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Articles 1 - 30 of 32
Full-Text Articles in Psychology
Preweanling Exposure To Selective Catecholamine Transporter Inhibitors Differentially Effects Morphine-Induced Antinociception In Adulthood, Joseph Marco Valentine
Preweanling Exposure To Selective Catecholamine Transporter Inhibitors Differentially Effects Morphine-Induced Antinociception In Adulthood, Joseph Marco Valentine
Theses Digitization Project
The purpose of this project is to determine how early methylphenidate exposure alters opioid receptor functioning in adulthood. To this end, we will administer selective monoamine transporter inhibitors for dopamine and norepinephrine (GBR-12904 and atomoxetine) during preweanling period and assess opioid function in adult rats by testing morphine-induced antinociception using the hot-plate and tail-flick tasks. In order to assess the effects of methylphenidate use on brain functions during development, investigations have been conducted in rats using ages roughly analogous to early and late childhood.
Adolescent And Adult Nicotine Exposure On The Acquisition Of Methamphetamine Self-Administration And The Reinstatement Of Extinguished Methamphetamine-Seeking In Male Rats, Joseph Allan Pipkin
Adolescent And Adult Nicotine Exposure On The Acquisition Of Methamphetamine Self-Administration And The Reinstatement Of Extinguished Methamphetamine-Seeking In Male Rats, Joseph Allan Pipkin
Theses Digitization Project
This study sought to determine the individual and combined contribution of adolescent and adult nicotine exposure on METH self-administration and METH-seeking behavior in male rats. Nicotine is a commonly abused substance among adolescents and is believed to be a "gateway" to other drugs of abuse. In support of the gateway hypothesis, cigarette smoking during adolescence is related to increased methamphetamine (METH) use in adulthood.
Monoamine Modulation Of Separation-Induced Ultrasonic Vocalizations In Preweanling F344 And Sd Rats, Cynthia Elizabeth Britt
Monoamine Modulation Of Separation-Induced Ultrasonic Vocalizations In Preweanling F344 And Sd Rats, Cynthia Elizabeth Britt
Theses Digitization Project
The purpose of this study was to determine if Fischer 344 (F344) rats, a strain which naturally shows deficits in social communication during adolescence, could be used as a model of the social communication deficits observed in autism. Thus, the goal was to determine if F344 rats would also show fewer emissions of isolated-induced ultrasonic vocalizations (an early onset form of social interaction) as compared to SD rats. Subjects consisted of 142 F344 rat pups (67 male and 75 female). Subjects were treated according to the "Guide for the Care and Use of Mammals in Neuroscience and Behavioral Research" under …
Role Of The Ventral Tegmental Area And Nucleus Accumbens For The One-Trial Behavioral Sensitization Of The Preweanling Rat, Alexandria Grace Pothier
Role Of The Ventral Tegmental Area And Nucleus Accumbens For The One-Trial Behavioral Sensitization Of The Preweanling Rat, Alexandria Grace Pothier
Theses Digitization Project
Behavioral sensitization is defined as an increase in behavioral responding that occurs after repeated administration of a psychostimulant. Behavioral sensitization is an important component of the addiction process that is mediated by different brain regions. In this thesis, lidocaine was used to determine those brain areas mediating one-trial behavioral sensitization in preweanling rats.
Paradoxical Behavior Effects Of Dopamine Receptor Inactivation In Preweanling Rats: Role Of The Dorsal Striatum, Taleen Siran Der-Ghazarian
Paradoxical Behavior Effects Of Dopamine Receptor Inactivation In Preweanling Rats: Role Of The Dorsal Striatum, Taleen Siran Der-Ghazarian
Theses Digitization Project
The purpose of this thesis was to: a) investigate the effects of intrastriatally administered N-ethoxycarbonyl-2ethoxy-1, 2-dihydroquinoline (EEDQ) on nonselective dopamine agonists (NPA) -induced locomotor activity in preweanling and adult rats; b) determine which dopamine receptor subtype (D1- or D2-like) is responsible for modulating EEDQ's paradoxical behavioral effects in preweanling rats; and c) examine the magnitude of EEDQ-induced D1- and D2-like receptor inactivation in both adult and preweanling rats. Subjects were 252 male and female rat pups of Sprague-Dawley descent (Charles River Laboratories, Hollister, CA, USA), born and raised at California State University, San Bernardino (CSUSB).
