Other Statistics and Probability Commons^™

Trans-10, Cis-12 Conjugated Linoleic Acid Causes Inflammation And Delipidation Of White Adipose Tissue In Mice: A Microarray And Histological Analysis, P. Christopher Larosa, Jess L. Miner, Yuannan Xia, You Zhou, Stephen D. Kachman, Michael Fromm

Department of Statistics: Faculty Publications

A combined histological and microarray analysis of the white adipose tissue (WAT) of mice fed trans-10, cis-12 conjugated linoleic acid (t10c12 CLA) was performed to better define functional responses. Mice fed t10c12 CLA for 14 days lost 85% of WAT mass, 95% of adipocyte lipid droplet volume, and 15 or 47% of the number of adipocytes and total cells, respectively. Microarray profiling of replicated pools (n = 2 per day x diet) of control and treated mice (n = 140) at seven time points after 1–17 days of t10c12 CLA feeding found between 2,682 and 4,216 …