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Functional connectivity; spatio-temporal dependency; EM algorithm; functional magnetic resonance imaging (fMRI); generalized fused lasso; group lasso; graphical lasso; network estimation; Gaussian graphical model; high-dimensional
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Full-Text Articles in Multivariate Analysis
Statistical Approaches For Estimation And Comparison Of Brain Functional Connectivity, Jifang Zhao
Statistical Approaches For Estimation And Comparison Of Brain Functional Connectivity, Jifang Zhao
Theses and Dissertations
Drug addiction can lead to many health-related problems and social concerns. Functional connectivity obtained from functional magnetic resonance imaging (fMRI) data promotes a variety of fundamental understandings in such association. Due to its complex correlation structure and large dimensionality, the modeling and analysis of the functional connectivity from neuroimage are challenging. By proposing a spatio-temporal model for multi-subject neuroimage data, we incorporate voxel-level spatio-temporal dependencies of whole-brain measurements to improve the accuracy of statistical inference. To tackle large-scale spatio-temporal neuroimage data, we develop a computationally efficient algorithm to estimate the parameters. Our method is used to identify functional connectivity and …