Multivariate Analysis Commons^™

Nonparametric Derivative Estimation Using Penalized Splines: Theory And Application, Bright Antwi Boasiako

Doctoral Dissertations

This dissertation is in the field of Nonparametric Derivative Estimation using
Penalized Splines. It is conducted in two parts. In the first part, we study the L2
convergence rates of estimating derivatives of mean regression functions using penalized splines. In 1982, Stone provided the optimal rates of convergence for estimating derivatives of mean regression functions using nonparametric methods. Using these rates, Zhou et. al. in their 2000 paper showed that the MSE of derivative estimators based on regression splines approach zero at the optimal rate of convergence. Also, in 2019, Xiao showed that, under some general conditions, penalized spline estimators …

Model-Free Descriptive Modeling For Multivariate Categorical Data With An Ordinal Dependent Variable, Li Wang

Doctoral Dissertations

In the process of statistical modeling, the descriptive modeling plays an essential role in accelerating the formulation of plausible hypotheses in the subsequent explanatory modeling and facilitating the selection of potential variables in the subsequent predictive modeling. Especially, for multivariate categorical data analysis, it is desirable to use the descriptive modeling methods for uncovering and summarizing the potential association structure among multiple categorical variables in a compact manner. However, many classical methods in this case either rely on strong assumptions for parametric models or become infeasible when the data dimension is higher. To this end, we propose a model-free method …

Regression Analysis For Ordinal Outcomes In Matched Study Design: Applications To Alzheimer's Disease Studies, Elizabeth Austin

Masters Theses

Alzheimer's Disease (AD) affects nearly 5.4 million Americans as of 2016 and is the most common form of dementia. The disease is characterized by the presence of neurofibrillary tangles and amyloid plaques [1]. The amount of plaques are measured by Braak stage, post-mortem. It is known that AD is positively associated with hypercholesterolemia [16]. As statins are the most widely used cholesterol-lowering drug, there may be associations between statin use and AD. We hypothesize that those who use statins, specifically lipophilic statins, are more likely to have a low Braak stage in post-mortem analysis.

In order to address this hypothesis, …