Ontogeny Of One-Trial Behavioral Sensitization In Preweanling, Adolescent, And Adult Rats: Differential Effects Of Cocaine And Methamphetamine, Olga Olia Kozanian
Ontogeny Of One-Trial Behavioral Sensitization In Preweanling, Adolescent, And Adult Rats: Differential Effects Of Cocaine And Methamphetamine, Olga Olia Kozanian
Theses Digitization Project
The purpose of this thesis was to assess the ontogeny of cocaine- and methamphetamine-induced one-trial locomotor sensitization in preweanling, adolescent, and adult rats. Subjects were 336 male and female rats of Sprague-Dawley descent that were raised at California State University, San Bernardino (CSUSB).
Persistence Of One-Trial Cocaine-Induced Behavioral Sensitization And Conditioned Activity In Preweanling Rats, Anthony Michael Cortez
Persistence Of One-Trial Cocaine-Induced Behavioral Sensitization And Conditioned Activity In Preweanling Rats, Anthony Michael Cortez
Theses Digitization Project
The purpose of this thesis was to determine the persistence of one-shot context-specific and context-independent behavioral sensitization by administering a single pretreatment injection of cocaine or saline in either the home cage or a novel test chamber on PD 19 or PD 79. In order to examine the persistence of conditioned activity, adult rats were given an injection of saline after 1, 3, or 5 abstinence days. Preweanling rats were given an injection of saline after only 1 abstinence day.
Environmental Enrichment Attenuates Nucleus Basalis Lesion Induced Impairments To Attention, Brandee Leianne Kinney-Hurd
Environmental Enrichment Attenuates Nucleus Basalis Lesion Induced Impairments To Attention, Brandee Leianne Kinney-Hurd
Theses Digitization Project
This experiment examined the effects of environmental enrichment on performance in an attention-dependent learning task in rats with selective lesions of the cholinergic nucleus basalis magnocellularis (NBM). The findings demonstrate that environmental enrichment can enhance attention-dependent learning performance in normal animals as well as attenuating NBM lesion-induced impairments otherwise seen following rearing in standard conditions.
Effects Of Chronic Paroxetine And Fluoxetine Treatment On Markers Of Suicidal Behavior In Adolescent Rats, Leslie Renee Horn
Effects Of Chronic Paroxetine And Fluoxetine Treatment On Markers Of Suicidal Behavior In Adolescent Rats, Leslie Renee Horn
Theses Digitization Project
Major depression is a common problem in adolescents. Unfortunately, one of the most effective antidepressants in adults, the selective serotonin reuptake inhibitor (SSRI) paroxetine, is not clinically effective in pediatric populations. There are many variables that increase the risk of suicide including genetic, social, psychological, and biological factors, making the evaluation of the effect of SSRIs on suicidal behavior difficult to assess in human adolescents. The goal of the present investigation was to compare the effects of paroxetine and fluoxetine in adolescent rats on markers associated with depression and suicidal behavior in humans.
Consequences Of Early Methylphenidate Exposure On Opioid System Functioning In Adult Rats, Matthew Scott Herbert
Consequences Of Early Methylphenidate Exposure On Opioid System Functioning In Adult Rats, Matthew Scott Herbert
Theses Digitization Project
Methylphenidate is the preferred treatment for attention-deficit hyperactivity disorder in preschool-aged children, even though few human studies have assessed the long-term consequences of early methyphenidate use. In rats, exposure to methylphenidate during a developmental period that approximates early childhood increases morphine-induced antinociception in adulthood. However, because morphine activates three distinct opioid receptors it is unknown which receptor is resonsible for this methylphenidate effect. The purpose of the present study was to assess the long-term effects of early methylphenidate exposure on DAMGO- and U50, 488-induced antinociception, a mu-opioid and kappa-opioid selective agonist.
Role Of Dorsostriatal D1 And D2 Receptors In Modulating The Kappa Opioid-Mediated Locomotor Activity Of Preweanling Rats: Importance Of Synergistic Activation, Sergios Charntikov
Role Of Dorsostriatal D1 And D2 Receptors In Modulating The Kappa Opioid-Mediated Locomotor Activity Of Preweanling Rats: Importance Of Synergistic Activation, Sergios Charntikov
Theses Digitization Project
Infusions of the nonselective dopamine agonist R( - ) propylnorapomorphine (NPA) into the dorsal striatum of preweanling rats atteuates kappa opioid-mediated locomotor activity. The purpose of this thesis was to ascertain which dopamine receptor subtype (D1 or D2) is responsible for this effect. It was hypothsized that a) D1, but not D2, receptors in the dorsal striatum underlie NPA's ability to attenuate the kappa opioid-mediated locomotor activity of preweanling rats, and b) microinjectng SKF38393 (a D1 agonist), and not quinpirole (a D2 agonist), would attenuate kappa opioid-mediated locomotion.
