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Articles 1 - 29 of 29
Full-Text Articles in Psychology
Vapourized Cannabis Extract Administration Impairs Memory And Alters Neural Activity In Laboratory Rats, Megan Chladny
Vapourized Cannabis Extract Administration Impairs Memory And Alters Neural Activity In Laboratory Rats, Megan Chladny
Theses and Dissertations (Comprehensive)
Although people have smoked cannabis for millennia, administration of cannabis by heating the dried plant material or distilled extracts to a temperature just below the combustion point (i.e., vapourization or "vaping") has rapidly increased over the past few years (Javadi-Payder, Cole, and Taffe, 2018; Manwell, Charchoglyan, Brewer, Matthews, Heipel, and Mallet, 2014). Conversely, most of the cannabinoid research using rodent models has used parenteral routes of administration to examine the effects of purified cannabis extracts such as ∆9-tetrahydrocannabinol (THC), making it difficult to directly compare laboratory research to human drug use. Building on previous studies showing that THC …
Spatial Memory And Executive Functioning In The Goto-Kakizaki Rat Model Of Diabetes, Lorielle Dietze
Spatial Memory And Executive Functioning In The Goto-Kakizaki Rat Model Of Diabetes, Lorielle Dietze
Theses and Dissertations (Comprehensive)
Type 2 diabetes mellitus is a disease that adversely affects cognitive function in areas extending to memory and executive functioning. The Goto-Kakizaki (GK) rat provides a model of type 2 diabetes that can illustrate the mechanisms by which this disease works. The present study compared hyperglycaemic GK rats and age-matched Wistar rats in the Morris water maze to assess spatial memory, and in a perceptual attentional set-shifting task to assess putative prefrontal-dependent executive functioning. Results showed there was no difference in path length during training trials, however, GK and Wistar rats differed in the path length travelled in the target …
Age, Access, And Sweets-Motivation, Gehan Senthinathan
Age, Access, And Sweets-Motivation, Gehan Senthinathan
Theses and Dissertations (Comprehensive)
Availability can have profound influence on the consumption of foods and drinks. The 2-phase intermittent-continuous protocol (ICP) examines sucrose solution intake in two groups of rats and finds intermittent access significantly increases intake. In Phase I, rats receive intermittent or continuous access to a 4% sucrose solution, and with adults this results in a long-term elevation (a doubling) in the intermittent group. In Phase II, when rats are shifted to common sucrose schedule, this difference is maintained. Adult rats given 16% sucrose in Phase I do not differ in consumption, but in Phase II with 4% sucrose, an unexpressed elevation …
Team Member Hormone Profiles And Group Cohesion, David Webster
Team Member Hormone Profiles And Group Cohesion, David Webster
Theses and Dissertations (Comprehensive)
Group cohesion in sport is associated with many positive outcomes for the team as a whole, as well as for the individuals. Hence, it is important to understand the antecedents of cohesion in various contexts, including sport. One antecedent that has yet to be examined in a sports context pertains to biological factors; specifically, the interaction of testosterone and cortisol levels. The dual-hormone hypothesis posits that testosterone levels are associated with status attainment for both individuals and groups, but only amongst those with low cortisol levels. Based on previous literature, a high testosterone-low cortisol hormonal profile should be associated with …
Investigating The Roles Of Mechanoreceptive Channels In Tactile Apparent Motion Perception: A Vibrotactile Study, Phill Kim, Philip Servos Dr.
Investigating The Roles Of Mechanoreceptive Channels In Tactile Apparent Motion Perception: A Vibrotactile Study, Phill Kim, Philip Servos Dr.
