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Full-Text Articles in Human Ecology
Glucose Transporter 2 Is Likely To Play A Role In The Brain Glucose Sensing, Bing Li
Glucose Transporter 2 Is Likely To Play A Role In The Brain Glucose Sensing, Bing Li
LSU Doctoral Dissertations
It has been proposed that the glucose sensing mechanism in the hypothalamus and hindbrain is similar to pancreatic â cells, and brain glucose sensing may be involved in the regulation of food intake. For the first part of the dissertation, it is proposed that molecules involved in â-cell glucose sensing, including glucokinase (GK), glucose transporter GLUT2, sulfonylurea receptor-1 (SUR1), glucagon-like peptide-1 receptor (GLP-1R), and the feeding-related neuropeptide Y (NPY), are colocalized in specific areas in the hypothalamus and hindbrain. GK, GLUT2, SUR1, GLP-1R and NPY mRNA expression in ten discrete brain areas were quantified by real time RT-PCR, which will …