Effects Of Early Amphetamine Exposure On Memory, Wendy Ann Holmquist
Effects Of Early Amphetamine Exposure On Memory, Wendy Ann Holmquist
Theses Digitization Project
The purpose of the current study was to determine if rat pups treated with amphetamine (AMPH) during a critical time of hippocamal development would exhibit deficits in spatial learning and memory when tested in the Morris water maze during adolescence. Exposure to amphetamine during early postnatal development induces long-term reductions in protein kinase A (PKA) activity. Because PKA activity is known to regulate the production of brain derived neurotrophic factor (BDNF), and reductions in BDNF are associated with memory deficits, it was hypothesized that early exposure to amphetamine would lead to declines in both BDNF levels and memory performance. The …
Acetylcholine Levels In The Prefrontal Cortex And Hippocampus During Trace And Delay Conditioning, Mary Melissa Flesher
Acetylcholine Levels In The Prefrontal Cortex And Hippocampus During Trace And Delay Conditioning, Mary Melissa Flesher
Theses Digitization Project
The goal of this experiment was to examine the pattern of ACh release in mPFC and HPC during performance in trace and delay appetitive conditioning.
Importance Of The Kappa Opoid System For Ultrasonic Vocalizations Of Young Rats: Role Of Peripherally-Versus Centrally-Located Kappa Opioid Receptors, James Roy Osburn
Importance Of The Kappa Opoid System For Ultrasonic Vocalizations Of Young Rats: Role Of Peripherally-Versus Centrally-Located Kappa Opioid Receptors, James Roy Osburn
Theses Digitization Project
The purpose of this thesis was to determine whether the kappa opioid receptors modulating ultrasonic vocalizations production are located in the central and/or peripheral nervous system.
The Effects Of Acute Posttraining Injections Of Cocaine On Spatial Memory In C57bl/6 Mice, Sergio Diaz IñIguez
The Effects Of Acute Posttraining Injections Of Cocaine On Spatial Memory In C57bl/6 Mice, Sergio Diaz IñIguez
Theses Digitization Project
The purpose of this study was to investigate the effects of cocaine on spatial memory consolidation using the Morris water maze. Specifically, male and female C57BL/6 mice were trained on a spatial water task, and then administered a single posttraining injection of saline or cocaine (1.25, 2.5, 5.0, or 20.0 mg/kg).
The Effects Of (Rs)-Mcpg On Amphetamine-Induced Sensitization In Neonatal Rats, Fiona Yeuk-Lun Choi
The Effects Of (Rs)-Mcpg On Amphetamine-Induced Sensitization In Neonatal Rats, Fiona Yeuk-Lun Choi
Theses Digitization Project
The purpose of the study was to investigate the role of metabotropic glutamate receptors (mGluR) in the ontogeny of amphetamine-induced behavioral sensitization. Eleven-day-old rat pups were given five daily bilateral infusions of the mGluR antagonist, (RS)-methyl-4-carboxyphenylglycine (MCPG) followed by a systemic injection of amphetamine and locomotor activity was measured. It was hypothesized that rats receving amphetamine pretreatment and an amphetamine challenge would exhibit a significant increase in activity, indicating short-term behavioral sensitization. As predicted, repeated amphetamine administration during the pretreatment phase produced progressively enhanced locomotor activity, indicating the development of behavioral sensitization. The effect of MCPG on locomotor activity appears …
Biconditional Discrimination Learning In Rats With 192 Igg-Saporin Lesions Of The Nucleus Basalis Magnocellularis, Michael Ryan Kitto
Biconditional Discrimination Learning In Rats With 192 Igg-Saporin Lesions Of The Nucleus Basalis Magnocellularis, Michael Ryan Kitto
Theses Digitization Project
The experiment tested the hypothesis that 192 IgG-saporin lesions of the nucleus basalis magnocellularis (NBM) in rats would impair performance in a biconditional visual discrimination task, which requires configural association learning. Experiment used 22 male Long-Evan rats (Harlan Sprague-Dawley). Behavioral testing was conducted in two identical T-mazes. Rats were randomly assigned to either a bilateral 192 IgG-saporin lesion group (n = 10) or to a control group (n = 12). Results support the hypothesis that NBM is critically involved in configural but not simple association learning and suggest that NBM may be involved more generally in cognitive flexibility.
