wildfires In California Using Meteorological And Vegetation Data, Matthew Walters

Graduate Theses and Dissertations

Wildfires have devastating ecological, environmental, economical, and public health impacts through the deterioration of water and air quality, CO2 emissions, property damage, and lung illnesses. The early detection and prevention of wildfires allow for the minimization of these risks. The use of Artificial Intelligence (AI) in wildfire detection and prediction has been highly researched as a tool to assist firefighters in stopping wildfires in its early stages. The three common wildfire prediction categories include image and video detection, behavior prediction, and susceptibility prediction. Data such as climate, weather, vegetation, satellite images, and historical wildfire data is most commonly used. Many …

The Impact Of Reliability In Conceptual Design - An Integrated Trade-Off Analysis, Tevari James Barker

Graduate Theses and Dissertations

Research presented in this paper focuses on developing models to estimate the systemreliability of Unmanned Ground Vehicles using knowledge and data from similar systems. Traditional reliability approaches often require detailed knowledge of a system and are used in later design stages as well as development, operational test and evaluation, and operations. The critical role of reliability and its impact on acquisition program performance, cost, and schedule motivate the need for improved system reliability models in the early design stages. Reliability is often a stand-alone requirement and not fully included in performance and life cycle cost models. This research seeks to …

Forecasting Hypotension By Learning From Multivariate Mixed Responses.., Jodie Ritter

Electronic Theses and Dissertations

Blood Pressure is the main determinant of blood flow to organs. Hypotension is defined as a systolic blood pressure less than 90 mmHg or a diastolic blood pressure less than 50 mmHg. The severity and duration of hypotension is associated with low blood flow to organs often result in organ damage and a high mortality rate. Predicting hypotension prior to surgery and during the surgery can reduce the incidence and duration resulting in better patient outcomes. This thesis uses preoperative bloodwork and vital signs as well as perioperative vital signs in 5-minute increments as inputs to forecast hypotension. Hypotension can …

Deep Learning Object-Based Detection Of Manufacturing Defects In X-Ray Inspection Imaging, Juan C. Parducci

Mechanical & Aerospace Engineering Theses & Dissertations

Current analysis of manufacturing defects in the production of rims and tires via x-ray inspection at an industry partner’s manufacturing plant requires that a quality control specialist visually inspect radiographic images for defects of varying sizes. For each sample, twelve radiographs are taken within 35 seconds. Some defects are very small in size and difficult to see (e.g., pinholes) whereas others are large and easily identifiable. Implementing this quality control practice across all products in its human-effort driven state is not feasible given the time constraint present for analysis.

This study aims to identify and develop an object detector capable …

Examining The Impact Of Design Features Of Electronic Health Records Patient Portals On The Usability And Information Communication For Shared Decision Making, Rong Yin

All Dissertations

The use of the Electronic Health Records (EHR) patient portal has been shown to be effective in generating positive outcomes in patients’ healthcare, improving patient engagement and patient-provider communication. Government legislation also required proof of its meaningful use among patients by healthcare providers. Typical patient portals also include features such as health information and patient education materials. However, little research has examined the specific use of patient portals related to individuals with specific diseases such as inflammatory bowel diseases (IBDs). IBDs are life-long, not curable, chronic diseases that can impact the whole population. Individuals with IBDs may have higher needs …

A Study Of Scheduling Problems With Sequence Dependent Restrictions And Preferences, Nitin Srinath

All Dissertations

In some applications like fabric dying, semiconductor wafer processing, and flexible manufacturing, the machines being used to process jobs must be set up and serviced frequently. These setup processes and associated setup times between jobs often depend on the jobs and the sequence in which jobs are placed onto machines. That is, the scheduling of jobs on machines must account for the sequence-dependent setup times as well. These setup times can be a major factor in operational costs. In fabric dyeing processes, the sequence in which jobs are processed is also important for quality, i.e., there is a strong preference …

Double Tolerance Design In Stochastic Production Environments, Di Liu

All Dissertations

In a production process, it is impossible to produce parts with exact specifications. Thus, specific ranges, i.e., tolerances, are commonly employed to define intervals for the quality characteristics of conforming products (Wu & Tang (1998)). Usually, a product is deemed conforming when the measurement of the quality characteristic falls within the tolerance. If the measurement falls outside the tolerance, the product is nonconforming and it can be reworked or scrapped. One of the important engineering problems commonly faced by practitioners is to determine optimal engineering tolerances to be used in production. As a result, tolerance design techniques are widely used …

Nanoparticulate Carriers For Drug Delivery, Samantha Lokelani Crossen, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

Drug delivery with nanoparticulate carriers is a new and upcoming research area that is making major changes within the pharmaceutical industry. Nanoparticulate carriers are discussed, particularly, engineered nanoparticulate carriers used as drug delivery systems for targeted delivery. Nanoparticulate carriers that are used for drug delivery systems include polymers, micelles, dendrimers, liposomes, ceramics, metals, and various forms of biological materials. The properties of these nanoparticulate carriers are very advantageous for targeted drug delivery and result in efficient drug accumulation at the targeted area of interest, reduced drug toxicity, reduced systemic side effects, and more efficient use of the drug overall. Nanoparticlulate …