Psychology Commons^™

Repeated Treatment With 5-Ht1a And 5-Ht1b Receptor Agonists: Evidence Of Tolerance And Behavioral Sensitization, Jordan Taylor

Electronic Theses, Projects, and Dissertations

Serotonin has been found to regulate several cognitive and physiological functions, and its role in depression and other neuropsychiatric disorders has been a focus of research. More specifically, a wealth of research regarding serotonin focuses on serotonergic medications in the treatment of neuropsychiatric disorders, such as depression and anxiety, and stimulates the 5-HT_1A and 5-HT_1B receptors. Within the last decade, there has been an increase in prescriptions of psychotropic medication for children, however, the efficacy and adverse effects of these drugs have not been evaluated in younger populations. While antidepressants reduce symptoms of depression in adults, they are …

Selectivity And Sociality: Aggression And Affiliation Shape Vole Social Relationships, Nicole S. Lee, Annaliese K. Beery

Psychology: Faculty Publications

The formation of selective social relationships is not a requirement of group living; sociality can be supported by motivation for social interaction in the absence of preferences for specific individuals, and by tolerance in place of social motivation. For species that form selective social relationships, these can be maintained by preference for familiar partners, as well as by avoidance of or aggression toward individuals outside of the social bond. In this review, we explore the roles that aggression, motivation, and tolerance play in the maintenance of selective affiliation. We focus on prairie voles (Microtus ochrogaster) and meadow voles (Microtus pennsylvanicus) …

The Lived Experiences Of Muslim Americans Regarding Prejudice And Discrimination By Non-Muslims, Munder Abderrazzaq

Walden Dissertations and Doctoral Studies

Opposition to Muslim Americans in the United States is openly expressed by majority members, which includes profiling and a recent presidential campaign proposing a “ban on Muslims.” There is a lack of qualitative studies in the United States that explore minorities’ point of view of about the tolerance displayed by majority members. Tolerance involves a degree of restraint about the disapproval and dislike of others of different religious, racial, political, and cultural backgrounds. This limits the ability to develop and implement appropriate policies that are needed to promote positive social change. In this phenomenological study, semistructured interviews were used to …

Effects Of Acute And Chronic Nicotine Administration On Choice Of Probabilistic Outcomes, Katya A. Nolder

Graduate Theses, Dissertations, and Problem Reports

Risky choice can be operationally defined as the choice for a larger, uncertain reinforcer over a smaller, certain reinforcer. Research suggests smokers engage in more risky or maladaptive decisions when compared to nonsmokers. The relation between nicotine and risky choice could benefit from further investigation, since nicotine is the active substance of tobacco products that maintains tobacco addiction. Acute nicotine administration has shown to alter risky choice; however, since the everyday smoker uses nicotine repeatedly, more research on chronic administration is warranted and would allow for assessment of tolerance or sensitization of these effects. The present study investigated effects of …

Acute Sensitivity And Tolerance To Alcohol As Predictors Of At-Risk Drinking, Holley Allen

Theses and Dissertations--Psychology

Laboratory studies have reliably shown that reduced sensitivity to alcohol’s subjective intoxicating effect is associated with heavier drinking. More recently, there has been research to suggest that heightened sensitivity to the disinhibiting effects of alcohol might also contribute to at-risk drinking. Most research on the acute effects of alcohol has focused on drinking magnitudes averaged across participants with little attention to how individual differences influence abuse potential. This study overcomes previous limitations by testing the degree to which individual differences in acute sensitivity and tolerance to the subjective intoxicating and disinhibiting effects of alcohol predict drinking behavior in a large …

The Modulation Of Reward To Nicotine And Ethanol By Sex And Stage Of Exposure, Kyle L. Dixon

Psychology ETDs

Tobacco and alcohol are among the most widely used and abused drugs in America, resulting in disastrous health consequences and a massive resource drain on society. Nicotine (the primary reinforcing component in tobacco) and alcohol are often used together, though there is limited research on exposure to both drugs at the same time. The present study attempted to fill this gap in knowledge by examining the reward for a cocktail of nicotine and alcohol in male and female Long-Evans rats with differing histories of drug exposure. The conditioned place preference paradigm was used to examine the effects of sex as …

