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Associations Between Male Testosterone And Immune Function In A Pathogenically Stressed Forager-Horticultural Population, Benjamin C. Trumble, Aaron D. Blackwell, Jonathan Stieglitz, Melissa Emery Thompson, Ivan Maldonado Suarez, Hillard Kaplan, Michael Gurven
Associations Between Male Testosterone And Immune Function In A Pathogenically Stressed Forager-Horticultural Population, Benjamin C. Trumble, Aaron D. Blackwell, Jonathan Stieglitz, Melissa Emery Thompson, Ivan Maldonado Suarez, Hillard Kaplan, Michael Gurven
ESI Publications
Objectives—Despite well-known fitness advantages to males who produce and maintain high endogenous testosterone levels, such phenotypes may be costly if testosterone-mediated investment in reproductive effort trade-off against investment in somatic maintenance. Previous studies of androgen-mediated trade-offs in human immune function find mixed results, in part because most studies either focus on a few indicators of immunity, are confounded by phenotypic correlation, or are observational. Here the association between male endogenous testosterone and 13 circulating cytokines are examined before and after ex vivo antigen stimulation with phytohaemagglutinin (PHA) and lipopolysaccharides (LPS) in a high pathogen population of Bolivian forager-horticulturalists.
Materials …