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Full-Text Articles in Clinical Psychology
Blood Phenylalanine Trajectory And Executive Function Outcomes In Individuals With Phenylketonuria, Clarissa Tardiff
Blood Phenylalanine Trajectory And Executive Function Outcomes In Individuals With Phenylketonuria, Clarissa Tardiff
Arts & Sciences Electronic Theses and Dissertations
Phenylketonuria (PKU) is an autosomal recessive disorder characterized by mutations in phenylalanine hydroxylase genes. As a result, phenylalanine (Phe) metabolism is disrupted, and this amino acid accumulates in blood and tissue (Pietz, 1998; Scriver et al., 2000). Although the most severe symptoms of PKU may be avoided by early detection and treatment, many individuals with early-treated PKU still experience difficulties in executive function, attention, and processing speed (Antenor-Dorsey et al., 2013; Araujo et al., 2013; Christ et al., 2020; Hawks, Strube, Johnson, Grange, & White, 2018; Hood, Grange, Christ, Steiner, & White, 2014; Janos et al., 2012; White et al., …
Developmental Trajectories Of Executive And Verbal Processes In Children With Phenylketonuria, Zoe Hawks
Developmental Trajectories Of Executive And Verbal Processes In Children With Phenylketonuria, Zoe Hawks
Arts & Sciences Electronic Theses and Dissertations
Phenylketonuria (PKU) is a recessive disorder characterized by disruption in the metabolism of the amino acid phenylalanine. Using a verbal fluency task, previous studies demonstrated that word production is reduced in individuals with PKU relative to controls. Beyond word production, verbal fluency output can be scored for clustering and switching, which enable characterization of verbal and executive processes, respectively. The present study is the first to evaluate clustering and switching in PKU within a longitudinal design, thereby elucidating the developmental time course of core cognitive processes. To this end, semantic (animals, food/drink) and phonemic (S words, F words) fluency data …