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The Effects Of Intranasal Orexin-A On Mk-801-Induced Attentional Deficits: Addressing Cognitive Impairment In An Nmda Receptor Hypofunction Model Of Schizophrenia, Eden Blake-Lea Maness
The Effects Of Intranasal Orexin-A On Mk-801-Induced Attentional Deficits: Addressing Cognitive Impairment In An Nmda Receptor Hypofunction Model Of Schizophrenia, Eden Blake-Lea Maness
Dissertations, Theses, and Masters Projects
Schizophrenia (SZ) is a debilitating condition wherein those afflicted experience positive symptoms, including hallucinations and delusions, as well as negative symptoms, including alterations of processing affecting cognition and social interactions. The NMDA receptor hypofunction model of SZ asserts that a reduction in hippocampal NMDA receptor input produces the pathology of this disorder, promoting excessive frontocortical excitatory neurotransmission – particularly overstimulation of basal forebrain cholinergic neurons – that ultimately impairs cognitive and sensorimotor processes. Orexin-A (OxA), a neuropeptide principally involved in wakefulness and appetitive behaviors, has been shown to demonstrate cognitive-enhancing qualities in models of psychiatric and neurodegenerative illness. In the …