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Articles 1 - 15 of 15
Full-Text Articles in Psychology
Effects Of Oxycodone And Methylphenidate On Self-Control With Aversive Outcomes, Jeremy Saul Langford
Effects Of Oxycodone And Methylphenidate On Self-Control With Aversive Outcomes, Jeremy Saul Langford
Graduate Theses, Dissertations, and Problem Reports
In the context of choice, one is said to show self-control under numerous conditions in which consideration is given to the delayed outcomes of each option. This can be difficult: both reinforcing and aversive outcomes become less effective as they are increasingly delayed. Several socially significant issues arise from a failure of delayed, aversive outcomes to impact choice, especially when immediate, reinforcing outcomes are available. Identifying the conditions under which choice is sensitive to delayed outcomes is critical to shifting choices toward alternatives in which contact with delayed, aversive outcomes is minimized. Two experiments were conducted with the aim of …
Behavioral Impairment Following Gestational Exposure To Titanium Dioxide Nanomaterial Aerosols In Male And Female Rats, Matthew Leland Eckard
Behavioral Impairment Following Gestational Exposure To Titanium Dioxide Nanomaterial Aerosols In Male And Female Rats, Matthew Leland Eckard
Graduate Theses, Dissertations, and Problem Reports
Engineered nanomaterials (ENMs) are beginning to be recognized as hazardous to human and animal health. Titanium dioxide (TiO2) is primarily used as a whitening agent in paints, plastics, and sunscreens. While relatively inert in its bulk form, nano-TiO2 (diameter) can produce prolonged inflammation and oxidative stress in target tissue. Recently, the potential for nano-TiO2 to cause neuroinflammation and damage has heightened concerns about its continued use. One important concern is that nano-TiO2, and other metal oxide ENMs, may affect fetal neurodevelopment. Accordingly, it is imperative to screen ENMs, like TiO2, for possible neurotoxicity following developmental exposures. The current set of …
Discriminative Stimulus Effects Of Gabapentin, Michael Zuidema
Discriminative Stimulus Effects Of Gabapentin, Michael Zuidema
All NMU Master's Theses
The present study sought to evaluate the discriminative stimulus effects of the anticonvulsant gabapentin in rats trained to discriminate 30.0 mg/kg gabapentin from vehicle in a two-lever drug discrimination task. All of the ten rats tested were able to establish gabapentin as an interoceptive cue. Gabapentin produced full generalization (≥ 80% gabapentin-lever responding) for itself at 30.0, 60.0, and 120.0 mg/kg doses. Pentobarbital produced full substitution, while pregabalin, carbamazepine, fentanyl, and buspirone produced partial substitution (≥ 60% gabapentin-lever responding) for gabapentin. Ethanol and raclopride did not substitute for gabapentin. The psychostimulant amphetamine did not produce substitution; however, the 0.25 mg/kg …
Nmda Receptor Blockade Specifically Impedes The Acquisition Of Incentive Salience Attribution, Jonathan J. Chow, Joshua S. Beckmann
Nmda Receptor Blockade Specifically Impedes The Acquisition Of Incentive Salience Attribution, Jonathan J. Chow, Joshua S. Beckmann
Psychology Faculty Publications
Glutamatergic signaling plays an important role in learning and memory. Using Pavlovian conditioned approach procedures, the mechanisms that drive stimulus-reward learning and memory have been investigated. However, there are instances where reward-predictive stimuli can function beyond being solely predictive and can be attributed with “motivational value” or incentive salience. Using a Pavlovian conditioned approach procedure consisting of two different but equally predictive stimuli (lever vs. tone) we investigated the role NMDA receptor function has in the attribution of incentive salience. The results revealed that the administration of MK-801, an NMDA receptor antagonist, during acquisition of Pavlovian conditioned approach promoted goal-tracking …
Effects Of Social Interaction On Morphine Conditioned Place Preference In Adolescent Male Rats, Virginia G. Weiss
Effects Of Social Interaction On Morphine Conditioned Place Preference In Adolescent Male Rats, Virginia G. Weiss
Theses and Dissertations--Psychology
The fact that adolescents commonly initiate drug use in social settings is well established. Both clinical and preclinical research has investigated how social interaction is altered by a variety of drugs of abuse. What is less understood is how the rewarding value of drugs of abuse is affected by the presence of social peers. This dissertation aimed to investigate the interaction of morphine and social play on conditioned place preference (CPP) in adolescent male Sprague Dawley rats, using both behavioral and immunohistochemistry (IHC) methods. Rats were exposed to morphine (0, 1, or 3 mg/kg; s.c.), social interaction, or a combination …
