Open Access. Powered by Scholars. Published by Universities.®
Adjuvant therapy; agitation; allergic disease; attention deficit disorder; behavior disorder; blindness; bradycardia; child care; clinical trial; cognitive defect; common cold; coughing; depression; diarrhea; drug blood level; drug efficacy; drug eruption; drug fatality; drug hypersensitivity; drug marketing; drug safety; drug surveillance program; drug withdrawal; dystonia; emotional disorder; epilepsy; febrile convulsion; glomerulus filtration; heart block; hostility; human; hyperkinesia; hypertension; hyponatremia; hypoplasia; hypotension; infection; irritability; liver dysfunction; liver metabolism; liver toxicity; mental disease; metabolic acidosis; metabolic syndrome X; muscle rigidity; nephrotoxicity; nocturnal enuresis; off label drug use; ovary polycystic disease; oxygen therapy; pancreatitis; patient education; patient monitoring; pediatric anesthesia; postmarketing surveillance; prematurity; prescription; priority journal; psychopharmacology; psychosis; respiration depression; retrolental fibroplasia; review; risk assessment; seizure; side effect; Stevens Johnson syndrome; suicidal behavior; suicidal ideation; suicide attempt; thyroid disease; tooth disease; treatment indication; tremor; upper respiratory tract infection; weight gain; alpha adrenergic receptor stimulating agent; amfebutamone; amphetamine; anticonvulsive agent; antidepressant agent; atomoxetine; atypical antipsychotic agent; chloramphenicol; chlordiazepoxide; desmopressin; diazepam; fluoxetine; flurazepam; haloperidol; lamotrigine; lithium derivative; loxapine; neuroleptic agent; olanzapine; pemoline; phenobarbital; placebo; promethazine; propofol; risperidone; serotonin uptake inhibitor; tricyclic antidepressant agent; unindexed drug; valproate semisodium; valproic acid; Thomas Jefferson University; Department of Psychiatry and Human Behavior
Articles 1 - 1 of 1
Full-Text Articles in Medicine and Health
Off-Label Psychopharmacologic Prescribing For Children: History Supports Close Clinical Monitoring., Julie M Zito, Albert T Derivan, Christopher J Kratochvil, Daniel J Safer, Joerg M Fegert, Laurence L Greenhill
Off-Label Psychopharmacologic Prescribing For Children: History Supports Close Clinical Monitoring., Julie M Zito, Albert T Derivan, Christopher J Kratochvil, Daniel J Safer, Joerg M Fegert, Laurence L Greenhill
Department of Psychiatry and Human Behavior Faculty Papers
The review presents pediatric adverse drug events from a historical perspective and focuses on selected safety issues associated with off-label use of medications for the psychiatric treatment of youth. Clinical monitoring procedures for major psychotropic drug classes are reviewed. Prior studies suggest that systematic treatment monitoring is warranted so as to both minimize risk of unexpected adverse events and exposures to ineffective treatments. Clinical trials to establish the efficacy and safety of drugs currently being used off-label in the pediatric population are needed. In the meantime, clinicians should consider the existing evidence-base for these drugs and institute close clinical monitoring.