Theses and Dissertations (Comprehensive)
Tactile apparent motion (TAM) is a perceptual phenomenon in which consecutive presentation of multiple tactile stimuli creates an illusion of motion. Employing a novel tactile display device, the Latero, allowed us to investigate this. The current study focused on the Rapidly Adapting (RA) channel and Slowly Adapting I (SAI) channel on the index finger. The experiment implemented vibrotactile masking stimuli to target the mechanoreceptive channels with the goal of gaining better insight into the involvement of mechanoreceptive channels in the perception of TAM. Masking stimuli were used because previous studies have used them to differentiate between different channels; a …
Social Problems, Biomedical Answers? How Causes Of Social Problems Affect Choice Of Solutions, Bianca C. Dreyer
Social Problems, Biomedical Answers? How Causes Of Social Problems Affect Choice Of Solutions, Bianca C. Dreyer
Theses and Dissertations (Comprehensive)
With rapid advances in behavioural genetics, scientists are identifying an increasing array of genetic influences on human behaviour. Public misconceptions about the function of genes often lead to the oversimplification of the role of genes in behaviour (Dar-Nimrod & Heine, 2011). To date, no study has systematically investigated whether simply learning about genetic causes of behaviour affects people’s preferred solutions to problematic behaviours. The present research program includes three studies that were designed to examine the psychological effects of exposure to genetic etiology for problematic behaviour, in particular aggression, and investigated how this information influences endorsement of solutions, rating of …
Age-Related Changes In Hippocampal Arc Expression Following Minimal Behavioural Induction, Irina V. Odintsova
Age-Related Changes In Hippocampal Arc Expression Following Minimal Behavioural Induction, Irina V. Odintsova
Theses and Dissertations (Comprehensive)
Normal ageing is associated with significant changes in cognitive function, including the decline of some forms of memory. The hippocampal formation is critical to learning and memory function, and plasticity in this region declines with age. Additionally, age-related differences in plasticity are greatest at lower levels of stimulation, thus peri-threshold plasticity may be of the greatest relevance for age-related changes in cognition. Moreover, the hippocampus is prone to changes in the expression of gene products that mediate plasticity with age. The current thesis attempts to link these observations by measuring hippocampal expression of Arc, an immediate-early gene that is critical …
A Bittersweet Investigation Of Availability And Nutritive Value As Determinants Of Volitional Sucrose Consumption, Milan D. Valyear
A Bittersweet Investigation Of Availability And Nutritive Value As Determinants Of Volitional Sucrose Consumption, Milan D. Valyear
Theses and Dissertations (Comprehensive)
Rats given ~24 h access to a 4% sucrose solution every 3rd day (E3DA) consume about 100 g more solution than rats with continuous, everyday access (EDA). Under the same EDA-E3DA conditions rats will consume similar amounts of a more concentrated 8 or 16% sucrose solutions (Eikelboom, Hewitt, & Adams, Unpublished). It maybe that with these more concentrated solutions rats hit a satiety limit that prevents a difference between EDA and E3DA consumption from being evident. Experiment 1 was conducted to investigate the effect of adding quinine to 4% and 8% sucrose solutions with the intention of reducing consumption …
Administration Of A Cannabinoid Receptor Antagonist Following Chronic ∆9-Tetrahydrocannabinol Induces Physical Withdrawal In The Absence Of A Dysphoric State, Brittany Ford
Theses and Dissertations (Comprehensive)
The selective cannabinoid CB1 receptor antagonist SR141716 has been shown to precipitate physical signs of withdrawal in ∆9-tetrahydrocannabinol (THC)-dependent rats; however, the affective state associated with this withdrawal state has not yet been well characterized. Thus, the aim of present study was to examine the physical and affective consequences of SR141716-precipitated THC withdrawal in male Sprague-Dawley rats. Rats were injected with THC (5 mg/kg, i.p.) or its vehicle twice daily for 13 consecutive days, and challenged with SRI 41716 (1 mg/kg, i.p.) or its vehicle 1 h later on days 3, 5, 7, 9, 11, and 13. Consistent …
Planning For The Close And Distant Future: The Impact Of Temporal Distance On Task Completion Prediction, Johanna Peetz
Planning For The Close And Distant Future: The Impact Of Temporal Distance On Task Completion Prediction, Johanna Peetz
