Psychology Commons^™

Triple-Negative Breast Cancer Survivors: Post-Traumatic Stress Disorder, Post-Traumatic Growth, Quality Of Life, And Unmet Mental Health Needs, Carla Horton Gray

Doctoral Dissertations and Projects

The purpose of this mixed-method study was to investigate levels of PTSD, PTG, QOL, their relationships, and unmet mental health needs of triple-negative breast cancer survivors diagnosed between stages 2b-4 and 2-5 years post-treatment. Participants were recruited through two cancer organizations, breast health navigators, TNBC support groups, and online breast cancer support groups. Sixty-one participants completed the PTSD Checklist-Civilian Version (PCL-C), Post-Traumatic Growth Inventory, and the Functional Assessment of Cancer Therapy-Breast (FACT-B). Thirty participants completed the optional short answer questions about unmet mental health needs. Participants’ mean score of 48 (SD=12.22) on the PCL-C was higher than 44, PTSD scores …

The Role Of Psychological Distress In Maintaining Exercise After Cancer Diagnosis, Patrick Tertulien

Walden Dissertations and Doctoral Studies

AbstractCancer affects the lives of thousands of people every day and is a leading cause of death. Exercise has been shown to yield mental and physical benefits for patients and survivors, but the experiences of cancer patients who face a multiplicity of psychological stressors have not been clearly described. The purpose of this qualitative study was to understand the psychological factors that are associated with continuing to exercise after cancer diagnosis, during and/or following their treatment. The focus was on how cancer survivors maintained a regular routine of exercise while experiencing psychological distress associated with cancer diagnosis, treatment, and concerns …

Electrophysiological Biomarkers Of Chemotherapy-Related Cognitive Impairment In Hematological Malignancy Patients, David E. Anderson

Theses & Dissertations

Multiple cancer populations frequently report cognitive impairment following treatment with chemotherapy agents (“chemo-brain”). Impaired neuropsychological performance is commonly reported in cognitive domains of attention and executive function. Understanding neural mechanisms underlying cognitive impairments is essential to developing prevention and rehabilitation strategies. Brain imaging studies frequently show chemotherapy-related impairments within the attentional control network, which is comprised of a constellation of cortical regions that govern reportedly impaired cognitive functions. In the current dissertation research, I developed a novel electrophysiology battery aimed at recording near-instantaneous neural activity within the attentional control network during cognitive task performance. Cancer patients diagnosed with hematological malignancy …

An Analysis Of Neurogenesis In A Mouse Model Of Chemotherapy Related Cognitive Impairment, Maxwell A. Hennings

Electronic Theses and Dissertations

Cancer patients treated with adjuvant chemotherapy often experience cognitive decline following treatment. This phenomenon, often dubbed “chemo brain” or “chemo fog” is usually temporary, but for a subset of survivors, these cognitive impairments can be long-lasting (>10 years) and negatively affect patients’ quality of life, career performance, and social fulfillment. While it is unclear what neurobiological mechanisms underlie chemotherapy related cognitive impairment, the majority of the animal literature has focused on adult neurogenesis. One process important for neurogenesis is the proliferation of new neurons within the dentate gyrus of the hippocampus. It is evident that many chemotherapy agents can …

Do Negative Expectations Affect Self-Reported Cognitive Functioning And Treatment Satisfaction After Chemotherapy Treatment For Cancer?, Brook Elizabeth Clark

Graduate Student Theses, Dissertations, & Professional Papers

This study investigated the effect of negative expectations on self-reports of cognitive functioning, treatment satisfaction, and endorsement of a common, negative chemotherapy-related stereotype in 56 adults who had completed systemic chemotherapy for cancer treatment. Participants were assigned to either a negative expectation group or a control group. The negative expectation group had the relationship between chemotherapy and cognitive deficits overtly brought to their attention, while the control group did not. Both groups completed self-report measures of cognitive functioning and treatment satisfaction, and then rated their degree of identification with a chemotherapy-related stereotype. It was hypothesized that the experimental group would …

