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Conformational Analysis Of Nonsteroidal Estrogen Analogs, Robert N. Spady
Conformational Analysis Of Nonsteroidal Estrogen Analogs, Robert N. Spady
Loma Linda University Electronic Theses, Dissertations & Projects
In target tissue, estrogens initiate a series of events, ending in protein synthesis, by binding to a cytoplasmic receptor. Once the estrogen binds, the receptor complex is activated--a process including dimerization of the estrogen complex with another subunit. In order to study the possible receptor-ligand interactions, conformational analysis was performed on several nonsteroidal estrogen analogs, using the CAMSEQ8 molecular mechanics program.
The probability that a molecule will exist in a given conformational energy well depends both on the energy and the shape of the well. A method has been previously worked out to calculate probabilities using both of these variables, …