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Full-Text Articles in Psychology
Discriminative Stimulus Effects Of Gabapentin, Michael Zuidema
Discriminative Stimulus Effects Of Gabapentin, Michael Zuidema
All NMU Master's Theses
The present study sought to evaluate the discriminative stimulus effects of the anticonvulsant gabapentin in rats trained to discriminate 30.0 mg/kg gabapentin from vehicle in a two-lever drug discrimination task. All of the ten rats tested were able to establish gabapentin as an interoceptive cue. Gabapentin produced full generalization (≥ 80% gabapentin-lever responding) for itself at 30.0, 60.0, and 120.0 mg/kg doses. Pentobarbital produced full substitution, while pregabalin, carbamazepine, fentanyl, and buspirone produced partial substitution (≥ 60% gabapentin-lever responding) for gabapentin. Ethanol and raclopride did not substitute for gabapentin. The psychostimulant amphetamine did not produce substitution; however, the 0.25 mg/kg …
Nmda Receptor Blockade Specifically Impedes The Acquisition Of Incentive Salience Attribution, Jonathan J. Chow, Joshua S. Beckmann
Nmda Receptor Blockade Specifically Impedes The Acquisition Of Incentive Salience Attribution, Jonathan J. Chow, Joshua S. Beckmann
Psychology Faculty Publications
Glutamatergic signaling plays an important role in learning and memory. Using Pavlovian conditioned approach procedures, the mechanisms that drive stimulus-reward learning and memory have been investigated. However, there are instances where reward-predictive stimuli can function beyond being solely predictive and can be attributed with “motivational value” or incentive salience. Using a Pavlovian conditioned approach procedure consisting of two different but equally predictive stimuli (lever vs. tone) we investigated the role NMDA receptor function has in the attribution of incentive salience. The results revealed that the administration of MK-801, an NMDA receptor antagonist, during acquisition of Pavlovian conditioned approach promoted goal-tracking …
Effects Of Social Interaction On Morphine Conditioned Place Preference In Adolescent Male Rats, Virginia G. Weiss
Effects Of Social Interaction On Morphine Conditioned Place Preference In Adolescent Male Rats, Virginia G. Weiss
Theses and Dissertations--Psychology
The fact that adolescents commonly initiate drug use in social settings is well established. Both clinical and preclinical research has investigated how social interaction is altered by a variety of drugs of abuse. What is less understood is how the rewarding value of drugs of abuse is affected by the presence of social peers. This dissertation aimed to investigate the interaction of morphine and social play on conditioned place preference (CPP) in adolescent male Sprague Dawley rats, using both behavioral and immunohistochemistry (IHC) methods. Rats were exposed to morphine (0, 1, or 3 mg/kg; s.c.), social interaction, or a combination …
Effects Of Reinforcement Rate On The Aversive Function Of Timeout From Positive Reinforcement, Cory Whirtley
Effects Of Reinforcement Rate On The Aversive Function Of Timeout From Positive Reinforcement, Cory Whirtley
Graduate Theses, Dissertations, and Problem Reports
Although the use of timeout from positive reinforcement is widespread and has been shown to be an effective punisher in clinical settings, the factors responsible for its effectiveness are not fully understood. The present experiment was designed to evaluate one of these factors, the reinforcement rate underway during periods of time-in. Rats’ lever pressing was maintained on variable-interval schedules of food reinforcement in a multiple schedule with two components. In one component, no timeouts were delivered. In the other component, when a variable-ratio schedule was met, lever presses were followed by a 30-s timeout during which a tone sounded, the …
Effects Of Delay And Signals On Choice Between Delayed Food Alone And Immediate Food With Delayed Shock, Forrest James Toegel
Effects Of Delay And Signals On Choice Between Delayed Food Alone And Immediate Food With Delayed Shock, Forrest James Toegel
Graduate Theses, Dissertations, and Problem Reports
Much of the research in the area of self-control has examined choice between small immediate reinforcers and large delayed reinforcers, but many problems result from situations in which a single choice produces consequences of conflicting valence: Those in which the immediate outcome is reinforcing and the delayed outcome is aversive. Recent research has evaluated how preference for a large reinforcer which is followed by a delayed shock changes as a function of the delay to shock and how the intensity and duration of delayed shock affects the value of a large reinforcer. The present set of experiments investigated how the …