Experimental Analysis of Behavior Commons^™

Assessing Sex Differences In The Effects Of Short-Term Rem Sleep On Anxiety- And Depressive-Like Behaviors In Rats, Nadia Meshkati

Seton Hall University Dissertations and Theses (ETDs)

Findings from both human and animal studies suggest rapid eye movement (REM) sleep disturbances following a traumatic event can lead to inability to extinguish the fear association, and eventually influence the development of post-traumatic stress disorder (PTSD). Additionally, research has demonstrated that sleep disruptions, including REM sleep deprivation (RSD), increases anxiety- and depressive-like behaviors and states in animals and people, with evidence of sex differences. Furthermore, it has yet to be determined whether short-term RSD, a more natural animal model of PTSD, can influence affective state of subjects. The present study applied short-term RSD to investigate sex differences in the …