Intramuscular Route Of Administration Increases Potency In Eliciting Cocaine-Induced Behavioral Sensitization, Beth Ann Rice, Raza Tariq, Chana K. Akins

Psychology Faculty Publications

Background: Cocaine is the number one abused psychostimulant drug that reaches addiction criterion in the US. In animals, repeated administration of cocaine results in behavioral sensitization which is thought to represent adaptations in the mesolimbic dopamine neural circuitry, the reward pathway. Cocaine-induced behavioral sensitization is evident in rodents and quail when cocaine is administered intraperitoneally (IP).

Objective: The purpose of the current study was to investigate dose-dependent and temporal effects of acute and chronic intramuscular (IM) administration of cocaine in male quail.

Method: After habituation to the test chambers, male quail received an IM injection of saline, 3 or 10 …

Antipsychotic-Induced Sensitization And Tolerance: Behavioral Characteristics, Developmental Impacts, And Neurobiological Mechanisms, Ming Li

Department of Psychology: Faculty Publications

Antipsychotic sensitization and tolerance refer to the increased and decreased drug effects due to past drug use, respectively. Both effects reflect the long-term impacts of antipsychotic treatment on the brain and result from the brain’s adaptive response to the foreign property of the drug. In this review, clinical evidence of the behavioral aspect of antipsychotic sensitization and tolerance is selectively reviewed, followed by an overview of preclinical literature that examines these behavioral characteristics and the related pharmacological and nonpharmacological factors. Next, recent work on the developmental impacts of adolescent antipsychotic sensitization and tolerance is presented and recent research that delineates …

Effects Of Repeated Quetiapine Treatment On Conditioned Avoidance Responding In Rats, Jun Gao, Min Feng, Natashia Swalve, Collin Davis, Nan Sui, Ming Li

Department of Psychology: Faculty Publications

The present study characterized the behavioral mechanisms of avoidance–disruptive effect of quetiapine in the conditioned avoidance response test under two behavioral testing (2 warning signals vs. 1 warning signal) and two drug administration conditions (subcutaneous vs. intravenous). In Experiments 1 and 2, well-trained adult male Sprague-Dawley rats were tested under the subcutaneous (s.c.) quetiapine treatment (5.0, 15.0, 25.0, 50.0 mg/kg) for 7 days in a novel procedure consisting of two conditioned stimuli (CS) (white noise serving as CS1 and pure tone as CS2). Only the highest dose (50.0 mg/kg) produced a persistent suppression of the avoidance response without impairing the …

Repeated Administration Of Aripiprazole Produces A Sensitization Effect In The Suppression Of Avoidance Responding And Phencyclidine-Induced Hyperlocomotion And Increases D2 Receptor-Mediated Behavioral Function, Jun Gao, Rongyin Qin, Ming Li

Department of Psychology: Faculty Publications

The present study investigated how repeated administration of aripiprazole (a novel antipsychotic drug) alters its behavioral effects in two behavioral tests of antipsychotic activity and whether this alteration is correlated with an increase in dopamine D₂ receptor function. Male adult Sprague-Dawley rats were first repeatedly tested with aripiprazole (3, 10 and 30 mg/kg, subcutaneously (sc)) or vehicle in a conditioned avoidance response (CAR) test or a phencyclidine (PCP) (3.20 mg/kg, sc)-induced hyperlocomotion test daily for five consecutive days. After 2–3 days of drug-free retraining or resting, all rats were then challenged with aripiprazole (1.5 or 3.0 mg/kg, sc). Repeated …

Repeated Effects Of The Neurotensin Receptor Agonist Pd149163 In Three Animal Tests Of Antipsychotic Activity: Assessing For Tolerance And Cross-Tolerance To Clozapine, Shinnyi Chou, Collin Davis, Sean Jones, Ming Li