Theses and Dissertations (Comprehensive)
Accurate project completion estimates are part of successful project completion. Thus, it is important to identify factors that reduce the tendency to make overly optimistic project completion predictions (Buehler et al., 2002). This research investigated the effect of temporal distance on project completion predictions. A review of past research provided evidence that could lead to a prediction of either increased or decreased optimism with increasing temporal distance. In a first study, participants predicted the completion date of a hypothetical school assignment that would begin either tomorrow (close future) and next term (distant future). Participants predicted to complete the project earlier …
Syntactic Processing In Individuals With Dyslexia: Using Erp To Address The Debate, Hilary Brown
Syntactic Processing In Individuals With Dyslexia: Using Erp To Address The Debate, Hilary Brown
Theses and Dissertations (Comprehensive)
Behavioural and ERP data were collected from university and college students with and without dyslexia to determine if a deficit in syntactic processing in post-secondary students with dyslexia can be explained by the degree of phonological processing deficits. Participants read and listened to sentences of differing syntactic complexity and working memory load, particularly object relative and subject relative sentences. Slow cortical waves showed greater negativity for the objective relative sentences as the sentence progressed for the control participants regardless of presentation format. The same result was seen for the participants with dyslexia when presented with sentences in an auditory format. …
The Effect Of Delta9-Tetrahydrocannabinol (Thc) And Cb1 Antagonists On Sucrose And Quinine Palatability: Direct Measurement With The Taste Reactivity Test, Maegan Jarrett
Theses and Dissertations (Comprehensive)
Anecdotal reports suggest that cannabinoid agonists enhance palatability and that antagonists reduce palatability; however there has been little direct experimental evidence for these claims. The taste reactivity (TR) test is a direct measure of palatability in rats (Grill & Norgren, 1978). In Experiments 1 and 4, the taste reactivity (TR) test was used to evaluate the potential of delta-9-tetrahydrocannabinol (THC) to modify both sucrose and quinine palatability. The TR test revealed that THC (0.5 mg/kg) increases the palatability of sucrose solutions at 120 min post-injection, regardless of the sucrose concentration. THC (0.5 mg/kg) also decreased the aversiveness of the quinine …
Effect Of Ondansetron And Delta(9)-Tetrahydrocannabinol On The Establishment Of Lithium-Induced Conditioned Taste Avoidance In The House Musk Shrew (Suncus Murinus), Magdalena Kwiatkowska
Effect Of Ondansetron And Delta(9)-Tetrahydrocannabinol On The Establishment Of Lithium-Induced Conditioned Taste Avoidance In The House Musk Shrew (Suncus Murinus), Magdalena Kwiatkowska
Theses and Dissertations (Comprehensive)
Recent evidence suggests that toxin-induced taste avoidance in the non-emetic rat is not mediated by conditioned sickness. In contrast, it appears that toxin-induced taste avoidance in an emetic species is mediated by conditioned sickness. The present experiments evaluated the potential of the anti-emetic agents, ondansetron [OND; a serotonin receptor (5-HT3) antagonist] and Delta(9)-tetrahydrocannabinol [THC; a cannabinoid (CB 1) agonist] to interfere with lithium chloride (LiCl)-induced taste avoidance in the house musk shrew (Suncus murinus). In Experiment 1, shrews were pretreated with OND (1.5 mg/kg) or saline 30 min prior to drinking 0.1% saccharin solution then they were injected with LiCl …
Temporal Response Of The Human Visual System To Suprathreshold Luminance And Opponent Colour Contrast Gratings, Melanie Bucking
Temporal Response Of The Human Visual System To Suprathreshold Luminance And Opponent Colour Contrast Gratings, Melanie Bucking
Theses and Dissertations (Comprehensive)
The goal of the present study was to characterize the temporal processing of both suprathreshold luminance and opponent-colour defined contrast in the human visual system. We used a detection task in five experiments; following a 900 Hz, 2-cycle tone, observers were presented with a sinusoidal grating stimulus. The interval separating the waming tone and the presentation of the grating was manipulated to determine the influences of attentional dwell time in a cross-modal task. This theory states that the first of two successive events will interfere with the processing of the second event. In all four luminance experiments the gratings were …
