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Full-Text Articles in Experimental Analysis of Behavior
Buprenorphine Effects On Anxiety-Like Behavior In B6 Mice, Megan K. Thibert
Buprenorphine Effects On Anxiety-Like Behavior In B6 Mice, Megan K. Thibert
Select or Award-Winning Individual Scholarship
Buprenorphine, a semi-synthetic opioid prescribed for the treatment of opioid use disorder (OUD), has been suggested as a potential pharmacological treatment for anxiety. Some preclinical and clinical studies provide support for the anxiolytic effects of buprenorphine, but research in this area is scarce, and findings to date have been mixed. The present study was designed to test the hypothesis that buprenorphine alters anxiety-like behavior in C57BL/IJ (B6) mice measured using the elevated zero maze (EZM). Adult, male mice (n=10) were given subcutaneous injections of saline (control) and three doses of buprenorphine (0.3, 1, and 10 mg/kg). One hour following injection, …
The Effects Of Venlafaxine And Voluntary Exercise On Chronic Unpredictable Stress Induced Anxiety, Marly Mcgowan
The Effects Of Venlafaxine And Voluntary Exercise On Chronic Unpredictable Stress Induced Anxiety, Marly Mcgowan
Senior Independent Study Theses
Anxiety disorders can impair cognition and emotional control, particularly in the face of novel situations, which is concerning due to the high prevalence of such diagnoses. Exposure to unpredictable chronic stress can provide a way to induce anxiety-like behaviors in rodents by disrupting the stress response systems, including the HPA axis and autonomic nervous system. Pharmacological treatments, including SNRIs like venlafaxine, and voluntary exercise are both anxiolytic treatments that can alleviate the impacts of chronic stress. Using unpredictable chronic stress to mimic the human condition, and exposure to venlafaxine and exercise to mitigate the stress, the open field and elevated …
Mechanisms Of Value-Biased Prioritization In Fast Sensorimotor Decision Making, Kivilcim Afacan-Seref
Mechanisms Of Value-Biased Prioritization In Fast Sensorimotor Decision Making, Kivilcim Afacan-Seref
Dissertations and Theses
In dynamic environments, split-second sensorimotor decisions must be prioritized according to potential payoffs to maximize overall rewards. The impact of relative value on deliberative perceptual judgments has been examined extensively, but relatively little is known about value-biasing mechanisms in the common situation where physical evidence is strong but the time to act is severely limited. This research examines the behavioral and electrophysiological indices of how value biases split-second perceptual decisions and the possible mechanisms underlying the process. In prominent decision models, a noisy but statistically stationary representation of sensory evidence is integrated over time to an action-triggering bound, and value-biases …
Reducing Subjectivity: Meditation And Implicit Bias, Diana M. Ciuca
Reducing Subjectivity: Meditation And Implicit Bias, Diana M. Ciuca
CMC Senior Theses
Implicit association of racial stereotypes is brought about by social conditioning (Greenwald & Krieger, 2006). This conditioning can be explained by attractor networks (Sharp, 2011). Reducing implicit bias through meditation can show the effectiveness of reducing the rigidity of attractor networks, thereby reducing subjectivity. Mindfulness meditation has shown to reduce bias from the use of one single guided session conducted before performing an Implicit Association Test (Lueke & Gibson, 2015). Attachment to socially conditioned racial bias should become less prevalent through practicing meditation over time. An experimental model is proposed to test this claim along with a reconceptualization of consciousness …