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Full-Text Articles in Other Psychology
The Effects Of Activity-Based Anorexia On The Rewarding Properties Of Methamphetamine And Wheel Running, Rachael M. Langa
The Effects Of Activity-Based Anorexia On The Rewarding Properties Of Methamphetamine And Wheel Running, Rachael M. Langa
Theses and Dissertations
An activity-based anorexia (ABA) paradigm in adolescent female mice was used to explore whether anorexia affects circuits underlying reward. The ABA paradigm significantly enhanced methamphetamine-induced conditioned place preference (CPP), but not wheel-induced CPP. These results indicate that the ABA paradigm enhances the rewarding properties of methamphetamine, but not wheel running.
Dopamine D1 And D3 Receptor Polypharmacology In Cocaine Reward And Cocaine Seeking, Ewa J. Galaj
Dopamine D1 And D3 Receptor Polypharmacology In Cocaine Reward And Cocaine Seeking, Ewa J. Galaj
Dissertations, Theses, and Capstone Projects
Background: In the search for efficacious pharmacotherapies to treat cocaine addiction much attention has been given to agents targeting D1 or D3 receptors because of the involvement of these receptors in cocaine-related behaviors. D1 and D3 receptor partial agonists and antagonists have been shown to reduce cocaine reward, reinstatement of cocaine seeking and conditioned place preference (CPP) in rodents and non-human primates. However, translation of these encouraging results with selective D1 or D3 receptor agents has been limited due to a number of factors including toxicity, poor pharmacokinetic properties and extrapyramidal and sedative side effects.
Purpose: Given the …