Open Access. Powered by Scholars. Published by Universities.®
- Institution
- Keyword
Articles 1 - 2 of 2
Full-Text Articles in Applied Statistics
Iterative Statistical Verification Of Probabilistic Plans, Colin M. Potts
Iterative Statistical Verification Of Probabilistic Plans, Colin M. Potts
Lawrence University Honors Projects
Artificial intelligence seeks to create intelligent agents. An agent can be anything: an autopilot, a self-driving car, a robot, a person, or even an anti-virus system. While the current state-of-the-art may not achieve intelligence (a rather dubious thing to quantify) it certainly achieves a sense of autonomy. A key aspect of an autonomous system is its ability to maintain and guarantee safety—defined as avoiding some set of undesired outcomes. The piece of software responsible for this is called a planner, which is essentially an automated problem solver. An advantage computer planners have over humans is their ability to consider and …
A Bayesian Regression Tree Approach To Identify The Effect Of Nanoparticles Properties On Toxicity Profiles, Cecile Low-Kam, Haiyuan Zhang, Zhaoxia Ji, Tian Xia, Jeffrey I. Zinc, Andre Nel, Donatello Telesca
A Bayesian Regression Tree Approach To Identify The Effect Of Nanoparticles Properties On Toxicity Profiles, Cecile Low-Kam, Haiyuan Zhang, Zhaoxia Ji, Tian Xia, Jeffrey I. Zinc, Andre Nel, Donatello Telesca
COBRA Preprint Series
We introduce a Bayesian multiple regression tree model to characterize relationships between physico-chemical properties of nanoparticles and their in-vitro toxicity over multiple doses and times of exposure. Unlike conventional models that rely on data summaries, our model solves the low sample size issue and avoids arbitrary loss of information by combining all measurements from a general exposure experiment across doses, times of exposure, and replicates. The proposed technique integrates Bayesian trees for modeling threshold effects and interactions, and penalized B-splines for dose and time-response surfaces smoothing. The resulting posterior distribution is sampled via a Markov Chain Monte Carlo algorithm. This …