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UW Biostatistics Working Paper Series
Competing risks; Genetic data; Nonparametric statistics; Mark variable; Proportionalhazards; Survival analysis
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Full-Text Articles in Statistical Methodology
The Two-Sample Problem For Failure Rates Depending On A Continuous Mark: An Application To Vaccine Efficacy, Peter B. Gilbert, Ian W. Mckeague, Yanqing Sun
The Two-Sample Problem For Failure Rates Depending On A Continuous Mark: An Application To Vaccine Efficacy, Peter B. Gilbert, Ian W. Mckeague, Yanqing Sun
UW Biostatistics Working Paper Series
The efficacy of an HIV vaccine to prevent infection is likely to depend on the genetic variation of the exposing virus. This paper addresses the problem of using data on the HIV sequences that infect vaccine efficacy trial participants to 1) test for vaccine efficacy more powerfully than procedures that ignore the sequence data; and 2) evaluate the dependence of vaccine efficacy on the divergence of infecting HIV strains from the HIV strain that is contained in the vaccine. Because hundreds of amino acid sites in each HIV genome are sequenced, it is natural to treat the divergence (defined in …