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Full-Text Articles in Multivariate Analysis
Reconstructability Of Epistatic Functions, Martin Zwick, Joe Fusion, Beth Wilmot
Reconstructability Of Epistatic Functions, Martin Zwick, Joe Fusion, Beth Wilmot
Systems Science Faculty Publications and Presentations
Background: Reconstructability Analysis (RA) has been used to detect epistasis in genomic data; in that work, even the simplest RA models (variable-based models without loops) gave performance superior to two other methods. A follow-on theoretical study showed that RA also offers higher-resolution models, namely variable-based models with loops and state-based models, likely to be even more effective in modeling epistasis, and also described several mathematical approaches to classifying types of epistasis.
Methods: The present paper extends this second study by discussing a non-standard use of RA: the analysis of epistasis in quantitative as opposed to nominal variables; such quantitative variables …