Applied Statistics Commons^™

Comparing Performance Of Gene Set Test Methods Using Biologically Relevant Simulated Data, Richard M. Lambert

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Today we know that there are many genetically driven diseases and health conditions. These problems often manifest only when a set of genes are either active or inactive. Recent technology allows us to measure the activity level of genes in cells, which we call gene expression. It is of great interest to society to be able to statistically compare the gene expression of a large number of genes between two or more groups. For example, we may want to compare the gene expression of a group of cancer patients with a group of non-cancer patients to better understand the genetic …

Statistical Design Of Experiment Techniques In Manufacturing, Caroline M. Kerfonta

Senior Theses

There are many statistical techniques used to design experiments. These techniques are used in many different fields. This thesis will focus on the use of the three most common techniques used to design statistical experiments in manufacturing.

The three techniques that will be investigated are completely randomized design, randomized block design, and factorial design. These techniques will be compared, contrasted, and explained. Research examples will be presented along with sample R code for each technique. These examples will be accompanied by analysis of the techniques as well as an overview of the uses and history of experiments in manufacturing

Bayesian Analytical Approaches For Metabolomics : A Novel Method For Molecular Structure-Informed Metabolite Interaction Modeling, A Novel Diagnostic Model For Differentiating Myocardial Infarction Type, And Approaches For Compound Identification Given Mass Spectrometry Data., Patrick J. Trainor

Electronic Theses and Dissertations

Metabolomics, the study of small molecules in biological systems, has enjoyed great success in enabling researchers to examine disease-associated metabolic dysregulation and has been utilized for the discovery biomarkers of disease and phenotypic states. In spite of recent technological advances in the analytical platforms utilized in metabolomics and the proliferation of tools for the analysis of metabolomics data, significant challenges in metabolomics data analyses remain. In this dissertation, we present three of these challenges and Bayesian methodological solutions for each. In the first part we develop a new methodology to serve a basis for making higher order inferences in metabolomics, …

Pseudo Power Law Statistics In A Jammed, Amorphous Solid, Jacob Brian Hass

Physics

Simulations have shown that in many solid materials, rearrangements within the solid obey power-law statistics. A connection has been proposed between these statistics and the ability of a system to reach a limit cycle under cyclic driving. We study experimentally a 2D jammed solid that reaches such a limit cycle. Our solid consists of microscopic plastic beads adsorbed at an oil-water interface and cyclically sheared by a magnetically driven needle. We track each particles trajectory in the solid to identify rearrangements. By associating particles both spatially and temporally, we can measure the extent of each rearrangement. We study specifically the …

Analysis Of 2016-17 Major League Soccer Season Data Using Poisson Regression With R, Ian D. Campbell

Undergraduate Theses and Capstone Projects

To the outside observer, soccer is chaotic with no given pattern or scheme to follow, a random conglomeration of passes and shots that go on for 90 minutes. Yet, what if there was a pattern to the chaos, or a way to describe the events that occur in the game quantifiably. Sports statistics is a critical part of baseball and a variety of other of today’s sports, but we see very little statistics and data analysis done on soccer. Of this research, there has been looks into the effect of possession time on the outcome of a game, the difference …

The Psychology Of Baseball: How The Mental Game Impacts The Physical Game, Kiera Dalmass

Honors Scholar Theses

The purpose of this study was to find whether or not sports psychology can be effective. Baseball was chosen as the sport for the study because baseball can be analyzed for nearly every single factor of the game, with the exception of the mental readiness or state of the player when he steps onto the field. It therefore provides the optimal atmosphere to provide clinical and statistical support to the field of sports psychology. Despite the various, numerous pieces of literature that praise and show support for sports psychology, there hasn’t been clinical research to support it. Additionally, multiple sports …

Developing Statistical Methods For Data From Platforms Measuring Gene Expression, Gaoxiang Jia

Statistical Science Theses and Dissertations

This research contains two topics: (1) PBNPA: a permutation-based non-parametric analysis of CRISPR screen data; (2) RCRnorm: an integrated system of random-coefficient hierarchical regression models for normalizing NanoString nCounter data from FFPE samples.

Clustered regularly-interspaced short palindromic repeats (CRISPR) screens are usually implemented in cultured cells to identify genes with critical functions. Although several methods have been developed or adapted to analyze CRISPR screening data, no single spe- cific algorithm has gained popularity. Thus, rigorous procedures are needed to overcome the shortcomings of existing algorithms. We developed a Permutation-Based Non-Parametric Analysis (PBNPA) algorithm, which computes p-values at the gene level …

Sabermetrics - Statistical Modeling Of Run Creation And Prevention In Baseball, Parker Chernoff

FIU Electronic Theses and Dissertations

The focus of this thesis was to investigate which baseball metrics are most conducive to run creation and prevention. Stepwise regression and Liu estimation were used to formulate two models for the dependent variables and also used for cross validation. Finally, the predicted values were fed into the Pythagorean Expectation formula to predict a team’s most important goal: winning.

Each model fit strongly and collinearity amongst offensive predictors was considered using variance inflation factors. Hits, walks, and home runs allowed, infield putouts, errors, defense-independent earned run average ratio, defensive efficiency ratio, saves, runners left on base, shutouts, and walks per …

On The Performance Of Some Poisson Ridge Regression Estimators, Cynthia Zaldivar

FIU Electronic Theses and Dissertations

Multiple regression models play an important role in analyzing and making predictions about data. Prediction accuracy becomes lower when two or more explanatory variables in the model are highly correlated. One solution is to use ridge regression. The purpose of this thesis is to study the performance of available ridge regression estimators for Poisson regression models in the presence of moderately to highly correlated variables. As performance criteria, we use mean square error (MSE), mean absolute percentage error (MAPE), and percentage of times the maximum likelihood (ML) estimator produces a higher MSE than the ridge regression estimator. A Monte Carlo …

Essentials Of Structural Equation Modeling, Mustafa Emre Civelek

Zea E-Books Collection

Structural Equation Modeling is a statistical method increasingly used in scientific studies in the fields of Social Sciences. It is currently a preferred analysis method, especially in doctoral dissertations and academic researches. However, since many universities do not include this method in the curriculum of undergraduate and graduate courses, students and scholars try to solve the problems they encounter by using various books and internet resources.

This book aims to guide the researcher who wants to use this method in a way that is free from math expressions. It teaches the steps of a research program using structured equality modeling …

Decision Trees: Predicting Future Losses For Insurance Data, Amanda Lahrmann

Williams Honors College, Honors Research Projects

Big data is a term that has come to the spotlight for companies within recent years. Data analysis and business intelligence have become prominent sectors of companies and agencies. But what is big data? How has it impacted large companies and agencies? Why must it be embraced?

The best way to approach utilizing a big data set is to establish a question to answer. For this data set, the question that must be answered is “What variables cause a loss to occur?” To answer this question, first, we must understand what is meant by a “loss”, and take a look …