Statistical Methodology Commons^™

On Simes’S Second Conjecture: An Extended Single-Step Simes Test Procedure For Multiple Testing, Matthew G. Hudson

Dissertations

One of the major concerns with multiple tests of significance is controlling the family wise error rate. Various methods have been developed to ensure that the false positive rate be maintained at some prespecified level. One of the most well know being the Bonferroni procedure. Simes presented an improved Bonferroni procedure for testing the global hypothesis that is more powerful and less conservative, especially with positively correlated tests. While Simes’s procedure is more powerful, it does not allow for making inferences on the individual hypotheses. However, the Simes procedure has since become the foundation of many p-value based multiple testing …