Design of Experiments and Sample Surveys Commons^™

Bayesian Approach To Average Power Calculations For Binary Regression Models With Misclassified Outcomes, Dunlei Cheng, James D. Stamey, Adam J. Branscum

Dunlei Cheng

We develop a simulation-based procedure for determining the required sample size in binomial regression risk assessment studies when response data are subject to misclassification. A Bayesian average power criterion is used to determine a sample size that provides high probability, averaged over the distribution of potential future data sets, of correctly establishing the direction of association between predictor variables and the probability of event occurrence. The method is broadly applicable to any parametric binomial regression model including, but not limited to, the popular logistic, probit, and complementary log-log models. We detail a common medical scenario wherein ascertainment of true disease …