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Experimental Analysis of Behavior Commons

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Full-Text Articles in Experimental Analysis of Behavior

Alterations To Taste Preference In Mc4r Haploinsufficiency Manifest Prior To Dietary Induced Obesity And Are Accompanied By Dendritic Spine Alterations To Medium Spiny Neurons Of The Nucleus Accumbens In Adulthood, Robert Francis Roscoe Jr. Dec 2014

Alterations To Taste Preference In Mc4r Haploinsufficiency Manifest Prior To Dietary Induced Obesity And Are Accompanied By Dendritic Spine Alterations To Medium Spiny Neurons Of The Nucleus Accumbens In Adulthood, Robert Francis Roscoe Jr.

Theses and Dissertations

Obesity has reached epidemic proportions in the United States and has become an increasing public health concern for developed nations. Haploinsufficiency of melanocortin receptor 4 has been identified as the single most common monogenetic cause of obesity in humans. Using the MC4R +/- haploinsufficient rat, we sought to determine potential alterations in body weight and morphology, locomotor activity, sucrose concentration preference, and progressive-ratio operant testing in a dietary-induced obesity environment. Rats were placed on four separate diets corresponding to 1.7% saturated fat with 12.2% total kcal/fat, 6% saturated fat with a 40% total kcal/fat, 12% saturated fat with a 40% …


Generalization Of Fear Effects In Reinstatement To A Discrete Stimulus, Lauren Best Aug 2014

Generalization Of Fear Effects In Reinstatement To A Discrete Stimulus, Lauren Best

USC Aiken Psychology Theses

The purpose of this study was to investigate generalization of reinstated fear effects to a discrete stimulus. McAllister and McAllister (2006) reported that reinstated fear could generalize over time to similar contexts. The present study aimed to determine if reinstated fear could generalize to similar or different stimuli than conditioning after a long delay between reinstatement and testing. Rat subjects were randomly assigned to six groups (n = 10) which received conditioning and extinction to a 3000 Hz tone. Reinstatement conditioning was then conducted with either the same, similar, or different CS as used in conditioning. Testing for reinstated fear …