The Effect Of Delta-9-Tetrahydrocannabinol (Thc) On Lithium-Induced Sickness Reactions In Both Rats (Rattus Norvegicus) And The House Musk Shrew (Suncus Murinus), Stephen W.P. Kemp
The Effect Of Delta-9-Tetrahydrocannabinol (Thc) On Lithium-Induced Sickness Reactions In Both Rats (Rattus Norvegicus) And The House Musk Shrew (Suncus Murinus), Stephen W.P. Kemp
Theses and Dissertations (Comprehensive)
The following experiments examined the ability of delta-9-tetrahydrocannabinol (THC) to attenuate lithium induced sickness in both the nonemetic rat (Rattus norvegicus) and the emetic house musk shrew (Suncus murinus). The ability of THC to attenuate the expression of previously established lithium induced conditioned sickness behavior in Suncus was also examined. Although unconditioned sickness behavior was displayed by both rats and shrews, THC did not attenuate this behavior in either species. However, THC did attenuate conditioned retching in the Suncus murinus. These results are the first to show the attenuation of conditioned sickness in Suncus by THC. They also experimentally verify …
Sensitization To Indirect And Direct Dopamine Agonists: Behavioural Differences In Wheel Running, Vanhthong Vilaysinh
Sensitization To Indirect And Direct Dopamine Agonists: Behavioural Differences In Wheel Running, Vanhthong Vilaysinh
Theses and Dissertations (Comprehensive)
Five experiments examined the effects of repeated exposure to stimulants, largely apomorphine (APO), on wheel running in male Sprague-Dawley rats. In these experiments, minor changes in procedure resulted in profound differences in the effects of APO on wheel running. Experiment 1 I compared changes in wheel running after repeated injections of 3.0 mg/kg amphetamine (AMP), 5.0 mg/kg of APO or vehicle (VEH). AMP resulted in a suppression in wheel running which become more pronounced over trials, while running in APO animals remained similar to the VEH group. Testing provided support for a conditioned suppression of wheel running rats previously treated …
The Effect Of Delta9-Tetrahydrocannabinol (Thc) On The Establishment And The Expression Of Place Conditioning (Rattus Norvegicus), Robert Ernest Sorge
The Effect Of Delta9-Tetrahydrocannabinol (Thc) On The Establishment And The Expression Of Place Conditioning (Rattus Norvegicus), Robert Ernest Sorge
Theses and Dissertations (Comprehensive)
The place conditioning paradigm has been used to assess the antinausea potential of drugs in non-emetic animal species. The present experiments were designed to determine the potential of A9-tetrahydrocannabinol (THC) to alleviate both conditioned and unconditioned sickness in rats (Rattus norvegiens). The results in the present study suggest that when the place aversion is strong (Experiment 1), THC may interfere with the establishment; however when the aversion is weak (Experiments 2 and 3), THC may interfere with the expression. Also, when administered during acquisition of a strong amphetamine-induced place preference, THC also seems to interfere with the establishment of the …
Ondansetron Interferes With The Establishment And Expression Of Lithium-Induced Conditioned Rejection Reactions, Cheryl Lynn Limebeer
Ondansetron Interferes With The Establishment And Expression Of Lithium-Induced Conditioned Rejection Reactions, Cheryl Lynn Limebeer
Theses and Dissertations (Comprehensive)
Conditioned rejection reactions displayed in the taste reactivity test may reflect conditioned nausea in rats because they are exclusively produced by emetic agents. The present experiments demonstrated that pretreatment with the anti-nausea agent, ondansetron, interfered with the establishment of conditioned rejection reactions (Experiment 1) and interfered with the expression of previously established conditioned rejection reactions (Experiment 2). Ondansetron selectively interfered with conditioned nausea as reflected by conditioned rejection reactions because it did not modify the unconditioned rejection reactions elicited by unpalatable quinine solution (Experiment 2). Although ondansetron blocked the expression of the selective taste reactivity reaction of conditioned rejection, it …
Effects Of Cholinergic And Dopaminergic Drugs On Number And Time Processing In Rats, Romina Coppa
Effects Of Cholinergic And Dopaminergic Drugs On Number And Time Processing In Rats, Romina Coppa
Theses and Dissertations (Comprehensive)
