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Effects Of Chronic Paroxetine And Fluoxetine Treatment On Markers Of Suicidal Behavior In Adolescent Rats, Leslie Renee Horn
Effects Of Chronic Paroxetine And Fluoxetine Treatment On Markers Of Suicidal Behavior In Adolescent Rats, Leslie Renee Horn
Theses Digitization Project
Major depression is a common problem in adolescents. Unfortunately, one of the most effective antidepressants in adults, the selective serotonin reuptake inhibitor (SSRI) paroxetine, is not clinically effective in pediatric populations. There are many variables that increase the risk of suicide including genetic, social, psychological, and biological factors, making the evaluation of the effect of SSRIs on suicidal behavior difficult to assess in human adolescents. The goal of the present investigation was to compare the effects of paroxetine and fluoxetine in adolescent rats on markers associated with depression and suicidal behavior in humans.