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Full-Text Articles in Computational Linguistics
Data-Driven Neuroanatomical Subtypes In Various Stages Of Schizophrenia: Linking Cortical Thickness, Glutamate, And Language Functioning, Liangbing Liang
Data-Driven Neuroanatomical Subtypes In Various Stages Of Schizophrenia: Linking Cortical Thickness, Glutamate, And Language Functioning, Liangbing Liang
Electronic Thesis and Dissertation Repository
The considerable variation in the spatial distribution of cortical thickness changes has been used to parse heterogeneity in schizophrenia. We aimed to recover a ‘cortical impoverishment’ subgroup with widespread cortical thinning. We applied hierarchical cluster analysis to cortical thickness data of three datasets in different stages of psychosis and studied the cognitive, functional, neurochemical, language and symptom profiles of the observed subgroups. Our consensus-based clustering procedure consistently produced a subgroup characterized by significantly lower cortical thickness. This ‘cortical impoverishment’ subgroup was associated with a higher symptom burden in a clinically stable sample and higher glutamate levels with language impairments in …
Quantifying Coherence In A Transdiagnostic Sample: A Methodological Investigation Of Computationally-Derived Coherence Using Ambulatory Assessment, Taylor L. Fedechko
Quantifying Coherence In A Transdiagnostic Sample: A Methodological Investigation Of Computationally-Derived Coherence Using Ambulatory Assessment, Taylor L. Fedechko
LSU Master's Theses
Schizophrenia is a clinical diagnosis assigned to individuals that experience positive (e.g., hallucinations and delusions), negative (e.g., blunted affect), and disorganized (e.g., incoherent speech) symptoms. One particularly disabling symptom is incoherence, which is defined as the meaning-based relationship between ideas. This symptom can drastically affect an individual’s quality of life by affecting areas such as social and occupational functioning. Currently, the mechanism behind this symptom is unknown and requires further study. One way to examine incoherence is to understand its level of expression in other clinical populations. With the advent of computationally-derived natural language processing (NLP), coherence can be quantified …