This study describes the effects of cholinergic and dopaminergic drugs on time and number processing by rats. Rats were trained to discriminate discrete sound sequences. On number trials, the duration of the sound sequence was a constant 4 seconds and the number of sounds was 2 or 8. On time trials, the number of sounds was held constant at 4, and the duration of the sound sequence was either 2 or 8 seconds. Psychophysical functions for number and time were obtained by presenting unreinforced sequences of intermediate number and duration. Accuracy of performance was greater with temporal signals than with …
Pentobarbital-Induced Place Aversion Learning, Gilbert Lew
Pentobarbital-Induced Place Aversion Learning, Gilbert Lew
Theses and Dissertations (Comprehensive)
Pentobarbital is self-administered by rats, but has also been reported to produce a conditioned place aversion. Since the self-administration and place preference paradigms both are considered to assess drug reward, we further examined the hedonic properties of pentobarbital using place conditioning. In Experiment 1, a dose of 15 mg/kg (ip) of pentobarbital produced a conditioned place aversion following 4 conditioning trials of various durations (5, 15, 30 or 60 min). Since rats are typically drug-experienced in the self-administration paradigm. Experiments 2 and 3 examined the effect of drug history on pentobarbital-induced place conditioning. Although preexposure to pentobarbital attenuated the place …
Specific Dopaminergic Manipulation Of The Internal Clock Mechanism, Lianne Elizabeth Stanford
Specific Dopaminergic Manipulation Of The Internal Clock Mechanism, Lianne Elizabeth Stanford
Theses and Dissertations (Comprehensive)
Using non-specific dopaminergic agents, Meck (1983, 1986) and his colleagues have repeatedly demonstrated manipulations of the internal clock mechanism, while showing no other changes to the psychophysical function (DL & WF). The current study used analyses and procedures similar to those of Meck (1983) and investigated the internal clock mechanism with the specific D2 agonist, quinpirole. Two groups were trained with saline and tested with quinpirole (0.08 mg/kg). One group was naive to the drug prior to testing (DN), while the other had previous drug exposure (DE). A third group (DT) was trained with quinpirole, and tested with saline. The …
Animal Memory Processes For Number And Time: Pigeons, Methamphetamine, And The Internal Clock Model, James W. Coyle
Animal Memory Processes For Number And Time: Pigeons, Methamphetamine, And The Internal Clock Model, James W. Coyle
Theses and Dissertations (Comprehensive)
The mode-control model of counting and timing (Meek & Church, 1983) suggests that discriminations based on number and time may be controlled by the same internal clock mechanism. In Experiment 1, two groups of pigeons were initially trained to perform delayed symbolic matching-to-sample (DSMTS) at a 5s fixed baseline delay, with sample stimuli that consisted of sequences of flashing light. Testing was conducted with a range of delays (0, 2.5, 5, 7.5, and 10s). In the Number Group, control by number was established by varying the number of flashes while holding time constant. In the Time Group, control by time, …
Mk-801 Interferes With The Acquisition Of Amphetamine- And Lithium-Induced Place Conditioning, Jonathan Francis Toth
Mk-801 Interferes With The Acquisition Of Amphetamine- And Lithium-Induced Place Conditioning, Jonathan Francis Toth
Theses and Dissertations (Comprehensive)
The place conditioning paradigm was used to assess the ability of the noncompetitive NMDA receptor antagonist, M- 801 to interfere with drug-place associations. MK-801 (0.1 mg/kg, ip) attenuated a place preference produced by 10 mg/kg, but not by 3 or 5 mg/kg of amphetamine. MK-801 alone produced neither a place preference nor a place aversion. Interference with amphetamine place preference learning was not the result of state-dependent learning produced by MK-801. Furthermore, MK-801 did not interfere with the expression of a previously established amphetamine place preference. Pretreatment with MK-801 also interfered with lithium-induced conditioned place aversion learning. These results suggest …
Morphine-Induced Modification Of Quinine Palatability: Effects Of Multiple Morphine-Quinine Trials, Sharon Nicola D.A. Clarke
Morphine-Induced Modification Of Quinine Palatability: Effects Of Multiple Morphine-Quinine Trials, Sharon Nicola D.A. Clarke
Theses and Dissertations (Comprehensive)
Contemporary research investigating the effects of opiate receptor agonists and antagonists indicates a role for endorphinergic mechanisms in the control of consummatory behaviours. One way in which opiates may exert an effect on feeding is by altering the hedonic properties or palatability of food and drink. Investigations of the role of palatability in the effect of opiates on feeding and drinking have primarily considered the effect of single exposures to opiates. Recognizing that chronic exposure to opiates may result in the development of tolerance to their palatability-altering properties, the taste reactivity test, a direct measure of the hedonic properties of …