The Long-Term Impact Of Chemotherapy On Neurogenesis And The Potential Use Of Fluoxetine As Preventative Treatment, Margaret Ross

Honors College

The present study attempts to investigate a potential underlying mechanism that contributes to cognitive impairments associated with chemotherapy treatment. In addition, it looks to investigate the potential preventative treatment using an antidepressant agent (Fluoxetine) to reduce the effects observed by chemotherapy treatment. One proposed explanation for Chemo Brain is a reduction in the proliferation of new brain cells. This study was designed to investigate this mechanism and was conducted in a series of two experiments. In experiment 1, 37 C57BL/6J male mice were administered saline or one of two chemotherapy agents; Cyclophosphamide or Doxorubicin over the course of eight days. …

Disruption Of White Matter Integrity In Adult Survivors Of Childhood Brain Tumors: Correlates With Long-Term Intellectual Outcomes, Tricia Z. King, Liya Wang, Hui Mao

Psychology Faculty Publications

Background

Although chemotherapy and radiation treatment have contributed to increased survivorship, treatment-induced brain injury has been a concern when examining long-term intellectual outcomes of survivors. Specifically, disruption of brain white matter integrity and its relationship to intellectual outcomes in adult survivors of childhood brain tumors needs to be better understood.

Methods

Fifty-four participants underwent diffusion tensor imaging in addition to structural MRI and an intelligence test (IQ). Voxel-wise group comparisons of fractional anisotropy calculated from DTI data were performed using Tract Based Spatial Statistics (TBSS) on 27 survivors (14 treated with radiation with and without chemotherapy and 13 treated without …

The Effect Of Patient Education On Anxiety Levels In Patients Receiving Chemotherapy For The First Time, Sarah Garcia

Evidence-Based Practice Project Reports

Cancer affects approximately 1.5 million people every year throughout the United States.Comprehensive care that includes psychosocial aspects is important to help patients effectively adapt to their diagnosis and treatment plan. Improper prevention and management of anxiety can lead to poor psychosocial outcomes, dissatisfaction with care, and decreased adherence to treatment. Current evidence suggests that education is effective at helping reduce anxiety in patients receiving chemotherapy for the first time. The purpose of this evidenced based practice project was to determine if nurse-led patient education regarding chemotherapy side effects, side-effect management, and orientation to the infusion center was effective at decreasing …

Long Term Effects Of Chemotherapy On Cognition, Preventative Potential Of Antidepressants, Ryan Hall

Honors College

Each year, over 1.6 million people in the U.S. alone will be diagnosed with some form of cancer. With advances in treatment, survival rates have risen to nearly 65%. While remission and survival are the ultimate goals of treatment, it has become clear that many cancer survivors (estimates range from 15% to 70%) treated with chemotherapy experience significant, long-lasting cognitive impairment. This chemotherapy associated cognitive impairment is often called "Chemo Fog" or "Chemo Brain." For some, the effects are mild, such as having difficulty with focusing, concentrating, and speed of processing. For others, the cognitive impairments can be significant and …

Neurocognitive Outcomes In Children Experiencing Seizures During Treatment For Acute Lymphoblastic Leukemia, Stephanie L. Nassar

Electronic Theses and Dissertations

There is a growing literature for cognitive late effects among childhood cancer survivors, yet little empirical information is known regarding specific neurocognitive outcomes of children who experience seizures while treated for acute lymphoblastic leukemia. This study examined prevalence of on-protocol seizures, seizure risk factors, and neurocognitive change in children with therapy-related seizures in comparison to the normative sample and a matched cohort of children without on-protocol seizures. Participants included children enrolled on the St. Jude frontline leukemia treatment protocol, Total Therapy 15 (TOTXV) - the first systematic investigation of intensified chemotherapy agents plus optimal intrathecal therapy without irradiation. Out of …