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Biomarkers Of Objective Criteria For Subtle Cognitive Decline In Parkinson’S Disease, Mary Ellen Garcia

Electronic Theses, Projects, and Dissertations

Mild cognitive impairment in Parkinson’s disease (PD-MCI) is the continuum from normal cognitive function to dementia. Recent studies suggest that objectively defined subtle cognitive decline (Obj-SCD), which uses non-traditional “process” neuropsychological scores, may be a better pathway to earlier detection of cognitive impairment. Obj-SCD has been defined as the stage where cognition is not impaired, but biomarkers are present or cognitive impairment is minimal but not sufficient to meet MCI or dementia criteria. We examined the longitudinal trajectories of neurodegenerative markers among individuals who are classified as cognitive normal (CN), Obj-SCD, and PD-MCI. Past literature has been inconsistent about the …