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Full-Text Articles in Applied Statistics
Comparison Of Methods For Estimating The Effect Of Salvage Therapy In Prostate Cancer When Treatment Is Given By Indication., Jeremy Taylor, Jincheng Shen, Edward Kennedy, Lu Wang, Douglas Schaubel
Comparison Of Methods For Estimating The Effect Of Salvage Therapy In Prostate Cancer When Treatment Is Given By Indication., Jeremy Taylor, Jincheng Shen, Edward Kennedy, Lu Wang, Douglas Schaubel
Edward H. Kennedy
For patients who were previously treated for prostate cancer, salvage hormone therapy is frequently given when the longitudinal marker prostate-specific antigen begins to rise during follow-up. Because the treatment is given by indication, estimating the effect of the hormone therapy is challenging. In a previous paper we described two methods for estimating the treatment effect, called two-stage and sequential stratification. The two-stage method involved modeling the longitudinal and survival data. The sequential stratification method involves contrasts within matched sets of people, where each matched set includes people who did and did not receive hormone therapy. In this paper, we evaluate …
The Effect Of Salvage Therapy On Survival In A Longitudinal Study With Treatment By Indication, Edward Kennedy, Jeremy Taylor, Douglas Schaubel, Scott Williams
The Effect Of Salvage Therapy On Survival In A Longitudinal Study With Treatment By Indication, Edward Kennedy, Jeremy Taylor, Douglas Schaubel, Scott Williams
Edward H. Kennedy
We consider using observational data to estimate the effect of a treatment on disease recurrence, when the decision to initiate treatment is based on longitudinal factors associated with the risk of recurrence. The effect of salvage androgen deprivation therapy (SADT) on the risk of recurrence of prostate cancer is inadequately described by the existing literature. Furthermore, standard Cox regression yields biased estimates of the effect of SADT, since it is necessary to adjust for prostate-specific antigen (PSA), which is a time-dependent confounder and an intermediate variable. In this paper, we describe and compare two methods which appropriately adjust for PSA …