Effects Of Delay And Signals On Choice Between Delayed Food Alone And Immediate Food With Delayed Shock, Forrest James Toegel
Effects Of Delay And Signals On Choice Between Delayed Food Alone And Immediate Food With Delayed Shock, Forrest James Toegel
Graduate Theses, Dissertations, and Problem Reports
Much of the research in the area of self-control has examined choice between small immediate reinforcers and large delayed reinforcers, but many problems result from situations in which a single choice produces consequences of conflicting valence: Those in which the immediate outcome is reinforcing and the delayed outcome is aversive. Recent research has evaluated how preference for a large reinforcer which is followed by a delayed shock changes as a function of the delay to shock and how the intensity and duration of delayed shock affects the value of a large reinforcer. The present set of experiments investigated how the …
Effects Of Reinforcement Rate On The Aversive Function Of Timeout From Positive Reinforcement, Cory Whirtley
Effects Of Reinforcement Rate On The Aversive Function Of Timeout From Positive Reinforcement, Cory Whirtley
Graduate Theses, Dissertations, and Problem Reports
Although the use of timeout from positive reinforcement is widespread and has been shown to be an effective punisher in clinical settings, the factors responsible for its effectiveness are not fully understood. The present experiment was designed to evaluate one of these factors, the reinforcement rate underway during periods of time-in. Rats’ lever pressing was maintained on variable-interval schedules of food reinforcement in a multiple schedule with two components. In one component, no timeouts were delivered. In the other component, when a variable-ratio schedule was met, lever presses were followed by a 30-s timeout during which a tone sounded, the …
The Effects Of Pre-Trial Event Stimulus Properties On Timing In The Peak Interval Procedure, Daniel A. Garces
The Effects Of Pre-Trial Event Stimulus Properties On Timing In The Peak Interval Procedure, Daniel A. Garces
Dissertations, Theses, and Capstone Projects
In the peak interval procedure, intruded conditioned stimuli produce shifts in peak/middle time towards later values, regardless of whether these stimuli are presented prior to or during the timing signal. Although the effects of during-trial stimulus properties—temporal location, duration, and salience—have been previously reported, no research exists on how before-trial stimulus properties influence the extent of shifts in middle time. In the present study, we manipulated within subjects both the temporal location and type (i.e., cue alone, response-independent reinforcer alone, or cue and response-contingent reinforcer together) of the pre-trial event. An individual-trial analysis suggested that the type of stimulus event …
Series Of Intermittent Heroin Injections Enhances Acquisition Of Operant Responding For Cues Paired With Natural Rewards, Jennifer Morrison
Series Of Intermittent Heroin Injections Enhances Acquisition Of Operant Responding For Cues Paired With Natural Rewards, Jennifer Morrison
Dissertations, Theses, and Capstone Projects
Repeated-intermittent heroin use has been implicated in altering learning processes. Ranaldi et al. (2009) and Morrison et al. (2011) demonstrated that repeated-intermittent heroin administration leads to an enhancement of conditioned reinforcement by a food-paired light stimulus; however, the mechanism governing this effect is still largely unknown. The aims of the present study were to examine modifications in Pavlovian and operant associations for cues paired with natural rewards after a series of intermittent heroin injections. The study consisted of three phases: (1) Pavlovian Conditioning Phase (4 days)- in which three groups of rats had a light stimulus paired with food, and …
An Exploration Of The Wheel-Induced Feeding-Suppression, Stephen Benjamin Peckham
An Exploration Of The Wheel-Induced Feeding-Suppression, Stephen Benjamin Peckham
Theses and Dissertations (Comprehensive)
Anorexia nervosa is an enigmatic human condition typified by food-restriction that is often accompanied by extensive exercise. This has been modeled in rats in the wheel-induced feeding-suppression (WIFS) model. In this model, animals are given access to a running-wheel, which induces a volitional drop in food-consumption. Short periods of wheel access have induced a feeding-suppression which is effectively reversed by chlorpromazine administration (Adams et al., 2009). Recent attempts at replicating Adams et al.’s (2009) feeding-suppression have, however, been unsuccessful (Peckham et al., 2013). These attempts raised questions as to whether or not the existing methodology is most effective at suppressing …
