Statistical Methodology Commons^™

Confidence Intervals For The Selected Population In Randomized Trials That Adapt The Population Enrolled, Michael Rosenblum

Johns Hopkins University, Dept. of Biostatistics Working Papers

It is a challenge to design randomized trials when it is suspected that a treatment may benefit only certain subsets of the target population. In such situations, trial designs have been proposed that modify the population enrolled based on an interim analysis, in a preplanned manner. For example, if there is early evidence that the treatment only benefits a certain subset of the population, enrollment may then be restricted to this subset. At the end of such a trial, it is desirable to draw inferences about the selected population. We focus on constructing confidence intervals for the average treatment effect …