Experimental Analysis of Behavior Commons^™

Bisphenol-A Exposure During Adolescence Leads To Enduring Alterations In Cognition And Dendritic Spine Density In Adult Male And Female Rats, Rachel E. Bowman, Victoria N. Luine, Samantha Diaz Weinstein, Hameda Khandaker, Sarah Dewolf, Maya Frankfurt

Psychology Faculty Publications

We have previously demonstrated that adolescent exposure of rats to bisphenol-A (BPA), an environmental endocrine disrupter, increases anxiety, impairs spatial memory, and decreases dendritic spine density in the CA1 region of the hippocampus (CA1) and medial prefrontal cortex (mPFC) when measured in adolescence in both sexes. The present study examined whether the behavioral and morphological alterations following BPA exposure during adolescent development are maintained into adulthood. Male and female, adolescent rats received BPA, 40 μg/kg/bodyweight, or control treatments for one week. In adulthood, subjects were tested for anxiety and locomotor activity, spatial memory, non-spatial visual memory, and sucrose preference. Additionally, …