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The Effect Of Delta9-Tetrahydrocannabinol (Thc) And Cb1 Antagonists On Sucrose And Quinine Palatability: Direct Measurement With The Taste Reactivity Test, Maegan Jarrett
Theses and Dissertations (Comprehensive)
Anecdotal reports suggest that cannabinoid agonists enhance palatability and that antagonists reduce palatability; however there has been little direct experimental evidence for these claims. The taste reactivity (TR) test is a direct measure of palatability in rats (Grill & Norgren, 1978). In Experiments 1 and 4, the taste reactivity (TR) test was used to evaluate the potential of delta-9-tetrahydrocannabinol (THC) to modify both sucrose and quinine palatability. The TR test revealed that THC (0.5 mg/kg) increases the palatability of sucrose solutions at 120 min post-injection, regardless of the sucrose concentration. THC (0.5 mg/kg) also decreased the aversiveness of the quinine …