An Evaluation Of Outcome Differentiation Using Biologically Neutral Stimuli, Wendy Ann Newell
An Evaluation Of Outcome Differentiation Using Biologically Neutral Stimuli, Wendy Ann Newell
Theses and Dissertations (Comprehensive)
This experiment investigated the specificity of encoding the outcomes of instrumental responding with rats. The first part of the study examined the differential outcome effect (DOE) using a 0.5 second flash of light as the outcome differentiator. Acquisition of a two-choice conditional discrimination was not enhanced if Response 1 (R1) in the presence of Stimulus 1 (S1) produced food plus a light flash, and R2 during S2 produced only food. Next, 2/3 of the animals were then trained to make two new responses (R3 and R4), one earning light plus food and the other earning food only. There was no …
Evidence For Common Coding Of Temporal And Nontemporal Information In Pigeons, Stephen Bridson
Evidence For Common Coding Of Temporal And Nontemporal Information In Pigeons, Stephen Bridson
Theses and Dissertations (Comprehensive)
Two experiments found evidence that pigeons commonly code temporal and visual samples that are associated with the same comparisons in many-to-one matching. In Experiment 1, pigeons were trained to match temporal (2-sec and 8-sec keylight durations) and color (red and green) samples to line tilt comparisons (vertical and horizontal). Similar rates of forgetting were found for all samples. Furthermore, retention of sample information appeared more similar for samples which shared common comparisons than those that did not. In Experiment 2, pigeons learned new comparison (circle and triangle) associations with either temporal or visual samples from Experiment 1. When tested on …
Individual Differences In Human Operant Heart Rate Conditioning: Autonomic, Cognitive And Dispositional Concomitants, Paul Favaro
Individual Differences In Human Operant Heart Rate Conditioning: Autonomic, Cognitive And Dispositional Concomitants, Paul Favaro
Theses and Dissertations (Comprehensive)
Research in human operant heart rate conditioning concerned with the elucidation of the mediators of operant heart rate changes has postulated five mediating mechanisms related to operant heart rate change: respiratory, somatic-muscular, central neurological, cognitive and dispositional (personality). However, examination of the literature indicates that much of this research has produced equivocal results, hence, a clear picture of mediation has not emerged. Experimenters interested in the events that mediate operant heart rate changes have not devoted much attention to the individual variability that is so pervasive in studies of human psychophysiology. Individuals may fundamentally differ in teh autonomic, central neurological, …
Genetic And Ontogenetic Variation In Response To Scopolamine And D-Amphetamine In Three Strains Of Mice, Gary Remington
Genetic And Ontogenetic Variation In Response To Scopolamine And D-Amphetamine In Three Strains Of Mice, Gary Remington
Theses and Dissertations (Comprehensive)
Highly inbred mice of three strains (A/J, DBA/2J and C57BL/6J) were tested in an acitivity task at 14, 21, or 28 days of age. Ten minutes prior to testing, mice received treatment of either saline, scopolamine (0.1 or 1.0 mg/kg) or d-amphetamine (0.5, 1.0 or 5.0 mg/kg). At 14 days of age DBA mice exhibited higher levels of activity than either A or C57 mice. However, the increase in activity in C57 was such that at 21 and 28 days no difference was observed relative to DBA mice, and activity was higher than that of A mice. With respect to …
An Investigation Of Some Electrophysiological Concomitants Of Hallucinations, Ronald S. Golemba
An Investigation Of Some Electrophysiological Concomitants Of Hallucinations, Ronald S. Golemba
Theses and Dissertations (Comprehensive)
The present research was designed to determine if a single LSD experience produces a detectable change in the electrical potential of the brain, and if so, how long that change lasts, and to examine the changes in the electrical potential of the brain associated with chemogenic and hypnogenic hallucinations. Four studies were conducted measuring the electrical potential between the front and back of the head in monkeys and humans. The frontal potential was shown to shift negatively with the use of LSD-type psychedelics but not with marijuana compounds. LSD caused the potential in humans to shift into the range commonly …