Department of Psychology: Faculty Publications

Neurotensin is an endogenous neuropeptide closely associated with the mesolimbic dopaminergic system and shown to possess antipsychotic-like effects. In particular, acute neurotensin receptor activation can inhibit conditioned avoidance response (CAR), attenuate phencyclidine (PCP)-induced prepulse inhibition (PPI) disruptions, and reverse PCP-induced hyperlocomotion. However, few studies have examined the long term effects of repeated neurotensin receptor activation and results are inconsistent. Since clinical administration of antipsychotic therapy often requires a prolonged treatment schedule, here we assessed the effects of repeated activation of neurotensin receptors using an NTS1 receptor selective agonist, PD149163, in 3 behavioral tests of antipsychotic activity. We also investigated whether …

Effect Of Environmental Cues On Behavioral Efficacy Of Haloperidol, Olanzapine And Clozapine In Rats, Tao Sun, Xinfeng Liu, Ming Li

Department of Psychology: Faculty Publications

Previous studies have reported that context can powerfully modulate the inhibitory effect of an antipsychotic drug on phencyclidine (PCP)-induced hyperlocomotion (a behavioral test used to evaluate putative antipsychotic drugs). The present study investigated the experimental conditions under which environmental stimuli exert their influence through associative conditioning processes. Experiment 1 examined the extent to which prior antipsychotic treatment in the home cages affected a drug’s ability to inhibit PCP-induced hyperlocomotion in a novel motor activity test apparatus. Five days of repeated haloperidol (0.05 mg/kg, sc) and olanzapine (2.0 mg/kg, sc) treatment in the home cages still potentiated their inhibition of PCP-induced …

Predicting Alcohol Consumption In Adolescent Rhesus Macaques (Macaca Mulatta), Andrea Nichole Sorenson

Theses and Dissertations

Numerous studies show that a low level of response to the intoxicating effects of alcohol is considered a risk factor for future alcoholism. However, assessing this sensitivity usually requires administering a controlled dose of alcohol, which has a number of inherent problems. Early observations in our lab suggest that the response to anesthetics that show cross tolerance with alcohol, like ketamine, are blunted in nonhuman primates at risk for high alcohol intake, and may be a viable measure of future alcohol consumption. This study was designed to test potential predictors of future alcohol consumption using the change in ketamine across …

Expertise, Democratic Values, And Tolerance, Erika D. Price

Dissertations

Political tolerance (the willingness to extend civil liberties to disliked groups) has been disturbingly low among the American public since measurement of tolerance began in the 1950's. The few voters who do exhibit tolerant attitudes tend to be people who know a great deal about politics (i.e. people high in "political expertise"). Researchers have theorized many explanations for why political experts are more tolerant on average; for example, experts may place more value on the legal and normative `rules' of democracy (i.e. "democratic norms"), which guarantee free speech, or they may consider democratic norms to be more important than non-experts …

Adult Response To Olanzapine Or Clozapine Treatment Is Altered By Adolescent Antipsychotic Exposure: A Preclinical Test In The Phencyclidine Hyperlocomotion Model, Qing Shu, Gang Hu, Ming Li

Department of Psychology: Faculty Publications

This study examined how repeated olanzapine (OLZ) or clozapine (CLZ) treatment in adolescence alters sensitivity to the same drug in adulthood in the phencyclidine (PCP) hyperlocomotion model. Male adolescent Sprague-Dawley rats (postnatal day (P) 44–48) were first treated with OLZ (1.0 or 2.0 mg/kg, subcutaneously (sc)) or CLZ (10.0 or 20.0 mg/kg, sc) and tested in the PCP (3.2 mg/kg, sc)-induced hyperlocomotion model for five consecutive days. Then a challenge test with OLZ (0.5 mg/kg) or CLZ (5.0 mg/kg) was administered either during adolescence (~P 51) or after the rats matured into adults (~P 76 and 91). During adolescence, repeated …

Examining The Vulnerability Of Inhibitory Control To The Impairing Effects Of Alcohol, Melissa A. Miller

Theses and Dissertations--Psychology

There is growing evidence that acute changes in fundamental mechanisms of impulse control contribute to the transition from social drinking to abusive drinking. One component of impulsivity concerns the ability to inhibit maladaptive behaviors (i.e., inhibitory control). Inhibitory mechanisms are reliably shown to be sensitive to the impairing effects of alcohol, and studies have begun to show that this impairment fails to recover at the same speed as other aspects of behavior. However, the degree to which inhibitory control develops tolerance to alcohol has only been examined under limited conditions. This dissertation consists of three studies examining contexts in which …

