Experimental Analysis of Behavior Commons^™

Impact Of Adolescent Social Isolation On Adult, Binge-Like Ethanol Consumption And Plasma Corticosterone In High-Alcohol-Preferring Mice, Eva Cullins

The Journal of Purdue Undergraduate Research

Adolescent stress exposure increases the likelihood of alcohol misuse and alcohol use disorder (AUD) in adulthood; however, it is not clear how genetic and environmental factors interact to increase risk. This study examined how adolescent social isolation affects adult binge-like ethanol drinking and levels of the stress hormone corticosterone in male and female mice with a genetic predisposition toward high alcohol preference (HAP). Twenty-eight HAP mice were separated into group-housed (GH) and socially isolated (SI) conditions (n = 13, 13). Binge drinking was assessed using a drinking in the dark (DID) procedure. Blood samples were taken before DID and after …