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Aspects Of Stochastic Geometric Mechanics In Molecular Biophysics, David Frost
Aspects Of Stochastic Geometric Mechanics In Molecular Biophysics, David Frost
All Dissertations
In confocal single-molecule FRET experiments, the joint distribution of FRET efficiency and donor lifetime distribution can reveal underlying molecular conformational dynamics via deviation from their theoretical Forster relationship. This shift is referred to as a dynamic shift. In this study, we investigate the influence of the free energy landscape in protein conformational dynamics on the dynamic shift by simulation of the associated continuum reaction coordinate Langevin dynamics, yielding a deeper understanding of the dynamic and structural information in the joint FRET efficiency and donor lifetime distribution. We develop novel Langevin models for the dye linker dynamics, including rotational dynamics, based …
Long Time Asymptotics Of Ornstein-Uhlenbeck Processes In Poisson Random Media, Fei Xing
Long Time Asymptotics Of Ornstein-Uhlenbeck Processes In Poisson Random Media, Fei Xing
Doctoral Dissertations
The Models of Random Motions in Random Media (RMRM) have been shown to have fruitful applications in various scientific areas such as polymer physics, statistical mechanics, oceanography, etc. In this dissertation, we consider a special model of RMRM: the Ornstein-Uhlenbeck process in a Poisson random medium and investigate the long time evolution of its random energy. We give complete answers to the long time asymptotics of the exponential moments of the random energy with both positive and negative coefficients, under both quenched and annealed regimes. Through these results, we find out a dramatic difference between the long time behavior of …
A Study Of Poisson And Related Processes With Applications, Phillip Mingola
A Study Of Poisson And Related Processes With Applications, Phillip Mingola
Chancellor’s Honors Program Projects
No abstract provided.