Repeated Asenapine Treatment Produces A Sensitization Effect In Two Preclinical Tests Of Antipsychotic Activity, Rongyin Qin, Yingzhu Chen, Ming Li

Department of Psychology: Faculty Publications

Among several commonly used atypical antipsychotic drugs, olanzapine and risperidone cause a sensitization effect in the conditioned avoidance response (CAR) and phencyclidine (PCP)- induced hyperlocomotion paradigms – two well established animal tests of antipsychotic drugs, whereas clozapine causes a tolerance effect. Asenapine is a novel antipsychotic drug recently approved for the treatment of schizophrenia and manic disorders. It shares several receptor binding sites and behavioral features with other atypical antipsychotic drugs. However, it is not clear what type of repeated effect (sensitization or tolerance) asenapine would induce, and whether such an effect is transferrable to other atypicals. In this study, …

The Role Of Distress Tolerance In Aggressive Behavior, Anne Winston Mcintyre

Dissertations

Berkowitz (1989) proposed that the degree of negative affect experienced following a frustrating event determines whether one will respond aggressively, suggesting that one possesses a certain amount of tolerance for distressing emotions. However, little research has been conducted on the relation between distress tolerance and aggression. Moreover, no published study has examined the relation between distress tolerance and behavioral aggression using a multi-modal assessment approach, nor examined the potential mediating role of negative affect in the relation between distress tolerance and aggression. To address this gap in the literature, college students (N = 87) aged 18 to 49 years (M …

Some Personality Predictors Of Tolerance To Human Diversity: The Roles Of Openness, Agreeableness And Empathy, Rivka Witenberg, Ninawa Butrus

Rivka T Witenberg Dr

The aim of this study was to determine the most salient predictors of tolerance to human diversity. A total of 118 individuals (M = 32.93 years, SD = 13.80) responded to dilemma-like stories involving holding prejudicial beliefs (beliefs), talking about them (speech) and acting on them (acts). Participants also completed the Openness and Agreeableness scales from the Big Five Inventory and the Interpersonal Reactivity Index. Differences in tolerance judgements were found to be related to differences in personality characteristics. Results showed that Openness and Agreeableness were predictors of tolerance in the belief dimension; whereas the most salient predictor of tolerance …

Environmental And Behavioral Controls Of The Expression Of Clozapine Tolerance: Evidence From A Novel Across-Model Transfer Paradigm, Min Feng, Nan Sui, Ming Li

Department of Psychology: Faculty Publications

Repeated administration of antipsychotic drugs induces a sensitization-like or tolerance-like effect in many behavioral tasks, including the conditioned avoidance response (CAR) and the phencyclidine (PCP)-induced hyperlocomotion, two rodent models with high predictive validity for antipsychotic activity. This study investigated the impacts of contextual and behavioral variables on the expression of clozapine tolerance using a recently validated across-model transfer paradigm (Zhang and Li, 2012). Male Sprague-Dawley rats were first repeatedly treated with clozapine (2.5–10.0 mg/kg, sc) in the CAR model or PCP (1.6 mg/kg, sc)-induced hyperlocomotion model for five consecutive days. They were then tested for the expression of clozapine tolerance …

Olanzapine Sensitization And Clozapine Tolerance: From Adolescence To Adulthood In The Conditioned Avoidance Response Model, Jing Qiao, Hong Li, Ming Li

Department of Psychology: Faculty Publications

Disruption of conditioned avoidance response (CAR) in rodents is one trademark feature of many antipsychotic drugs. In adult rats, repeated olanzapine (OLZ) treatment causes an enhanced disruption of avoidance response (sensitization), whereas repeated clozapine (CLZ) treatment causes a decreased disruption (tolerance). The present study addressed (1) whether OLZ sensitization and CLZ tolerance can be induced in adolescent rats, and (2) the extent to which OLZ sensitization and CLZ tolerance induced in adolescence persists into adulthood. Male adolescent Sprague–Dawley rats (approximate postnatal days (BP) 43–47) were first treated with OLZ (1.0 or 2.0 mg/kg, subcutaneously (sc)) or CLZ (10 or 20 …