Top-Down Modulation By Medial Prefrontal Cortex Of Basal Forebrain Activation Of Auditory Cortex During Learning, Candice Monique Chavez
Top-Down Modulation By Medial Prefrontal Cortex Of Basal Forebrain Activation Of Auditory Cortex During Learning, Candice Monique Chavez
Theses Digitization Project
The experiment tested the hypothesis that the acetylcholine (ACh) release in the rat auditory cortex is greater in rats undergoing auditory classical conditioning compared to rats in a truly random control paradigm where no associative learning takes place and that this is mediated by prefrontal afferent projections influencing the nucleus basalis magnocellularis (NBM), which in turn modulates ACh release in neocortex. Rats with bilateral ibotenic acid lesions of medial prefrontal and agranular insular cortices were tested in an auditory classical conditioning task while ACh was collected from the primary auditory cortex. It was hypothesized that lesions of these prefrontal areas …
Actions Of A Partial D2-Like Agonist During Low Or High Dopaminergic Tone: A Neurochemical Study Using Preweanling Rats, Shelly Taeko Yoshida
Actions Of A Partial D2-Like Agonist During Low Or High Dopaminergic Tone: A Neurochemical Study Using Preweanling Rats, Shelly Taeko Yoshida
Theses Digitization Project
The neurochemical effects of partial D2-like agonists (i.e., terguride) to alter striatal DOPA accumulation under high and low dopaminergic tone was examined in preweanling rats. The results indicate that terguride has agonist-like (quinpirole-like) effects under a low dopaminergic tone and antagonist-like (haloperidol-like) effects under a high dopaminergic tone during the preweanling period.
Effect Of Preweanling Methylphenidate Exposure On The Induction, Extinction And Reinstatement Of Morphine-Induced Conditioned Place Preference In Rats, Kellie Lynn Kucher
Effect Of Preweanling Methylphenidate Exposure On The Induction, Extinction And Reinstatement Of Morphine-Induced Conditioned Place Preference In Rats, Kellie Lynn Kucher
Theses Digitization Project
This study examined the effect of preweanling methyphenidate exposure on later drug reward. We examined the induction, extinction, and reinstatement of morphine induced conditioned place preference (CPP) in rats that received methylphenidate pretreatment during the preweanling period.
The Effect Of Early Psychostimulant Treatment On Abuse Liability And Dopamine Receptors, Steven Wayne Villafranca
The Effect Of Early Psychostimulant Treatment On Abuse Liability And Dopamine Receptors, Steven Wayne Villafranca
Theses Digitization Project
Examines whether the reinforcing properties of drugs of abuse were altered in adulthood by methylphenidate, more commonly known as Ritalin. Subjects were 108 rats of Sprague-Dawley descent (Harlan). Methylphenidate, or saline was administered daily to the subjects from the postnatal period (11-20 days old). The rats preference for morphine during early adulthood was measured using conditioned place preference. The number of dopamine D₂ receptors was measured in each rat and the correlation between receptor number and morphine preference was determined. Results indicate that rats pretreated with methylphenidate showed greater preference for morphine than saline pretreated rats and suggests that exposure …
192 Igg-Saporin Lesions Of The Nucleus Basalis Magnocellularis Impair Serial Reversal Learning In Rats, Sara Michelle Cabrera
192 Igg-Saporin Lesions Of The Nucleus Basalis Magnocellularis Impair Serial Reversal Learning In Rats, Sara Michelle Cabrera
Theses Digitization Project
In order to assess flexibility in acquiring and using conflicting response rules, rats with selective lesions of the NBM or sham-lesion controls were subjected to serial reversal training in a simple operant discrimination paradigm. The NBM lesion group did not differ from the control group in acquisition of the original rules; the NBM lesion group required more time to master the changes in rules in the first reversal, but not in subsequent reversals.
Cholinergic Basal Forebrain Involvement In The Acquisition Of Differential Reinforcement Of Low Rate Responding Tasks In Rats, Sean Ryan Corley
Cholinergic Basal Forebrain Involvement In The Acquisition Of Differential Reinforcement Of Low Rate Responding Tasks In Rats, Sean Ryan Corley
Theses Digitization Project
It was hypothesized that 192 IgG-saporin lesions of the basal forebrain cholinergic system (BFCS) would disrupt differential reinforcement of low rate (DRL) learning in an uncued DRL task, but would not impair acquisition and performance in the cued version of the task. Results suggest that BFCS lesions impair vigilance to the external cues despite continued practice in the cued DRL, whereas continuous attention to internally produced cues recovers with extended practice in the uncued DRL.
