Applied Statistics Commons^™

Comparing Performance Of Gene Set Test Methods Using Biologically Relevant Simulated Data, Richard M. Lambert

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Today we know that there are many genetically driven diseases and health conditions. These problems often manifest only when a set of genes are either active or inactive. Recent technology allows us to measure the activity level of genes in cells, which we call gene expression. It is of great interest to society to be able to statistically compare the gene expression of a large number of genes between two or more groups. For example, we may want to compare the gene expression of a group of cancer patients with a group of non-cancer patients to better understand the genetic …

Pooling Of Variances: The Skeleton In The Mixed Model Closet?, Philip M. Dixon

Conference on Applied Statistics in Agriculture and Natural Resources

I explore three related issues concerning pooling of error variances: when is it appropriate (or not) to pool, how best to evaluate equality of variances, and whether there is a cost to never pooling. I focus on pooling decisions in a combined analysis of a multi-site experiment. A-priori, sites should have different error variances. My primary question is whether an analysis that ignores unequal variances is wrong.

I find that ignoring heteroscedasticity between sites maintains, or provides slightly conservative, tests of average treatment effects and treatment-by-site interactions. Models with site-specific variances do provide more powerful tests when variances are different. …

Examining Quadratic Relationships Between Traits And Methods In Two Multitrait-Multimethod Models, Fredric A. Hintz

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Psychological researchers are interested in the validity of the measures they use, and the multitrait-multimethod design is one of the most frequently employed methods to examine validity. Confirmatory factor analysis is now a commonly used analytic tool for examining multitrait-multimethod data, where an underlying mathematical model is fit to data and the amount of variance due to the trait and method factors is estimated. While most contemporary confirmatory factor analysis methods for examining multi-trait multi-method data do not allow relationships between the trait and method factors, a few recently proposed models allow for the examination of linear relationships between traits …