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Structural And Functional Brain Imaging In Acute Hiv, Vishal Samboju, Carissa Philippi, Phillip Chan, Yann Cobigo, James Fletcher, Merlin Robb, Merlin Robb, Joanna Hellmuth, Khunthalee Benjapornpong, Netsiri Dumrongpisutikul, Mantana Pothisri, Robert Paul, Jintanat Ananworanich, Serena Spudich, Victor Valcour, Rv Teams

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Background:HIV RNA is identified in cerebrospinalfluid (CSF) within eightdays of estimated viral exposure. Neurological findings and impaired neuropsychological testing performance are documented in a subset of individuals with acuteHIV infection (AHI). The purpose of this study was to determine whether microstructural white matter and resting-state functional connectivity (rsFC) are disruptedin AHI.Methods:We examined 49 AHI (100% male; mean age = 30 ± SD 9.9) and 23 HIV-uninfected Thai participants (78% male; age = 30 ± 5.5) with diffusion tensor imaging (DTI) and rsFC acquired at 3 Tesla, and four neuropsychological tests (summarized as NPZ-4). MRI for the AHI group was performed …