Does Nicotine Alter What Is Learned About Non-Drug Incentives?, Tarra L. Baker
Does Nicotine Alter What Is Learned About Non-Drug Incentives?, Tarra L. Baker
Undergraduate Honors Theses
Nicotine is one of the most addictive drugs known to man, yet it has limited reinforcing effects in humans and non-human animals when it is not self-administered in tobacco products. One hypothesis for these paradoxical effects of nicotine is that the effects of the drug in the brain alter acquisition of incentive learning. The hypothesis for this study is that nicotine will increase the value of cues paired with a reward. To test this hypothesis, 26 Sprague Dawley Male rats were randomly assigned to one of three groups Pre-NIC (the critical experimental group), Post-NIC and SAL. Each group received a …
Assessing The Generality Of A Bout Analysis In The Description Of Operant Behavior, J. Adam Bennett
Assessing The Generality Of A Bout Analysis In The Description Of Operant Behavior, J. Adam Bennett
Dissertations
Operant psychologists typically use response rate as a primary measure of behavior. Although response rate has proven a useful dependent measure resulting in the identification of many important behavioral regularities, many researchers have argued that the measure has significant limitations. Primarily, response rate treats all responses in the measured response class as functionally equivalent and distributed uniformly across time. This conceptualization of behavior is useful as long as all responses are affected similarly by different experimental manipulations. Research has shown, however, that certain manipulations differentially affect responses with relatively short or long interresponse times. This has led to a new …
A Rat Model Of Gambling Behavior And Its Extinction: Effects Of "Win" Probability On Choice In A Concurrent-Chains Procedure, David N. Kearns, Maria A. Gomez-Serrano
A Rat Model Of Gambling Behavior And Its Extinction: Effects Of "Win" Probability On Choice In A Concurrent-Chains Procedure, David N. Kearns, Maria A. Gomez-Serrano
Analysis of Gambling Behavior
Two experiments examined the effects of varying the probability of “wins” within a rat model of gambling. On a concurrent-chains procedure, rats could choose between a “work” lever on which a fixed 20 responses produced a food pellet or a “gamble” lever, where on some trials (“wins”) only one response was required for reinforcement while on other trials 40 responses were required. Despite the fact that the work lever was always associated with the higher overall reinforcement rate, rats frequently chose to respond on the gamble lever. The frequency with which rats chose the gamble lever varied as a function …
Blocking Of Acquisition But Not Expression Of Conditioned Fear-Potentiated Startle By Nmda Antagonists In The Amygdala, Mindy Miserendino, Catherine B. Sananes, Kathleen R. Melia, Michael Davis
Blocking Of Acquisition But Not Expression Of Conditioned Fear-Potentiated Startle By Nmda Antagonists In The Amygdala, Mindy Miserendino, Catherine B. Sananes, Kathleen R. Melia, Michael Davis
Psychology Faculty Publications
Assessed the role of N-methyl-{d}-aspartate (NMDA) receptors in the amygdala in associative fear conditioning. 132 rats were implanted with cannulae aimed at the basolateral amygdaloid nuclei, while 13 controls had cannulae aimed at the interpositus nuclei of the cerebellum. NMDA antagonists infused into the amygdala blocked the acquisition, but not the expression, of fear conditioning measured with a behavioral assay mediated by a defined neural circuit (fear-potentiation of the acoustic startle reflex). This effect showed anatomical and pharmacological specificity, and was not attributable to reduced salience of the stimuli of light or shock used in training. An NMDA-dependent process in …
Sub-Aversive Response Contingent Foot Shock As A Positive Reinforcer, Robert Lea Fulwiler
Sub-Aversive Response Contingent Foot Shock As A Positive Reinforcer, Robert Lea Fulwiler
All Master's Theses
Forty-eight rats were divided into 8 groups; four were maintained under normal conditions and the other four under sensory deprivation and tested at o, 3, 6, and 9 days after condition institution. The response was placing the head through a hole in the operant chamber and the stimulus (0, 1.2, 4, or 12 Vac) was contingent upon the response. Analysis ot variance disclosed significant differences (p<.01) between the deprived and the non-deprived groups at days 6 and 9; and a significant interaction between deprivation condition and time of test. No differences were shown between the stimulus intensities indicating that the stimulus did not have a reinforcing effect.