Tolerance To The Impairing Effects Of Alcohol On The Inhibition And Activation Of Behavior, Erik Wayne Ostling

University of Kentucky Master's Theses

Moderate doses of alcohol impair response inhibition activation. Recent work has shown that, during a single dose, response inhibition recovers from the impairing effects of alcohol more slowly than response activation. Evidence for a lag in tolerance development to inhibitory versus activational mechanisms suggests that, as blood alcohol declines, drinkers’ response inhibition might continue to be impaired, despite the recovery of response activation. However, this has not been studied across repeated doses. This study examined how cross-session tolerance to alcohol develops differentially between response activation and inhibition. Thirty-two healthy adults performed a cued go/no-go task that measured response activation and …

The Development Of Context-Specific Operant Sensitization To D-Amphetamine, Wesley Paul Thomas

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Animal models have previously been used to study tolerance and sensitization using two different procedures that are difficult to compare. Tolerance has been studied by administering a drug to a subject that is engaged in an operant behavior, and sensitization by administering a drug to a subject that is not engaged in an operant behavior. Previous research has shown that sensitization can occur when d-amphetamine is administered to rats emitting an operant behavior for a food presentation. The first goal of the experiment was to show operant sensitization using dose response curves. The second goal of the present experiment was …

The Moral Dimension Of Children’S And Adolescents’ Conceptualisation Of Tolerance To Human Diversity, Rivka Witenberg

Rivka T Witenberg Dr

This study examined the kinds of justifications children and adolescents used to support tolerant and intolerant judgements about human diversity. For the tolerant responses, three main belief categories emerged, based on the beliefs that others should be treated fairly (fairness), empathetically (empathy) and that reason/logic ought to govern judgements (reasonableness). Fairness emerged as the most used belief to support tolerant judgements and the most commonly used combination of beliefs was found to be fairness/empathy, linking tolerance to moral reasoning, rules, and values. Specifically noticeable was that 6 to 7 year olds appealed to fairness more often in comparison to the …

A Different Kind Of Sameness: Beyond Formal Equality And Antisubordination Principles In Gay Legal Theory And Constitutional Doctrine, Nancy Levit

Nancy Levit

Gay legal theory is at a crossroads reminiscent of the sameness/difference debate in feminist circles and the integrationist debate in critical race theory. Formal equality theorists take the heterosexual model as the norm and then seek to show that gays, lesbians, bisexuals, and transsexuals - except for their choice of partners - are just like heterosexuals. Antisubordination theorists attack the heterosexual model itself and seek to show that a society that insists on such a model is unjust. Neither of these strategies is wholly satisfactory. The formal equality model will fail to bring about fundamental reforms as long as sexual …

A Comparison Of White Male College Students Attending An Urban Black University And An Urban White University: White Racial Identity And Perceived Comfort With Blacks, Cheryl Lorraine Evans

Theses and Dissertations in Urban Services - Urban Education

The purpose of this study was to determine the difference in White Racial Identity and degree of tolerance for Blacks between two samples of White male undergraduate students attending an urban Black university and those attending an urban White university. The theoretical framework for this study was based in Social Contact Theory as a contributor to racial tolerance and Racial Identity Development Theory as a factor in human growth toward increasing acceptance of diversity. This was a quasi-experimental post-hoc design using intact groups.

The study analyzed the responses of 182 White male undergraduates using three instruments. A Background Questionnaire, designed …

An Examination Of Operant-Respondent Interaction In The Development Of Tolerance To Ethanol, Brady Justin Phelps

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

In four experiments, pigeons performed on schedules of food reinforcement across two different contexts. One context consisted of having the operant chamber fully illuminated, with increased noise levels, and reflective aluminum foil draped over the chamber sidewalls. This context was paired with oral injections of water. Another context consisting of having the chamber dark except for response keylight and at ambient noise levels was paired with oral injections of ethanol. Ethanol dosages were determined by using a dose that doubled the average variable-ratio postreinforcement pause. These procedures established the dark context as a conditioned stimulus capable of producing Pavlovian conditioned …