The Effects Of Neonatal Manganese Exposure On Impulsivity, Unlearned Motoric Function, And Reward, Carmela Marie Reichel
The Effects Of Neonatal Manganese Exposure On Impulsivity, Unlearned Motoric Function, And Reward, Carmela Marie Reichel
Theses Digitization Project
This study examined the effects of low to moderate doses of manganese (0, 250, or 750 _g per day from PD 1-21) on a comprehensive battery of behaviors in rats during the neonatal period, preweanling period, and in adulthood.
Long-Term Effects Of 3,4- Methylenedioxymethamphetamine (Mdma) On Serotonergic And Dopaminergic Functioning, Jodi Lynn Kohutek
Long-Term Effects Of 3,4- Methylenedioxymethamphetamine (Mdma) On Serotonergic And Dopaminergic Functioning, Jodi Lynn Kohutek
Theses Digitization Project
Methylenedioxymethamphetamine (MDMA) popularly known as "Ecstasy" continues to gain popularity as a recreational drug that has been shown to increase serotonin and dopamine levels. The present study has demonstrated that repeated exposure to MDMA produces long-term damage to serotonergic and dopaminergic neurons in various regions of the rat brain.
The Effects Of Lesions To The Superior Colliculus And Ventromedial Thalamus On [Kappa]-Opioid-Mediated Locomotor Activity In The Preweanling Rat, Arturo Rubin Zavala
The Effects Of Lesions To The Superior Colliculus And Ventromedial Thalamus On [Kappa]-Opioid-Mediated Locomotor Activity In The Preweanling Rat, Arturo Rubin Zavala
Theses Digitization Project
The purpose of this thesis was to determine the neuronal circuitry mediating U50,488-induced locomotion in preweanling rats. To this end, preweanling rats received bilateral electrolytic lesions of the ventromedial thalamus or superior colliculus and, two days later, the same rats received a challenge injection of U50,488. It was predicted that bilateral lesions of the ventromedial thalamus or superior colliculus would attenuate the U50,488-induced locomotor activity of 18-day-old rats.
Induction And Expression Of Cocaine-Induced Behavioral Sensitization: Modulation By A Partial D₂-Like Agonist, Janet Marie Sibole
Induction And Expression Of Cocaine-Induced Behavioral Sensitization: Modulation By A Partial D₂-Like Agonist, Janet Marie Sibole
Theses Digitization Project
The purpose of this study was to investigate whether a partial D₂-like dopamine agonist (i.e. terguride) would block the induction or expression of cocaine-induced behavioral sensitization in pre-weanling rats. The ability of terguride to induce behavioral sensitization was also examined, as partial D₂-like agonists have agonistic actions in cases of low dopaminergic tone.
Ultrasonic Vocalizations Of Preweanling Rats The Interaction Of K-Opioid And A₂-Noradrenergic Systems, Arbi Nazarian
Ultrasonic Vocalizations Of Preweanling Rats The Interaction Of K-Opioid And A₂-Noradrenergic Systems, Arbi Nazarian
Theses Digitization Project
No abstract provided.
Role Of The Dopamine D₁-Like Receptor In Amphetamine-Induced Behavioral Sensitization: A Study Using Dopamine D₁A-Receptor Deficient Mice, Patrick Eugene Karper
Role Of The Dopamine D₁-Like Receptor In Amphetamine-Induced Behavioral Sensitization: A Study Using Dopamine D₁A-Receptor Deficient Mice, Patrick Eugene Karper
Theses Digitization Project
The ability of the indirect dopamine agonist, amphetamine, to produce behavioral sensitization was assessed in adult D₁A-deficient and wild-type mice. It was originally predicted that : 1) dopamine (DA) D₁-like receptors are necessary for the occurrence of short- and long-term amphetamine-induced behavioral sensitization, 2) DA D₁-like receptors are necessary for environmental conditioning factors associated with amphetamine-induced behavioral sensitiazation, and 3) DA D₅ receptors are required for amphetamine-induced behavioral sensitization. Locomotor activity and sterotyped sniffing were assessed in each of three experiments.
The Effects Of The Kappa Opioid Agonist U-50,488 On Locomotor Activity Of The Preweanling Rat Following Bilateral Microinjection Into The Substantia Nigra Pars Reticulata And Striatum, Robert Linwood Collins
The Effects Of The Kappa Opioid Agonist U-50,488 On Locomotor Activity Of The Preweanling Rat Following Bilateral Microinjection Into The Substantia Nigra Pars Reticulata And Striatum, Robert Linwood Collins
Theses Digitization Project
No abstract provided.